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Journal Articles

The phase 2 LYSA study of prednisone, vinblastine, doxorubicin, and bendamustine for untreated Hodgkin lymphoma in older patients

Clinical Trials & Observations
Hervé Ghesquières, Daphné Krzisch, Emmanuelle Nicolas-Virelizier, Salim Kanoun, Anne Claire Gac, Stéphanie Guidez, Mohamed Touati, Kamel Laribi, Franck Morschhauser, Christophe Bonnet, Agathe Waultier-Rascalou, Frédérique Orsini-Piocelle, Marc André, Marguerite Fournier, Fabienne Morand, Alina Berriolo-Riedinger, Barbara Burroni, Diane Damotte, Alexandra Traverse-Glehen, Philippe Quittet, Olivier Casasnovas
Journal: Blood
Blood (2024) 143 (11): 983–995.
https://doi.org/10.1182/blood.2023021564
Published: 2024
Includes: Supplemental data
Journal Articles

A New Machine Learning-Based Prognostic Prediction Strategy for Patients with Diffuse-Large B-Cell Lymphoma

Valentin Daguerre, Elisabeth Daguenet, Nicolas Jacquet-Francillon, Ludovic Fouillet, Ugo Thévenet, Maxime Bonjour, Herve Ghesquieres, Imran Ahmad, Jerome Cornillon
Journal: Blood
Blood (2023) 142 (Supplement 1): 4505.
https://doi.org/10.1182/blood-2023-181710
Published: 2023
Journal Articles

Optical Genome Mapping Provides New Molecular Insights in High-Risk Mantle Cell Lymphoma: A Lysa Study

Sophie Kaltenbach, Yannick LE Bris, Bruno Tesson, Aurore Touzart, Guillaume Charbonnier, Vincent Ribrag, Remy Gressin, Clementine Sarkozy, Catherine Thieblemont, Franck Morschhauser, Corinne Haioun, Violaine Safar, Herve Ghesquieres, Barbara Burroni, Marie-Helene Delfau, Elizabeth A. Macintyre, Mary Callanan, Vahid Asnafi, Steven Le Gouill, Olivier Hermine, Morgane Cheminant
Journal: Blood
Blood (2023) 142 (Supplement 1): 6107.
https://doi.org/10.1182/blood-2023-173815
Published: 2023
Journal Articles

Genomic, Transcriptional, and Immunological Validation of Distinct Molecular Subtypes of Classic Hodgkin Lymphoma through Tissue-Based and Noninvasive Methods

Stefan K. Alig, Mohammad Shahrokh Esfahani, Andrea Garofalo, Michael Yu Li, Cédric Rossi, Timothy Flerlage, Jamie E. Flerlage, Ragini Adams, Michael S. Binkley, Navika Shukla, Michael Jin, Mari Olsen, Adele Telenius, Jurik A Mutter, Joseph Schroers-Martin, Brian J. Sworder, Shinya Rai, Daniel King, Andre Schultz, Jan Lukas Bögeholz, Shengqin Su, Karan R Kathuria, Chih Long Liu, Xiaoman Kang, Deanna M. Langfitt, Kristine Faye Pobre-Piza, Feng Tian, Maya J. Strohband, Valeria Spina, Thomas Tousseyn, Lieselot Buedts, Luc-Matthieu Fornecker, Sharon M. Castellino, Ranjana H. Advani, Davide Rossi, Ryan C Lynch, Herve Ghesquieres, Olivier Casasnovas, David M. Kurtz, Lianna J. Marks, Michael P. Link, Marc Andre, Peter Vandenberghe, Christian Steidl, Maximilian Diehn, Ash A. Alizadeh
Journal: Blood
Blood (2023) 142 (Supplement 1): 177.
https://doi.org/10.1182/blood-2023-186810
Published: 2023
Journal Articles

First Line Therapy Evaluation Using Propensity Score Approach in Newly Diagnosed Advanced Classical Hodgkin Lymphoma Patients from Prospective Real-World Realysa Cohort and Phase 3 AHL2011 Trial

Cedric Rossi, Amira Marouf, Benedicte Deau Fischer, Fanny Cherblanc, Emeline Cugnod, Loic Chartier, Luc Matthieu Fornecker, Marc Andre, Rene-Olivier Casasnovas, Herve Ghesquieres
Journal: Blood
Blood (2023) 142 (Supplement 1): 3056.
https://doi.org/10.1182/blood-2023-178154
Published: 2023
Journal Articles

Results from the Cohort-Expansion Stage of a Phase I Trial of Tinostamustine Monotherapy in Advanced Hodgkin Lymphoma (HL), Non-Hodgkin Lymphoma (NHL) and Multiple Myeloma (MM) (NCT02576496)

Anna Maria Sureda Balari, Herve Ghesquieres, Franck Morschhauser, Pim Mutsaers, Enrique M Ocio, Tomas Janik, Nick Manamley, Kasia Hilgier, Pier Luigi Zinzani
Journal: Blood
Blood (2023) 142 (Supplement 1): 1706.
https://doi.org/10.1182/blood-2023-181822
Published: 2023
Journal Articles

Skeletal Muscle Index, As a Measure of Muscle Mass, Is a Significant Prognostic Factor for Newly Diagnosed Diffuse Large B-Cell Primary CNS Lymphoma Patients

Gabriel Antherieu, Edith Julia, Alizee Maarek, Violaine Safar, Emmanuelle Ferrant, Alexandra Traverse-Glehen, Anne Lazareth, Helene Lequeu, Stéphanie Cordeil, Guillaume Aussedat, Camille Golfier, Dana Ghergus, Pierre Sesques, Lionel Karlin, Fadhela Bouafia Sauvy, Gilles Salles, Emmanuel Bachy, Emmanuel Jouanneau, Francois Ducray, Loic Boussel, Herve Ghesquieres
Journal: Blood
Blood (2023) 142 (Supplement 1): 1764.
https://doi.org/10.1182/blood-2023-179765
Published: 2023
Journal Articles

The Post-CAR Prognostic Index (PC-PI): A New Prognostic Score to Predict Overall Survival in Large B-Cell Lymphoma Patients Progressing after Chimeric Antigen Receptor T-Cell Therapy

Gloria Iacoboni, Victor Navarro Garces, Josu Iraola, Pierre Sesques, Kai Rejeski, Fabio Serpenti, Mariana Bastos-Oreiro, ANA Africa Martin Lopez, Javier Delgado, Ariadna Perez, Manuel Guerreiro, Ana Carolina Caballero Gonzalez, Nuria Martinez-Cibrian, Hugo Daniel Luzardo Henriquez, Jose Maria Sanchez Pina, Juan-Manuel Sancho, Herve Ghesquieres, Alberto Mussetti, Pere Barba, Lucia Lopez Corral, Rafael Hernani, Juan Luis Reguera, Anna Maria Sureda Balari, Francesc Bosch, Alejandro Martin Garcia-Sancho, Mi Kwon, Andrea Kuhnl, Marion Subklewe, Emmanuel Bachy, Guillermo Villacampa, Pau Abrisqueta Costa
Journal: Blood
Blood (2023) 142 (Supplement 1): 227.
https://doi.org/10.1182/blood-2023-184942
Published: 2023
Journal Articles

TRANSCEND FL: Phase 2 Study Primary Analysis of Lisocabtagene Maraleucel as Second-Line Therapy in Patients with High-Risk Relapsed or Refractory Follicular Lymphoma

Franck Morschhauser, Saurabh Dahiya, M. Lia Palomba, Alejandro Martin Garcia-Sancho, Juan Luis Reguera, John Kuruvilla, Ulrich Jaeger, Guillaume Cartron, Koji Izutsu, Martin Dreyling, Brad S. Kahl, Herve Ghesquieres, Kirit Ardeshna, Hideki Goto, Anna Maria Barbui, Jeremy S. Abramson, Peter Borchmann, Isabelle Fleury, Stephan Mielke, Alan Skarbnik, Sven de Vos, Manali Kamdar, Reem Karmali, Andreas Viardot, Thalia Farazi, Omotayo Fasan, James Lymp, Min Vedal, Rina Nishii, Ariel Avilion, Jessica Papuga, Loretta J. Nastoupil
Journal: Blood
Blood (2023) 142 (Supplement 1): 602.
https://doi.org/10.1182/blood-2023-179474
Published: 2023
Journal Articles

Validation of POD24 As a Robust Early Clinical End Point of Poor Survival in Mantle Cell Lymphoma from 1280 Patients on Clinical Trials

Clementine Sarkozy, Loïc Chartier, Vincent Ribrag, Remy Gressin, Christian Geisler, Hanneke Kluin-Nelemans, Catherine Thieblemont, Franck Morschhauser, Corinne Haioun, Violaine Safar, Herve Ghesquieres, Wolframm Klapper, Barbara Burroni, Christiane Pott, Marie-Helene Delfau, Elizabeth A. Macintyre, Mary Callanan, Michael Unterhalt, Eva Hoster, Martin Dreyling, Steven Le Gouill, Olivier Hermine, Morgane Cheminant
Journal: Blood
Blood (2023) 142 (Supplement 1): 299.
https://doi.org/10.1182/blood-2023-173615
Published: 2023
Journal Articles

Englumafusp Alfa (CD19-4-1BBL) and Glofitamab Combination in Patients with Relapsed/Refractory Non-Hodgkin Lymphoma (R/R NHL): Biomarker Results from a Phase I Dose-Escalation Trial

Koorosh Korfi, Ailsa Christiansen, Zhiwen Jiang, Sabine Wilson, Samuel Tracy, Annika Blank, Sylvia Herter, Natalie Dimier, Bruno Gomes, Pablo Umana, Herve Ghesquieres, Roch Houot, Fritz Offner, Harriet Walter, Nancy L. Bartlett, Guillaume Cartron, Michael Dickinson, William Townsend, Giuseppe Gritti, Francesc Bosch Albareda, Franck Morschhauser, Martin Hutchings, Carmelo Carlo-Stella, Katharina Lechner
Journal: Blood
Blood (2023) 142 (Supplement 1): 3017.
https://doi.org/10.1182/blood-2023-173677
Published: 2023
Journal Articles

Hematopoietic Stem Cell Transplantation for DLBCL: 55,000 Cases from EBMT As a Comparator for CAR T-Cells

Philipp Berning, Ariane Boumendil, Anthony H. Goldstone, Anna Maria Sureda Balari, Peter Dreger, Silvia Montoto, Maud Ngoya, Hervé Finel, Patrice Chevallier, Didier Blaise, Tim Struessmann, Ben Carpenter, Edouard Forcade, Cristina Castilla-Llorente, Marek Trněný, Herve Ghesquieres, Capria Saveria, Catherine Thieblemont, Igor Wolfgang Blau, Ellen Meijer, Annoek E.C. Broers, Anne Huynh, Denis Caillot, Wolf Roesler, Stéphanie Nguyen Quoc, Jörg Bittenbring, Arnon Nagler, Bertram Glass, Norbert Schmitz
Journal: Blood
Blood (2023) 142 (Supplement 1): 441.
https://doi.org/10.1182/blood-2023-184788
Published: 2023
Journal Articles

Tislelizumab, an Anti-PD1 Antibody, in Patients with Relapsed/Refractory Classical Hodgkin Lymphoma in Tirhol Bgb-A317-210: A Prospective Multicenter Lysa Phase 2 Study Conducted in Western Countries

Herve Ghesquieres, Krimo Bouabdallah, Marc Andre, Philippe Quittet, Cecile Borel, Aspasia Stamatoulas Bastard, Michael Gilbertson, Fabien Le Bras, Catherine Thieblemont, Baptiste Delapierre, Mohamed Touati, Pierre Feugier, Julien Lazarovici, Nadine Morineau, Thomas Gastinne, Isabelle Chaillol, Rod Ramchandren, Harsh Shah, Dipenkumar Modi, Heather Allewelt, Pierre Fustier, Jianfeng Xu, Amit Agarwal, Franck Morschhauser, Cedric Rossi
Journal: Blood
Blood (2023) 142 (Supplement 1): 1717.
https://doi.org/10.1182/blood-2023-188545
Published: 2023
Journal Articles

Distinct Circulating Genomic Features of Classical Hodgkin Lymphoma of Older Adults

Cédric Rossi, Jan Boegeholz, Stefan K. Alig, Andrea Garofalo, Mohammad Shahrokh Esfahani, Joseph Schroers-Martin, Mari Olsen, Xiaoman Kang, David M. Kurtz, Takeshi Sugio, Mark P. Hamilton, Marc Andre, Rene-Olivier Casasnovas, Luc Matthieu Fornecker, Maximilian Diehn, Herve Ghesquieres, Ash A. Alizadeh
Journal: Blood
Blood (2023) 142 (Supplement 1): 4369.
https://doi.org/10.1182/blood-2023-178257
Published: 2023
Journal Articles

Favorable Outcomes of Splenic Marginal Zone Lymphoma in an International Study of 934 Patients with Long Follow-up

Ahmed Ludvigsen Al-Mashhadi, Mikkel Runason Runason Simonsen, Chan Yoon Cheah, Rose-Marie Amini, Bente Arboe, James R. Cerhan, Iman Chanchiri, Michael Roost Clausen, Jonathan Day, Toby A. Eyre, Anne Ortved Gang, Herve Ghesquieres, Thomas M. Habermann, Eliza A Hawkes, Steven R. Hwang, Jennifer B Jørgensen, Arushi Khurana, Claire Maquet, Ng Layshe, Stephen S. Opat, Martin Bjerregård Pedersen, Christian Bjørn Poulsen, Alexandros Rampotas, Andreea Sima, Karin Ekstroem Smedby, Knut Smeland, Elizabeth Smyth, Gita Thanarajasingam, Judith Trotman, Katharine Xing, Simon Østergaard, Diego Villa, Tarec C El-Galaly
Journal: Blood
Blood (2023) 142 (Supplement 1): 4396.
https://doi.org/10.1182/blood-2023-173247
Published: 2023
Journal Articles

CD20low/CD68high a Promising Microenvironnement Profile Identifying Classical Hodgkin Lymphoma Patients with Poor Outcome a Lysa Study

Alexandra Traverse-Glehen, Laurent Martin, Camille Laurent, Peggy Dartigues, Barbara Burroni, Diane Damotte, Marie Parrens, Herve Ghesquieres, Marguerite Fournier, Salim Kanoun, Anne Ségolène Cottereau, Marc Andre, Cédric Rossi, René-Olivier Casasnovas
Journal: Blood
Blood (2023) 142 (Supplement 1): 3011.
https://doi.org/10.1182/blood-2023-174784
Published: 2023
Journal Articles

Synthetic Control Arm from Clinical Trials and Real-World Data from Lysa Group for Untreated Diffuse Large B Cell Lymphoma Patients Aged over 80 Years: A Bona Fide S trategy for Innovative Clinical Trials

Valentin Letailleur, Isabelle Chaillol, Fanny Cherblanc, Herve Ghesquieres, Frederic Peyrade, Fabrice Jardin, Stephanie Guidez, Fontanet Delices Bijou, Pierre Sesques, Cédric Rossi, Luc Matthieu Fornecker, Ludovic Fouillet, Sylvain Carras, Benoit Tessoulin
Journal: Blood
Blood (2023) 142 (Supplement 1): 72.
https://doi.org/10.1182/blood-2023-177708
Published: 2023
Journal Articles

An Updated Comparison of Clinical Outcomes from 4-Year Follow-up of Zuma-5 (Axicabtagene Ciloleucel) and the International Scholar-5 External Control Cohort in Relapsed/Refractory Follicular Lymphoma

John G. Gribben, Paola Ghione, Maria Lia Palomba, Markqayne D Ray, Eve H Limbrick-Oldfield, Steve Kanters, Sabela Bobillo, Maria Teresa Ribiero, Caron A Jacobson, Sattva S. Neelapu, Herve Ghesquieres, Olga Nikolajeva, Jiali Yan, Hailin Wang, Anik R Patel
Journal: Blood
Blood (2023) 142 (Supplement 1): 4869.
https://doi.org/10.1182/blood-2023-186842
Published: 2023
Journal Articles

Pembrolizumab in relapsed or refractory primary mediastinal large B-cell lymphoma: final analysis of KEYNOTE-170

Clinical Trials & Observations Brief Report
Pier Luigi Zinzani, Catherine Thieblemont, Vladimir Melnichenko, Krimo Bouabdallah, Jan Walewski, Alejandro Majlis, Laura Fogliatto, A. Martin Garcia-Sancho, Beth Christian, Zafer Gulbas, Muhit Özcan, Guilherme Fleury Perini, Herve Ghesquieres, Margaret A. Shipp, Seth Thompson, Samhita Chakraborty, Patricia Marinello, Philippe Armand
Journal: Blood
Blood (2023) 142 (2): 141–145.
https://doi.org/10.1182/blood.2022019340
Published: 2023
Journal Articles

BTG1 inactivation drives lymphomagenesis and promotes lymphoma dissemination through activation of BCAR1

Lorric Delage, Mireille Lambert, Émilie Bardel, Cindy Kundlacz, Dimitri Chartoire, Axel Conchon, Anne-Laure Peugnet, Lucas Gorka, Patrick Auberger, Arnaud Jacquel, Carole Soussain, Olivier Destaing, Henri-Jacques Delecluse, Susanne Delecluse, Samir Merabet, Alexandra Traverse-Glehen, Gilles Salles, Emmanuel Bachy, Marc Billaud, Hervé Ghesquières, Laurent Genestier, Jean-Pierre Rouault, Pierre Sujobert
Journal: Blood
Blood (2023) 141 (10): 1209–1220.
https://doi.org/10.1182/blood.2022016943
Published: 2023
Includes: Multimedia, Supplemental data