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Michael D. Jain
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Journal Articles

Antibiotic-induced loss of gut microbiome metabolic output correlates with clinical responses to CAR T-cell therapy

Clinical Trials & Observations
Rishika Prasad, Abdur Rehman, Lubna Rehman, Faezeh Darbaniyan, Viktoria Blumenberg, Maria-Luisa Schubert, Uria Mor, Eli Zamir, Sabine Schmidt, Tomo Hayase, Chia-Chi Chang, Lauren McDaniel, Ivonne Flores, Paolo Strati, Ranjit Nair, Dai Chihara, Luis E. Fayad, Sairah Ahmed, Swaminathan P. Iyer, Michael Wang, Preetesh Jain, Loretta J. Nastoupil, Jason Westin, Reetakshi Arora, Joel Turner, Fareed Khawaja, Ranran Wu, Jennifer B. Dennison, Meghan Menges, Melanie Hidalgo-Vargas, Kayla Reid, Marco L. Davila, Peter Dreger, Felix Korell, Anita Schmitt, Mark R. Tanner, Richard E. Champlin, Christopher R. Flowers, Elizabeth J. Shpall, Samir Hanash, Sattva S. Neelapu, Michael Schmitt, Marion Subklewe, Johannes Francois-Fahrmann, C. K. Stein-Thoeringer, Eran Elinav, Michael D. Jain, Eiko Hayase, Robert R. Jenq, Neeraj Y. Saini
Journal: Blood
Blood (2025) 145 (8): 823–839.
https://doi.org/10.1182/blood.2024025366
Published: 2025
Includes: Supplemental data
Journal Articles

Outcomes Among Adult Recipients of CAR T-cell Therapy for Burkitt Lymphoma

Laura Samples, Hossein Sadrzadeh, Matthew J. Frigault, Caron A. Jacobson, Mehdi Hamadani, Ashwath Gurumurthi, Paolo Strati, Roni Shouval, Ariela Noy, Peter A Riedell, Saurabh Dahiya, David G Maloney, Brian G Till, Alexandre V. Hirayama, Jordan Gauthier, Ajay K Gopal, Stephen D Smith, Christina Poh, Ryan C Lynch, Chaitra Ujjani, Mengyang Di, Vikram Raghunathan, Mehrdad Shakib-Azar, Kikkeri N Naresh, Ted A Gooley, Jean A. Yared, Michael D Jain, Frederick L Locke, Lori A. Leslie, Narendranath Epperla, Monalisa Ghosh, Alan P Skarbnik, Brian T. Hill, Manali Kamdar, Valentín Ortiz-Maldonado, Nuria Martínez-Cibrian, Leyla Shune, Mazyar Shadman
Journal: Blood
Blood blood.2024026831.
https://doi.org/10.1182/blood.2024026831
Published: 2025
Includes: Supplemental data
Journal Articles

Clonal Evolution of Lymphoid Malignancies Following the Mutagenic Impact of Radiotherapy

Benjamin Diamond, Dhanvantri Chahar, Michael D. Jain, Alexandra Maria Poos, Michael Durante, Bachisio Ziccheddu, Marcella Kaddoura, Marios Papadimitriou, Kylee H Maclachlan, Tomas Jelinek, Faith E Davies, Nicholas B Figura, Gareth Morgan, Elias K. Mai, Hartmut Goldschmidt, Katja C. Weisel, Roland Fenk, Saad Z. Usmani, Ola Landgren, Frederick Locke, Marc S. Raab, Jonathan H. Schatz, Niels Weinhold, Francesco Maura
Journal: Blood
Blood (2024) 144 (Supplement 1): 1607.
https://doi.org/10.1182/blood-2024-200927
Published: 2024
Journal Articles

CD20xCD3 Bispecific Antibodies As Standard of Care (SOC) for Relapse/Refractory (R/R) Large B-Cell Lymphoma (LBCL) - a Multicenter Retrospective Study

Ning Dong, Sushmita Khadka, Jose Sandoval-Sus, Carlos Silva Rondon, Ariel Perez, Tiba Al Sagheer, Madiha Iqbal, Juan Pablo Alderuccio, Cristian Rodriguez Arocho, Syeda Saba Kareem, Michael D. Jain, Julio C. Chavez
Journal: Blood
Blood (2024) 144 (Supplement 1): 3091.
https://doi.org/10.1182/blood-2024-203538
Published: 2024
Journal Articles

Intrinsic Tumor Drivers and Immune Escape Mechanisms in CD19 CAR T-Cell Therapy Resistance for Aggressive Large B Cell Lymphoma

Bachisio Ziccheddu, Michael D. Jain, Monika Chojnacka, Michael Durante, Venu Venkatarame Gowda Saralamma, Austin Daniel Newsam, Jerald Noble, Nicholas B Figura, Meghan Menges, Ola Landgren, Marco Davila, Jonathan H. Schatz, Francesco Maura, Frederick L. Locke
Journal: Blood
Blood (2024) 144 (Supplement 1): 232.
https://doi.org/10.1182/blood-2024-208372
Published: 2024
Journal Articles

Pre-Apheresis Prediction of Toxicity and Response in Patients Receiving BCMA-Directed CAR-T for Relapsed/Refractory Multiple Myeloma

Kai Rejeski, Doris K. Hansen, David M. Cordas Dos Santos, Andre De Menezes Silva Corraes, Omar Castaneda, Christen M Dillard, Winfried Alsdorf, Jan H. Frenking, Anna Purcarea, Saurabh Chhabra, Ciara Louise Freeman, Mirco Julian Friedrich, Mahmoud R. Gaballa, Rebecca Gonzalez, Syed Hamza Bin Waqar, Yi Lisa Hwa, Michael D. Jain, Ricardo D. Parrondo, Oren Pasvolsky, Wajma Shahbaz, Roni Shouval, Genevieve Spiess, Haily Stephens, Sebastian Theurich, Florian Bassermann, Judith S. Hecker, Marc S. Raab, Katja C. Weisel, Frederick L. Locke, Marion Subklewe, Krina K. Patel, Yi Lin
Journal: Blood
Blood (2024) 144 (Supplement 1): 895.
https://doi.org/10.1182/blood-2024-208376
Published: 2024
Journal Articles

Delayed Immune Reconstitution and Increased Infections in Allogeneic Transplant Recipients with B Cell Malignancies Treated Previously with CAR T-Cell Therapy

Jamila Mammadova, Yanina Pasikhova, Jongphil Kim, Junmin Whiting, Farhad Khimani, Michael D. Jain, Sayeef Mirza, Rawan Faramand, Julio C. Chavez, Bijal D Shah, Olga Klinkova, Aliyah Baluch, Jose L. Ochoa-Bayona, Fabiana Perna, Taiga Nishihori, Nelli Bejanyan, Frederick Locke, Aleksandr Lazaryan
Journal: Blood
Blood (2024) 144 (Supplement 1): 2103.
https://doi.org/10.1182/blood-2024-201878
Published: 2024
Journal Articles

Non-Engrafting CD8-Depleted Human Leukocyte Antigen (HLA) Mismatched Unrelated Donor Lymphocyte Infusion (DLI) Achieves Remissions in Transplant-Naive Myelodysplastic Syndrome (MDS) and Secondary Acute Myeloid Leukemia (sAML)

Hany Elmariah, Jongphil Kim, Kayla Reid, Christopher Cubitt, Andrew T. Kuykendall, Jeffrey E Lancet, Rami S. Komrokji, David Sallman, Eric Padron, Onyee Chan, Kendra L. Sweet, Alison R. Walker, Albert J Ribickas, Stephanie Dormesy, Debra A Kessler, Priscilla M Abedu, Asmita Mishra, Farhad Khimani, Lia Perez, Joseph A. Pidala, Claudio Anasetti, Ephraim Joseph Fuchs, Philip Imus, Michael D. Jain, Frederick L. Locke, Marco Davila, Nelli Bejanyan, Amy E. DeZern
Journal: Blood
Blood (2024) 144 (Supplement 1): 2071.
https://doi.org/10.1182/blood-2024-208021
Published: 2024
Journal Articles

Exercise Prehabilitation for Older Adults Undergoing CAR-T: Feasibility and Preliminary Outcomes from a Single-Arm Pilot Study

Nathan Parker, Morgan Bean, Mart Theodore De Vera, Rachel Carmella, Jessica McCoy, Salvatore Corallo, Luis Cuadrado Delgado, Meghan Menges, Omar Castaneda, Julio C. Chavez, Rawan Faramand, Michael D. Jain, Heather S.L. Jim, Aleksandr Lazaryan, Sayeef Mirza, Laura B. Oswald, Bijal D Shah, Frederick L. Locke, Ciara Louise Freeman
Journal: Blood
Blood (2024) 144 (Supplement 1): 7224.
https://doi.org/10.1182/blood-2024-208557
Published: 2024
Journal Articles

PBCAR19B, an Immune Evading Allogeneic CAR T Stealth Cell, Demonstrates Potent Anti-Tumor Responses and Prolonged B Cell Depletion Supporting Sustained Immune Evasion in Patients with Relapsed/Refractory (R/R) B-Cell Lymphoma (NHL)

Usama Gergis, Aaron Martin, Alex Vogel, Jeff Smith, Andreas Klein, Ran Reshef, Rajneesh Nath, Adam J. Olszewski, Alan List, Alex F. Herrera, Michael D. Jain
Journal: Blood
Blood (2024) 144 (Supplement 1): 7175.
https://doi.org/10.1182/blood-2024-210499
Published: 2024
Journal Articles

Impact of Neurological and Psychiatric Comorbidities on Toxicity and Outcomes of Patients with DLBCL Who Receive Axicabtagene Ciloleucel

Rebecca Albuquerque, Anna Shamis, Athanasios Tsalatsanis, Ambuj Kumar, Zain Ahmad, Hasiq Ovais, Aleksandr Lazaryan, Farhad Khimani, Rawan Faramand, Ciara Louise Freeman, Bijal D Shah, Sameh Gaballa, Julio C. Chavez, Fabiana Perna, Jose L. Ochoa-Bayona, Frederick L. Locke, Michael D. Jain, Taiga Nishihori, Abu-Sayeef Mirza
Journal: Blood
Blood (2024) 144 (Supplement 1): 7734.
https://doi.org/10.1182/blood-2024-208905
Published: 2024
Journal Articles

Impact of Autoimmune Disease on Toxicity and Outcomes after Axicabtagene Ciloleucel in Patients with Diffuse Large B Cell Lymphoma

Anna Shamis, Rebecca Albuquerque, Athanasios Tsalatsanis, Ambuj Kumar, Zain Ahmad, Hasiq Ovais, Aleksandr Lazaryan, Farhad Khimani, Rawan Faramand, Ciara Louise Freeman, Bijal D Shah, Sameh Gaballa, Julio C. Chavez, Fabiana Perna, Jose L. Ochoa-Bayona, Frederick Locke, Michael D. Jain, Taiga Nishihori, Abu-Sayeef Mirza
Journal: Blood
Blood (2024) 144 (Supplement 1): 7733.
https://doi.org/10.1182/blood-2024-208743
Published: 2024
Journal Articles

Cohort Comparison of Therapy-Related Myeloid Neoplasms after CAR T-Cell Therapy, Autologous Stem Cell Transplant, and Standard Cancer Therapies

Jaime Roman Diaz, Saurabh Dahiya, Francesca Emily Sillito, Maeve O'Reilly, Kai Rejeski, Veit L. Buecklein, Marion Subklewe, Gloria Iacoboni, Pere Barba, Claire Roddie, Frederick Locke, Jay Y. Spiegel, Najla H. Al Ali, Zachary Thompson, Jongphil Kim, Rami S. Komrokji, Michael D. Jain
Journal: Blood
Blood (2024) 144 (Supplement 1): 7239.
https://doi.org/10.1182/blood-2024-201666
Published: 2024
Journal Articles

A Novel Composite Endpoint of Toxicity- and Progression-Free Survival after B-Cell Maturation Antigen (BCMA)-Directed Chimeric Antigen Receptor T-Cell Therapy for Relapsed/Refractory Multiple Myeloma

Razan Mohty, Whiting Junmin, Aditi Saha, Jongphil Kim, Taiga Nishihori, Gabriel De Avila, Salvatore Corallo, Marian Dam, Jessica Marin, Hien Liu, Sepideh Mokhtari, Michael D. Jain, Fabiana Perna, Brandon Blue, Ariel F. Grajales-Cruz, Omar Castaneda, Kenneth Shain, Rachid Baz, Ciara Louise L. Freeman, Melissa Alsina, Frederick L. Locke, Doris K. Hansen, Aleksandr Lazaryan
Journal: Blood
Blood (2023) 142 (Supplement 1): 3336.
https://doi.org/10.1182/blood-2023-184406
Published: 2023
Journal Articles

Cladribine and Cyclophosphamide Lymphodepletion Prior to Brexucabtagene Autoleucel in Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia and Mantle Cell Lymphoma

Filip Ionescu, Rawan Faramand, Hanna Bailey, Christina A Bachmeier, Elizabeth DiMaggio, Turab Mohammed, Leidy Lismeris Isenalumhe, Frederick L. Locke, Michael D. Jain, Bijal D. Shah
Journal: Blood
Blood (2023) 142 (Supplement 1): 6904.
https://doi.org/10.1182/blood-2023-190973
Published: 2023
Journal Articles

Predictors of Cytokine Release Syndrome and Neurotoxicity in Patients with Large B-Cell Lymphoma and Their Impact on Survival

Roni Shouval, Christopher Strouse, Soyoung Kim, Temitope Oloyede, Sairah Ahmed, Farrukh T. Awan, Veronika Bachanova, Talha Badar, Pere Barba, Amer M. Beitinjaneh, Amanda F Cashen, Bhagirathbhai Dholaria, Mahmoud Elsawy, Siddhartha Ganguly, Praveen Ramakrishnan Geethakumari, Uri Greenbaum, Hamza Hashmi, Laquisa C. Hill, Michael D. Jain, Tania Jain, Partow Kebriaei, Adam S Kittai, Frederick L. Locke, Premal D. Lulla, Elena Mead, Joseph P McGuirk, Alberto Mussetti, Taiga Nishihori, Amanda L. Olson, Martina Pennisi, Miguel-Angel Perales, Peter A. Riedell, Wael Saber, Sayeef Mirza, Margarida Magalhaes-Silverman, Elizabeth J. Shpall, Mohamed Sorror, Kitsada Wudhikarn, Cameron J. Turtle, Marcelo Pasquini, Amy Moskop
Journal: Blood
Blood (2023) 142 (Supplement 1): 355.
https://doi.org/10.1182/blood-2023-181181
Published: 2023
Journal Articles

Impact of Sarcopenia and Subsequent Muscle Loss on Post-CAR T-Cell Outcomes in Relapsed/Refractory Large B-Cell Lymphoma

Khushali Jhaveri, Ram Thapa, Jerald Noble, Dalia Ercan, Pranit Singh, Johannes Fahrmann, Neeraj Y. Saini, Ranran Wu, Jennifer Dennison, Samir Hanash, Robert R. Jenq, Karnav Modi, Nicholas Figura, Julio C Chavez, Bijal D. Shah, Taiga Nishihori, Aleksandr Lazaryan, Farhad Khimani, Christina A Bachmeier, Kenneth Gage, Asmita Mishra, Fabiana Perna, Marco Davila, Kai Rejeski, Marion Subklewe, Frederick L. Locke, Ciara Louise L. Freeman, Nathan Parker, Michael D. Jain
Journal: Blood
Blood (2023) 142 (Supplement 1): 2130.
https://doi.org/10.1182/blood-2023-187294
Published: 2023
Journal Articles

Clinical Impact of Neoantigen Burden and HLA Loss in Aggressive B-Cell Lymphomas Treated with CD19 CAR T-Cell

Bachisio Ziccheddu, Michael D. Jain, Monika Chojnacka, Michael Durante, Julieta Abraham Miranda, Meghan Menges, Ola Landgren, Marco Davila, Jonathan H. Schatz, Francesco Maura, Frederick L. Locke
Journal: Blood
Blood (2023) 142 (Supplement 1): 4362.
https://doi.org/10.1182/blood-2023-182821
Published: 2023
Journal Articles

Poor Hematopoietic Reserve at the Time of CD19 CAR T-Cell Infusion Is Associated with Long Term B-Cell Aplasia

Grace Johnson, Kedar Patel, Brian Arciola, Ariel Perez Perez, Anthony Wood, Filip Ionescu, Jennifer M Logue, Omar Albanyan, Hassaan Yasin, Christina A Bachmeier, Kayla Reid, Meghan Menges, Salvatore Corallo, Bijal D. Shah, Julio C Chavez, Farhad Khimani, Taiga Nishihori, Rawan Faramand, Hien Liu, Aleksandr Lazaryan, Kai Rejeski, Marion Subklewe, Fabiana Perna, Marco Davila, Rahul Mhaskar, Frederick L. Locke, Michael D. Jain
Journal: Blood
Blood (2023) 142 (Supplement 1): 3512.
https://doi.org/10.1182/blood-2023-185097
Published: 2023
Journal Articles

CAR-T Phenotype and Efficacy Is Impaired By Lymphoma-Associated CD39 + T Cells

Michael D. Jain, Xiaoqing Yu, Reginald Atkins, Joel G. Turner, Jerald Noble, Meghan Menges, Kayla Reid, Salvatore Corallo, Ling Cen, Sean J. Yoder, Julieta Abraham Miranda, Samira Naderinezhad, Hien Liu, Bijal D. Shah, Julio C Chavez, Erin Dean, Johannes Fahrmann, Neeraj Y. Saini, Samir Hanash, Rebecca S. Hesterberg, Paulo C. Rodriguez, John L. Cleveland, Marco Davila, Xuefeng Wang, Frederick L. Locke
Journal: Blood
Blood (2023) 142 (Supplement 1): 3500.
https://doi.org/10.1182/blood-2023-178113
Published: 2023