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Journal Articles

Baseline Immune State and T-cell Clonal Kinetics are Associated with Durable Response to CAR-T Therapy in Large B-cell Lymphoma

Clinical Trials & Observations
Katie Maurer, Isabella N Grabski, Roch Houot, Satyen H. Gohil, Shogo Miura, Robert A Redd, Haoxiang Lyu, Wesley Lu, Yohei Arihara, Justin Budka, Mikaela McDonough, Michela Ansuinelli, Carol G Reynolds, Heather Jacene, Shuqiang Li, Kenneth J Livak, Jerome Ritz, Brodie Miles, Mike Mattie, Donna S. Neuberg, Rafael A. Irizarry, Philippe Armand, Catherine J Wu, Caron A. Jacobson
Journal: Blood
Blood blood.2024024381.
https://doi.org/10.1182/blood.2024024381
Published: 2024
Includes: Supplemental data
Journal Articles

Efficacy of CAR T-cell therapy is not impaired by previous bispecific antibody treatment in large B-cell lymphoma

Clinical Trials & Observations
Gilles Crochet, Gloria Iacoboni, Audrey Couturier, Emmanuel Bachy, Josu Iraola-Truchuelo, Thomas Gastinne, Guillaume Cartron, Tom Fradon, Bastien Lesne, Mi Kwon, Romain Gounot, Nuria Martínez-Cibrian, Cristina Castilla-Llorente, Pau Abrisqueta, Manuel Guerreiro, Clémentine Sarkozy, Jose María Aspa-Cilleruelo, Vincent Camus, Stéphanie Guidez, Adrien Chauchet, Eric Deconinck, Krimo Bouabdallah, Francesc Bosch, Pere Barba, Franck Morschhauser, Roch Houot
Journal: Blood
Blood (2024) 144 (3): 334–338.
https://doi.org/10.1182/blood.2024024526
Published: 2024
Includes: Supplemental data
Journal Articles

Obinutuzumab vs rituximab for transplant-eligible patients with mantle cell lymphoma

Clinical Trials & Observations
Clémentine Sarkozy, Mary Callanan, Catherine Thieblemont, Lucie Obéric, Barbara Burroni, Krimo Bouabdallah, Gandhi Damaj, Benoit Tessoulin, Vincent Ribrag, Roch Houot, Franck Morschhauser, Samuel Griolet, Clémentine Joubert, Victoria Cacheux, Vincent Delwail, Violaine Safar, Remy Gressin, Morgane Cheminant, Marie-Hélène Delfau-Larue, Olivier Hermine, Elizabeth Macintyre, Steven Le Gouill
Journal: Blood
Blood (2024) 144 (3): 262–271.
https://doi.org/10.1182/blood.2024023944
Published: 2024
Includes: Supplemental data
Journal Articles

High efficacy of CD19 CAR T cells in patients with transformed Waldenström macroglobulinemia

Clinical Trials & Observations
Eric Durot, Damien Roos-Weil, Adrien Chauchet, Justine Decroocq, Roberta Di Blasi, Thomas Gastinne, Hedi Bensaber, Morgane Cheminant, Caroline Jacquet, Stéphanie Guidez, François-Xavier Gros, Emmanuel Bachy, Arthur Coste, Pascale Cony-Makhoul, Steven P. Treon, Alain Delmer, Ran Reshef, Steven Le Gouill, Jorge J. Castillo, Roch Houot
Journal: Blood
Blood (2024) 143 (26): 2804–2807.
https://doi.org/10.1182/blood.2024024452
Published: 2024
Includes: Supplemental data
Journal Articles

Efficacy of Chimeric Antigen Receptor T-Cell Therapy Is Not Impaired By Previous Bispecific Antibody Treatment in Patients with Large B-Cell Lymphoma

Gloria Iacoboni, Gilles Crochet, Audrey Couturier, Emmanuel Bachy, Josu Iraola, Thomas Gastinne, Charles Herbaux, Tom Fradon, Mi Kwon, Romain Gounot, Nuria Martinez-Cibrian, Cristina Castilla-Llorente, Manuel Guerreiro, Clementine Sarkozy, Jose Aspa-Cilleruelo, Vincent Camus, Stephanie Guidez, Adrien Chauchet, Eric Deconinck, Krimo Bouabdallah, Pere Barba, Roch Houot, Franck Morschhauser
Journal: Blood
Blood (2023) 142 (Supplement 1): 228.
https://doi.org/10.1182/blood-2023-185035
Published: 2023
Journal Articles

Impact of Paraclinical Investigations in the Management of CAR T-Cell-Associated Neurotoxicity: Lessons Learned from Real World Experience

Mattéo Mauget, Guillaume Manson, Roch Houot
Journal: Blood
Blood (2023) 142 (Supplement 1): 4881.
https://doi.org/10.1182/blood-2023-180199
Published: 2023
Journal Articles

Results of the Phase II of Epirchop Study, Evaluating the Efficacy of Tazemetostat in Combination with R-CHOP in Elderly Newly Diagnosed Diffuse Large B Cell Lymphoma (DLBCL): A Lysa Study

Clementine Sarkozy, Thierry Jo Molina, Roch Houot, Sydney Dubois, Gian Matteo Pica, Philippe Ruminy, Charles Herbaux, Thomas Gastinne, Corinne Haioun, Stephanie Guidez, Christophe Bonnet, Marc Andre, Liana Vereseza, Choquet Sylvain, Loic Ysebaert, Emmanuel Bachy, Fabrice Jardin, Franck Morschhauser, Vincent Ribrag
Journal: Blood
Blood (2023) 142 (Supplement 1): 853.
https://doi.org/10.1182/blood-2023-174607
Published: 2023
Journal Articles

Post-Transplant Lymphoproliferative Disorders (PTLD) in Real Life: Data from the French K-Virogref Registry on 525 Adult Patients

Antoine Tichadou, Elise Toussaint, Luc Matthieu Fornecker, Veronique Morel, Inès Boussen, Damien Roos Weil, Marine Baron, Madalina Uzunov, Laetitia Souchet, Louise Roulin, Nabih Azar, Stéphane Lepretre, Bijou Fontanet, Caroline Jacquet, Eric Durot, David Boutboul, Felipe Suarez, Thomas Cluzeau, Mohamed Touati, Emmanuel Bachy, Roch Houot, Fabrice Jardin, Romain Guieze, Loic Ysebaert, Laure Farnault de Lassus, Sylvain Choquet
Journal: Blood
Blood (2023) 142 (Supplement 1): 443.
https://doi.org/10.1182/blood-2023-189133
Published: 2023
Journal Articles

Invasive Fungal Infections after CAR T-Cell Therapy for B-Cell Lymphoma: A Study from the French Descart Registry

Amélie Bouvier, Amandine Durand, Nicolas Gower, Cristina Castilla-Llorente, Arnaud Campidelli, Remy Dulery, Jean-Pierre Gangneux, Magalie Joris, Martin Eloit, Amandine Fayard, Roberta Di Blasi, Blandine Denis, Charles Herbaux, Franck Morschhauser, Olivier Casasnovas, Roch Houot, Cécile Angebault, Emmanuel Bachy, Fabien Le Bras, Thomas Gastinne, Jean-Jacques Tudesq, Giovanna Melica
Journal: Blood
Blood (2023) 142 (Supplement 1): 2140.
https://doi.org/10.1182/blood-2023-185632
Published: 2023
Journal Articles

Is CAR T a Drug or a Therapeutic Pathway? Systematic Review, (Re-)Estimation of Efficacy Endpoints and Metanalyses in Large B-Cell Lymphoma Real World Reports

Pier Luigi Zinzani, Rossana Di Staso, Beatrice Casadei, Frederick L. Locke, Michael D. Jain, Timothy Voorhees, Adam S Kittai, Mariana Bastos-Oreiro, Antonio Gutiérrez, Alejandro Martin Garcia-Sancho, Maria Jose Terol, Monica Mead, Michael J. Maranzano, Gloria Iacoboni, Pere Barba, Mi Kwon, Rebeca Bailen, Juan Luis Reguera, Agrima Mian, Brian T. Hill, Emmanuel Bachy, Franck Morschhauser, Roch Houot, Catherine Thieblemont, Steven Le Gouill, Riccardo Masetti, Davide Gori, Lisa Argnani
Journal: Blood
Blood (2023) 142 (Supplement 1): 6938.
https://doi.org/10.1182/blood-2023-178526
Published: 2023
Journal Articles

Low Tmtv Influences Response and Outcomes in R/R DLBCL 3L+ Patients Treated with CAR-T Cells : First Results of FDG-PET/CT Analysis in the French Descar-T Registry

Yassine Al Tabaa, Clément Bailly, Xavier Pallard, Anne Ségolène Cottereau, Jérémie Tordo, Pierre Sesques, Guillaume Cartron, Roch Houot, Roberta Di Blasi, Salim Kanoun, Caroline Milin, Françoise Kraeber-Bodéré, Laetitia Vercellino
Journal: Blood
Blood (2023) 142 (Supplement 1): 3019.
https://doi.org/10.1182/blood-2023-185794
Published: 2023
Journal Articles

Englumafusp Alfa (CD19-4-1BBL) and Glofitamab Combination in Patients with Relapsed/Refractory Non-Hodgkin Lymphoma (R/R NHL): Biomarker Results from a Phase I Dose-Escalation Trial

Koorosh Korfi, Ailsa Christiansen, Zhiwen Jiang, Sabine Wilson, Samuel Tracy, Annika Blank, Sylvia Herter, Natalie Dimier, Bruno Gomes, Pablo Umana, Herve Ghesquieres, Roch Houot, Fritz Offner, Harriet Walter, Nancy L. Bartlett, Guillaume Cartron, Michael Dickinson, William Townsend, Giuseppe Gritti, Francesc Bosch Albareda, Franck Morschhauser, Martin Hutchings, Carmelo Carlo-Stella, Katharina Lechner
Journal: Blood
Blood (2023) 142 (Supplement 1): 3017.
https://doi.org/10.1182/blood-2023-173677
Published: 2023
Journal Articles

R-GemOx Plus Nivolumab Vs R-GemOx As Second-Line Therapy for Large B-Cell Lymphoma in Transplant-Ineligible Patients: Interim Analysis of the Niveau Trial, an International, Randomized Phase 3 Study of the AGMT, GLA, HOVON, Lysa and PLRG

Gerhard Held, Bettina Altmann, Andrea Kerkhoff, Thomas Gastinne, Thomas Weber, Rene-Olivier Casasnovas, Hervé Tilly, Maria Gomes Da Silva, Jörg Hoffmann, Sanne Tonino, Stéphane Vigouroux, Martin Dreyling, Violaine Safar, Marc Andre, Stephanie Mayer, Franck Morschhauser, Pierre Feugier, Christian W. Scholz, Anna Dabrowska-Iwanicka, Philippe Gaulard, Thierry Jo Molina, Andreas Rosenwald, Richard Greil, Ulrich Jaeger, Abraham Avigdor, Lorenz Thurner, Stephanie Maurer, Markus Löffler, Marita Ziepert, Corinne Haioun, Viola Poeschel, Roch Houot
Journal: Blood
Blood (2023) 142 (Supplement 1): 435.
https://doi.org/10.1182/blood-2023-172951
Published: 2023
Journal Articles

Real-Word Experience of CAR T-Cells in Patients with Relapsed/Refractory Follicular Lymphoma : A Descart Registry Analysis from the Lysa

Loic Ysebaert, Roch Houot, Olivier Casasnovas, Choquet Sylvain, Fabrice Jardin, Michael Loschi, Gabriel Brisou, Catherine Thieblemont, Jacques-Olivier Bay, Cristina Castilla-Llorente, Tom Fradon, Steven Le Gouill, Franck Morschhauser, Guillaume Cartron, Emmanuel Bachy
Journal: Blood
Blood (2023) 142 (Supplement 1): 296.
https://doi.org/10.1182/blood-2023-184653
Published: 2023
Journal Articles

Early Results Indicate Acceptable Safety and Promising Efficacy of Venetoclax in Combination with Pola-R-CHP for Untreated High-Risk BCL-2-Positive B-Cell Lymphoma Including Double/Triple Hit Lymphoma

Andrew D. Zelenetz, Catherine S. Diefenbach, Charles Herbaux, Monica Tani, Roch Houot, Mariana Bastos-Oreiro, Herve Tilly, Thomas Gastinne, Catherine Thieblemont, Ethan Troy-Barnes, Stefano Olivieri, Murali Kesavan, Manisha Kanwar, Simona Barlera, Katerina Hatzi, Yanwen Jiang, Michelle Boyer, Franck Morschhauser
Journal: Blood
Blood (2023) 142 (Supplement 1): 439.
https://doi.org/10.1182/blood-2023-174855
Published: 2023
Journal Articles

French Early Nationwide Idecabtagene Vicleucel (Ide-Cel) Chimeric Antigen Receptor (CAR) T-Cell Therapy Experience in Patients with Relapsed/Refractory Multiple Myeloma (FENIX): Update of the IFM Study from the Descar-T Registry

Sarah Cayla, Benoit Ferment, Noemie Bigot, Denis Caillot, Ingrid Lafon, Lionel Karlin, Anne Lazareth, Cyrille Touzeau, Xavier Leleu, Niels Moya, Stephanie Harel, Aurore Perrot, Pierre Bories, Laure Vincent, Sylvain Lamure, Mohamad Mohty, Florent Malard, Salomon Manier, Ibrahim Yakoub-Agha, Anne-Marie Stoppa, Gabriel Brisou, Olivier Decaux, Roch Houot, Steven Le Gouill, Jerome Lambert, Thierry Facon, Herve Avet Loiseau, Philippe Moreau, Bertrand Arnulf
Journal: Blood
Blood (2023) 142 (Supplement 1): 2139.
https://doi.org/10.1182/blood-2023-188655
Published: 2023
Journal Articles

Obinutuzumab Versus Rituximab in Transplant Eligible Untreated MCL Patients, a Matching Comparison between the Lyma and Lyma-101 Trials

Clementine Sarkozy, Mary Callanan, Catherine Thieblemont, Lucie Oberic, Barbara Burroni, Krimo Bouabdallah, Gandhi Laurent Damaj, Benoit Tessoulin, Vincent Ribrag, Roch Houot, Franck Morschhauser, Victoria Cacheux, Vincent Delwail, Violaine Safar, Remy Gressin, Morgane Cheminant, Olivier Hermine, Elizabeth A. Macintyre, Steven Le Gouill
Journal: Blood
Blood (2023) 142 (Supplement 1): 980.
https://doi.org/10.1182/blood-2023-174416
Published: 2023
Journal Articles

CD19-Targeting CAR T-Cell Therapy in Transformed Waldenström Macroglobulinemia/Lymphoplasmacytic Lymphoma: A Descar-T and US Collaborative Study

Eric Durot, Damien Roos-Weil, Adrien Chauchet, Justine Decroocq, Roberta Di Blasi, Thomas Gastinne, Hedi Bensader, Morgane Cheminant, Caroline Jacquet, Stephanie Guidez, François-Xavier Gros, Emmanuel Bachy, Pascale Cony-Makhoul, Steven P Treon, Alain Jacques Delmer, Ran Reshef, Steven Le Gouill, Jorge J. Castillo, Roch Houot
Journal: Blood
Blood (2023) 142 (Supplement 1): 616.
https://doi.org/10.1182/blood-2023-173988
Published: 2023
Journal Articles

Preliminary Findings of a Phase Ib/II Trial Indicate Manageable Safety and Promising Efficacy for Mosunetuzumab in Combination with Lenalidomide (M+Len) in Previously Untreated (1L) Follicular Lymphoma (FL)

Franck Morschhauser, Krish Patel, Sabela Bobillo, Raul Cordoba, Toby A. Eyre, Mark Bishton, Roch Houot, Hui-Lai Zhang, Liqun Zou, Wendy Osborne, Laura Gálvez-Carvajal, Catherine Thieblemont, Donald Yee, Andrea Knapp, Enkhtsetseg Purev, Haocheng Li, Vivian Chen, Karl L. Banta, Jason Sit, Emmanuel Bachy
Journal: Blood
Blood (2023) 142 (Supplement 1): 605.
https://doi.org/10.1182/blood-2023-174432
Published: 2023
Journal Articles

Glofitamab Monotherapy in Patients with Non-Hodgkin B-Cell Lymphoma after Failing CAR T-Cell Infusion: Primary Analysis of the Bicar Study, a Phase II Lysa Study

Pierre Sesques, Roch Houot, Yassine Al Tabaa, Fabien Le Bras, Loic Ysebaert, Fabrice Jardin, Choquet Sylvain, Jacques-Olivier Bay, Francois Xavier Gros, Franck Morschhauser, Olivier Casasnovas, Thomas Gastinne, Catherine Thieblemont, Magalie Joris, Laure Ricard, Caroline Regny, Laurianne Drieu La Rochelle, Pierre Feugier, Ambroise Marcais, Karin Tarte, Camille Laurent, Guillaume Cartron
Journal: Blood
Blood (2023) 142 (Supplement 1): 893.
https://doi.org/10.1182/blood-2023-177703
Published: 2023