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Thomas Gastinne
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Journal Articles

Outcomes and treatment patterns of patients with primary mediastinal b-cell lymphoma after CAR-t cell therapy failure : A descar-t analysis

Free
Jean Galtier, Pierre Sesques, Vivien Dupont, Emmanuel Bachy, Roberta Di Blasi, Catherine Thieblemont, Gabriel Brisou, Thomas Gastinne, Guillaume Cartron, François-Xavier Gros, Franck Morschhauser, Axel André, Jacques-Olivier Bay, Magalie Joris, Aline Schmidt, Audrey Demailly, Steven Le Gouill, Roch Houot, Krimo Bouabdallah, Vincent Camus
Journal: Blood
Blood (2025) 146 (Supplement 1): 3733.
https://doi.org/10.1182/blood-2025-3733
Published: 2025
Journal Articles

Glofitamab is superior to non a-CD3xC20 treatments for patients with diffuse large B-cell lymphoma who are refractory or relapse immediately after anti-CD19 CAR T-cell therapy: Final results of the bicar study (LYSA) and indirect comparison with a synthetic control arm from the descart registry.

Free
Pierre Sesques, Roch Houot, Yassine Al Tabaa, Fabien Le Bras, Loic Ysebaert, Sylvain Choquet, Vincent Camus, Jacques-Olivier Bay, François-Xavier Gros, Franck Morschhauser, Olivier Casasnovas, Thomas Gastinne, Catherine Thieblemont, Magalie Joris, Laure Ricard, Caroline Regny, Laurianne Drieu La Rochelle, Pierre Feugier, Ambroise Marçais, Isabelle Chaillol, Karin Tarte, Camille Laurent, Guillaume Cartron
Journal: Blood
Blood (2025) 146 (Supplement 1): 1958.
https://doi.org/10.1182/blood-2025-1958
Published: 2025
Journal Articles

Valemetostat monotherapy in patients with relapsed or refractory B-cell lymphoma: Final results of the Phase 2 valym study from the lysa

Free
Emmanuel Bachy, Fontanet Bijou, Bohrane Slama, Romain Guieze, Keiko Nakajima, Gandhi Damaj, Gian Matteo Pica, Nadine Morineau, Charles Herbaux, Roch Houot, Bernard Drenou, François Lemonnier, Marlene Ochmann, Antoine Bonnet, Pierre Sujobert, Gaetan Vanstraelen, Marc Andre, Delphine Pranger, Marguerite Fournier, Sylvia Snauwaert, Thomas Gastinne, Fabrice Jardin, Julie Gay, Alexandra Traverse Glehen, Katell Le Du, Jean Marc Schiano De Colella, Franck Morschhauser
Journal: Blood
Blood (2025) 146 (Supplement 1): 1797.
https://doi.org/10.1182/blood-2025-1797
Published: 2025
Journal Articles

Results of the primary end-point of the LOC-R01: A randomized phase II Study of lenalidomide and ibrutinib in association with rituximab-methotrexate procarbazine vincristin (R-MPV) as a targeted induction treatment for patients aged 18 to 65 with a newly diagnosed primary central nervous system lymphoma (PCNSL)

Free
Carole Soussain, Caroline Houillier, Marion Chevrier, Delphine Leclercq, Joya El Haddad, Anna Schmitt, Lucie Oberic, Cécile Moluçon-Chabrot, Julie Abraham, Fabrice Jardin, Gandhi Damaj, Laurence Schenone, Jérôme Paillassa, Agathe Waultier-Rascalou, Kossi Agbetiafa, Remy Gressin, Choquet Sylvain, Thomas Gastinne, Luc Taillandier, Luc-Matthieu Fornecker, Lise Willems, Adrien Chauchet, Guido Ahle, Gabriel Antherieu, Adrien Gilbert, Khe Hoang-Xuan, Olivier Lantz, Chaimae Saji, Ana Lalanne, Herve Ghesquieres
Journal: Blood
Blood (2025) 146 (Supplement 1): 58.
https://doi.org/10.1182/blood-2025-58
Published: 2025
Journal Articles

Treatment options, responses and outcome of 1220 classic Hodgkin lymphoma patients included in realysa, a prospective multicentric lysa cohort

Free
Herve Ghesquieres, Catherine Thieblemont, Aurelien Belot, Cecile Borel, Fanny Cherblanc, Jean Galtier, Alexia Torroja, Doriane Cavalieri, Alice Pauc, Bastien Lesne, Sandy Amorim, Alexandra Traverse Glehen, Barbara Burroni, Salim Kanoun, Anne Ségolène Cottereau, Nadine Morineau, Mohamed Touati, Adrien Chauchet, Fontanet Bijou, Sydney Dubois, Ludovic Fouillet, Christophe Fruchart, Thomas Gastinne, Sandra Leguyader Peyrou, Alain Monnereau, Luc-Matthieu Fornecker, Jehan Dupuis, Cedric Rossi
Journal: Blood
Blood (2025) 146 (Supplement 1): 1853.
https://doi.org/10.1182/blood-2025-1853
Published: 2025
Journal Articles

CAR T-cell therapy in secondary CNS lymphomas: A real-world study from the descar-t registry

Free
Caroline Houillier, Elena Robin-Marieton, Cécile Pizot, Roch Houot, Fabien Le Bras, Aline Schmidt, François-Xavier Gros, Catherine Thieblemont, Guillaume Cartron, Thomas Gastinne, Cristina Castilla-Llorente, Justine Decroocq, Blandine Guffroy, Ibrahim Yakoub-Agha, Emmanuel Gyan, Julie Abraham, Olivier Hermine, Adrien Chauchet, Amandine Durand, Marie-Thérèse Rubio, Jacques-Olivier Bay, Emmanuel Bachy, Steven Le Gouill, Khe Hoang-Xuan, Carole Soussain, Hélène Tonoli, Luc-Matthieu Fornecker, Choquet Sylvain
Journal: Blood
Blood (2025) 146 (Supplement 1): 1012.
https://doi.org/10.1182/blood-2025-1012
Published: 2025
Journal Articles

Comparison of axicabtagene ciloleucel to standard regimens as second line treatment for large B cell lymphoma in real life: A lysa study from descar-T and realysa registries

Free
Gabriel Brisou, Aurelien Belot, Emmanuel Bachy, Herve Ghesquieres, François-Xavier Gros, Krimo Bouabdallah, Guillaume Cartron, Roberta Di Blasi, Roch Houot, Cedric Rossi, Amandine Durand, Fabien Le Bras, Corinne Haioun, Thomas Gastinne, Remy Dulery, Pierre Bories, Fabrice Jardin, Blandine Guffroy, Luc-Matthieu Fornecker, Cristina Castilla-Llorente, Gandhi Damaj, Franck Morschhauser, Michael Loschi, Stephanie Guidez, Choquet Sylvain, Aline Schmidt, Laurianne Drieu La Rochelle, Marie-Thérèse Rubio, Sylvain Carras, Jacques-Olivier Bay, Adrien Chauchet, Magalie Joris, Ludovic Fouillet, Laure Lebras, Julie Abraham, Fontanet Bijou, Olivier Hermine, Antoine Bonnet, Justine Decroocq, Sandy Amorim, Nadine Morineau, Pauline Lionne, Sophie Dennetiere, Laura Herbreteau, Bernard Drenou, Launay Vincent, Gaelle Olivier, Gaëlle Labouré, Olivier Fitoussi, Christophe Fruchart, Cecile Leyronnas, Fanny Cherblanc, Elodie Gat, Benoit Tessoulin
Journal: Blood
Blood (2025) 146 (Supplement 1): 2764.
https://doi.org/10.1182/blood-2025-2764
Published: 2025
Journal Articles

Severe infections after CD19-directed chimeric antigen receptor T-cell therapy for Relapsed/Refractory large B-cell lymphoma, a retrospective real-life study from the DESCAR-T registry (LYSA)

Free
Tiy Morris, Amandine Fayard, Vivien Dupont, Elisabeth Daguenet, Catherine Thieblemont, Emmanuel Bachy, Guillaume Manson, Charles Herbaux, Ibrahim Yakoub-Agha, Thomas Gastinne, Didier Blaise, Louise Roulin, François-Xavier Gros, Pierre Bories, Roch Houot, Steven Le Gouill, Elisabeth Botelho-Nevers, Ludovic Fouillet, Jerome Cornillon
Journal: Blood
Blood (2025) 146 (Supplement 1): 1014.
https://doi.org/10.1182/blood-2025-1014
Published: 2025
Journal Articles

Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy for Transformed Waldenström Macroglobulinemia/Lymphoplasmacytic Lymphoma: a DESCAR-T Registry and International Collaborative Study

Free
Eric Durot, Lukshe Kanagaratnam, Sylvain Choquet, Pierre Sesques, Jehan Dupuis, Thomas Gastinne, Peter Forsberg, Emmanuel Gyan, Adrien Chauchet, Justine Decroocq, Roberta Di Blasi, Hedi Bensaber, Caroline Jacquet, Morgane Cheminant, Stephanie Guidez, François-Xavier Gros, Lucile Bussot, Steeve Chevreux, Thomas Hueso, Gabriel Brisou, Arnaud Campidelli, Elodie Gat, Simone Ferrero, Anna Maria Frustaci, Marzia Varettoni, Charalampia Kyriakou, Steven Treon, Prashant Kapoor, Ran Reshef, Jorge Castillo, Emmanuel Bachy, Roch Houot, Damien Roos Weil
Journal: Blood
Blood (2025) 146 (Supplement 1): 5490.
https://doi.org/10.1182/blood-2025-5490
Published: 2025
Journal Articles

Glofitamab for patients with Non–Large B-cell lymphoma refractory or relapsing after anti-CD19 CAR T-cell therapy: Final bicar study (LYSA) results.

Free
Guillaume Cartron, Roch Houot, Yassine Al Tabaa, Fabien Le Bras, Loic Ysebaert, Sylvain Choquet, Vincent Camus, Jacques-Olivier Bay, François-Xavier Gros, Franck Morschhauser, Olivier Casasnovas, Thomas Gastinne, Catherine Thieblemont, Magalie Joris, Laure Ricard, Caroline Regny, Laurianne Drieu La Rochelle, Pierre Feugier, Ambroise Marçais, Samuel Griolet, Karin Tarte, Camille Laurent, Pierre Sesques
Journal: Blood
Blood (2025) 146 (Supplement 1): 5923.
https://doi.org/10.1182/blood-2025-5923
Published: 2025
Journal Articles

Pirtobrutinib in Relapsed/Refractory (R/R) Waldenström macroglobulinemia (WM): Up to 5 years of follow-up from the Phase 1/2 BRUIN study

Free
Chan Cheah, Manish Patel, Toby Eyre, Wojciech Jurczak, David Lewis, Thomas Gastinne, Shuo Ma, Jonathon Cohen, Krish Patel, Jennifer Brown, Lydia Scarfo, Talha Munir, Ewa Lech-Maranda, Marc Hoffmann, Chaitra Ujjani, Bita Fakhri, Michael Wang, Koji Izutsu, Hirokazu Nagai, Constantine Tam, Joanna Rhodes, Julie Vose, Matthew McKinney, James Gerson, Minal Barve, Bryone Kuss, Youngil Koh, Aisling Barrett, Steven Treon, Jorge Castillo, John Seymour, Amy Ruppert Stark, Samuel McNeely, Richard Walgren, Donald Tsai, Katherine Bao, Binoj Chandrasekharan Nair, Jennifer Woyach, Lia Palomba
Journal: Blood
Blood (2025) 146 (Supplement 1): 226.
https://doi.org/10.1182/blood-2025-226
Published: 2025
Journal Articles

5-y Follow-up of Combination of Ibrutinib, Obinutuzumab and Venetoclax for Patients with Newly Diagnosed Mantle Cell Lymphoma, the Oasis Trial

Free
Benoit Tessoulin, Franck Morschhauser, David Chiron, Krimo Bouabdallah, Guillaume Cartron, Cedric Rossi, Caroline Milin, Ludovic Fouillet, Charles Herbaux, Emmanuelle Tchernonog, Rory McCulloch, Thomas Gastinne, Mary B. Callanan, Steven Le Gouill
Journal: Blood
Blood (2024) 144 (Supplement 1): 1657.
https://doi.org/10.1182/blood-2024-206778
Published: 2024
Journal Articles

Final Analysis of the Safety and Efficacy of Venetoclax in Combination with Pola-R-CHP for Untreated High-Risk BCL-2-Positive B-Cell Lymphoma Including Double/Triple Hit Lymphoma

Free
Catherine S. Diefenbach, Andrew D. Zelenetz, Charles Herbaux, Monica Tani, Roch Houot, Mariana Bastos-Oreiro, Hervé Tilly, Thomas Gastinne, Catherine Thieblemont, Wilfred Leung, Katerina Hatzi, Murali Kesavan, Simona Barlera, Michelle Boyer, Franck Morschhauser
Journal: Blood
Blood (2024) 144 (Supplement 1): 577.
https://doi.org/10.1182/blood-2024-198624
Published: 2024
Journal Articles

Hemophagocytic Lymphohistiocytosis-like Syndrome after Anti-CD19 CAR T-Cells for B-Cell Lymphoma and B-Cell Acute Lymphoblastic Leukemia: A Lysa, Sfce and Graall Study from the Descar-T Registry

Free
Nicolas Gower, Cécile Pizot, Marie-Emilie Dourthe, Thomas Gastinne, Gabriel Brisou, Stephanie Guidez, Jean-Jacques Tudesq, Adrien Chauchet, Laura Herbreteau, Arnaud Campidelli, Pierre Sesques, Edmond Chiche, Francois Xavier Gros, Amandine Durand, Marion Lubnau, Arthur Sterin, Roberta Di Blasi, Jacques-Olivier Bay, Alexandra Marquet, Elodie Gat, Roch Houot, Franck Morschhauser, Jérôme Paillassa
Journal: Blood
Blood (2024) 144 (Supplement 1): 528.
https://doi.org/10.1182/blood-2024-208304
Published: 2024
Journal Articles

A Real-World Weighted Comparison of Tisagenlecleucel and Axicabtagene Ciloleucel CAR T Cells in Relapsed or Refractory Diffuse Large B Cell Lymphoma Aged 75 Years and Older : A Lysa Study from the Descar-T Registry

Free
Blandine Guffroy, Emmanuel Bachy, Roberta Di Blasi, Hanane Guedon, Fabien Le Bras, Ibrahim Yakoub-Agha, Stephanie Guidez, Laure Ricard, Thomas Gastinne, Cristina Castilla-Llorente, Justine Decroocq, Gabriel Brisou, Sylvain Choquet, Olivier Casasnovas, Michael Loschi, Jacques-Olivier Bay, Fabrice Jardin, Anne Cuozzo, Elodie Gat, Alexandra Marquet, Steven Le Gouill, Roch Houot, Pierre Bories
Journal: Blood
Blood (2024) 144 (Supplement 1): 3129.
https://doi.org/10.1182/blood-2024-203186
Published: 2024
Journal Articles

Health-Related Quality of Life after Axi-Cel As a Second-Line Therapy in Patients with High-Risk Relapsed/Refractory Large B-Cell Lymphoma Who Are Ineligible for Autologous Stem Cell Transplantation: Results of the Alycante Phase II Trial

Free
Emilie Charton, Amelie Anota, Emmanuel Bachy, Guillaume Cartron, François-Xavier Gros, Franck Morschhauser, Lucie Oberic, Thomas Gastinne, Pierre Feugier, Remy Dulery, Catherine Thieblemont, Magalie Joris, Fabrice Jardin, Sylvain Choquet, Olivier Casasnovas, Gabriel Brisou, Morgane Cheminant, Jacques-Olivier Bay, Francesco Llamas Gutierrez, Cédric Portugues, Emmanuel Itti, Xavier Pallard, Paul Blanc-Durand, Yassine Al Tabaa, Clément Bailly, Camille Laurent, Francois Lemonnier, Roch Houot
Journal: Blood
Blood (2024) 144 (Supplement 1): 4505.
https://doi.org/10.1182/blood-2024-200614
Published: 2024
Journal Articles

Efficacy of CAR T-cell therapy is not impaired by previous bispecific antibody treatment in large B-cell lymphoma

Free
Clinical Trials & Observations
Gilles Crochet, Gloria Iacoboni, Audrey Couturier, Emmanuel Bachy, Josu Iraola-Truchuelo, Thomas Gastinne, Guillaume Cartron, Tom Fradon, Bastien Lesne, Mi Kwon, Romain Gounot, Nuria Martínez-Cibrian, Cristina Castilla-Llorente, Pau Abrisqueta, Manuel Guerreiro, Clémentine Sarkozy, Jose María Aspa-Cilleruelo, Vincent Camus, Stéphanie Guidez, Adrien Chauchet, Eric Deconinck, Krimo Bouabdallah, Francesc Bosch, Pere Barba, Franck Morschhauser, Roch Houot
Journal: Blood
Blood (2024) 144 (3): 334–338.
https://doi.org/10.1182/blood.2024024526
Published: 2024
Includes: Supplemental data
Journal Articles

High efficacy of CD19 CAR T cells in patients with transformed Waldenström macroglobulinemia

Free
Clinical Trials & Observations
Eric Durot, Damien Roos-Weil, Adrien Chauchet, Justine Decroocq, Roberta Di Blasi, Thomas Gastinne, Hedi Bensaber, Morgane Cheminant, Caroline Jacquet, Stéphanie Guidez, François-Xavier Gros, Emmanuel Bachy, Arthur Coste, Pascale Cony-Makhoul, Steven P. Treon, Alain Delmer, Ran Reshef, Steven Le Gouill, Jorge J. Castillo, Roch Houot
Journal: Blood
Blood (2024) 143 (26): 2804–2807.
https://doi.org/10.1182/blood.2024024452
Published: 2024
Includes: Supplemental data
Journal Articles

Glofitamab Monotherapy in Patients with Non-Hodgkin B-Cell Lymphoma after Failing CAR T-Cell Infusion: Primary Analysis of the Bicar Study, a Phase II Lysa Study

Free
Pierre Sesques, Roch Houot, Yassine Al Tabaa, Fabien Le Bras, Loic Ysebaert, Fabrice Jardin, Choquet Sylvain, Jacques-Olivier Bay, Francois Xavier Gros, Franck Morschhauser, Olivier Casasnovas, Thomas Gastinne, Catherine Thieblemont, Magalie Joris, Laure Ricard, Caroline Regny, Laurianne Drieu La Rochelle, Pierre Feugier, Ambroise Marcais, Karin Tarte, Camille Laurent, Guillaume Cartron
Journal: Blood
Blood (2023) 142 (Supplement 1): 893.
https://doi.org/10.1182/blood-2023-177703
Published: 2023
Journal Articles

R-GemOx Plus Nivolumab Vs R-GemOx As Second-Line Therapy for Large B-Cell Lymphoma in Transplant-Ineligible Patients: Interim Analysis of the Niveau Trial, an International, Randomized Phase 3 Study of the AGMT, GLA, HOVON, Lysa and PLRG

Free
Gerhard Held, Bettina Altmann, Andrea Kerkhoff, Thomas Gastinne, Thomas Weber, Rene-Olivier Casasnovas, Hervé Tilly, Maria Gomes Da Silva, Jörg Hoffmann, Sanne Tonino, Stéphane Vigouroux, Martin Dreyling, Violaine Safar, Marc Andre, Stephanie Mayer, Franck Morschhauser, Pierre Feugier, Christian W. Scholz, Anna Dabrowska-Iwanicka, Philippe Gaulard, Thierry Jo Molina, Andreas Rosenwald, Richard Greil, Ulrich Jaeger, Abraham Avigdor, Lorenz Thurner, Stephanie Maurer, Markus Löffler, Marita Ziepert, Corinne Haioun, Viola Poeschel, Roch Houot
Journal: Blood
Blood (2023) 142 (Supplement 1): 435.
https://doi.org/10.1182/blood-2023-172951
Published: 2023