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Yuexi Shi
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Journal Articles

MLN0128, a Second-Generation mTOR Kinase Inhibitor, Disrupts Survival Signaling and Triggers Apoptosis in AML

Zhihong Zeng, MD, Rui-Yu Wang, MD PhD, Yuexi Shi, MD, Yihua Qiu, MD, Duncan H Mak, MS, Kevin Coombes, PhD, Suk Young Yoo, PhD, Katti Jessen, Yi Liu, PhD, Christian Rommel, PhD, Hagop M. Kantarjian, MD, Steven M. Kornblau, MD, David Fruman, PhD, Michael Andreeff, MD PhD, Marina Konopleva, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3613.
https://doi.org/10.1182/blood.V124.21.3613.3613
Published: 2014
Journal Articles

SDF-1 Inhibition Using Spiegelmer ® Nox-A12 As a Novel Strategy For Targeting AML Cells Within Their BM Microenvironment

Rodrigo Jacamo, PhD, Zhihong Zeng, MD, Ye Chen, PhD, Yuexi Shi, Teresa McQueen, BS, Anna Kruschinski, PhD, Marina Konopleva, MD, PhD, Peter P. Ruvolo, PhD, Michael Andreeff, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 2454.
https://doi.org/10.1182/blood.V122.21.2454.2454
Published: 2013
Journal Articles

Leukemia Microenvironment and Pathologic Hypoxia: Sensitivity to Hypoxia-Activated Cytotoxin TH-302

Juliana M Benito, PhD, Volgin Y Andrei, Ye Chen, PhD, Lu Hongbo, Yuexi Shi, Teresa McQueen, Patrick A Zweidler-McKay, MD, PhD, Damian R Handisides, Charles Hart, Michael Andreeff, MD, PhD, Marina Konopleva, M.D., Ph.D.
Journal: Blood
Blood (2012) 120 (21): 1523.
https://doi.org/10.1182/blood.V120.21.1523.1523
Published: 2012
Journal Articles

Unique Effects of p53 −/− Leukemic Cells On Mesenchymal Stromal Cell Gene Expression Profile in Vitro

Xiaoyang Ling, PhD, Ye Chen, PhD, Peter P. Ruvolo, PhD, Vivian Ruvolo, Zhiqiang Wang, Ph.D., Min Zhang, Ph.D., Yuexi Shi, Marina Konopleva, MD, PhD, Richard E Davis, MD, Michael Andreeff, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 3468.
https://doi.org/10.1182/blood.V120.21.3468.3468
Published: 2012
Journal Articles

ARC Is Regulated by MAPK and PI3K and Confers Drug Resistance and Survival Advantage to AML in Vitro and in Vivo

Po Yee Mak, M.S., Duncan H Mak, M.S., Yuexi Shi, Vivian Ruvolo, Rodrigo Jacamo, Ph.D, Michael Andreeff, MD, PhD, Bing Z Carter, Ph.D
Journal: Blood
Blood (2012) 120 (21): 893.
https://doi.org/10.1182/blood.V120.21.893.893
Published: 2012
Journal Articles

Role of Connective Tissue Growth Factor (CTGF) in Survival and Chemosensitivity of Acute Lymphoblastic Leukemia

Hongbo Lu, MMSC, Venkata Lokesh Battula, Ph.D., Yuexi Shi, Richard B Lock, PhD, Suzanne Spong, Ph.D, Michael Andreeff, M.D., Ph.D., Marina Konopleva, M.D., Ph.D.
Journal: Blood
Blood (2011) 118 (21): 2593.
https://doi.org/10.1182/blood.V118.21.2593.2593
Published: 2011
Journal Articles

TGF-β Neutralizing Antibody 1D11 Inhibits LIF-JAK-Stat3 Signaling and Enhances Cytarabine Induced Apoptosis in AML Cells in Bone Marrow Microenvironment

Yoko Tabe, MD, PhD, Yuexi Shi, Zhihong Zeng, Linhua Jin, PhD, Yixin Zhou, Takashi Miida, MD, PhD, Michael Andreeff, M.D., Ph.D., Marina Konopleva, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 926.
https://doi.org/10.1182/blood.V118.21.926.926
Published: 2011
Journal Articles

Targeting CXCR4, SDF1 and Beta-Adrenergic Receptors In the AML Microenvironment by Novel Antagonist POL6326, G-CSF and Isoproterenol

Ye Chen, PhD, Zhihong Zeng, PhD, Yuexi Shi, PhD, Rodrigo Jacamo, PhD, Christian Ludin, PhD, Klaus Dembowsky, PhD, Paul S. Frenette, MD, FRCPC, Marina Konopleva, MD, PhD, Michael Andreeff, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 2179.
https://doi.org/10.1182/blood.V116.21.2179.2179
Published: 2010
Journal Articles

Targeting mTORC1/2 by a mTOR Kinase Inhibitor (PP242) induces Apoptosis In AML Cells Under Conditions Mimicking Bone Marrow Microenvironment

Zhihong Zeng, Yuexi Shi, Twee Tsao, Yihua Qiu, Steven M. Kornblau, MD, Keith Baggerly, Wenbin Liu, Yi Liu, PhD, Christian Rommel, PhD, David A. Fruman, Michael Andreeff, MD, PhD, Marina Konopleva, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 778.
https://doi.org/10.1182/blood.V116.21.778.778
Published: 2010
Journal Articles

Targeting the Leukemia-Associated Hypoxic Microenvironment with Hypoxia-Activated Prodrug PR-104

Juliana Benito, Ph.D., Yuexi Shi, Barbara Szymanska, Hernan Carol, Ingrid Bohem, Hongbo Lu, MMSC, Sergej Konoplev, MD, PhD, Wendy Fang, Steven M. Kornblau, MD, Patrick Zweidler-McKay, MD, PhD, William Wilson, PhD, Dario Campana, MD, PhD, Gautam Borthakur, MD, Carlos E. Bueso-Ramos, Hagop M. Kantarjian, MD, Elizabeth J. Shpall, Deborah A Thomas, MD, Craig T. Jordan, PhD, Richard B Lock, PhD, Michael Andreeff, MD, PhD, Marina Konopleva, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 868.
https://doi.org/10.1182/blood.V116.21.868.868
Published: 2010
Journal Articles

The Synergistic Effect of DNA Methylation Inhibitor 5-Azacytidine and Bcl-2 Signaling Blockade ABT-737 Combination Treatment Induce Apoptosis In AML

Yuexi Shi, Twee Tsao, Hongbo Lu, MMSC, Sergej Konoplev, MD, PhD, Wendy D. Schober, Michael Andreeff, MD, PhD, Marina Konopleva, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 3311.
https://doi.org/10.1182/blood.V116.21.3311.3311
Published: 2010
Journal Articles

Combination of Sorafenib and Arsenic Trioxide Exerts Synergistic Anti-Leukemia Effects in Sorafenib-Resistant FLT3-ITD-Harboring AML Cells

Weiguo Zhang, MD, PhD, Marina Konopleva, MD, PhD, Yuexi Shi, Xiaoyang Ling, PhD, Michael Andreeff, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 2656.
https://doi.org/10.1182/blood.V112.11.2656.2656
Published: 2008
Journal Articles

Disruption of Leukemia/Stroma Cell Interactions by CXCR4 Antagonist CTCE-9908 Enhances Chemotherapy-Induced Apoptosis in AML

Hongbo Lu, Zhihong Zeng, PhD, Yuexi Shi, Sergej Konoplev, MD, PhD, Donald Wong, PhD, Marina Konopleva, MD, PhD, Michael Andreeff, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 2415.
https://doi.org/10.1182/blood.V112.11.2415.2415
Published: 2008