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Ciara Louise L. Freeman
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Journal Articles

A Pro-Inflammatory State and Peak Cytokines Are Associated with Toxicity and Early Responses in Real-World Multiple Myeloma Patients Treated with Idecabtagene Vicleucel

Doris K. Hansen, Lauren C. Peres, Julieta Abraham Miranda, Kayla Reid, Gabriel De Avila, David Huggar, Pallavi Patwardhan, Laura B. Oswald, Ariel F. Grajales-Cruz, Brandon Blue, Hien Liu, Taiga Nishihori, Kenneth Shain, Rachid Baz, Melissa Alsina, Omar Castaneda, Simran K. Tiwana, Afraim Botros, Frederick L. Locke, Ciara Louise L. Freeman
Journal: Blood
Blood (2023) 142 (Supplement 1): 1004.
https://doi.org/10.1182/blood-2023-174506
Published: 2023
Journal Articles

Paired Analysis from Patients with Myeloma Elucidates Favorable CAR-T Manufacture and Phenotype, Starting from Mobilized Pre-Transplant Apheresis Vs. Non-Mobilized Apheresis after Four Prior Lines

Ciara Louise L. Freeman, Julieta Abraham Miranda, Meghan Menges, Jerald Noble, Hien Liu, Salvatore Corallo, Albert J Ribickas, Constanza Savid-Frontera, Gabriel De Avila, Omar Castaneda, Jose L. Ochoa-Bayona, Rachid Baz, Doris K. Hansen, Melissa Alsina, Kenneth H. Shain, Taiga Nishihori, Reginald Atkins, Frederick L. Locke
Journal: Blood
Blood (2023) 142 (Supplement 1): 1931.
https://doi.org/10.1182/blood-2023-187539
Published: 2023
Journal Articles

Teclistamab Induces Favorable Responses in Patients with Relapsed and Refractory Multiple Myeloma after Prior BCMA-Directed Therapy

Ariel F. Grajales-Cruz, Omar Castaneda, Doris K. Hansen, Mariola A Vazquez-Martinez, Brandon Blue, Sushmita Khadka, Hien Liu, Jose L. Ochoa-Bayona, Ciara Louise L. Freeman, Frederick L. Locke, Taiga Nishihori, Kenneth Shain, Rachid Baz, Melissa Alsina
Journal: Blood
Blood (2023) 142 (Supplement 1): 3351.
https://doi.org/10.1182/blood-2023-184928
Published: 2023
Journal Articles

Selinexor Disrupts Epigenetic Programing and Modulates Immunogenicity in Multiple Myeloma

Praneeth Reddy Sudalagunta, Rafael Renatino-Canevarolo, Mark B Meads, David Noyes, Alexandra Achille, Maria Silva, Xiaohong Zhao, Raghunandan Reddy Alugubelli, Daniel Lastorino, Oliver Hampton, Ciara Louise L. Freeman, Stephen Wu, Andrea Ellero, Lauren C. Peres, Doris K. Hansen, Tomer Mark, Christopher J. Walker, Pietro Taverna, Rachid Baz, Kenneth Shain, Ariosto Siqueira Silva
Journal: Blood
Blood (2023) 142 (Supplement 1): 3301.
https://doi.org/10.1182/blood-2023-190658
Published: 2023
Journal Articles

A Novel Composite Endpoint of Toxicity- and Progression-Free Survival after B-Cell Maturation Antigen (BCMA)-Directed Chimeric Antigen Receptor T-Cell Therapy for Relapsed/Refractory Multiple Myeloma

Razan Mohty, Whiting Junmin, Aditi Saha, Jongphil Kim, Taiga Nishihori, Gabriel De Avila, Salvatore Corallo, Marian Dam, Jessica Marin, Hien Liu, Sepideh Mokhtari, Michael D. Jain, Fabiana Perna, Brandon Blue, Ariel F. Grajales-Cruz, Omar Castaneda, Kenneth Shain, Rachid Baz, Ciara Louise L. Freeman, Melissa Alsina, Frederick L. Locke, Doris K. Hansen, Aleksandr Lazaryan
Journal: Blood
Blood (2023) 142 (Supplement 1): 3336.
https://doi.org/10.1182/blood-2023-184406
Published: 2023
Journal Articles

Fludarabine Lymphodepletion Exposure Is Associated with Idecabtagene Vicleucel Toxicity in Relapsed and Refractory Multiple Myeloma Patients: Real-World Experience from the US Myeloma Immunotherapy Consortium

Charlotte B Wagner, Karen Sweiss, Eric Anto, Rebecca Gonzalez, Omar Alexis Castaneda Puglianini, Ciara Louise L. Freeman, Filip Ionescu, Krina K. Patel, Christopher Ferreri, Mahmoud Gaballa, Leyla Shune, Joseph P McGuirk, Surbhi Sidana, Vanna Hovanky, Jack Khouri, Danai Dima, Hamza Hashmi, James A Davis, Aimaz Afrough, Gurbakhash Kaur, Larry D. Anderson, Jr., Peter A. Forsberg, Megan Herr, Doris K. Hansen, Douglas Sborov, Mehmet H. Kocoglu
Journal: Blood
Blood (2023) 142 (Supplement 1): 4880.
https://doi.org/10.1182/blood-2023-187440
Published: 2023
Journal Articles

Single Cell RNA Sequencing of Sequential Samples before and after BCMA-Directed CAR-T Reveal Features Associated with Non-Durable Response, Exhausted T-Cells and Decreased Expression of Genes Encoding Key Surface Targets in Particular in Patients with Extramedullary Disease

Ciara Louise L. Freeman, Xiaohong Zhao, Mark B Meads, Jerald Noble, Raghunandan Reddy Alugubelli, Rafael Renatino-Canevarolo, Oliver Hampton, Praneeth Reddy Sudalagunta, Ariosto Siqueira Silva, Rachid Baz, Melissa Alsina, Doris K. Hansen, Xiaofei Song, Kenneth H. Shain
Journal: Blood
Blood (2023) 142 (Supplement 1): 3304.
https://doi.org/10.1182/blood-2023-191013
Published: 2023
Journal Articles

Real World Outcomes with Idecabtagene Vicleucel (Ide-Cel) CAR-T Cell Therapy for Relapsed/Refractory Multiple Myeloma

Surbhi Sidana, Nausheen Ahmed, Othman S Akhtar, Michael Heim, Ruta Brazauskas, Doris K. Hansen, Christopher Ferreri, Ciara Louise L. Freeman, Aimaz Afrough, Larry D. Anderson, Jr., Binod Dhakal, Devender Dhanda, Lohith Gowda, Hamza Hashmi, Melanie Harrison, Amani Kitali, Sayeef Mirza, Jinalben Patel, Pallavi Patwardhan, Saad Z Usmani, Krina K. Patel, Siddhartha Ganguly, Marcelo Pasquini
Journal: Blood
Blood (2023) 142 (Supplement 1): 1027.
https://doi.org/10.1182/blood-2023-181762
Published: 2023
Journal Articles

Alternative Lymphodepletion Strategies Lead to Similar Response Rates and Toxicities in Standard-of-Care BCMA-Directed CAR-T Therapy in Relapsed Refractory Multiple Myeloma

Shonali Midha, Ashwath Gurumurthi, Patrick Costello, Robert A. Redd, Ciara Louise L. Freeman, Omar Castaneda, Rebecca Gonzalez, Filip Ionescu, Mahmoud Gaballa, Nilesh Kalariya, Jack Khouri, Danai Dima, Mehmet H. Kocoglu, Douglas Sborov, Charlotte B Wagner, Shebli Atrash, Peter M. Voorhees, Hamza Hashmi, James A Davis, Peter A. Forsberg, Joseph P McGuirk, Leyla Shune, Megan Herr, Ran Reshef, Yi Lin, Myo Htut, Thomas Martin, Surbhi Sidana, Doris K. Hansen, Omar Nadeem, Krina K. Patel
Journal: Blood
Blood (2023) 142 (Supplement 1): 3499.
https://doi.org/10.1182/blood-2023-187565
Published: 2023
Journal Articles

Impact of Sarcopenia and Subsequent Muscle Loss on Post-CAR T-Cell Outcomes in Relapsed/Refractory Large B-Cell Lymphoma

Khushali Jhaveri, Ram Thapa, Jerald Noble, Dalia Ercan, Pranit Singh, Johannes Fahrmann, Neeraj Y. Saini, Ranran Wu, Jennifer Dennison, Samir Hanash, Robert R. Jenq, Karnav Modi, Nicholas Figura, Julio C Chavez, Bijal D. Shah, Taiga Nishihori, Aleksandr Lazaryan, Farhad Khimani, Christina A Bachmeier, Kenneth Gage, Asmita Mishra, Fabiana Perna, Marco Davila, Kai Rejeski, Marion Subklewe, Frederick L. Locke, Ciara Louise L. Freeman, Nathan Parker, Michael D. Jain
Journal: Blood
Blood (2023) 142 (Supplement 1): 2130.
https://doi.org/10.1182/blood-2023-187294
Published: 2023
Journal Articles

Expression of Cell Surface Immunotherapy Targets across the Multiple Myeloma Disease Spectrum: Implications for Sequencing and Multi-Target Strategies

Ciara Louise L. Freeman, Meghan Menges, Jerald Noble, Raghunandan Reddy Alugubelli, Rafael Renatino-Canevarolo, Oliver Hampton, Praneeth Reddy Sudalagunta, Salvatore Corallo, Ariosto Siqueira Silva, Mark B Meads, Rachid Baz, Melissa Alsina, Doris K. Hansen, Taiga Nishihori, Omar Castaneda, Brandon Blue, Ariel F. Grajales-Cruz, Yunfei Wang, Patrick Hwu, John Koomen, Kenneth H. Shain, Frederick L. Locke
Journal: Blood
Blood (2023) 142 (Supplement 1): 4678.
https://doi.org/10.1182/blood-2023-185930
Published: 2023
Journal Articles

Chimeric Antigen Receptor T Cells Targeting LILRB4, an Immunoreceptor Mediating T-Cell Suppression, Are Potently Effective in Multiple Myeloma

Francesco Di Meo, Samuel John, Chengcheng Zhang, Ciara Louise L. Freeman, Fabiana Perna
Journal: Blood
Blood (2023) 142 (Supplement 1): 4804.
https://doi.org/10.1182/blood-2023-182022
Published: 2023
Journal Articles

Facility-Related Healthcare Resource Utilization (HCRU) for Patients Treated with Idecabtagene Vicleucel (Ide-Cel, bb2121) in a Real-World (RW) Setting: A Single-Center Experience

Lauren C. Peres, Pallavi Patwardhan, David Huggar, Gabriel De Avila, Laura B. Oswald, Ariel F. Grajales-Cruz, Brandon Blue, Julieta Abraham Miranda, Kayla Reid, Hien Liu, Taiga Nishihori, Kenneth H. Shain, Rachid Baz, Melissa Alsina, Omar Castaneda, Frederick L. Locke, Ciara Louise L. Freeman, Simrandeep Tiwana, Afraim Botros, Doris K. Hansen
Journal: Blood
Blood (2023) 142 (Supplement 1): 5081.
https://doi.org/10.1182/blood-2023-173812
Published: 2023