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Gabriel De Avila
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Journal Articles

A Pro-Inflammatory State and Peak Cytokines Are Associated with Toxicity and Early Responses in Real-World Multiple Myeloma Patients Treated with Idecabtagene Vicleucel

Doris K. Hansen, Lauren C. Peres, Julieta Abraham Miranda, Kayla Reid, Gabriel De Avila, David Huggar, Pallavi Patwardhan, Laura B. Oswald, Ariel F. Grajales-Cruz, Brandon Blue, Hien Liu, Taiga Nishihori, Kenneth Shain, Rachid Baz, Melissa Alsina, Omar Castaneda, Simran K. Tiwana, Afraim Botros, Frederick L. Locke, Ciara Louise L. Freeman
Journal: Blood
Blood (2023) 142 (Supplement 1): 1004.
https://doi.org/10.1182/blood-2023-174506
Published: 2023
Journal Articles

Paired Analysis from Patients with Myeloma Elucidates Favorable CAR-T Manufacture and Phenotype, Starting from Mobilized Pre-Transplant Apheresis Vs. Non-Mobilized Apheresis after Four Prior Lines

Ciara Louise L. Freeman, Julieta Abraham Miranda, Meghan Menges, Jerald Noble, Hien Liu, Salvatore Corallo, Albert J Ribickas, Constanza Savid-Frontera, Gabriel De Avila, Omar Castaneda, Jose L. Ochoa-Bayona, Rachid Baz, Doris K. Hansen, Melissa Alsina, Kenneth H. Shain, Taiga Nishihori, Reginald Atkins, Frederick L. Locke
Journal: Blood
Blood (2023) 142 (Supplement 1): 1931.
https://doi.org/10.1182/blood-2023-187539
Published: 2023
Journal Articles

Facility-Related Healthcare Resource Utilization (HCRU) for Patients Treated with Idecabtagene Vicleucel (Ide-Cel, bb2121) in a Real-World (RW) Setting: A Single-Center Experience

Lauren C. Peres, Pallavi Patwardhan, David Huggar, Gabriel De Avila, Laura B. Oswald, Ariel F. Grajales-Cruz, Brandon Blue, Julieta Abraham Miranda, Kayla Reid, Hien Liu, Taiga Nishihori, Kenneth H. Shain, Rachid Baz, Melissa Alsina, Omar Castaneda, Frederick L. Locke, Ciara Louise L. Freeman, Simrandeep Tiwana, Afraim Botros, Doris K. Hansen
Journal: Blood
Blood (2023) 142 (Supplement 1): 5081.
https://doi.org/10.1182/blood-2023-173812
Published: 2023
Journal Articles

A Novel Composite Endpoint of Toxicity- and Progression-Free Survival after B-Cell Maturation Antigen (BCMA)-Directed Chimeric Antigen Receptor T-Cell Therapy for Relapsed/Refractory Multiple Myeloma

Razan Mohty, Whiting Junmin, Aditi Saha, Jongphil Kim, Taiga Nishihori, Gabriel De Avila, Salvatore Corallo, Marian Dam, Jessica Marin, Hien Liu, Sepideh Mokhtari, Michael D. Jain, Fabiana Perna, Brandon Blue, Ariel F. Grajales-Cruz, Omar Castaneda, Kenneth Shain, Rachid Baz, Ciara Louise L. Freeman, Melissa Alsina, Frederick L. Locke, Doris K. Hansen, Aleksandr Lazaryan
Journal: Blood
Blood (2023) 142 (Supplement 1): 3336.
https://doi.org/10.1182/blood-2023-184406
Published: 2023
Journal Articles

Sarcopenia Prevalence and Influence on the Development of Toxicity and Length of Stay in Patients with Relapsed and Refractory Myeloma Treated with Commercial Anti-BCMA CART Cells

Nathan Parker, Karnav Modi, Ricardo Villanueva, Lawrence Skelson, Ashley Scotto, Margaret Booth-Jones, Gabriel De Avila, Michael D. Jain, Asmita Mishra, Rawan Faramand, Othman Salim Akhtar, Jason Brayer, Omar Castaneda-Puglianini, Ariel F. Grajales-Cruz, Rachid C. Baz, Brandon J. Blue, Kenneth H. Shain, Melissa Alsina, Hien D. Liu, Taiga Nishihori, Frederick L. Locke, Doris K. Hansen, Ciara L. Freeman
Journal: Blood
Blood (2022) 140 (Supplement 1): 4688–4690.
https://doi.org/10.1182/blood-2022-168071
Published: 2022
Journal Articles

High Metabolic Tumor Volume Is Associated with Higher Toxicity and Decreased Efficacy of BCMA CAR-T Cell Therapy in Multiple Myeloma

Ricardo Villanueva, Doris K. Hansen, Rolf Petter Tonseth, Kenneth L Gage, Zhouping Wei, Gabriel De Avila, Rachid C. Baz, Ariel F Grajales-Cruz, Omar Castaneda-Puglianini, Brandon J. Blue, Jason Brayer, Kenneth H. Shain, Melissa Alsina, Hien D. Liu, Taiga Nishihori, Meghan A Menges, Frederick L. Locke, Yoganand Balagurunathan, Ciara L. Freeman
Journal: Blood
Blood (2022) 140 (Supplement 1): 10402–10404.
https://doi.org/10.1182/blood-2022-167804
Published: 2022
Journal Articles

Factors Associated with Refractoriness or Early Progression after Idecabtagene Vicleucel (Ide-cel) in Patients with Relapsed/Refractory Multiple Myeloma (RRMM): U.S. Myeloma CAR T Consortium Real World Experience

Hamza Hashmi, Doris K. Hansen, Lauren C. Peres, Omar Alexis Castaneda Puglianini, Ciara L. Freeman, Gabriel De Avila, Surbhi Sidana, Leyla O. Shune, Douglas W. Sborov, James Davis, Charlotte B. Wagner, M. Hakan Kocoglu, Shebli Atrash, Peter M. Voorhees, Gary Simmons, Christopher J. Ferreri, Nilesh Kalariya, Aishwarya Sannareddy, Danai Dima, Jack Khouri, Joseph P. McGuirk, Frederick L. Locke, Rachid C. Baz, Krina Patel, Melissa Alsina
Journal: Blood
Blood (2022) 140 (Supplement 1): 4642–4645.
https://doi.org/10.1182/blood-2022-164828
Published: 2022
Journal Articles

Baseline Systemic Inflammatory Markers Interleukin 6 and Ferritin Are Associated with Toxicities and Progression-Free Survival in Multiple Myeloma Patients Treated with Idecabtagene Vicleucel

Doris K. Hansen, Lauren C. Peres, Ciara L. Freeman, Omar Alexis Castaneda Puglianini, Rawan Faramand, Laura B. Oswald, Kayla M. Reid, Gabriel De Avila, Brandon J. Blue, Ariel F. Grajales-Cruz, Jose Ochoa, Alexandria Shrewsbury, Cole T. Powell, Christina Copponex, Krista H. Kottra, Rebecca Gonzalez, Jennifer M. Logue, Farhad Khimani, Hany Elmariah, Michael D. Jain, Taiga Nishihori, Hien D. Liu, Jason Brayer, Ken H. Shain, Rachid Baz, Frederick L. Locke, Melissa Alsina, Marco L. Davila
Journal: Blood
Blood (2022) 140 (Supplement 1): 12778–12780.
https://doi.org/10.1182/blood-2022-158080
Published: 2022
Journal Articles

A Multiomic Approach to Reversing Therapy Resistance in Multiple Myeloma Using Paired Ex Vivo Drug Sensitivity Measures and RNA Sequencing Data

Praneeth Reddy Sudalagunta, Mark B. Meads, Rafael Renatino-Canevarolo, Maria L. Coelho Siqueira Silva, Xiaohong Zhao, Rhett Waldron, Christopher Cubitt, Raghunandan Reddy Alugubelli, Gabriel De Avila, Oliver Hampton, Robert Gatenby, Rachid C. Baz, Kenneth H. Shain, Ariosto Siqueira Silva
Journal: Blood
Blood (2022) 140 (Supplement 1): 4245–4246.
https://doi.org/10.1182/blood-2022-162454
Published: 2022
Journal Articles

Multiple Myeloma Evolution Is Characterized By Dynamic Epigenetic Landscapes

Rafael Renatino-Canevarolo, Mark B. Meads, Maria L. Coelho Siqueira Silva, Praneeth Reddy Sudalagunta, Christopher Cubitt, Gabriel De Avila, Raghunandan Reddy Alugubelli, Amit Kulkarni, Qi Zhang, Oliver Hampton, Rachid C. Baz, Kenneth H. Shain, Ariosto Siqueira Silva
Journal: Blood
Blood (2022) 140 (Supplement 1): 3036–3037.
https://doi.org/10.1182/blood-2022-163511
Published: 2022
Journal Articles

Racial and Ethnic Differences in Clinical Outcomes Among Multiple Myeloma Patients Treated with CAR T Therapy

Lauren C. Peres, Laura B. Oswald, Christen Dillard, Gabriel De Avila, Taiga Nishihori, Brandon J. Blue, Ciara L. Freeman, Frederick L. Locke, Melissa Alsina, Omar Alexis Castaneda Puglianini, Leyla O. Shune, Douglas W. Sborov, Charlotte B Wagner, Danai Dima, Hamza Hashmi, James Davis, M. Hakan Kocoglu, Shebli Atrash, Gary Simmons, Nilesh Kalariya, Christopher J. Ferreri, Aishwarya Sannareddy, Aimaz Afrough, Peter M. Voorhees, Jack Khouri, Joseph P. McGuirk, Surbhi Sidana, Doris K. Hansen, Krina Patel
Journal: Blood
Blood (2022) 140 (Supplement 1): 623–625.
https://doi.org/10.1182/blood-2022-158478
Published: 2022
Journal Articles

Acid Ceramidase (ASAH1) Is a Key Mediator of Drug Resistance in Refractory Multiple Myeloma

Ryan T Bishop, Tao Li, Raghunandan Reddy Alugubelli, Mark Meads, Bin Fang, Gabriel De Avila, Oliver Hampton, Steven Grant, John M. Koomen, Ariosto Siqueira Silva, Kenneth H. Shain, Conor Lynch
Journal: Blood
Blood (2022) 140 (Supplement 1): 5977–5978.
https://doi.org/10.1182/blood-2022-170103
Published: 2022
Journal Articles

Racial and Ethnic Differences in Clonal Hematopoiesis, Tumor Markers, and Clinical Outcomes of Patients with Multiple Myeloma

Nancy Gillis, Lauren C Peres, Christelle M Colin-Leitzinger, Mingxiang Teng, Raghunandan Reddy Alugubelli, Gabriel De Avila, Dongliang Du, Erin M Siegel, Jamie Teer, Oliver Hampton, Melissa Alsina, Jason Brayer, Brandon J. Blue, Ariosto Siqueira Silva, Rachid Baz, Taiga Nishihori, Kenneth H. Shain
Journal: Blood
Blood (2021) 138 (Supplement 1): 402.
https://doi.org/10.1182/blood-2021-147340
Published: 2021
Journal Articles

Characterization of Synergistic Selinexor Combinations of Dexamethasone, Pomalidomide, Elotuzumab and Daratumumab in Primary MM Samples Ex Vivo

Kenneth H. Shain, MD PhD, Rafael Renatino-Canevarolo, PhD, Mark B. Meads, PhD, Praneeth Reddy Sudalagunta, PhD, Maria D Coelho Siqueira Silva, MSc, Christopher Cubitt, Gabriel De Avila, BS, Raghunandan Reddy Alugubelli, Amit Kulkarni, PhD, Qi Zhang, PhD, Oliver Hampton, Constantine Logothetis, MD, Christian Argueta, PhD, Yosef Landesman, PhD, Ariosto Siqueira Silva, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 29–30.
https://doi.org/10.1182/blood-2020-140485
Published: 2020
Journal Articles

Dynamic Epigenetic Landscapes Define Multiple Myeloma Progression and Drug Resistance

Rafael Renatino-Canevarolo, PhD, Mark B. Meads, PhD, Maria Silva, Praneeth Reddy Sudalagunta, PhD, Christopher Cubitt, Gabriel De Avila, BS, Raghunandan R Alugubelli, MS, Amit Kulkarni, PhD, Qi Zhang, PhD, Oliver Hampton, Kenneth H. Shain, MD PhD, Ariosto Siqueira Silva, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 32–33.
https://doi.org/10.1182/blood-2020-142872
Published: 2020
Journal Articles

Ex Vivo Drug Sensitivity and Functional Genomics Platform Identifies Novel Combinations Targeting Intrinsic and Extrinsic Apoptotic Signaling Pathways in Multiple Myeloma

Ariosto Siqueira Silva, PhD, Rafael Renatino-Canevarolo, PhD, Mark B. Meads, PhD, Maria D Coelho Siqueira Silva, MSc, Praneeth Reddy Sudalagunta, PhD, Christopher Cubitt, Gabriel De Avila, BS, Raghunandan Reddy Alugubelli, Amit Kulkarni, PhD, Melissa Mitchell, Hongyue Dai, Qi Zhang, PhD, Oliver Hampton, Xin Lu, Dimple A. Modi, PhD, Monica Motwani, PhD, Jason Harb, PhD, Jeremy A. Ross, Kenneth H. Shain, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 49–50.
https://doi.org/10.1182/blood-2020-134924
Published: 2020
Journal Articles

Composition of Immune Subpopulations Influence Multiple Myeloma Disease Progression

Rupal Ramakrishnan, Alexandra Achille, Tuan Nyugen, Ian Taylor, BS, Gabriel De Avila, BS, Raghunandanreddy Alugubelli, MS, Mark B. Meads, PhD, Ariosto Siqueira Silva, PhD, Kenneth H. Shain, MD PhD, Jason B. Brayer, PhDMD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4392.
https://doi.org/10.1182/blood-2019-131966
Published: 2019
Journal Articles

Re-Constructing and Exploiting Transcriptional Regulatory Networks in Multiple Myeloma Drug Resistance

Rafael Renatino-Canevarolo, PhD, Praneeth Reddy Sudalagunta, PhD, Maria D Coelho Siqueira Silva, MSc, Mark B. Meads, PhD, Alexandre Tungesvik, MD, Gabriel De Avila, Alugubelli Raghunandan Reddy, Minerva Nong, Jamie Teer, PhD, Eric A. Welsh, PhD, Tint Lwin, MD PhD, Amit Kulkarni, PhD, Hongyue Dai, PhD, William S. Dalton, PhDMD, Kenneth H. Shain, MD PhD, Ariosto Siqueira Silva, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5544.
https://doi.org/10.1182/blood-2019-128442
Published: 2019
Journal Articles

Reinforcement Learning to Optimize the Treatment of Multiple Myeloma

Kenneth H. Shain, MD PhD, Daniel Hart, Ariosto Siqueira Silva, PhD, Raghunandanreddy Alugubelli, MS, Gabriel De Avila, BS, Praneeth Reddy Sudalagunta, PhD, Alexandre Tungesvik, MD, Amit Kulkarni, PhD, Carmelo Blancuicett, PhD MD, Hongyue Dai, PhD, Taiga Nishihori, MD, Jason B. Brayer, PhDMD, Brandon Blue, MD, Melissa Alsina, MD, Rachid Baz, MD, William S. Dalton, PhDMD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5511.
https://doi.org/10.1182/blood-2019-132234
Published: 2019
Journal Articles

A CK1δ/CK1ε Regulated Metabolic Circuit Is a Therapeutic Vulnerability for Multiple Myeloma

Karen L Burger, PhD, Mark B. Meads, PhD, Anders Berglund, Paula S. Oliveira, Allison Distler, Praneeth Reddy Sudalagunta, PhD, Timothy Jacobson, Jamie Teer, PhD, Eric A. Welsh, PhD, Hongyue Dai, PhD, John M. Koomen, PhD, Alugubelli Raghunandan Reddy, Gabriel De Avila, Alexandre Tungesvik, MD, William Roush, PhD, Ariosto Siqueira Silva, PhD, Kenneth H. Shain, MD PhD, John Cleveland, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5537.
https://doi.org/10.1182/blood-2019-130830
Published: 2019