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Giovanna Lucchini
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Journal Articles

CD19/CD22 targeting with cotransduced CAR T cells to prevent antigen-negative relapse after CAR T-cell therapy for B-cell ALL

Clinical Trials & Observations Brief Report
Sara Ghorashian, Giovanna Lucchini, Rachel Richardson, Kyvi Nguyen, Craig Terris, Aleks Guvenel, Macarena Oporto-Espuelas, Jenny Yeung, Danielle Pinner, Jan Chu, Lindsey Williams, Ka-Yuk Ko, Chloe Walding, Kelly Watts, Sarah Inglott, Rebecca Thomas, Christopher Connor, Stuart Adams, Emma Gravett, Kimberly Gilmour, Alka Lal, Sangeetha Kunaseelan, Bilyana Popova, Andre Lopes, Yenting Ngai, Allan Hackshaw, Evangelia Kokalaki, Milena Balasch Carulla, Khushnuma Mullanfiroze, Arina Lazareva, Vesna Pavasovic, Anupama Rao, Jack Bartram, Ajay Vora, Robert Chiesa, Juliana Silva, Kanchan Rao, Denise Bonney, Robert Wynn, Martin Pule, Rachael Hough, Persis J. Amrolia
Journal: Blood
Blood (2024) 143 (2): 118–123.
https://doi.org/10.1182/blood.2023020621
Published: 2024
Includes: Supplemental data
Journal Articles

A Single Centre Cohort Study of Monitoring B Cell Populations in the Bone Marrow and Peripheral Blood Post Tisagenlecleucel Therapy of Relapsed/Refractory Acute Lymphoblastic Leukaemia

Sneha Fernandes, Archana Rauthan, Macarena Oporto Epuelas, Katherine Berry, Saskia Burridge, Charlotte Twigdon-Williams, Christopher Connor, Mark Davis, Kimberly Gilmour, Rebecca Thomas, Phil Ancliff, Jack Bartram, Robert Chiesa, Giovanna Lucchini, Vesna Pavasovic, Anupama Rao, Kanchan Rao, Sujith Samarasinghe, Juliana Silva, Ajay Vora, Persis Amrolia, Sara Ghorashian
Journal: Blood
Blood (2023) 142 (Supplement 1): 3508.
https://doi.org/10.1182/blood-2023-182730
Published: 2023
Journal Articles

Tvt CAR7: Phase 1 Clinical Trial of Base-Edited "Universal” CAR7 T Cells for Paediatric Relapsed/Refractory T-ALL

Robert Chiesa, Christos Georgiadis, Giorgio Ottaviano, Farhatullah Syed, Toni Braybrook, Annie Etuk, Hong Zhan, Soragia Athina Gkazi, Roland Preece, Stuart Adams, Rebecca Thomas, Arnold Awuah, Kimberly Gilmour, Lana Mhaldien, Jan Chu, Danielle Pinner, Agnieszka Kubat, Paul Veys, Kanchan Rao, Giovanna Lucchini, David O'Connor, Ajay Vora, Waseem Qasim
Journal: Blood
Blood (2022) 140 (Supplement 1): 4579–4580.
https://doi.org/10.1182/blood-2022-169114
Published: 2022
Journal Articles

Dual Antigen Targeting with Co-Transduced CD19/22 CAR T Cells May Prevent Antigen-Negative Relapse after CAR T Cell Therapy for Relapsed/Refractory ALL

Sara Ghorashian, Giovanna Lucchini, Rachel Richardson, Kyvi Nguyen, Craig Terris, Macarena Oporto-Espuelas, Jenny Yeung, Danielle Pinner, Jan Chu, Lindsey Williams, Ka-yuk Ko, Chloe Walding, Kelly Watts, Sarah Inglott, Stuart Adams, Emma Gravett, Kimberly Gilmour, Alka Lal, Sangeetha Kunaseelan, Bilyana Popova, Andre Lopes, Yenting Ngai, Evangelia K Kokalaki, Milena Balasch Carulla, Khushnuma Mullanfiroze, Arina Lazareva, Vesna Pavasovic, Anupama Rao, Jack Bartram, Ajay Vora, Robert Chiesa, Juliana Silva, Kanchan Rao, Katherine Clesham, Denise Bonney, Robert F Wynn, Martin Pule, Rachael E Hough, Persis J Amrolia
Journal: Blood
Blood (2022) 140 (Supplement 1): 10352–10354.
https://doi.org/10.1182/blood-2022-164879
Published: 2022
Journal Articles

Outcomes of Children and Young Adults with Acute Lymphoblastic Leukaemia Administered Inotuzumab Pre CAR-T Therapy

Khushnuma Mullanfiroze, Giorgio Ottaviano, Avijeet K Mishra, Maria Gabelli, Arina Lazareva, Saskia Burridge, Susan Farish, Jan Chu, Kirsty Sharplin, David I. Marks, Maeve A O'Reilly, Emma Nicholson, Kelly Watts, Denise Bonney, Danny Cheng, Jack Bartram, Sujith Samarasinghe, Vesna Pavasovic, Anupama Rao, Philip Ancliffe, Ajay Vora, Giovanna Lucchini, Robert Chiesa, Paul Veys, Kanchan Rao, Persis J Amrolia, Sara Ghorashian
Journal: Blood
Blood (2021) 138 (Supplement 1): 1743.
https://doi.org/10.1182/blood-2021-148820
Published: 2021
Journal Articles

COVID-19 Infection of HSCT Recipients Is Associated with High Mortality but No Detectable Cytokine Storm at Presentation

Giovanna Lucchini, Elena Cozma, Aimee Jackson, Kimberly Gilmour, Rachel Elizabeth Protheroe, Eleni Tholouli, Robert F Wynn, Keith Wilson, Karl S Peggs, Victoria Potter, Anne Parker, Charles Craddock, Shankara Paneesha, Emma Nicholson, David I. Marks, Oana Mirci-Danicar, Christopher Parrish, Alexander M Martin, Graham McIlroy, Rebecca Bishop, Rebecca Collings, Ellie Williams, Persis J Amrolia
Journal: Blood
Blood (2021) 138 (Supplement 1): 1788.
https://doi.org/10.1182/blood-2021-146515
Published: 2021
Journal Articles

ALL Maintenance Treatment for Early Loss of B-Cell Aplasia after Tisagenlecleucel Therapy

Maria Gabelli, Macarena Oporto Espuelas, Denise Bonney, Saskia Burridge, Susan Farish, Khushnuma Mullanfiroze, Arina Lazareva, Sujith Samarasinghe, Philip Ancliffe, Ajay Vora, Jack Bartram, Emma Hedges, Kirsty Ware, Lindsey Young, Chiara Cugno, Lenka Chenchara, Juliana Silva, Oana Mirci-Danicar, Lynne Riley, Vesna Pavasovic, Anupama Rao, Paul Veys, Giovanna Lucchini, Robert Chiesa, Kanchan Rao, Persis J Amrolia, Sara Ghorashian
Journal: Blood
Blood (2021) 138 (Supplement 1): 3859.
https://doi.org/10.1182/blood-2021-152344
Published: 2021
Journal Articles

Hematopoietic cell transplantation in chronic granulomatous disease: a study of 712 children and adults

Robert Chiesa, Junfeng Wang, Henric-Jan Blok, Sheree Hazelaar, Benedicte Neven, Despina Moshous, Ansgar Schulz, Manfred Hoenig, Fabian Hauck, Amal Al Seraihy, Jolanta Gozdzik, Per Ljungman, Caroline A. Lindemans, Juliana F. Fernandes, Krzysztof Kalwak, Brigitte Strahm, Urs Schanz, Petr Sedlacek, Karl-Walter Sykora, Serap Aksoylar, Franco Locatelli, Polina Stepensky, Robert Wynn, Su Han Lum, Marco Zecca, Fulvio Porta, Mervi Taskinen, Brenda Gibson, Susanne Matthes, Musa Karakukcu, Mathias Hauri-Hohl, Paul Veys, Andrew R. Gennery, Giovanna Lucchini, Matthias Felber, Michael H. Albert, Dmitry Balashov, Arjan Lankester, Tayfun Güngör, Mary A. Slatter
Journal: Blood
Blood (2020) 136 (10): 1201–1211.
https://doi.org/10.1182/blood.2020005590
Published: 2020
Includes: Supplemental data
Journal Articles

Therapy of Paediatric B-ALL with a Fast Off Rate CD19 CAR Leads to Enhanced Expansion and Prolonged CAR T Cell Persistence in Patients with Low Bone Marrow Tumour Burden, and Is Associated with a Favourable Toxicity Profile

Sara Ghorashian, FRCPath, PhD, Anne Marijn Kramer, MD, Shimobi Onuoha, PhD, Gary Wright, Jack Luke Bartram, MD, Rachel Richardson, MSc, Sarah J Albon, MSc, Joan Casanovas Company, Fernanda Castro, Bilyana Popova, Krystal Villanueva, Jenny Yeung, Aleks Guvenel, PhD, Patrycja Wawrzyniecka, Danielle Pinner, Jan Chu, Giovanna Lucchini, Juliana Silva, MD, Oana Ciocarlie, Arina Lazareva, Sarah Inglott, Kimberly Gilmour, Gulrukh Ahsan, Kim Champion, Andre Lopes, Allan Hackshaw, Farzin Farzaneh, PhD, Robert Chiesa, Kanchan Rao, Denise Bonney, Sujith Samarasinghe, Nicholas John Goulden, MD PhD MRCPath, Ajay Vora, Paul Veys, MD PhD, Rachael E Hough, MD, Robert Wynn, Martin Pule, MD, Persis J Amrolia, FRCP, FRCPath, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 225.
https://doi.org/10.1182/blood-2019-125009
Published: 2019
Journal Articles

Children and Adults with Steroid-Refractory Acute Graft-Versus-Host Disease Respond to Treatment with the Mesenchymal Stroma Cell Preparation "MSC-FFM": Treatment Results for 92 Consecutive Patients

Peter Bader, MD PhD, Selim Kuci, Zyrafete Kuci, Shahrzad Bakhtiar, MD, Oliver Basu, Gesine Bug, Michael Dennis, MDMRCP,FRCPath, Johann Greil, MD, Aniko Barta, MD, Krisztián Kallay, MD, Peter Lang, MD, Giovanna Lucchini, MD, Raj Pol, Ansgar Schulz, MD, Karl-Walter Sykora, MD, Irene Teichert von Luettichau, MD, Grit Herter-Sprie, MD, Mohammad Ashab Uddin, Philip Jenkin, Abdulrahman Alsultan, Jochen Büchner, MDPhD, Jerry Stein, MD, Agnes Kelemen, MD, Andrea Jarisch, PhD MD, Jan Soerensen, MD, Emilia Salzmann-Manrique, Martin Hutter, Richard Schaefer, Erhard Seifried, MD, Shankara Paneesha, MD, Igor Novitzky-Basso, Aharon Gefen, Neta Nevo, MD, Gernot Beutel, MD, Paul G. Schlegel, MD, Thomas Klingebiel, MD, Halvard Bonig, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 603.
https://doi.org/10.1182/blood-2018-99-110599
Published: 2018
Journal Articles

Treatment dilemmas in asymptomatic children with primary hemophagocytic lymphohistiocytosis

Giovanna Lucchini, Rebecca Marsh, Kimberly Gilmour, Austen Worth, Zohreh Nademi, Anupama Rao, Claire Booth, Persis Amrolia, Juliana Silva, Robert Chiesa, Robert Wynn, Kai Lehmberg, Itziar Astigarraga, Tayfun Güngör, Jan Stary, Despina Moshous, Marianne Ifversen, Daniel Zinn, Michael Jordan, Ashish Kumar, Takahiro Yasumi, Paul Veys, Kanchan Rao
Journal: Blood
Blood (2018) 132 (19): 2088–2096.
https://doi.org/10.1182/blood-2018-01-827485
Published: 2018
Includes: Supplemental data
Journal Articles

Treatment Dilemmas in Asymptomatic Children with Primary Haemophagocytic Lymphohistiocytosis

Giovanna Lucchini, MD, Rebecca A Marsh, Kimberly Gilmour, Austen Worth, Anupama Rao, Claire Booth, Persis J Amrolia, Juliana Silva, MD, Robert Chiesa, Robert Wynn, MD, Kai Lehmberg, Itziar Astigarraga, Tayfun Guengoer, Jan Stary, Despina Moshous, Marianne Ifversen, Stephan Ehl, Daniel Zinn, MD, Paul Veys, MD PhD, Kanchan Rao
Journal: Blood
Blood (2017) 130 (Supplement 1): 3564.
https://doi.org/10.1182/blood.V130.Suppl_1.3564.3564
Published: 2017
Journal Articles

Preliminary Results of UCART19, an Allogeneic Anti-CD19 CAR T-Cell Product in a First-in-Human Trial (PALL) in Pediatric Patients with CD19+ Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia

Waseem Qasim, MD PhD, Oana Ciocarlie, Stuart Adams, PhD, Sarah Inglott, Claire Murphy, Christine Rivat, Gary Wright, Giovanna Lucchini, MD, Juliana Silva, MD, Kanchan Rao, Amina Zinaï, MD, Florence Binlich, MD, Sandra Dupouy, Pharm.D, PhD, Jeanne Pauly, PharmD, Svetlana Balandraud, MD, Frédéric Dubois, Cyril Konto, MD, Premal Patel, MD PhD BSPharm, Robert Chiesa, Sujith Samarasinghe, Havinder Hara, Alayna Boyle, Jan Chu, Danielle Pinner, Persis J Amrolia, Ajay Vora, MD, Anupama Rao, Philip Ancliffe, MD, Paul Veys, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1271.
https://doi.org/10.1182/blood.V130.Suppl_1.1271.1271
Published: 2017
Journal Articles

A Novel Low Affinity CD19CAR Results in Durable Disease Remissions and Prolonged CAR T Cell Persistence without Severe CRS or Neurotoxicity in Patients with Paediatric ALL

Sara Ghorashian, FRCPath, PhD, Anne Marijn Kramer, MD, Sarah Jayne Albon, BSc, MSc, Gary Wright, Fernanda Castro, Bilyana Popova, Joan Casanovas Company, Catherine Irving, Winston Vetharoy, Rachel Richardson, Danielle Pinner, Jan Chu, Giovanna Lucchini, MD, Juliana Silva, MD, Oana Ciocarlie, Sarah Inglott, Kim Champion, Allan Hackshaw, Farzin Farzaneh, PhD, Robert Chiesa, Kanchan Rao, Anupama Gopala Rao, MB, MRCP, MRCPath, Philip Ancliffe, MD, Sujith Samarasinghe, Ajay Vora, MD, Paul Veys, MD PhD, Rachael Hough, MD BMBS, FRCP, FRCPath, Robert Wynn, MD, Martin Pule, PhD, Persis J Amrolia
Journal: Blood
Blood (2017) 130 (Supplement 1): 806.
https://doi.org/10.1182/blood.V130.Suppl_1.806.806
Published: 2017
Journal Articles

Allogeneic Stem Cell Transplantation for the Treatment of Lymphoproliferative Disorders in Patients Affected By Primary Immunodeficiencies: The UK Experience

Giulia Prunotto, Giovanna Lucchini, MD, Sujith Samarasinghe, Robert Wynn, MD, Ajay Vora, MD, Ben Carpenter, Claire Gowdy, Kieran Mchugh, Andrew Gennery, MD, Paul Veys, MD PhD, Christopher Bacon, Simon Bomken
Journal: Blood
Blood (2017) 130 (Supplement 1): 4573.
https://doi.org/10.1182/blood.V130.Suppl_1.4573.4573
Published: 2017
Journal Articles

Treatment of Patients with Therapy-Refractory Acute GvHD with the Novel MSC Product "MSC-Ffm" Resulted in Excellent Response and Low Mortality: Post-Approval Observational Data from 69 Consecutive Patients

Peter Bader, MD PhD, Selim Kuci, Zyrafete Kuci, Shahrzad Bakhtiar, MD, Oliver Basu, MD, Gesine Bug, MD, Michael Dennis, MDMRCP,FRCPath, Johann Greil, MD, Aniko Barta, MD, Krisztián Kallay, MD, Peter J. Lang, MD, Giovanna Lucchini, MD, Raj Pol, Ansgar S. Schulz, MD, Karl-Walter Sykora, MD, Irene Teichert von Luettichau, MD, Grit Herter-Sprie, MD, Mohammad Ashab Uddin, Philip Jenkin, Abdulrahman S. Alsultan, MD, Jochen Büchner, MDPhD, Jerry Stein, MD, Agnes Kelemen, MD, Shankaranarayana Paneesha, Andrea Jarisch, PhD MD, Jan Soerensen, MD, Emilia Salzmann-Manrique, Erhard Seifried, MD PhD, Thomas Klingebiel, MD, Halvard Bonig, MD MA
Journal: Blood
Blood (2017) 130 (Supplement 1): 514.
https://doi.org/10.1182/blood.V130.Suppl_1.514.514
Published: 2017
Journal Articles

Stem cell transplantation for tetratricopeptide repeat domain 7A deficiency: long-term follow-up

Clinical Trials & Observations
Jochen Kammermeier, Giovanna Lucchini, Sung-Yun Pai, Austen Worth, Dyanne Rampling, Persis Amrolia, Juliana Silva, Robert Chiesa, Kanchan Rao, Gabriele Noble-Jamieson, Marco Gasparetto, Drew Ellershaw, Holm Uhlig, Neil Sebire, Mamoun Elawad, Luigi Notarangelo, Neil Shah, Paul Veys
Journal: Blood
Blood (2016) 128 (9): 1306–1308.
https://doi.org/10.1182/blood-2016-01-696385
Published: 2016
Includes: Supplemental data
Journal Articles

The Best of Both? Megadose Stem Cells with CD34 Selection and T-Cell Addback Enables Engraftment from Mismatched Unrelated Donors Using Reduced Toxicity Conditioning in Primary Immunodeficiency

Juliana Montibeller Silva, MD, Kanchan Rao, MNAMS (Paed), MRCP (Paed), Robert Chiesa, Stuart Adams, PhD, Margaret Brocklesby, Gulrukh Ahsan, Giovanna Lucchini, Paul Veys, Persis Jal Amrolia, Nicholas Goulden, MD PhD
Journal: Blood
Blood (2015) 126 (23): 4303.
https://doi.org/10.1182/blood.V126.23.4303.4303
Published: 2015
Journal Articles

Allogeneic Stem Cell Transplantation for Refractory Acute Myeloid Leukemia in Pediatric Patients: The UK Experience

Patricia M O'Hare, Giovanna Lucchini, Michelle Cummins, Paul Veys, Mike Potter, Sarah Lawson, Ajay J. Vora, Robert Wynn, Andrew Peniket, Keiren Kirkland, Rachel Pearce, Julia Perry, Persis Jal Amrolia
Journal: Blood
Blood (2015) 126 (23): 4404.
https://doi.org/10.1182/blood.V126.23.4404.4404
Published: 2015
Journal Articles

Safe and Effective Treatment of Graft Versus Host Disease with Platelet Lysate-Expanded Human Mesenchymal Stromal Cells: A Phase 1 Study On 47 Adult and Pediatric Patients

Martino Introna, MD, Giovanna Lucchini, Erica Dander, PhD, Attilio Rovelli, MD, Adriana Balduzzi, MD, Daniela Longoni, Fabio Pavan, Francesca Masciochi, Alessandra Algarotti, MD, Caterina Micò, MD, Anna Grassi, MD, Irene Cavattoni, MD, Sara Deola, MD, Giuseppe Gaipa, Daniela Belotti, Paolo Perseghin, MD, Matteo Parma, MD, Enrico Maria Pogliani, MD, Josée Golay, PhD, Elisa Gotti, Chiara Capelli, Sergio Cortelazzo, MD, Giovanna D'Amico, Andrea Biondi, MD, Alessandro Rambaldi, MD, Ettore Biagi, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 743.
https://doi.org/10.1182/blood.V120.21.743.743
Published: 2012