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Jay Y. Spiegel
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Journal Articles

Limited Duration Loncastuximab Tesirine with Rituximab Induces High Complete Metabolic Response Rate in High-Risk Relapsed/Refractory Follicular Lymphoma - a Phase 2 Study

Juan Pablo Alderuccio, Alvaro J. Alencar, Jonathan H. Schatz, Russ Kuker, Georgio Pongas, Isildinha M. Reis, Jay Y. Spiegel, Laura Medina Andara, Lazaros J. Lekakis, Joseph S. Gyedu, Jose Sandoval-Sus, Amer M. Beitinjaneh, Nathalie Padron, Izidore S. Lossos, Joseph D. Rosenblatt, David S. Lessen, Craig H. Moskowitz
Journal: Blood
Blood (2023) 142 (Supplement 1): 984.
https://doi.org/10.1182/blood-2023-178825
Published: 2023
Journal Articles

Five Year Outcomes of Patients with Large B-Cell Lymphoma Treated with Standard-of-Care Axicabtagene Ciloleucel: Results from the US Lymphoma CAR-T Cell Consortium

Jay Y. Spiegel, Michael D. Jain, Loretta J. Nastoupil, John Tamaresis, Armin Ghobadi, Yi Lin, Lazaros J. Lekakis, Patrick M. Reagan, Olalekan O. Oluwole, Joseph P McGuirk, Abhinav Deol, Kathleen Dorritie, Alison R Sehgal, Andre Goy, Brian T. Hill, Charalambos Andreadis, Javier L. Munoz, Matthew L. Ulrickson, Jason Westin, Julio C. Chavez, Dilan A Patel, Miriam T. Jacobs, Radhika Bansal, N. Nora Bennani, Vivek Patel, Aaron P. Rapoport, Julie M. Vose, David B. Miklos, Sattva S. Neelapu, Frederick L. Locke, Matthew A Lunning, Saurabh Dahiya
Journal: Blood
Blood (2023) 142 (Supplement 1): 1032.
https://doi.org/10.1182/blood-2023-179868
Published: 2023
Journal Articles

Second-Line Chimeric Antigen Receptor T Cell Therapy (CAR-T) As Standard of Care for Relapsed-Refractory Large B-Cell Lymphoma (LBCL)

Saurabh Dahiya, Jay Y. Spiegel, Dasom Lee, Turab Mohammed, Forat Lutfi, Anmol Goyal, Caroline Hana, Julio C Chavez, Filip Ionescu, Matthew J. Frank, Sushma Bharadwaj, Jose Sandoval-Sus, Amer M. Beitinjaneh, Lazaros J. Lekakis, Joseph P McGuirk, Frederick L. Locke, David B. Miklos, Michael D. Jain
Journal: Blood
Blood (2023) 142 (Supplement 1): 4876.
https://doi.org/10.1182/blood-2023-188918
Published: 2023
Journal Articles

Incidence and Outcomes of Cytomegalovirus Reactivation after Chimeric Antigen Receptor T Cell Therapy

Rick Y. Lin, Anthony Anderson, Mohammed Raja, Michele I. Morris, Antonio M. Jimenez Jimenez, Amer M. Beitinjaneh, Trent Wang, Mark S. Goodman, Lazaros J. Lekakis, Jay Y. Spiegel, Denise L. Pereira, Krishna V. Komanduri, Jose F. Camargo
Journal: Blood
Blood (2023) 142 (Supplement 1): 3516.
https://doi.org/10.1182/blood-2023-175081
Published: 2023
Journal Articles

Determinants of Resistance to Engineered T-Cell Therapies Targeting CD19 in Large B-Cell Lymphomas

Brian Sworder, David M. Kurtz, Stefan K. Alig, Matthew J Frank, Navika D. Shukla, Andrea Garofalo, Charles Macaulay, Mohammad Shahrokh Esfahani, Mari Olsen, James Hamilton, III, Hitomi Hosoya, Mark P Hamilton, Jay Y. Spiegel, John H. Baird, Mia Carleton, Alexander F.M. Craig, Sheren F. Younes, Bita Sahaf, Natasha Sheybani, Joseph Schroers-Martin, Chih Long Liu, Jean S Oak, Michael C. Jin, Sara Beygi, Andreas Hüttmann, Christine Hanoun, Ulrich Dührsen, Jason Westin, Michael S. Khodadoust, Yasodha Natkunam, Robbie G. Majzner, Crystal L. Mackall, Maximilian Diehn, David B. Miklos, Ash A. Alizadeh
Journal: Blood
Blood (2022) 140 (Supplement 1): 1301–1303.
https://doi.org/10.1182/blood-2022-165545
Published: 2022
Journal Articles

Treating CAR-T relapses: check not checkmate

Clinical Trials & Observations
Jay Y. Spiegel, Krishna V. Komanduri
Journal: Blood
Blood (2022) 139 (7): 955–957.
https://doi.org/10.1182/blood.2021013896
Published: 2022
Journal Articles

Long-Term Outcomes of Patients with Large B-Cell Lymphoma Treated with Standard-of-Care Axicabtagene Ciloleucel: Results from the US Lymphoma CAR-T Cell Consortium

Jay Y. Spiegel, Michael D. Jain, Loretta Nastoupil, John Tamaresis, Armin Ghobadi, Yi Lin, Lazaros J. Lekakis, Patrick M. Reagan, Olalekan O. Oluwole, Joseph P. McGuirk, Abhinav Deol, Alison R. Sehgal, Andre H. Goy, Brian T. Hill, Charalambos Andreadis, Javier Muñoz, Matthew L. Ulrickson, Jason R. Westin, Julio C. Chavez, Miriam T. Jacobs, N Nora Bennani, Aaron P. Rapoport, Julie M. Vose, David B. Miklos, Sattva S. Neelapu, Frederick L. Locke, Saurabh Dahiya, Matthew A. Lunning
Journal: Blood
Blood (2021) 138 (Supplement 1): 3826.
https://doi.org/10.1182/blood-2021-147488
Published: 2021
Journal Articles

CD22-CAR T-Cell Therapy Mediates High Durable Remission Rates in Adults with Large B-Cell Lymphoma Who Have Relapsed after CD19-CAR T-Cell Therapy

Matthew J. Frank, John H. Baird, Shabnum Patel, Juliana Craig, Jay Y. Spiegel, Zachary Ehlinger, Harshini Chinnasamy, Sheren F. Younes, Jean S. Oak, Yasodha Natkunam, Warren D. Reynolds, Maria Iglesias, Emma Crawford, Hrishikesh K. Srinagesh, Emily L. Egeler, Sally Arai, Laura J. Johnston, Robert Lowsky, Robert S. Negrin, Andrew R. Rezvani, Parveen Shiraz, Surbhi Sidana, Wen-Kai Weng, Liora M. Schultz, Sneha Ramakrishna, Kara L. Davis, Bita Sahaf, Steven A. Feldman, Crystal L. Mackall, David B. Miklos, Lori Muffly
Journal: Blood
Blood (2021) 138 (Supplement 1): 741.
https://doi.org/10.1182/blood-2021-152145
Published: 2021
Journal Articles

CD22-directed CAR T-cell therapy induces complete remissions in CD19-directed CAR–refractory large B-cell lymphoma

Clinical Trials & Observations Brief Report
John H. Baird, Matthew J. Frank, Juliana Craig, Shabnum Patel, Jay Y. Spiegel, Bita Sahaf, Jean S. Oak, Sheren F. Younes, Michael G. Ozawa, Eric Yang, Yasodha Natkunam, John Tamaresis, Zachary Ehlinger, Warren D. Reynolds, Sally Arai, Laura Johnston, Robert Lowsky, Everett Meyer, Robert S. Negrin, Andrew R. Rezvani, Parveen Shiraz, Surbhi Sidana, Wen-Kai Weng, Kara L. Davis, Sneha Ramakrishna, Liora Schultz, Chelsea Mullins, Allison Jacob, Ilan Kirsch, Steven A. Feldman, Crystal L. Mackall, David B. Miklos, Lori Muffly
Journal: Blood
Blood (2021) 137 (17): 2321–2325.
https://doi.org/10.1182/blood.2020009432
Published: 2021
Includes: Supplemental data
Journal Articles

Outcomes of patients with large B-cell lymphoma progressing after axicabtagene ciloleucel therapy

Clinical Trials & Observations
Jay Y. Spiegel, Saurabh Dahiya, Michael D. Jain, John Tamaresis, Loretta J. Nastoupil, Miriam T. Jacobs, Armin Ghobadi, Yi Lin, Matthew Lunning, Lazaros Lekakis, Patrick Reagan, Olalekan Oluwole, Joseph McGuirk, Abhinav Deol, Andre Goy, Khoan Vu, Charalambos Andreadis, Javier Munoz, N. Nora Bennani, Julie M. Vose, Kathleen A. Dorritie, Sattva S. Neelapu, Frederick L. Locke, Aaron P. Rapoport, Brian T. Hill, David B. Miklos
Journal: Blood
Blood (2021) 137 (13): 1832–1835.
https://doi.org/10.1182/blood.2020006245
Published: 2021
Includes: Supplemental data
Journal Articles

Bleeding and Thrombosis Are Associated with Endothelial Dysfunction in CAR-T Cell Therapy and Are Increased in Patients Experiencing Neurologic Toxicity

Andrew Johnsrud, MD, Juliana Craig, BA, John H. Baird, MD, Jay Y. Spiegel, MDFRCPC, Lori S. Muffly, MD MS, James Zehnder, MD, Robert S. Negrin, MD, Laura J. Johnston, MD, Sally Arai, MD MS, Judith A Shizuru, MD PhD, Robert Lowsky, MD FRCP, Everett H Meyer, MD PhD, Wen-Kai Weng, MD PhD, Parveen Shiraz, MD, Andrew R. Rezvani, MD, Theresa Latchford, RN, Crystal L. Mackall, MD, David B. Miklos, MD PhD, Matthew J. Frank, MD PhD, Surbhi Sidana, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 32–33.
https://doi.org/10.1182/blood-2020-142218
Published: 2020
Journal Articles

Molecular Imaging of Chimeric Antigen Receptor T Cells By ICOS-Immunopet

Federico Simonetta, MD PhD, Israt S. Alam, PhD, Juliane K. Lohmeyer, MD, Bita Sahaf, PhD, Zinaida Good, PhD, Weiyu Chen, PhD, Zunyu Xiao, MD PhD, Toshihito Hirai, MD PhD, Lukas Scheller, MD, Pujan Engels, M.Sc., Ophir Vermesh, MD PhD, Elise Robinson, Tom Haywood, PhD, Ataya Sathirachindra, Jeanette Baker, Meena B. Malipatlolla, Liora M. Schultz, MD, Jay Y. Spiegel, MDFRCPC, Jason T. Lee, PhD, David B. Miklos, MD PhD, Crystal L. Mackall, MD, Sanjiv S. Gambhir, MD PhD, Robert S. Negrin, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 5–6.
https://doi.org/10.1182/blood-2020-136331
Published: 2020
Journal Articles

Monitoring Measurable Residual Disease Using Peripheral Blood in Acute Lymphoblastic Leukemia: Results of a Prospective, Observational Study

Lori S. Muffly, MD MS, Vandana Sundaram, MPH, Connie Chen, Ilana Yurkiewicz, MD BS, Eric Kuo, Sarah Burnash, Jay Y. Spiegel, MDFRCPC, Kelly Chyan, Sally Arai, MD MS, Matthew J. Frank, MD PhD, Laura J. Johnston, MD, Robert Lowsky, MD FRCP, Everett H Meyer, MD PhD, Robert S. Negrin, MD, Andrew R. Rezvani, MD, Surbhi Sidana, MD, Parveen Shiraz, MD, Judith A Shizuru, MD PhD, Wen-Kai Weng, MD PhD, Michaela Liedtke, MD, Hyma T. Vempaty, MD, David B. Miklos, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 22–23.
https://doi.org/10.1182/blood-2020-138988
Published: 2020
Journal Articles

CD22-Directed CAR T-Cell Therapy Mediates Durable Complete Responses in Adults with Relapsed or Refractory Large B-Cell Lymphoma after Failure of CD19-Directed CAR T-Cell Therapy and High Response Rates in Adults with Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia

John H. Baird, MD, Matthew J. Frank, MD PhD, Juliana Craig, BA, Shabnum Patel, PhD, Jay Y. Spiegel, MDFRCPC, Bita Sahaf, PhD, Sheren F. Younes, MD PhD, Jean S. Oak, MD PhD, Yasodha Natkunam, MD PhD, Zachary Ehlinger, MS, Warren D. Reynolds, BS, Sally Arai, MD MS, Laura J. Johnston, MD, Robert Lowsky, MD FRCP, Robert S. Negrin, MD, Andrew R. Rezvani, MD, Parveen Shiraz, MD, Surbhi Sidana, MD, Wen-Kai Weng, MD PhD, Liora M. Schultz, MD, Sneha Ramakrishna, MD, Kara L Davis, DO, Steven A. Feldman, PhD, Crystal L. Mackall, MD, David B. Miklos, MD PhD, Lori S. Muffly, MD MS
Journal: Blood
Blood (2020) 136 (Supplement 1): 28–29.
https://doi.org/10.1182/blood-2020-139087
Published: 2020
Journal Articles

CD58 Aberrations Limit Durable Responses to CD19 CAR in Large B Cell Lymphoma Patients Treated with Axicabtagene Ciloleucel but Can be Overcome through Novel CAR Engineering

Robbie G. Majzner, MD, Matthew J. Frank, MD PhD, Christopher Mount, MD PhD, Aidan Tousley, David M. Kurtz, MDPhD, Brian Sworder, MD PhD, Katherine A Murphy, Antigoni Manousopoulou, Kennedy Kohler, Maria Caterina Rotiroti, PhD, Jay Y. Spiegel, MDFRCPC, Yasodha Natkunam, MD PhD, Sheren F. Younes, MD PhD, Elena Sotillo, PhD, Vandon Duong, Charles Macaulay, MSc, BA, Zinaida Good, PhD, Peng Xu, MD, Louai Labanieh, Leo D Wang, MD PhD, Ash A. Alizadeh, MD PhD, Michelle Monje, MD PhD, David B. Miklos, MD PhD, Crystal L. Mackall, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 53–54.
https://doi.org/10.1182/blood-2020-139605
Published: 2020
Journal Articles

Detectable Circulating Tumor DNA 28 Days after the CD19 CAR T-Cell Therapy, Axicabtagene Ciloleucel, Is Associated with Poor Outcomes in Patients with Diffuse Large B-Cell Lymphoma

Matthew J. Frank, MD PhD, Nasheed Hossain, MD, Ali Bukhari, MD, Erin Dean, MD, Jay Y. Spiegel, MDFRCPC, Gursharan K. Claire, MPH, Ilan M. Kirsch, Allison P. Jacob, Chelsea D Mullins, BS, Lik Wee Lee, PhD, Katherine A. Kong, Juliana Craig, BA, Crystal L. Mackall, MD, Aaron P. Rapoport, Saurabh Dahiya, MD, Frederick L. Locke, MD, David B Miklos, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 884.
https://doi.org/10.1182/blood-2019-132057
Published: 2019
Journal Articles

Circulating DNA for Molecular Response Prediction, Characterization of Resistance Mechanisms and Quantification of CAR T-Cells during Axicabtagene Ciloleucel Therapy

Brian Sworder, MD PhD, David M. Kurtz, MD PhD, Charles Macaulay, MSc, BA, Matthew J. Frank, MD PhD, Stefan Alig, MD, Andrea Garofalo, BS, BA, Bita Sahaf, PhD, Mohammad Shahrokh Esfahani, Jay Y. Spiegel, MDFRCPC, Jean Oak, MD PhD, Sara Beygi, MD, Michael C. Jin, BS, Jacob J Chabon, Michael S. Khodadoust, MD PhD, Robbie G. Majzner, MD, Crystal L. Mackall, MD, Maximilian Diehn, MD PhD, David B Miklos, MD PhD, Ash A. Alizadeh, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 550.
https://doi.org/10.1182/blood-2019-129015
Published: 2019
Journal Articles

Characteristics and Outcomes of Patients Receiving Bridging Therapy While Awaiting Manufacture of Standard of Care Axicabtagene Ciloleucel CD19 Chimeric Antigen Receptor (CAR) T-Cell Therapy for Relapsed/Refractory Large B-Cell Lymphoma: Results from the US Lymphoma CAR-T Consortium

Michael D. Jain, MD PhD, Miriam T. Jacobs, MD, Loretta J. Nastoupil, MD MSc, Jay Y. Spiegel, MDFRCPC, Gao Feng, Yi Lin, MD PhD, Matthew A. Lunning, DO, FACP, Saurabh Dahiya, MD, Lazaros J Lekakis, MD, Patrick M Reagan, MD, Olalekan O. Oluwole, MBBS, MPH, Joseph P. McGuirk, DO, Abhinav Deol, MD, Andre Goy, MD, Brian T. Hill, MD, Javier Munoz, MD, Julio Chavez, Aaron P. Rapoport, Julie M Vose, MDMBA, David B Miklos, MD PhD, Sattva S Neelapu, MD, N. Nora Bennani, MD, Charalambos Andreadis, MD MSCE, Alison R. Sehgal, MD, Armin Ghobadi, MD, Frederick L. Locke, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 245.
https://doi.org/10.1182/blood-2019-129624
Published: 2019
Journal Articles

Characteristics and Outcomes of Patients Who Did Not Develop CRS after Axicabtagene Ciloleucel for Relapsed/Refractory Large B-Cell Lymphoma: Results from the US Lymphoma CAR-T Consortium

Miriam T. Jacobs, MD, Michael D. Jain, MD PhD, Jay Y. Spiegel, MDFRCPC, Loretta J. Nastoupil, MD MSc, Yibo Li, MD, Gao Feng, Matthew A. Lunning, DO, FACP, Lazaros J Lekakis, MD, Saurabh Dahiya, MD, Patrick M Reagan, MD, Olalekan O. Oluwole, MBBS, MPH, Joseph P. McGuirk, DO, Abhinav Deol, MD, Alison R. Sehgal, MD, Andre Goy, MD, Brian T. Hill, MD, Charalambos Andreadis, MD MSCE, Javier Munoz, MD, Julio Chavez, N. Nora Bennani, MD, Aaron P. Rapoport, Julie M Vose, MDMBA, David B Miklos, MD PhD, Sattva S Neelapu, MD, Armin Ghobadi, MD, Frederick L. Locke, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1583.
https://doi.org/10.1182/blood-2019-131168
Published: 2019
Journal Articles

Phase I Trial Using CD19/CD22 Bispecific CAR T Cells in Pediatric and Adult Acute Lymphoblastic Leukemia (ALL)

Liora M Schultz, MD, Lori S Muffly, MD, Jay Y. Spiegel, MDFRCPC, Sneha Ramakrishna, MD, Nasheed Hossain, MD, Christina Baggott, RN, PhD, Bita Sahaf, PhD, Shabnum Patel, PhD, Juliana Craig, BA, Jenny Yoon, Meena Kadapakkam, MD, Robbie G. Majzner, MD, Matthew J. Frank, MD PhD, Courtney Erickson, Anne Cunniffe Marcy, MSBH, Michelle Fujimoto, Neehar Bhatia, Everett H Meyer, MD PhD, Katherine A. Kong, Emily Egeler, Sharon Mavroukakis, Haiying Qin, MS, Terry J. Fry, MD, Steven A Feldman, PhD, David B Miklos, MD PhD, Crystal L. Mackall, MD, Kara L. Davis, DO
Journal: Blood
Blood (2019) 134 (Supplement_1): 744.
https://doi.org/10.1182/blood-2019-129411
Published: 2019