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Journal Articles

Targeting Autophagy Kinase ULK1 Can Reverse Bcl2 Inhibitor (ABT-199) Induced Autophagy to Overcome Acquired Resistance in Acute Myeloid Leukemia

Seemana Bhattacharya, PhD, Sujan Piya, PhD, Qi Zhang, PhD, Natalia Baran, PhD MD, Teresa McQueen, MS, R. Eric Davis, MD, Nicholas Cosford, PhD, Marina Y. Konopleva, MD PhD, Michael Andreeff, MD PhD, Gautam Borthakur, MD

Blood (2018) 132 (Supplement 1): 3934.

https://doi.org/10.1182/blood-2018-99-114817

Published: 2018

Journal Articles

Single-Cell Mass Cytometry Characterizes Phenotypic and Functional Heterogeneity in Acute Myeloid Leukemia at Diagnosis, in Remission and Relapse

Lina Han, PhD, Peng Qiu, PhD, Jeffrey L. Jorgensen, MD PhD, Duncan Mak, BSc, MPhil, Jared K Burks, PhD, Teresa McQueen, MS, Zhihong Zeng, MD, Farhad Ravandi, MD, Gail J. Roboz, MD, Hagop M. Kantarjian, MD, Steven M. Kornblau, MD, Michael Andreeff, MD PhD, Monica L. Guzman, PhD, Marina Y. Konopleva, MD PhD

Blood (2018) 132 (Supplement 1): 912.

https://doi.org/10.1182/blood-2018-99-111970

Published: 2018

Journal Articles

Disruption of NOTCH1-MYC-CD44 Axis Targets Leukemia Initiating Cells (LIC) in T-ALL

Sujan Piya, PhD, Seemana Bhattacharya, PhD, Hong Mu, MD PhD, Vivian Ruvolo, MS, Natalia Baran, PhDMD, Teresa McQueen, MS, R. Eric Davis, MD, Yimin Qian, PhD, Kanak Raina, PhD, M. James You, MD PhD, Marina Y. Konopleva, MD PhD, Hagop M. Kantarjian, MD, Michael Andreeff, MD PhD, Gautam Borthakur, MD

Blood (2018) 132 (Supplement 1): 890.

https://doi.org/10.1182/blood-2018-99-115692

Published: 2018

Journal Articles

Up-Regulation of iNOS in AML Blasts Creates an Immunosuppressive Microenvironment, Inhibits T-Cell Proliferation and Transforms T-Cells Towards a Tumor-Tolerating Phenotype

Rodrigo Jacamo, PhD, Nguyet-Minh Hoang, B.A., Ahmed Al Rawi, Charlie Ly, BS, Robin Parihar, MDPhD, Teresa McQueen, MS, Peter P. Ruvolo, PhD, Patrick Williams, MD PhD, Gheath Alatrash, DO, PhD, Marina Konopleva, MD PhD, Michael Andreeff, MD PhD

Blood (2017) 130 (Supplement 1): 2443.

https://doi.org/10.1182/blood.V130.Suppl_1.2443.2443

Published: 2017

Journal Articles

Bone Marrow Stromal Cells Induce ALDH+ Stem Cell Phenotype and Chemotherapy Resistance in AML Cells through TGF-β1 Mediated Signaling: Reversal By TGFβ Inhibitor Galunisertib

Ximin Zhou, Bin Yuan, Yuanqing Yan, Khoa Nguyen, Vivian Ruvolo, PhD, Hong Mu, MD PhD, Teresa McQueen, MS, Elizabeth J Shpall, MD, Kim-Ann Do, Marina Konopleva, MD PhD, Michael Andreeff, MD PhD, Venkata Lokesh Battula, PhD

Blood (2017) 130 (Supplement 1): 1163.

https://doi.org/10.1182/blood.V130.Suppl_1.1163.1163

Published: 2017

Journal Articles

Inhibition of Unc-51 like Autophagy Activating Kinase 1 (ULK1) Is Highly Synergistic with Chemotherapy and Bcl2 Inhibition in Acute Myeloid Leukemia (AML)

Seemana Bhattacharya, PhD, Sujan Piya, PhD, Teresa McQueen, MS, Marina Konopleva, MD PhD, Michael Andreeff, MD PhD, Gautam Borthakur, MD

Blood (2017) 130 (Supplement 1): 1248.

https://doi.org/10.1182/blood.V130.Suppl_1.1248.1248

Published: 2017

Journal Articles

BRD4 Proteolysis Targeting Chimera (PROTAC) ARV-825 Targets Both NOTCH1-MYC Regulatory Circuit and Leukemia-Microenvironment in T-ALL

Sujan Piya, PhD, Hong Mu, MD PhD, Seemana Bhattacharya, PhD, Teresa McQueen, MS, Richard E Davis, BSPharm, MS, Vivian Ruvolo, PhD, Natalia Baran, PhD MD, Yimin Qian, PhD, Kanak Raina, PhD, Craig M Crews, PhD, M. James You, MD PhD, Patrick Zweider McKay, MDPhD, Marina Konopleva, MD PhD, Hagop M. Kantarjian, MD, Michael Andreeff, MD PhD, Gautam Borthakur, MD

Blood (2017) 130 (Supplement 1): 716.

https://doi.org/10.1182/blood.V130.Suppl_1.716.716

Published: 2017

Journal Articles

Comparison of Induction Chemotherapy in NSG and NOD- Rag1 null IL2rg null Mouse Models of FLT3 Mutant AML

Hong Mu, MD PhD, Marina Konopleva, MD PhD, Rodrigo Jacamo, PhD, Bing Z Carter, PhD, Teresa McQueen, MS, Michael Andreeff, MD PhD

Blood (2017) 130 (Supplement 1): 2692.

https://doi.org/10.1182/blood.V130.Suppl_1.2692.2692

Published: 2017

Journal Articles

Targeting Aggregation of Wilde-Type p53 and Mutant p53 with ReACp53 As a Novel Therapeutic Concept for AML

Jianfang Zeng, MD PhD, Alice Soragni, PhD, Jo Ishizawa, MDPhD, Vivian Ruvolo, MS, Christopher B. Benton, MD, Teresa McQueen, MS, Peter Ruvolo, PhD, Yuan Qi, PhD, Xiaoping Su, PhD, Jared Burks, PhD, David S. Eisenberg, PhD, Michael Andreeff, MD PhD

Blood (2016) 128 (22): 3944.

https://doi.org/10.1182/blood.V128.22.3944.3944

Published: 2016

Journal Articles

Silencing TG2 in Acute Myeloid Leukemia. Possible Role of TG2 in Microenvironment-Mediated Chemoresistance

Rodrigo Omar Jacamo, PhD, Qi Zhang, MD PhD, Teresa McQueen, MS, Richard Eric Davis, MD, Marina Konopleva, MD PhD, Michael Andreeff, MD PhD

Blood (2016) 128 (22): 5087.

https://doi.org/10.1182/blood.V128.22.5087.5087

Published: 2016

Journal Articles

BRD4 Proteolysis Targeting Chimera (PROTAC) ARV-825, Causes Sustained Degradation of BRD4 and Modulation of Chemokine Receptors, Cell Adhesion and Metabolic Targets in Leukemia Resulting in Profound Anti-Leukemic Effects

Sujan Piya, PhD, Seemana Bhattacharya, PhD, Hong Mu, MD PhD, Philip L Lorenzi, PhD, Teresa McQueen, MS, Eric Richard Davis, MD, Vivian Ruvolo, MS, Natalia Baran, PhD, Yimin Qian, PhD, Craig Crews, PhD, Hagop M. Kantarjian, MD, Michael Andreeff, MD PhD, Gautam Borthakur, MD

Blood (2016) 128 (22): 748.

https://doi.org/10.1182/blood.V128.22.748.748

Published: 2016

Journal Articles

Atg7 suppression enhances chemotherapeutic agent sensitivity and overcomes stroma-mediated chemoresistance in acute myeloid leukemia

Sujan Piya, Steven M. Kornblau, Vivian R. Ruvolo, Hong Mu, Peter P. Ruvolo, Teresa McQueen, R. Eric Davis, Numsen Hail, Jr, Hagop Kantarjian, Michael Andreeff, Gautam Borthakur

Blood (2016) 128 (9): 1260–1269.

https://doi.org/10.1182/blood-2016-01-692244

Published: 2016

Includes: Supplemental data

Journal Articles

Role of Mesenchymal Stem Cell Galectin 3 in the AML Tumor Microenvironment

Peter Ruvolo, PhD, Yihua Qiu, MD, Vivian Ruvolo, MS, Rui-Yu Wang, MD PhD, Zhihong Zeng, MD, Jared Burks, PhD, Rongqing Pan, MS, Numsen Hail, Jr., PhD, Teresa McQueen, Suk-Young Yoo, Steven M. Kornblau, MD, Michael Andreeff, MD PhD

Blood (2015) 126 (23): 1198.

https://doi.org/10.1182/blood.V126.23.1198.1198

Published: 2015

Journal Articles

Concurrent Inhibition of Beta-Catenin/CBP and FLT3 Strongly Suppresses c-Myc and Synergistically Induces Apoptosis in FLT3 Mutant AML Cells

Xuejie Jiang, Po Yee Mak, MPhil, Hong Mu, MD PhD, Weiguo Zhang, MD, PhD, Duncan Mak, BSc, MPhil, Peter Ruvolo, PhD, Teresa McQueen, Hongsheng Zhou, Jorge E. Cortes, Michael Andreeff, MD, PhD, Bing Z Carter

Blood (2015) 126 (23): 3685.

https://doi.org/10.1182/blood.V126.23.3685.3685

Published: 2015

Journal Articles

Acute Myelogenous Leukemia (AML) Mesenchymal Stromal Cell (MSC) Have Distinct Protein Expression Patterns Compared to Normal MSC

Steven M. Kornblau, MD, Peter Ruvolo, PhD, Rui-Yu Wang, MD PhD, Vivian Ruvolo, MS, Yihua Qiu, MD, Venkata Lokesh Battula, PhD, Zhihong Zeng, MD, Teresa McQueen, Suk-Young Yoo, Marina Konopleva, MD PhD, Michael Andreeff, MD, PhD

Blood (2015) 126 (23): 3813.

https://doi.org/10.1182/blood.V126.23.3813.3813

Published: 2015

Journal Articles

The Peptidic CXCR4 Antagonist, BL-8040, Significantly Reduces Bone Marrow Immature Leukemia Progenitors By Inducing Differentiation, Apoptosis and Mobilization: Results of the Dose Escalation Clinical Trial in Acute Myeloid Leukemia

Blood (2015) 126 (23): 2546.

https://doi.org/10.1182/blood.V126.23.2546.2546

Published: 2015

Journal Articles

BRD4 Proteolysis Targeting Chimera (PROTAC) Leads to Sustained Degradation of BRD4 with Broad Activity Against Acute Leukemias and Overcomes Stroma Mediated Resistance By Modulating Surface Expression of CXCR4

Sujan Piya, Teresa McQueen, Duncan Mak, BSc, MPhil, Marina Konopleva, MD PhD, Patrick Zweidler-McKay, MD PhD, Jing Lu, PhD, Yimin Qian, PhD, Michael Andreeff, MD PhD, Gautam Borthakur, MD

Blood (2015) 126 (23): 675.

https://doi.org/10.1182/blood.V126.23.675.675

Published: 2015

Journal Articles

Antileukemia activity of the novel peptidic CXCR4 antagonist LY2510924 as monotherapy and in combination with chemotherapy

Byung-Sik Cho, Zhihong Zeng, Hong Mu, Zhiqiang Wang, Sergej Konoplev, Teresa McQueen, Marina Protopopova, Jorge Cortes, Joseph R. Marszalek, Sheng-Bin Peng, Wencai Ma, R. Eric Davis, Donald E. Thornton, Michael Andreeff, Marina Konopleva

Blood (2015) 126 (2): 222–232.

https://doi.org/10.1182/blood-2015-02-628677

Published: 2015

Includes: Supplemental data

Journal Articles

Ablation of Autophagy-Related E1 Ligase Atg7 Primes Acute Myelogenous Leukemia Cells to Apoptosis, Sensitizes to Chemotherapy and Overcomes Stroma Mediated Protection

Sujan Piya, PhD, Vivian R Ruvolo, MA, Peter P. Ruvolo, PhD, Richard E. Davis, MD, Zhiqiang Wang, Teresa McQueen, BS, Wendy D Schober, PhD, Michael Andreeff, MD PhD, Gautam Borthakur, MD

Blood (2014) 124 (21): 901.

https://doi.org/10.1182/blood.V124.21.901.901

Published: 2014

NARROW

Targeting Autophagy Kinase ULK1 Can Reverse Bcl2 Inhibitor (ABT-199) Induced Autophagy to Overcome Acquired Resistance in Acute Myeloid Leukemia

Single-Cell Mass Cytometry Characterizes Phenotypic and Functional Heterogeneity in Acute Myeloid Leukemia at Diagnosis, in Remission and Relapse

Disruption of NOTCH1-MYC-CD44 Axis Targets Leukemia Initiating Cells (LIC) in T-ALL

Up-Regulation of iNOS in AML Blasts Creates an Immunosuppressive Microenvironment, Inhibits T-Cell Proliferation and Transforms T-Cells Towards a Tumor-Tolerating Phenotype

Bone Marrow Stromal Cells Induce ALDH+ Stem Cell Phenotype and Chemotherapy Resistance in AML Cells through TGF-β1 Mediated Signaling: Reversal By TGFβ Inhibitor Galunisertib

Inhibition of Unc-51 like Autophagy Activating Kinase 1 (ULK1) Is Highly Synergistic with Chemotherapy and Bcl2 Inhibition in Acute Myeloid Leukemia (AML)

BRD4 Proteolysis Targeting Chimera (PROTAC) ARV-825 Targets Both NOTCH1-MYC Regulatory Circuit and Leukemia-Microenvironment in T-ALL

Comparison of Induction Chemotherapy in NSG and NOD- Rag1 null IL2rg null Mouse Models of FLT3 Mutant AML

Targeting Aggregation of Wilde-Type p53 and Mutant p53 with ReACp53 As a Novel Therapeutic Concept for AML

Silencing TG2 in Acute Myeloid Leukemia. Possible Role of TG2 in Microenvironment-Mediated Chemoresistance

BRD4 Proteolysis Targeting Chimera (PROTAC) ARV-825, Causes Sustained Degradation of BRD4 and Modulation of Chemokine Receptors, Cell Adhesion and Metabolic Targets in Leukemia Resulting in Profound Anti-Leukemic Effects

Atg7 suppression enhances chemotherapeutic agent sensitivity and overcomes stroma-mediated chemoresistance in acute myeloid leukemia

Effects of CCL2/CCR2 Blockade in Acute Myeloid Leukemia

Role of Mesenchymal Stem Cell Galectin 3 in the AML Tumor Microenvironment

Concurrent Inhibition of Beta-Catenin/CBP and FLT3 Strongly Suppresses c-Myc and Synergistically Induces Apoptosis in FLT3 Mutant AML Cells

Acute Myelogenous Leukemia (AML) Mesenchymal Stromal Cell (MSC) Have Distinct Protein Expression Patterns Compared to Normal MSC

The Peptidic CXCR4 Antagonist, BL-8040, Significantly Reduces Bone Marrow Immature Leukemia Progenitors By Inducing Differentiation, Apoptosis and Mobilization: Results of the Dose Escalation Clinical Trial in Acute Myeloid Leukemia

BRD4 Proteolysis Targeting Chimera (PROTAC) Leads to Sustained Degradation of BRD4 with Broad Activity Against Acute Leukemias and Overcomes Stroma Mediated Resistance By Modulating Surface Expression of CXCR4

Antileukemia activity of the novel peptidic CXCR4 antagonist LY2510924 as monotherapy and in combination with chemotherapy

Ablation of Autophagy-Related E1 Ligase Atg7 Primes Acute Myelogenous Leukemia Cells to Apoptosis, Sensitizes to Chemotherapy and Overcomes Stroma Mediated Protection

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American Society of Hematology

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ASH Publications

American Society of Hematology

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