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Juan Luis Reguera
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Journal Articles

Outcomes of CAR-T Cell Therapy for Large B Cell Lymphoma in Patients of 70 Years and Older: Multicentric Experience on Behalf of Geth-TC/Geltamo

Rebeca Bailen, Mi Kwon, Gloria Iacoboni, Juan Luis Reguera, Lucia Lopez Corral, Rafael Hernani, Valentin Ortiz-Maldonado, Manuel Guerreiro, Ana Carolina Caballero Gonzalez, Luisa Guerra, Jose Maria Sanchez Pina, Alberto Mussetti, Juan-Manuel Sancho, Mariana Bastos-Oreiro, Eva Catalá, Javier Delgado Serrano, Hugo Daniel Luzardo Henriquez, Jaime Sanz Caballer, Maria Calbacho, Cecilia Carpio, Josep-Maria Ribera, Anna Torrent, Anna Maria Sureda Balari, Javier Briones, Juan Carlos Hernandez Boluda, Nuria Martinez-Cibrian, Alejandro Martin Garcia-Sancho, Pere Barba
Journal: Blood
Blood (2023) 142 (Supplement 1): 4883.
https://doi.org/10.1182/blood-2023-185858
Published: 2023
Journal Articles

New Optimized Academic Anti-BCMA CAR (CARTemis-1): How Does the Manufacturing Process Impact CAR-T Cell Features?

Belén Sierro-Martínez, Virginia Escamilla Gomez, Laura Perez-Ortega, Beatriz Guijarro-Albaladejo, Paola Hernández-Díaz, María de la Rosa-Garrido, Maribel Lara-Chica, Juan Luis Reguera, Luzalba Sanoja Flores, Blanca Arribas-Arribas, Miguel-Ángel Montiel-Aguilera, Gloria Carmona, Maria-Jose Robles, Teresa Caballero, Javier Briones, Hermann Einsele, Michael Hudecek, Jose A. Pérez-Simón, Estefania Garcia-Guerrero
Journal: Blood
Blood (2023) 142 (Supplement 1): 6866.
https://doi.org/10.1182/blood-2023-186095
Published: 2023
Journal Articles

TRANSCEND FL: Phase 2 Study Primary Analysis of Lisocabtagene Maraleucel as Second-Line Therapy in Patients with High-Risk Relapsed or Refractory Follicular Lymphoma

Franck Morschhauser, Saurabh Dahiya, M. Lia Palomba, Alejandro Martin Garcia-Sancho, Juan Luis Reguera, John Kuruvilla, Ulrich Jaeger, Guillaume Cartron, Koji Izutsu, Martin Dreyling, Brad S. Kahl, Herve Ghesquieres, Kirit Ardeshna, Hideki Goto, Anna Maria Barbui, Jeremy S. Abramson, Peter Borchmann, Isabelle Fleury, Stephan Mielke, Alan Skarbnik, Sven de Vos, Manali Kamdar, Reem Karmali, Andreas Viardot, Thalia Farazi, Omotayo Fasan, James Lymp, Min Vedal, Rina Nishii, Ariel Avilion, Jessica Papuga, Loretta J. Nastoupil
Journal: Blood
Blood (2023) 142 (Supplement 1): 602.
https://doi.org/10.1182/blood-2023-179474
Published: 2023
Journal Articles

Impact of Patient Selection and Management over Different Time Periods on the Outcome of Patients with Large B-Cell Lymphoma Receiving Chimeric Antigen Receptor T-Cell Therapy

Anna Torrent, Mireia Morgades, Gloria Iacoboni, Juan Luis Reguera, Mi Kwon, Lucia Lopez Corral, Rafael Hernani, Valentin Ortiz-Maldonado, Jaime Sanz, Ana Carolina Caballero Gonzalez, Luisa Guerra, Jose Maria Sanchez Pina, Alberto Mussetti, Alejandro Martin Garcia-Sancho, Mariana Bastos-Oreiro, Javier Delgado, Cecilia Carpio, Juan-Manuel Sancho, Antonio Perez Martinez, Pere Barba
Journal: Blood
Blood (2023) 142 (Supplement 1): 267.
https://doi.org/10.1182/blood-2023-186388
Published: 2023
Journal Articles

Is CAR T a Drug or a Therapeutic Pathway? Systematic Review, (Re-)Estimation of Efficacy Endpoints and Metanalyses in Large B-Cell Lymphoma Real World Reports

Pier Luigi Zinzani, Rossana Di Staso, Beatrice Casadei, Frederick L. Locke, Michael D. Jain, Timothy Voorhees, Adam S Kittai, Mariana Bastos-Oreiro, Antonio Gutiérrez, Alejandro Martin Garcia-Sancho, Maria Jose Terol, Monica Mead, Michael J. Maranzano, Gloria Iacoboni, Pere Barba, Mi Kwon, Rebeca Bailen, Juan Luis Reguera, Agrima Mian, Brian T. Hill, Emmanuel Bachy, Franck Morschhauser, Roch Houot, Catherine Thieblemont, Steven Le Gouill, Riccardo Masetti, Davide Gori, Lisa Argnani
Journal: Blood
Blood (2023) 142 (Supplement 1): 6938.
https://doi.org/10.1182/blood-2023-178526
Published: 2023
Journal Articles

Sequential Scmultiomics of In Vivo CAR-T Cells Allows Characterization of Transcriptional Differences between Patients, and Identifies IL10 As a Potential Mechanism of Resistance to CAR-T Cells in MM

Juan Roberto Rodriguez-Madoz, Lorea Jordana-Urriza, Guillermo Serrano, Aina Oliver-Caldes, Maria Erendira Calleja-Cervantes, Patxi San-Martin, Amaia Vilas-Zornoza, Asier Ullate-Agote, Aintzane Zabaleta, Diego Alignani, Teresa Lozano, Valentin Cabanas Perianes, Juan Luis Reguera, Almudena Navarro-Bailon, Marta Español-Rego, Mariona Pascal, Jose Maria Moraleda, Jose A. Perez-Simon, Maria Victoria Mateos, Fermin Sanchez-Guijo Martin, Alvaro Urbano-Ispizua, Manel Juan, Ana Alfonso Pierola, Jose J. Rifon, Paula Rodriguez Otero, Bruno Paiva, Susana Inogés, Ascensión López-Díaz De Cerio, Juan J Lasarte, Jesús San Miguel, Carlos Fernández de Larrea, Mikel Hernaez, Felipe Prosper
Journal: Blood
Blood (2023) 142 (Supplement 1): 3433.
https://doi.org/10.1182/blood-2023-182887
Published: 2023
Journal Articles

Patient-Reported Outcomes (PROs) from the Phase 2 TRANSCEND FL Study of Lisocabtagene Maraleucel (liso-cel) in Patients (pts) with Relapsed or Refractory Follicular Lymphoma (FL)

Guillaume Cartron, Alejandro Martin Garcia-Sancho, Juan Luis Reguera, Saurabh Dahiya, Shien Guo, Ling Shi, Laurie Eliason, Jinender Kumar, Thalia Farazi, Omotayo Fasan, Koji Izutsu
Journal: Blood
Blood (2023) 142 (Supplement 1): 668.
https://doi.org/10.1182/blood-2023-180175
Published: 2023
Journal Articles

The Post-CAR Prognostic Index (PC-PI): A New Prognostic Score to Predict Overall Survival in Large B-Cell Lymphoma Patients Progressing after Chimeric Antigen Receptor T-Cell Therapy

Gloria Iacoboni, Victor Navarro Garces, Josu Iraola, Pierre Sesques, Kai Rejeski, Fabio Serpenti, Mariana Bastos-Oreiro, ANA Africa Martin Lopez, Javier Delgado, Ariadna Perez, Manuel Guerreiro, Ana Carolina Caballero Gonzalez, Nuria Martinez-Cibrian, Hugo Daniel Luzardo Henriquez, Jose Maria Sanchez Pina, Juan-Manuel Sancho, Herve Ghesquieres, Alberto Mussetti, Pere Barba, Lucia Lopez Corral, Rafael Hernani, Juan Luis Reguera, Anna Maria Sureda Balari, Francesc Bosch, Alejandro Martin Garcia-Sancho, Mi Kwon, Andrea Kuhnl, Marion Subklewe, Emmanuel Bachy, Guillermo Villacampa, Pau Abrisqueta Costa
Journal: Blood
Blood (2023) 142 (Supplement 1): 227.
https://doi.org/10.1182/blood-2023-184942
Published: 2023
Journal Articles

Longitudinal Transcriptomic Analysis of CAR-T Cells at Single-Cell Level Allows the Identification of Molecular Mechanisms Promoting Long-Term CAR-T Cell Persistence in MM

Juan Roberto Rodriguez-Madoz, Lorea Jordana-Urriza, Guillermo Serrano, Aina Oliver-Caldes, Maria Erendira Calleja-Cervantes, Patxi San-Martin, Amaia Vilas-Zornoza, Asier Ullate-Agote, Aintzane Zabaleta, Diego Alignani, Teresa Lozano, Valentin Cabanas Perianes, Juan Luis Reguera, Almudena Navarro-Bailon, Marta Español-Rego, Mariona Pascal, Jose Maria Moraleda, Jose A. Perez-Simon, Maria Victoria Mateos, Fermin Sanchez-Guijo Martin, Alvaro Urbano-Ispizua, Manel Juan, Ana Alfonso Pierola, Jose J. Rifon, Paula Rodriguez Otero, Bruno Paiva, Susana Inogés, Ascensión López-Díaz De Cerio, Juan J Lasarte, Jesús San Miguel, Carlos Fernández de Larrea, Mikel Hernaez, Felipe Prosper
Journal: Blood
Blood (2023) 142 (Supplement 1): 2069.
https://doi.org/10.1182/blood-2023-182933
Published: 2023
Journal Articles

ARI0002h (Cesnicabtagene Autoleucel), an Academic Point-of-Care B-Cell Maturation Antigen (BCMA)-Directed Chimeric Antigen Receptor (CAR) T-Cell Strategy: Activity and Safety after Fractionated Initial Therapy and Booster Dose in 60 Patients with Relapsed/Refractory Multiple Myeloma

Aina Oliver-Caldes, Veronica Gonzalez-Calle, Valentín Cabañas, Nieves Lopez-Muñoz, Paula Rodriguez Otero, Juan Luis Reguera, Marta Español-Rego, Susana Inoges, Aintzane Zabaleta, Lucia Lopez Corral, Beatriz Martin-Antonio, Lorena Perez-Amill, Bruno Paiva, Laura Rosiñol, Ascensión López-Díaz De Cerio, Sergio Navarro, Joan Cid, Natalia Tovar, Joaquin Saez-Peñataro, Miriam Lopez Parra, Eulalia Olesti, Elena Guillén, Sara Varea, Julio Delgado, Jose Maria Sanchez Pina, Anthony Battram, Marta Sonia Gonzalez Perez, Andres Sanchez Salinas, Valentin Ortiz-Maldonado, Felipe Prosper, Manel Juan, Joaquin Martinez Lopez, Jose Maria Moraleda, Maria Victoria Mateos, Mariona Pascal, Alvaro Urbano-Ispizua, Carlos Fernández de Larrea
Journal: Blood
Blood (2023) 142 (Supplement 1): 1026.
https://doi.org/10.1182/blood-2023-180828
Published: 2023
Journal Articles

Salvage Treatment with Novel Agents Is Preferable to Standard Chemotherapy in Patients with Large B-Cell Lymphoma Progressing after Chimeric Antigen Receptor T-Cell Therapy

Gloria Iacoboni, Josu Iraola-Truchuelo, Alberto Mussetti, Paula Fernández-Caldas, Víctor Navarro Garcés, ANA Africa Martin Lopez, Javier Delgado, Ariadna Pérez Martínez, Manuel Guerreiro, Ana Carolina Carolina Caballero Gonzalez, Nuria Martínez-Cibrián, Hugo Daniel Luzardo Henriquez, Jose M. Sanchez, Juan-Manuel Sancho, Pere Barba, Mi Kwon, Lucía López Corral, Rafael Hernani, Juan Luis Reguera, Anna Sureda, Alejandro Martín García-Sancho, Mariana Bastos-Oreiro, Pau Abrisqueta
Journal: Blood
Blood (2022) 140 (Supplement 1): 378–380.
https://doi.org/10.1182/blood-2022-169219
Published: 2022
Journal Articles

Identification of Molecular Mechanisms Governing CAR-T Cell Response in MM Patients Using Single Cell Transcriptomics

Lorea Jordana-Urriza, Guillermo Serrano, Maria Erendira Calleja-Cervantes, Patxi San Martin-Uriz, Amaia Vilas-Zornoza, Asier Ullate-Agote, Aintzane Zabaleta, Diego Alignani, Teresa Lozano, Valentin Cabañas, Almudena Navarro-Bailón, Aina Oliver-Caldes, Marta Español-Rego, Mariona Pascal, Manel Juan, Álvaro Urbano-Ispizua, Juan Luis Reguera, Jose Maria Moraleda, Maria-Victoria Mateos, Fermin Sanchez-Guijo, Ana Alfonso Pierola, José J. Rifón Roca, Paula Rodríguez-Otero, Carlos Fernandez de Larrea, Bruno Paiva, Susana Inogés, Ascensión López-Diaz de Cerio, Juan Jose Lasarte, Jesús San-Miguel, Juan Roberto Rodriguez-Madoz, Mikel Hernáez, Felipe Prósper
Journal: Blood
Blood (2022) 140 (Supplement 1): 7366–7368.
https://doi.org/10.1182/blood-2022-163082
Published: 2022
Journal Articles

Impact of Scholar-1 Refractoriness Criteria on the Efficacy of CAR-T Therapy in Aggressive B Cell Lymphoma, Compared with Non-Refractory Patients: A Real World Geltamo/Geth Study

Mariana Bastos-Oreiro, Antonio Gutierrez, Gloria Iacoboni, Lucía López Corral, Juan Luis Reguera, Nuria Martínez-Cibrian, María José Terol, Ana Carolina Carolina Caballero Gonzalez, Jaime Sanz, Luisa Maria Guerra, Pau Abrisqueta, Gillen Oarbeascoa, Javier Delgado, Rafael Hernani, Alberto Mussetti, Ana Jimenez-Ubieto, Juan-Manuel Sancho, Anna Sureda, Antonio Perez, Pere Barba, Mi Kwon, Alejandro Martín García-Sancho
Journal: Blood
Blood (2022) 140 (Supplement 1): 1849–1851.
https://doi.org/10.1182/blood-2022-166329
Published: 2022
Journal Articles

Recent Bendamustine Treatment before Apheresis Has a Negative Impact on Outcomes in Patients with Large B-Cell Lymphoma Receiving Chimeric Antigen Receptor T-Cell Therapy

Gloria Iacoboni, ANA Africa Martin Lopez, Katarzyna Aleksandra Jalowiec, Mi Kwon, Kai Rejeski, Víctor Navarro Garcés, Paula Amat, Juan Luis Reguera, Laura Gallur, Sara Gutierrez-Herrero, Claire Roddie, Gillen Oarbeascoa, Ana Benzaquén, Cecilia Carpio, Lucía López Corral, Rafael Hernani, Mariana Bastos-Oreiro, Marion Subklewe, Maeve O'Reilly, Lourdes Martín, Pere Barba
Journal: Blood
Blood (2022) 140 (Supplement 1): 1592–1594.
https://doi.org/10.1182/blood-2022-169783
Published: 2022
Journal Articles

Detection, Monitoring and Cell Kinetics of Circulating CAR-T Cells in B-Cell Malignancies

Belén Sierro, Clara Beatriz Garcia-Calderon, Luzalba Sanoja-Flores, Victoria Ruiz-Maldonado, Javier Delgado Serrano, Agueda Molinos-Quintana, Juan Luis Reguera, Beatriz Guijarro-Albaladejo, Marta Reinoso-Segura, Estefania Garcia-Guerrero, Jose A. Perez-Simon, Teresa Caballero
Journal: Blood
Blood (2022) 140 (Supplement 1): 7550–7551.
https://doi.org/10.1182/blood-2022-163106
Published: 2022
Journal Articles

Role of Allogeneic Hematopoietic Cell Transplant for Relapsed/Refractory Large B-Cell Lymphomas in the CART Era

Alberto Mussetti, Leyre Bento, Mariana Bastos-Oreiro, Carmen Albo, Rebeca Bailen, Pere Barba, Ana Benzaquén, Javier Briones, Ana Carolina Caballero, António Campos, Ignacio Español, Christelle Ferra, Sebastián Garzón López, Pedro Antonio González Sierra, Luisa Maria Guerra, Rafael Hernani, Gloria Iacoboni, Ana Isabel Jiminez Ubieto, Mi Kwon, Lucía López Corral, Oriana López-Godino, Maria Carmen Martinez Munoz, Nuria Martínez-Cibrián, Juan Montoro Gómez, Laura Pérez-Ortega, Guillermo Ortí, Valentín Ortiz-Maldonado, Maria-Jesús Pascual, María Perera, Antonio Perez, Juan Luis Reguera, Jose M. Sanchez, Jaime Sanz, Anna Torrent, Lucrecia Yáñez, Rosario Varela, Izaksun Ceberio Echechipia, Dolores Caballero, Anna Sureda
Journal: Blood
Blood (2022) 140 (Supplement 1): 665–667.
https://doi.org/10.1182/blood-2022-160000
Published: 2022
Journal Articles

CAR-T Related Cytopenia Profile in Relapsed/Refractory Multiple Myeloma: Results of Patients Treated with ARI0002h, an Academic BCMA-Directed CAR-T Cell

Aina Oliver-Caldes, Luis Gerardo Rodríguez-Lobato, Veronica Gonzalez-Calle, Natalia Tovar, Valentin Cabañas, Paula Rodríguez-Otero, Juan Luis Reguera, Marta Español-Rego, Beatriz Martin-Antonio, Aintzane Zabaleta, Marta Lasa, Susana Inogés, Ascensión López-Diaz de Cerio, Bruno Paiva, Sara Varea, Joaquin Saez-Peñataro, Manel Juan, Laura Rosiñol, Felipe Prosper, Jose M. Moraleda, Álvaro Urbano-Ispizua, Mariona Pascal, Maria-Victoria Mateos, Carlos Fernandez de Larrea
Journal: Blood
Blood (2022) 140 (Supplement 1): 10347–10349.
https://doi.org/10.1182/blood-2022-166525
Published: 2022
Journal Articles

Correlative Biological Studies Related to the Response, Peak and Persistence of ARI0002h, an Academic BCMA-Directed CAR-T Cell, with Fractionated Initial Infusion and Booster Dose for Patients with Relapsed and/or Refractory Multiple Myeloma (RRMM)

Aina Oliver-Caldés, Marta Español-Rego, Aintzane Zabaleta, Susana Inogés, Ascensión López-Diaz de Cerio, Veronica Gonzalez-Calle, Valentin Cabañas, Beatriz Martin-Antonio, Lorena Pérez-Amill, Juan Luis Reguera, Juan Roberto Rodriguez-Madoz, Paula Rodríguez-Otero, Daniel Benítez-Ribas, Mari-Pau Mena, Marta Lasa, Luis Gerardo Rodríguez-Lobato, Azucena González, Laura Rosinol, Jose Maria Moraleda, Felipe Prósper, Álvaro Urbano-Ispizua, Maria-Victoria Mateos, Manel Juan, Bruno Paiva, Mariona Pascal, Carlos Fernandez de Larrea
Journal: Blood
Blood (2021) 138 (Supplement 1): 552.
https://doi.org/10.1182/blood-2021-148281
Published: 2021
Journal Articles

Real-World Evidence of Brexucabtagene Autoleucel for the Treatment of Relapsed or Refractory Mantle Cell Lymphoma

Gloria Iacoboni, Kai Rejeski, Lina Camacho, Annalisa Chiappella, Serafina Guadagnuolo, Lucía López Corral, Mariana Bastos-Oreiro, Javier Delgado Serrano, Christian Schmidt, Cecilia Carpio, Juan Luis Reguera, Mi Kwon, Alejandro Martín García-Sancho, Pier Luigi Zinzani, Paolo Corradini, Marion Subklewe, Pere Barba
Journal: Blood
Blood (2021) 138 (Supplement 1): 2827.
https://doi.org/10.1182/blood-2021-153087
Published: 2021
Journal Articles

Results from a Pilot Study of ARI0002h, an Academic BCMA-Directed CAR-T Cell Therapy with Fractionated Initial Infusion and Booster Dose in Patients with Relapsed and/or Refractory Multiple Myeloma

Carlos Fernandez de Larrea, Veronica Gonzalez-Calle, Valentin Cabañas, Aina Oliver-Caldes, Marta Español-Rego, Paula Rodriguez-Otero, Juan Luis Reguera, Lucía López Corral, Susana Inogés, Beatriz Martin-Antonio, Bruno Paiva, Laura Rosinol, Ascensión López-Diaz de Cerio, Natalia Tovar, Miriam Lopez Parra, Luis Gerardo Rodríguez-Lobato, Sara Varea, Andres Sanchez Salinas, Valentín Ortiz-Maldonado, Jose A. Perez-Simon, Felipe Prósper, Manel Juan, Jose Maria Moraleda, Maria-Victoria Mateos, Mariona Pascal, Álvaro Urbano-Ispizua
Journal: Blood
Blood (2021) 138 (Supplement 1): 2837.
https://doi.org/10.1182/blood-2021-147188
Published: 2021