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Journal Articles

Development of a Phase 1 Study Evaluating the Activity of Modular CAR T for Multiple Myeloma (MCARTY) Targeting BCMA and CD19 for Improved Persistence

Lydia Sarah Hui Lee, Wen Chean Lim, Catriona Mactier, Juliana Dias Alves Pinto, Vitoria Pereira, Mhairi Vaughan, Louisa Green, Evie Lewin, John Garcia, Giulia Agliardi, Yashma Pathak, Riaz Jannoo, Leigh Wood, Bilyana Popova, Helen Holmes, Simon Thomas, Victoria Spanswick, William Wilson, Christopher Parrish, Rakesh Popat, Claire Roddie, Kwee Yong, Martin A. Pule
Journal: Blood
Blood (2023) 142 (Supplement 1): 350.
https://doi.org/10.1182/blood-2023-185085
Published: 2023
Journal Articles

High Neoantigen Load Confers a Major Benefit from Autologous Stem Cell Transplantation Compared to Consolidation in Newly Diagnosed Multiple Myeloma

Ieuan Walker, Venetia D'Arcy, Kane Foster, Garima Khandelwal, Georgina S.F. Anderson, William Wilson, Evie Fitzsimons, Daria Galas-Filipowicz, Rakesh Popat, Karthik Ramasamy, Matthew Streetly, Ceri Bygrave, Reuben Benjamin, Ruth M de Tute, Marquita Camilleri, Selina J Chavda, Gavin Pang, Sumaiya Kamora, James D. Cavenagh, Elizabeth Phillips, Laura Clifton-Hadley, Charlotte Tyson, Fuad Fananapazir, Krupali Parikh, Roger Owen, Javier Herrero, Kwee Yong, Michael A. Chapman
Journal: Blood
Blood (2023) 142 (Supplement 1): 3306.
https://doi.org/10.1182/blood-2023-186318
Published: 2023
Journal Articles

Long-Term Efficacy and Safety of Obecabtagene Autoleucel (obe-cel) in Adult Patients (pts) with Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia ([R/R B-ALL]; Pooled Analysis from ALLCAR19 and FELIX Phase Ib Studies) or Other B-cell Malignancies (ALLCAR19 Extension Study)

Claire Roddie, Eleni Tholouli, Paul Shaughnessy, Elias Jabbour, Aaron C. Logan, Katharine Hodby, Luke Mountjoy, Adrian John Clifton Bloor, David Irvine, David C. Linch, Kim H. Orchard, William Wilson, Bilyana Popova, Juliana Dias, Giulia Agliardi, Victoria Spanswick, Helen Lowe, Marina Mitsikakou, Eftychia Charalambous, Joanna Dawes, Meera Raymond, Yanqing Hu, Wolfram Brugger, Martin A. Pule, Jae H. Park, Karl Peggs
Journal: Blood
Blood (2023) 142 (Supplement 1): 2114.
https://doi.org/10.1182/blood-2023-180666
Published: 2023
Journal Articles

Impact of Autologous Stem Cell Transplant (ASCT) Versus Consolidation on Health-Related Quality of Life (HRQoL) for Patients with Multiple Myeloma Receiving Carfilzomib Maintenance: Results from the Cardamon Trial

Rakesh Popat, William Wilson, Marquita Camilleri, Karthik Ramasamy, Matthew Streetly, Jonathan Sive, Ceri Bygrave, Reuben Benjamin, Michael A Chapman, Selina J Chavda, Beth Phillips, Maria del Mar Cuadrado, Gavin Pang, Richard Jenner, Tushhar Dadaga, Sumaiya Kamora, Ruth M. de Tute, James Cavenagh, Laura Clifton-Hadley, Roger G Owen, Kwee Yong
Journal: Blood
Blood (2022) 140 (Supplement 1): 10191–10192.
https://doi.org/10.1182/blood-2022-166344
Published: 2022
Journal Articles

Brexucabtagene Autoleucel for Relapsed/Refractory Mantle Cell Lymphoma: Real-World Outcomes in the United Kingdom

Maeve A O'Reilly, Robin Sanderson, William Wilson, David Burns, Caroline Besley, Thomas Creasey, Ben Uttenthal, Johnathon Elliot, Claire Roddie, Andrea Kuhnl, Shankara Paneesha, Frances Seymour, Sunil Iyengar, Lourdes Rubio, Matthew Wilson, Stephen Boyle, Kathleen PL Cheok, Graham P. Collins, Rod Johnson, Andrew K. McMillan
Journal: Blood
Blood (2022) 140 (Supplement 1): 7519–7521.
https://doi.org/10.1182/blood-2022-165031
Published: 2022
Journal Articles

Safety, Efficiency and Long-Term Follow-up of AUTO1, a Fast-Off Rate CD19 CAR in Relapsed/Refractory B-Cell Acute Lymphoblastic Leukaemia and Other B-Cell Malignancies

Claire Roddie, Juliana Dias Alves Pinto, Maeve A O'Reilly, Marina Mitsikakou, Eftychia Charalambous, Louisa Green, Mhairi Vaughan, Giulia Agliardi, John Garcia, Evie Lewin, Mark W. Lowdell, Maria A V Marzolini, Leigh Wood, Helen Holmes, Yenting Ngai, Bilyana Popova, William Wilson, Sangeetha Kunaseelan, Victoria Spanswick, Helen Lowe, Leah Ensell, John A. Hartley, Simon Morley, David C. Linch, Adrian Bloor, David A. Irvine, Martin Pule, Karl S Peggs
Journal: Blood
Blood (2022) 140 (Supplement 1): 7452–7453.
https://doi.org/10.1182/blood-2022-167053
Published: 2022
Journal Articles

Developing a Flow Cytometric Signature of Carfilzomib Responsiveness in Myeloma

Ieuan Walker, Venetia D'arcy, Antonio Rodriguez Romera, Georgina Anderson, Anna Aubareda, James Roy, Garima Khandelwal, William Wilson, Evelyn Fitzsimons, Daria Galas-Filipowicz, Kane Foster, Rakesh Popat, Karthik Ramasamy, Matthew Streetly, Ceri Bygrave, Reuben Benjamin, Ruth M. de Tute, Marquita Camilleri, Selina J Chavda, Gavin Pang, Tushhar Dadaga, Sumaiya Kamora, James Cavenagh, Elizabeth H. Phillips, Laura Clifton-Hadley, Roger G Owen, Javier Herrero, Kwee Yong, Michael A Chapman
Journal: Blood
Blood (2022) 140 (Supplement 1): 10106–10107.
https://doi.org/10.1182/blood-2022-169882
Published: 2022
Journal Articles

Pembrowm: Results of a Multi-Centre Phase II Trial Investigating the Safety and Efficacy of Rituximab and Pembrolizumab in Relapsed/Refractory Waldenström's Macroglobulinaemia

Jaimal Kothari, Toby A. Eyre, Ali Rismani, Helen McCarthy, Angela Collins, David John Lewis, Suzanne O Arulogun, William Wilson, Laura Clifton-Hadley, Darren Edwards, Kushani Ediriwickrema, Rebecca Auer, Guy Pratt, Ruth M. de Tute, Roger G Owen, Shirley D'Sa
Journal: Blood
Blood (2022) 140 (Supplement 1): 3624–3626.
https://doi.org/10.1182/blood-2022-167158
Published: 2022
Journal Articles

Long Term Follow-up of International Randomised Phase 3 Study of Rituximab Versus a Watch and Wait Approach for Patients with Asymptomatic, Low Tumour Burden Follicular Lymphoma Shows Rituximab Is Highly Effective at Delaying Time to New Treatment without Detrimental Impact Following Next Line of Therapy

Michael Northend, William Wilson, Laura Clifton-Hadley, Zaynab Rana, Tanya-Louise Martin, Moya Young, Fiona Miall, David Cunningham, Jan Walewski, Burhan Ferhanoglu, Amanda Johnston, John F. Seymour, David C. Linch, Kirit M. Ardeshna
Journal: Blood
Blood (2022) 140 (Supplement 1): 1456–1458.
https://doi.org/10.1182/blood-2022-156790
Published: 2022
Journal Articles

PET-CT for Assessment of Multiple Myeloma Disease Burden and Metabolic Response before and after Carfilzomib-Based Induction, Consolidation and Carfilzomib Maintenance Therapy: Data from the UK NCRI Cardamon Study

Ceri A Bygrave, Manil Subesinghe, William Wilson, Rakesh Popat, Karthik Ramasamy, Gavin Pang, Richard Jenner, Sumaiya Kamora, Tushhar Dadaga, Lucy Pike, Matthew Streetly, Marquita Camilleri, Roger G Owen, James Cavenagh, Jonathan Sive, Michael Chapman, Elizabeth H Phillips, Selina J Chavda, Maria del Mar Cuadrado, Reuben Benjamin, Lydia Eccersley, Sally Moore, Lalita Banerjee, Laura Clifton-Hadley, Sally F Barrington, Kwee Yong
Journal: Blood
Blood (2021) 138 (Supplement 1): 2750.
https://doi.org/10.1182/blood-2021-150177
Published: 2021
Journal Articles

Upfront Autologous Stem Cell Transplantation (ASCT) Vs Carfilzomib-Cyclophosphamide-Dexamethasone (KCd) Consolidation in Transplant-Eligible, Newly Diagnosed (NDTE) Multiple Myeloma (MM): Results of the Cardamon Study According to Cytogenetic Risk

Kwee Yong, William Wilson, Marquita Camilleri, Karthik Ramasamy, Matthew Streetly, Jonathan Sive, Ceri A Bygrave, Michael Chapman, Ruth M. de Tute, Selina J Chavda, Elizabeth H Phillips, Maria del Mar Cuadrado, Gavin Pang, Richard Jenner, Tushhar Dadaga, Sumaiya Kamora, James Cavenagh, Laura Clifton-Hadley, Roger G Owen, Rakesh Popat
Journal: Blood
Blood (2021) 138 (Supplement 1): 2911.
https://doi.org/10.1182/blood-2021-147771
Published: 2021
Journal Articles

Serological Response to the BNT162b2 mRNA or Chadox-Ncov-19 COVID-19 Vaccine after First and Second Doses in Plasma Cell Disorder Patients: Influence of Host and Disease Factors

Wei Yee Chan, Lara Howells, William Wilson, Emilie Sanchez, Louise Ainley, Selina J Chavda, Emma Dowling, Nuno Correia, Catherine SY Lecat, Annabel McMillan, Brendan Wisniowski, Shameem Mahmood, Xenofon Papanikolaou, Lydia Lee, Jonathan Sive, Charalampia Kyriakou, Ashutosh D. Wechalekar, Rakesh Popat, Neil K Rabin, Eleni Nastouli, Kwee Yong, Ke Xu
Journal: Blood
Blood (2021) 138 (Supplement 1): 1628.
https://doi.org/10.1182/blood-2021-149027
Published: 2021
Journal Articles

Safety and Efficacy of AUTO1, a Fast-Off Rate CD19 CAR in Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma (B-NHL) and Chronic Lymphocytic Leukaemia (CLL)

Claire Roddie, Juliana Dias, Maeve A O'Reilly, Amaia Cadinanos Garai, Louisa Green, Mahnaz Abbasian, Marina Mitsikakou, Mhairi Vaughan, Vitoria Meyer Cantinho Pereira, Maria A V Marzolini, Leigh Wood, Joanna Olejnik, Yenting Ngai, Bilyana Popova, William Wilson, Victoria Spanswick, Helen Lowe, Leah Ensell, John A. Hartley, Farzin Farzaneh, Mark W. Lowdell, David C. Linch, Martin Pule, Karl S Peggs
Journal: Blood
Blood (2021) 138 (Supplement 1): 3823.
https://doi.org/10.1182/blood-2021-146316
Published: 2021
Journal Articles

Efficacy and Safety of Carfilzomib at 56mg/m 2 with Cyclophosphamide and Dexamethasone (K56Cd) in Newly Diagnosed Multiple Myeloma Patients Followed By ASCT or K56Cd Consolidation: Initial Results of the Phase 2 Cardamon Study

Kwee Yong, Rakesh Popat, William Wilson, Gavin Pang, Richard Jenner, Ruth M De Tute, BSc,MSc, Karthik Ramasamy, MBBS MRCP FRCPath PhD, Matthew Streetly, MD, Jamie Cavenagh, MD PhD, Jonathan Sive, MD, Michael Chapman, PhD MRCP, FRCPath, Ceri Bygrave, MD FRCPath, MPhil, Beth Phillips, MBBS, FRCPath, BSc, Selina J Chavda, Andres E. Virchis, FRCP, FRCPath, Reuben Benjamin, FRCPath, MRCP, MBBS, PhD, Sarah Arnott, Fenella Willis, Sandra Hassan, MBBS, MRCP, FRCPath, MDRes), Sally Moore, Laura Clifton-Hadley, PhDBSc, Roger G Owen, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 861.
https://doi.org/10.1182/blood-2019-127992
Published: 2019
Journal Articles

Frequency of Marrow Infiltrating PD-1 Expressing CD4 Effectors Following Autologous Stem Cell Transplant (ASCT) for Multiple Myeloma Is Prognostic for Clinical Outcome

Nouf Alrasheed, Lydia Lee, Huw Richards, William Wilson, Oliver C Cohen, MBBS, BSc, FRCPath, Selina J Chavda, Jake Henry, Andrew Furness, Melody Chin, Daria Galas-Filipowicz, Charalampia Kyriakou, Neil K Rabin, Sergio A Quezada, Kwee Yong
Journal: Blood
Blood (2019) 134 (Supplement_1): 4368.
https://doi.org/10.1182/blood-2019-126682
Published: 2019
Journal Articles

Targeting the Leukemia-Associated Hypoxic Microenvironment with Hypoxia-Activated Prodrug PR-104

Juliana Benito, Ph.D., Yuexi Shi, Barbara Szymanska, Hernan Carol, Ingrid Bohem, Hongbo Lu, MMSC, Sergej Konoplev, MD, PhD, Wendy Fang, Steven M. Kornblau, MD, Patrick Zweidler-McKay, MD, PhD, William Wilson, PhD, Dario Campana, MD, PhD, Gautam Borthakur, MD, Carlos E. Bueso-Ramos, Hagop M. Kantarjian, MD, Elizabeth J. Shpall, Deborah A Thomas, MD, Craig T. Jordan, PhD, Richard B Lock, PhD, Michael Andreeff, MD, PhD, Marina Konopleva, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 868.
https://doi.org/10.1182/blood.V116.21.868.868
Published: 2010