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Claire Roddie
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Journal Articles

The present and future for CAR-T cell therapy in adult B-cell ALL

Claire Roddie, Alexandros Rampotas
Journal: Blood
Blood blood.2023022922.
https://doi.org/10.1182/blood.2023022922
Published: 2024
Journal Articles

Development of a Phase 1 Study Evaluating the Activity of Modular CAR T for Multiple Myeloma (MCARTY) Targeting BCMA and CD19 for Improved Persistence

Lydia Sarah Hui Lee, Wen Chean Lim, Catriona Mactier, Juliana Dias Alves Pinto, Vitoria Pereira, Mhairi Vaughan, Louisa Green, Evie Lewin, John Garcia, Giulia Agliardi, Yashma Pathak, Riaz Jannoo, Leigh Wood, Bilyana Popova, Helen Holmes, Simon Thomas, Victoria Spanswick, William Wilson, Christopher Parrish, Rakesh Popat, Claire Roddie, Kwee Yong, Martin A. Pule
Journal: Blood
Blood (2023) 142 (Supplement 1): 350.
https://doi.org/10.1182/blood-2023-185085
Published: 2023
Journal Articles

Obecabtagene Autoleucel (obe-cel, AUTO1) for Relapsed/Refractory Adult B-cell Acute Lymphoblastic Leukemia (R/R B-ALL): Pooled Analysis of the Ongoing FELIX Phase Ib/II Study

Claire Roddie, Karamjeet S. Sandhu, Eleni Tholouli, Paul Shaughnessy, Pere Barba, Manuel Guerreiro, Michael R. Bishop, Jean A. Yared, Armin Ghobadi, Deborah Yallop, Aaron C. Logan, Amer M. Beitinjaneh, Jeremy M. Pantin, Martha Arellano, Sridhar Chaganti, Ram Malladi, Tobias Menne, Virginia Escamilla Gómez, Katharine Hodby, Krishna Gundabolu, Luke Mountjoy, Kristen M. O'Dwyer, Sameem Abedin, Hassan Alkhateeb, Bijal D. Shah, Pierre Lao-Sirieix, Gianfranco Pittari, Kapil Saxena, Yiyun Zhang, Wolfram Brugger, Martin A. Pule, Jae H. Park, Daniel J. DeAngelo, Elias Jabbour
Journal: Blood
Blood (2023) 142 (Supplement 1): 222.
https://doi.org/10.1182/blood-2023-179454
Published: 2023
Journal Articles

Long-Term Efficacy and Safety of Obecabtagene Autoleucel (obe-cel) in Adult Patients (pts) with Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia ([R/R B-ALL]; Pooled Analysis from ALLCAR19 and FELIX Phase Ib Studies) or Other B-cell Malignancies (ALLCAR19 Extension Study)

Claire Roddie, Eleni Tholouli, Paul Shaughnessy, Elias Jabbour, Aaron C. Logan, Katharine Hodby, Luke Mountjoy, Adrian John Clifton Bloor, David Irvine, David C. Linch, Kim H. Orchard, William Wilson, Bilyana Popova, Juliana Dias, Giulia Agliardi, Victoria Spanswick, Helen Lowe, Marina Mitsikakou, Eftychia Charalambous, Joanna Dawes, Meera Raymond, Yanqing Hu, Wolfram Brugger, Martin A. Pule, Jae H. Park, Karl Peggs
Journal: Blood
Blood (2023) 142 (Supplement 1): 2114.
https://doi.org/10.1182/blood-2023-180666
Published: 2023
Journal Articles

Immune effector cell–associated hematotoxicity: EHA/EBMT consensus grading and best practice recommendations

Kai Rejeski, Marion Subklewe, Mahmoud Aljurf, Emmanuel Bachy, Adriana Balduzzi, Pere Barba, Benedetto Bruno, Reuben Benjamin, Matteo G. Carrabba, Christian Chabannon, Fabio Ciceri, Paolo Corradini, Julio Delgado, Roberta Di Blasi, Raffaella Greco, Roch Houot, Gloria Iacoboni, Ulrich Jäger, Marie José Kersten, Stephan Mielke, Arnon Nagler, Francesco Onida, Zinaida Peric, Claire Roddie, Annalisa Ruggeri, Fermín Sánchez-Guijo, Isabel Sánchez-Ortega, Dominik Schneidawind, Maria-Luisa Schubert, John A. Snowden, Catherine Thieblemont, Max Topp, Pier Luigi Zinzani, John G. Gribben, Chiara Bonini, Anna Sureda, Ibrahim Yakoub-Agha
Journal: Blood
Blood (2023) 142 (10): 865–877.
https://doi.org/10.1182/blood.2023020578
Published: 2023
Includes: Supplemental data
Journal Articles

Dual targeting of CD19 and CD22 with bicistronic CAR-T cells in patients with relapsed/refractory large B-cell lymphoma

Clinical Trials & Observations
Claire Roddie, Lazaros J. Lekakis, Maria A. V. Marzolini, Aravind Ramakrishnan, Yiyun Zhang, Yanqing Hu, Vijay G. R. Peddareddigari, Nushmia Khokhar, Robert Chen, Silvia Basilico, Meera Raymond, Frederick Arce Vargas, Kevin Duffy, Wolfram Brugger, Maeve A. O’Reilly, Leigh Wood, David C. Linch, Karl S. Peggs, Carlos Bachier, Elizabeth Lihua Budde, Connie Lee Batlevi, Nancy Bartlett, David Irvine, Eleni Tholouli, Wendy Osborne, Kirit M. Ardeshna, Martin A. Pule
Journal: Blood
Blood (2023) 141 (20): 2470–2482.
https://doi.org/10.1182/blood.2022018598
Published: 2023
Includes: Supplemental data
Journal Articles

Brexucabtagene Autoleucel for Relapsed/Refractory Mantle Cell Lymphoma: Real-World Outcomes in the United Kingdom

Maeve A O'Reilly, Robin Sanderson, William Wilson, David Burns, Caroline Besley, Thomas Creasey, Ben Uttenthal, Johnathon Elliot, Claire Roddie, Andrea Kuhnl, Shankara Paneesha, Frances Seymour, Sunil Iyengar, Lourdes Rubio, Matthew Wilson, Stephen Boyle, Kathleen PL Cheok, Graham P. Collins, Rod Johnson, Andrew K. McMillan
Journal: Blood
Blood (2022) 140 (Supplement 1): 7519–7521.
https://doi.org/10.1182/blood-2022-165031
Published: 2022
Journal Articles

Recent Bendamustine Treatment before Apheresis Has a Negative Impact on Outcomes in Patients with Large B-Cell Lymphoma Receiving Chimeric Antigen Receptor T-Cell Therapy

Gloria Iacoboni, ANA Africa Martin Lopez, Katarzyna Aleksandra Jalowiec, Mi Kwon, Kai Rejeski, Víctor Navarro Garcés, Paula Amat, Juan Luis Reguera, Laura Gallur, Sara Gutierrez-Herrero, Claire Roddie, Gillen Oarbeascoa, Ana Benzaquén, Cecilia Carpio, Lucía López Corral, Rafael Hernani, Mariana Bastos-Oreiro, Marion Subklewe, Maeve O'Reilly, Lourdes Martín, Pere Barba
Journal: Blood
Blood (2022) 140 (Supplement 1): 1592–1594.
https://doi.org/10.1182/blood-2022-169783
Published: 2022
Journal Articles

Improvement in Lymphoma CAR-T Outcomes over Time in the UK - CAR-T Learning Curve or Better Bridging?

Stephen Boyle, Robin Sanderson, Maeve A. O'Reilly, Tobias F. Menne, Jane Norman, Adrian Bloor, Sanne Lugthart, Sridhar Chaganti, Carlos Gonzalez-Arias, Ceri Jones, Anne-Louise Latif, Reuben Benjamin, Piers Patten, Deborah Yallop, Victoria Potter, Claire Roddie, Andrea Kuhnl
Journal: Blood
Blood (2022) 140 (Supplement 1): 4649–4651.
https://doi.org/10.1182/blood-2022-159217
Published: 2022
Journal Articles

Safety, Efficiency and Long-Term Follow-up of AUTO1, a Fast-Off Rate CD19 CAR in Relapsed/Refractory B-Cell Acute Lymphoblastic Leukaemia and Other B-Cell Malignancies

Claire Roddie, Juliana Dias Alves Pinto, Maeve A O'Reilly, Marina Mitsikakou, Eftychia Charalambous, Louisa Green, Mhairi Vaughan, Giulia Agliardi, John Garcia, Evie Lewin, Mark W. Lowdell, Maria A V Marzolini, Leigh Wood, Helen Holmes, Yenting Ngai, Bilyana Popova, William Wilson, Sangeetha Kunaseelan, Victoria Spanswick, Helen Lowe, Leah Ensell, John A. Hartley, Simon Morley, David C. Linch, Adrian Bloor, David A. Irvine, Martin Pule, Karl S Peggs
Journal: Blood
Blood (2022) 140 (Supplement 1): 7452–7453.
https://doi.org/10.1182/blood-2022-167053
Published: 2022
Journal Articles

Systematic Intention to Treat Analysis of Real-World Outcomes in Children and Young Adults Receiving Tisagenlecleucel: From Elegibility through Treatment Failure

Macarena Oporto Espuelas, Saskia Burridge, Denise Bonney, Kelly Watts, Claire Roddie, Maeve A O'Reilly, Geoff Shenton, John A Snowden, Caroline Furness, Katarzyna Aleksandra Aleksandra Jalowiec, Lorna Neill, Katherine Clesham, Emma Nicholson, Anna Castleton, Amit Patel, Caroline Besley, Robert F Wynn, Ajay Vora, David I. Marks, Lindsay George, Ben Uttenthal, Sridhar Chaganti, Michelle Cummins, Persis J Amrolia, Rachael E Hough, Sara Ghorashian
Journal: Blood
Blood (2022) 140 (Supplement 1): 2408–2410.
https://doi.org/10.1182/blood-2022-162863
Published: 2022
Journal Articles

Safety and Efficacy of AUTO1, a Fast-Off Rate CD19 CAR in Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma (B-NHL) and Chronic Lymphocytic Leukaemia (CLL)

Claire Roddie, Juliana Dias, Maeve A O'Reilly, Amaia Cadinanos Garai, Louisa Green, Mahnaz Abbasian, Marina Mitsikakou, Mhairi Vaughan, Vitoria Meyer Cantinho Pereira, Maria A V Marzolini, Leigh Wood, Joanna Olejnik, Yenting Ngai, Bilyana Popova, William Wilson, Victoria Spanswick, Helen Lowe, Leah Ensell, John A. Hartley, Farzin Farzaneh, Mark W. Lowdell, David C. Linch, Martin Pule, Karl S Peggs
Journal: Blood
Blood (2021) 138 (Supplement 1): 3823.
https://doi.org/10.1182/blood-2021-146316
Published: 2021
Journal Articles

Industrialization of an Academic Miltenyi Prodigy-Based CAR T Process

Abigail Culshaw, Frederick Arce Vargas, Gerardo Santiago Toledo, Claire Roddie, Paul Shaughnessy, Virginie Cerec, Kevin Duffy, Serena Perna, Wolfram Brugger, Michael Merges, Martin Pule
Journal: Blood
Blood (2021) 138 (Supplement 1): 477.
https://doi.org/10.1182/blood-2021-153031
Published: 2021
Journal Articles

CAR-T Toxicity Management and Steroid Use in High-Grade B-Cell Lymphoma: Impact on Real-World Survival Outcomes in the UK

Robin Sanderson, Andrea Kuhnl, Eleni Tholouli, Tobias F Menne, Amit Patel, Sridhar Chaganti, Caroline Besley, Emma Nicholson, Anne-Louise Latif, Ceri Jones, Lourdes Rubio, Charlotte Stenson, Amrith Mathew, Kirsty Sharplin, Jessica Bazin, Lorna Neill, Kathleen Pao Lynn Cheok, Katarzyna Aleksandra Aleksandra Jalowiec, Claire Roddie, Maeve A O'Reilly
Journal: Blood
Blood (2021) 138 (Supplement 1): 531.
https://doi.org/10.1182/blood-2021-149501
Published: 2021
Journal Articles

Steroid Use, Advanced Stage Disease and ≥3 Lines of Prior Chemotherapy Are Associated with a Higher Risk of Infection Following CD19 CAR T-Cell Therapy for B-NHL: Real World Data from a Large UK Center

Lorna Neill, Strachan C Mackenzie, MBBS, BSc, MRCP, Maria A V Marzolini, William Townsend, MRCP,MDFRCPath, Kirit M. Ardeshna, Kate Cwynarski, Surjo De, Vanya Gant, Lhara Mure, Sara McElduff, Chantelle Hughes, Karl S Peggs, MD PhD, Claire Roddie, PhD MD, Maeve A O'Reilly, MBBCHBAO
Journal: Blood
Blood (2020) 136 (Supplement 1): 20–21.
https://doi.org/10.1182/blood-2020-138865
Published: 2020
Journal Articles

Intention to Treat Analysis of Real-World Outcomes Following Tisgenlecleucel Therapy for Pediatric and Young Adult ALL through a National Access Programme

Sara Ghorashian, FRCPath, PhD, Caroline Furness, Michelle Cummins, John A Snowden, BSc (Hons), MBChB, MD FRCP, FRCPath, Maeve A O'Reilly, MBBCHBAO, Claire Roddie, PhD MD, Lorna Neill, Emma Nicholson, Caroline Besley, MBBChir, MRCPath, MRCP, Sridhar Chaganti, MDPhDMRCP,FRCPath, John Gillson, MD, Antonio Pagliuca, MBBS, MA, FRCP, FRCPath, Anna Castleton, FRCPath, Amit Patel, MBBS,PhDFRCPath,MRCP, Peter Clark, MA MDFRCP, Robert Fernley, Robert Wynn, MD, Ajay Vora, MD, David I. Marks, MB, MS, FRACP, PhD FRCPath, Geoff Shenton, Persis J Amrolia, FRCP, FRCPath, PhD, Denise Bonney, Rachael E Hough, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 18–19.
https://doi.org/10.1182/blood-2020-138438
Published: 2020
Journal Articles

ALLCAR19: Updated Data Using AUTO1, a Novel Fast-Off Rate CD19 CAR in Relapsed/Refractory B-Cell Acute Lymphoblastic Leukaemia and Other B-Cell Malignancies

Claire Roddie, PhD MD, Maeve A O'Reilly, MBBCHBAO, Maria A V Marzolini, Leigh Wood, BA, Juliana Dias, Amaia Cadinanos Garai, BSc MSc, Leticia Bosshard, Mahnaz Abbasian, Mark W. Lowdell, BSc, MSc, PhD FRCPath, Graham Wheeler, Joanna Olejnik, Bilyana Popova, MSc, Laura Clifton-Hadley, PhDBSc, Yashma Pathak, Victoria Spanswick, Helen Lowe, John A. Hartley, PhD, Farhatullah Syed, Waseem Qasim, MBBS, PhD, Farzin Farzaneh, PhD, David C. Linch, Martin Pule, MDPhD, Karl S Peggs, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 3–4.
https://doi.org/10.1182/blood-2020-137768
Published: 2020
Journal Articles

Real-World Data of High-Grade Lymphoma Patients Treated with CD19 CAR-T in England

Andrea Kuhnl, Claire Roddie, PhD MD, Nuria Martinez-Cibrian, Tobias F Menne, MD PhD FRCPath, Kim Linton, MBChB PhD, Sanne Lugthart, Sridhar Chaganti, MDPhDMRCP,FRCPath, Robin Sanderson, MRCP,FRCPath, Maria A V Marzolini, Jane Norman, MD, Wendy Osborne, MD, John Radford, Stephen Robinson, MBBS, PhD BSc, Ram Malladi, Piers E.M. Patten, BSc, MRCP, MRCPath, PhD, Maeve A O'Reilly, MBBCHBAO, Muhammad Saif, MD, Geoff Shenton, Adrian Bloor, FRCPath, Clare J Rowntree, MBBS, PhD FRCP, FRCPath, David A. Irvine, BSc, MBBChir, MRCP, FRCPath, PhD, Orla Stewart, Arzhang Ardavan, Kate Robinson, Antonio Pagliuca, MBBS, MA, FRCP, FRCPath, Kristian M Bowles, MBBS, PhD, Graham P. Collins, MA, MBBS, MRCP, FRCPath, DPhil, Rod Johnson, Andrew K McMillan, FRCP
Journal: Blood
Blood (2019) 134 (Supplement_1): 767.
https://doi.org/10.1182/blood-2019-124177
Published: 2019
Journal Articles

AUTO1, a Novel Fast Off CD19CAR Delivers Durable Remissions and Prolonged CAR T Cell Persistence with Low CRS or Neurotoxicity in Adult ALL

Claire Roddie, PhD MD, Maeve A O'Reilly, MBBCHBAO, Maria A V Marzolini, Leigh Wood, BA, Juliana Dias Alves Pinto, PhD, Mahnaz Abbasian, Ketki Vispute, Mark W. Lowdell, BSc, MSc, PhD FRCPath, Graham Wheeler, Joanna Olejnik, Bilyana Popova, Kim Champion, Alexia Gali, Yashma Pathak, Victoria Spanswick, Helen Lowe, John A. Hartley, PhD, Farzin Farzaneh, PhD, David C. Linch, Martin Pule, Karl S Peggs
Journal: Blood
Blood (2019) 134 (Supplement_1): 226.
https://doi.org/10.1182/blood-2019-131086
Published: 2019
Journal Articles

Automated Manufacture of Matched Donor-Derived Allogeneic CD19 CAR T-Cells for Relapsed/Refractory B-ALL Following Allogeneic Stem Cell Transplantation: Toxicity, Efficacy and the Important Role of Lymphodepletion

Claire Roddie, PhD MD, Maeve A O'Reilly, MBBCHBAO, Maria A V Marzolini, Leigh Wood, BA, Juliana Dias Alves Pinto, PhD, Mahnaz Abbasian, Ketki Vispute, Leticia Bosshard, Mark W. Lowdell, BSc, MSc, PhD FRCPath, Graham Wheeler, Alex Day, Bilyana Popova, Kim Champion, Yashma Pathak, Alexia Gali, Nasir Mahmoud, Victoria Spanswick, Helen Lowe, John A. Hartley, PhD, Farzin Farzaneh, PhD, Lauren Nickolay, PhD, Fahetullah Syed, Waseem Qasim, MBBS, PhD, David C. Linch, Martin Pule, Karl S Peggs
Journal: Blood
Blood (2019) 134 (Supplement_1): 776.
https://doi.org/10.1182/blood-2019-129640
Published: 2019