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David B. Miklos
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Journal Articles

Real-world and clinical trial outcomes in large B-cell lymphoma with axicabtagene ciloleucel across race and ethnicity

Clinical Trials & Observations
Frederick L. Locke, Tanya Siddiqi, Caron A. Jacobson, Armin Ghobadi, Sairah Ahmed, David B. Miklos, Miguel-Angel Perales, Javier Munoz, Warren B. Fingrut, Martina Pennisi, Jordan Gauthier, Mazyar Shadman, Lohith Gowda, Abu-Sayeef Mirza, Muhammad Bilal Abid, Sanghee Hong, Navneet S. Majhail, Mohamed A. Kharfan-Dabaja, Arushi Khurana, Talha Badar, Yi Lin, N. Nora Bennani, Megan M. Herr, Zhen-Huan Hu, Hai-Lin Wang, Anjani Baer, Elande Baro, Harry Miao, Clare Spooner, Hairong Xu, Marcelo C. Pasquini
Journal: Blood
Blood (2024) 143 (26): 2722–2734.
https://doi.org/10.1182/blood.2023023447
Published: 2024
Includes: Supplemental data
Journal Articles

CAR19 Therapy Drives Expansion of Clonal Hematopoiesis and Associated Cytopenias

Mark P. Hamilton, Brian J. Sworder, Stefan K. Alig, Zinaida Good, Jan Boegeholz, Joseph Schroers-Martin, John Tamaresis, Mohammad Shahrokh Esfahani, Ying Lu, Mari Olsen, Chih Long Liu, Zachary Ehlinger, Moksha Desai, Felicia Liu-Fei, Lori S. Muffly, Robert S. Negrin, Sally Arai, Laura Johnston, Robert Lowsky, Everett H. Meyer, Andrew R. Rezvani, Judith Shizuru, Wen-Kai Weng, Parveen Shiraz, Surbhi Sidana, Sushma Bharadwaj, Melody Smith, Saurabh Dahiya, Bita Sahaf, Maximilian Diehn, Matthew J. Frank, Crystal L. Mackall, David M. Kurtz, David B. Miklos, Ash A. Alizadeh
Journal: Blood
Blood (2023) 142 (Supplement 1): 360.
https://doi.org/10.1182/blood-2023-182522
Published: 2023
Journal Articles

Impact of Obesity on Efficacy, Safety, and Expansion Kinetics of Chimeric Antigen Receptor-T (CAR T) Therapy in Patients with Relapsed or Refractory Large B Cell Lymphoma (LBCL)

Anmol Goyal, Sushma Bharadwaj, Dasom Lee, Eric Lau, Mark P. Hamilton, Alexandria Jensen, Bita Sahaf, Shriya Syal, Sunita Patil, Juancarlos E Cancilla, Theresa Latchford, Wen-Kai Weng, Melody Smith, Matthew J. Frank, David B. Miklos, Saurabh Dahiya
Journal: Blood
Blood (2023) 142 (Supplement 1): 3783.
https://doi.org/10.1182/blood-2023-186828
Published: 2023
Journal Articles

ALLO-647 for Lymphodepletion in the Allogeneic CAR T Setting: Safety Experience with ALLO-501/501A in Patients (Pts) with Relapsed/Refractory (r/r) Large B-Cell and Follicular Lymphomas

Frederick L. Locke, Javier L. Munoz, Michael T. Tees, Lazaros J. Lekakis, Herbert A. Eradat, Sven de Vos, Rajneesh Nath, Don A. Stevens, Shahbaz A. Malik, Geoffrey P. Shouse, Mehdi Hamadani, Olalekan O. Oluwole, Miguel-Angel Perales, David B. Miklos, Anh Nguyen, Amy Feng, Lynn Navale, Elaine Murray, Greg P. Kaufman, Kazuharu Kai, John B. Le Gall, Sattva S. Neelapu
Journal: Blood
Blood (2023) 142 (Supplement 1): 2095.
https://doi.org/10.1182/blood-2023-189196
Published: 2023
Journal Articles

Transcriptional Profiling Associated with CD22 CAR T Cell Clinical Response in LBCL

Anne Marijn Kramer, Mark P. Hamilton, Snehit Prabhu, Moksha Desai, Adam Kuo, Zachary Ehlinger, Neha Agarwal, Yi-Jiun Su, Nikolaos Gkitsas, Carley Fowler, Vimal Keerthi, Aidan Retherford, Dorota Klysz, Ramya Tunuguntla, Steven Feldman, Bita Sahaf, John H. Baird, Lori S. Muffly, Crystal L. Mackall, David B. Miklos, Zinaida Good, Matthew J. Frank
Journal: Blood
Blood (2023) 142 (Supplement 1): 2091.
https://doi.org/10.1182/blood-2023-187615
Published: 2023
Journal Articles

Manufacturing of a Subsequent Autologous CAR-T Product after Prior CAR-T Is Safe and Feasible

Yi-Jiun Su, Anne Marijn Kramer, Mark P. Hamilton, Neha Agarwal, Steven Feldman, Bita Sahaf, Adam Kuo, Crystal L. Mackall, Lori S. Muffly, David B. Miklos, Matthew J. Frank
Journal: Blood
Blood (2023) 142 (Supplement 1): 1037.
https://doi.org/10.1182/blood-2023-185413
Published: 2023
Journal Articles

Second-Line Chimeric Antigen Receptor T Cell Therapy (CAR-T) As Standard of Care for Relapsed-Refractory Large B-Cell Lymphoma (LBCL)

Saurabh Dahiya, Jay Y. Spiegel, Dasom Lee, Turab Mohammed, Forat Lutfi, Anmol Goyal, Caroline Hana, Julio C Chavez, Filip Ionescu, Matthew J. Frank, Sushma Bharadwaj, Jose Sandoval-Sus, Amer M. Beitinjaneh, Lazaros J. Lekakis, Joseph P McGuirk, Frederick L. Locke, David B. Miklos, Michael D. Jain
Journal: Blood
Blood (2023) 142 (Supplement 1): 4876.
https://doi.org/10.1182/blood-2023-188918
Published: 2023
Journal Articles

Post-CAR-T Minimal Residual Disease (MRD) Monitoring in Mantle Cell Lymphoma Enables Early Relapse Detection

Snegha Ananth, Yi-Jiun Su, Mark P. Hamilton, Neha Agarwal, Wen-Kai Weng, Saurabh Dahiya, Sushma Bharadwaj, Jayasindhu Mallampet, Melody Smith, Katherine Ann Kong, Abigail Twoy, David B. Miklos, Matthew J. Frank
Journal: Blood
Blood (2023) 142 (Supplement 1): 1673.
https://doi.org/10.1182/blood-2023-188338
Published: 2023
Journal Articles

Improved Overall Survival with Axicabtagene Ciloleucel Vs Standard of Care in Second-Line Large B-Cell Lymphoma Among the Elderly: A Subgroup Analysis of ZUMA-7

Marie José Kersten, Umar Farooq, Aaron P. Rapoport, Frederick L. Locke, Lori A. Leslie, Armin Ghobadi, David B. Miklos, Caron A. Jacobson, Javier L. Munoz, Patrick B Johnston, Samantha M. Jaglowski, Ian W. Flinn, Tom van Meerten, Miguel-Angel Perales, Peter Vandenberghe, Peter A. Riedell, Kathleen Dorritie, David Szwajcer, Dimitrios Tzachanis, Saran Vardhanabhuti, Linqiu Du, Simone Filosto, Shilpa A. Shahani, Christina To, Jason Westin
Journal: Blood
Blood (2023) 142 (Supplement 1): 1761.
https://doi.org/10.1182/blood-2023-173873
Published: 2023
Journal Articles

Pre- and Post-Treatment Immune Contexture Correlates with Long Term Response in Large B Cell Lymphoma Patients Treated with Axicabtagene Ciloleucel (axi-cel)

Mike Mattie, Melanie Grosso, Aurelie Auguste, Denis Arnaud, Frederick L. Locke, Sattva S. Neelapu, David B. Miklos, Caron A Jacobson, Lazaros J. Lekakis, Yi Lin, Armin Ghobadi, Jenny J. Kim, Jenny Nater, Rhine R. Shen, Jerome Galon
Journal: Blood
Blood (2023) 142 (Supplement 1): 226.
https://doi.org/10.1182/blood-2023-187574
Published: 2023
Journal Articles

Phase 1 Trial Results for Patients with Advanced Hematologic Malignancies Undergoing Reduced Intensity Allogeneic HCT with Orca-T Donor Cell Therapy Product and Single Agent Tacrolimus

Alejandro Villar-Prados, Everett H. Meyer, Katherine Sutherland, Robert S. Negrin, Sally Arai, Matthew J. Frank, Laura Johnston, Robert Lowsky, David B. Miklos, Lori S. Muffly, Saurabh Dahiya, Andrew R. Rezvani, Surbhi Sidana, Parveen Shiraz, Judith Shizuru, Wen-Kai Weng, Melody Smith, Sushma Bharadwaj, John Tamaresis, Anna Pavlova, Scott McClellan
Journal: Blood
Blood (2023) 142 (Supplement 1): 3560.
https://doi.org/10.1182/blood-2023-188162
Published: 2023
Journal Articles

CD22 CAR T Cell-Related IEC-HS Is Associated with an IFN-γ Cytokine Signature

Hrishikesh Srinagesh, John H. Baird, Neha Agarwal, Yi-Jiun Su, Anne Marijn Kramer, Agnes Reschke, Nikeshan Jeyakumar, Sushma Bharadwaj, Liora Michal Schultz, Sneha Ramakrishna, Kara L. Davis, Bita Sahaf, Steven Feldman, Crystal L. Mackall, David B. Miklos, Lori S. Muffly, Matthew J. Frank
Journal: Blood
Blood (2023) 142 (Supplement 1): 4839.
https://doi.org/10.1182/blood-2023-178283
Published: 2023
Journal Articles

Assessment of Early Intervention Strategies for Management of Cytokine Release Syndrome and Neurologic Events after Brexucabtagene Autoleucel (Brexu-Cel) Treatment in Patients with Relapsed or Refractory Mantle Cell Lymphoma (R/R MCL) in ZUMA-2

Olalekan O. Oluwole, Patrick M. Reagan, David B. Miklos, Frederick L. Locke, Andre Goy, Caron A. Jacobson, Javier L. Munoz, Edouard Forcade, Max S. Topp, Dan Zheng, Ana Nunes, Wangshu Zhang, Rhine R. Shen, Ioana Kloos, Marie José Kersten, Michael L. Wang
Journal: Blood
Blood (2023) 142 (Supplement 1): 2120.
https://doi.org/10.1182/blood-2023-174681
Published: 2023
Journal Articles

Five Year Outcomes of Patients with Large B-Cell Lymphoma Treated with Standard-of-Care Axicabtagene Ciloleucel: Results from the US Lymphoma CAR-T Cell Consortium

Jay Y. Spiegel, Michael D. Jain, Loretta J. Nastoupil, John Tamaresis, Armin Ghobadi, Yi Lin, Lazaros J. Lekakis, Patrick M. Reagan, Olalekan O. Oluwole, Joseph P McGuirk, Abhinav Deol, Kathleen Dorritie, Alison R Sehgal, Andre Goy, Brian T. Hill, Charalambos Andreadis, Javier L. Munoz, Matthew L. Ulrickson, Jason Westin, Julio C. Chavez, Dilan A Patel, Miriam T. Jacobs, Radhika Bansal, N. Nora Bennani, Vivek Patel, Aaron P. Rapoport, Julie M. Vose, David B. Miklos, Sattva S. Neelapu, Frederick L. Locke, Matthew A Lunning, Saurabh Dahiya
Journal: Blood
Blood (2023) 142 (Supplement 1): 1032.
https://doi.org/10.1182/blood-2023-179868
Published: 2023
Journal Articles

Effective Prevention of Steroid-Requiring Chronic Graft-Vs.-Host Disease with B Cell Depletion: A Randomized, Placebo-Controlled Trial

Corey Cutler, Haesook T. Kim, Hassan El Banna, Elizabeth Halloran, Emily Matozel, Vincent Ho, John Koreth, Mahasweta Gooptu, Roman M. Shapiro, Amar H Kelkar, Christopher James Gibson, Carol Reynolds, Michela Ansuinelli, Rayuko Tamada, Chloe Au, Zachariah Defilipp, Areej El-Jawahri, Yi-Bin Chen, Najla H El Jurdi, Daniel Weisdorf, Daniel R. Couriel, Catherine J. Lee, Bita Sahaf, Juliana Craig, Kathleen Ji, Robert J. Soiffer, David B. Miklos, Joseph Antin, Jerome Ritz
Journal: Blood
Blood (2023) 142 (Supplement 1): 649.
https://doi.org/10.1182/blood-2023-180142
Published: 2023
Journal Articles

Analysis of PET-CT Derived Radiomic Biomarkers with Efficacy, Safety, and Expansion of Axicabtagene Ciloleucel (Axi-Cel) in Patients with Relapsed or Refractory Large B-Cell Lymphoma (LBCL)

Sushma Bharadwaj, Eric Lau, Ayesha Hashmi, Mark P. Hamilton, Alexandria Jensen, Anmol Goyal, Mallika Marar, Caroline Lee, Snegha Ananth, Bita Sahaf, Jayasindhu Mallampet, Zachary Ehlinger, Shriya Syal, Sunita Patil, Henry Guo, Melody Smith, Wen-Kai Weng, Matthew J. Frank, Michael S. Binkley, David B. Miklos, Saurabh Dahiya
Journal: Blood
Blood (2023) 142 (Supplement 1): 2125.
https://doi.org/10.1182/blood-2023-187617
Published: 2023
Journal Articles

Curative Potential of Axicabtagene Ciloleucel (Axi-Cel): An Exploratory Long-Term Survival Assessment in Patients with Refractory Large B-Cell Lymphoma from ZUMA-1

Sattva S. Neelapu, Caron A. Jacobson, Armin Ghobadi, David B. Miklos, Lazaros J. Lekakis, Clare Spooner, Jenny J. Kim, Harry Miao, Allen Xiaodong Xue, Yan Zheng, Frederick L. Locke
Journal: Blood
Blood (2023) 142 (Supplement 1): 4864.
https://doi.org/10.1182/blood-2023-174288
Published: 2023
Journal Articles

Long-Term Efficacy and Immune Reconstitution with Bendamustine As a Lymphodepleting Agent for Axicabtagene Ciloleucel (Axi-Cel) in Patients with Refractory or Relapsed Large B-Cell Lymphoma (LBCL)

Sushma Bharadwaj, Eric Lau, Anmol Goyal, Mark P. Hamilton, Hrishikesh Srinagesh, Alexandria Jensen, Shriya Syal, Jayasindhu Mallampet, Theresa Latchford, Bita Sahaf, Wen-Kai Weng, Melody Smith, Holden T Maecker, Matthew J. Frank, David B. Miklos, Saurabh Dahiya
Journal: Blood
Blood (2023) 142 (Supplement 1): 4878.
https://doi.org/10.1182/blood-2023-188166
Published: 2023
Journal Articles

Improved outcomes for relapsed/refractory Hodgkin lymphoma after autologous transplantation in the era of novel agents

Clinical Trials & Observations
Michael A. Spinner, R. A. Sica, John S. Tamaresis, Ying Lu, Cheryl Chang, Robert Lowsky, Matthew J. Frank, Laura J. Johnston, David B. Miklos, Lori S. Muffly, Robert S. Negrin, Andrew R. Rezvani, Parveen Shiraz, Judith A. Shizuru, Wen-Kai Weng, Michael S. Binkley, Richard T. Hoppe, Ranjana H. Advani, Sally Arai
Journal: Blood
Blood (2023) 141 (22): 2727–2737.
https://doi.org/10.1182/blood.2022018827
Published: 2023
Includes: Supplemental data
Journal Articles

Five-year follow-up of ZUMA-1 supports the curative potential of axicabtagene ciloleucel in refractory large B-cell lymphoma

Clinical Trials & Observations
Sattva S. Neelapu, Caron A. Jacobson, Armin Ghobadi, David B. Miklos, Lazaros J. Lekakis, Olalekan O. Oluwole, Yi Lin, Ira Braunschweig, Brian T. Hill, John M. Timmerman, Abhinav Deol, Patrick M. Reagan, Patrick Stiff, Ian W. Flinn, Umar Farooq, Andre H. Goy, Peter A. McSweeney, Javier Munoz, Tanya Siddiqi, Julio C. Chavez, Alex F. Herrera, Nancy L. Bartlett, Adrian A. Bot, Rhine R. Shen, Jinghui Dong, Kanwarjit Singh, Harry Miao, Jenny J. Kim, Yan Zheng, Frederick L. Locke
Journal: Blood
Blood (2023) 141 (19): 2307–2315.
https://doi.org/10.1182/blood.2022018893
Published: 2023
Includes: Supplemental data