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Kenneth H. Shain
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Journal Articles

Daratumumab with lenalidomide as maintenance after transplant in newly diagnosed multiple myeloma: the AURIGA study

Clinical Trials & Observations
Ashraf Z Badros, Laahn Foster, Larry D. Anderson, Jr., Chakra P. Chaulagain, Erin M Pettijohn, Andrew J Cowan, Caitlin L. Costello, Sarah Larson, Douglas W Sborov, Kenneth H Shain, Rebecca Silbermann, Nina Shah, Alfred Chung, Maria Krevvata, Huiling Pei, Sharmila Patel, Vipin Khare, Annelore Cortoos, Robin Carson, Thomas Lin, Peter M Voorhees
Journal: Blood
Blood blood.2024025746.
https://doi.org/10.1182/blood.2024025746
Published: 2024
Includes: Supplemental data
Journal Articles

Single Cell RNA Sequencing of Sequential Samples before and after BCMA-Directed CAR-T Reveal Features Associated with Non-Durable Response, Exhausted T-Cells and Decreased Expression of Genes Encoding Key Surface Targets in Particular in Patients with Extramedullary Disease

Ciara Louise L. Freeman, Xiaohong Zhao, Mark B Meads, Jerald Noble, Raghunandan Reddy Alugubelli, Rafael Renatino-Canevarolo, Oliver Hampton, Praneeth Reddy Sudalagunta, Ariosto Siqueira Silva, Rachid Baz, Melissa Alsina, Doris K. Hansen, Xiaofei Song, Kenneth H. Shain
Journal: Blood
Blood (2023) 142 (Supplement 1): 3304.
https://doi.org/10.1182/blood-2023-191013
Published: 2023
Journal Articles

Paired Analysis from Patients with Myeloma Elucidates Favorable CAR-T Manufacture and Phenotype, Starting from Mobilized Pre-Transplant Apheresis Vs. Non-Mobilized Apheresis after Four Prior Lines

Ciara Louise L. Freeman, Julieta Abraham Miranda, Meghan Menges, Jerald Noble, Hien Liu, Salvatore Corallo, Albert J Ribickas, Constanza Savid-Frontera, Gabriel De Avila, Omar Castaneda, Jose L. Ochoa-Bayona, Rachid Baz, Doris K. Hansen, Melissa Alsina, Kenneth H. Shain, Taiga Nishihori, Reginald Atkins, Frederick L. Locke
Journal: Blood
Blood (2023) 142 (Supplement 1): 1931.
https://doi.org/10.1182/blood-2023-187539
Published: 2023
Journal Articles

Expression of Cell Surface Immunotherapy Targets across the Multiple Myeloma Disease Spectrum: Implications for Sequencing and Multi-Target Strategies

Ciara Louise L. Freeman, Meghan Menges, Jerald Noble, Raghunandan Reddy Alugubelli, Rafael Renatino-Canevarolo, Oliver Hampton, Praneeth Reddy Sudalagunta, Salvatore Corallo, Ariosto Siqueira Silva, Mark B Meads, Rachid Baz, Melissa Alsina, Doris K. Hansen, Taiga Nishihori, Omar Castaneda, Brandon Blue, Ariel F. Grajales-Cruz, Yunfei Wang, Patrick Hwu, John Koomen, Kenneth H. Shain, Frederick L. Locke
Journal: Blood
Blood (2023) 142 (Supplement 1): 4678.
https://doi.org/10.1182/blood-2023-185930
Published: 2023
Journal Articles

Genomic and Transcriptomic Landscape of Hyper-Apobec Multiple Myeloma

Marios Papadimitriou, Marilena Tauro, Bachisio Ziccheddu, Alexandra Maria Poos, Abdessamad Youssfi Alaoui, Mark B Meads, Kylee H Maclachlan, Saad Z Usmani, Marc S. Raab, Gareth J. Morgan, Niels Weinhold, Kenneth H. Shain, Ola Landgren, Francesco Maura
Journal: Blood
Blood (2023) 142 (Supplement 1): 639.
https://doi.org/10.1182/blood-2023-184784
Published: 2023
Journal Articles

Facility-Related Healthcare Resource Utilization (HCRU) for Patients Treated with Idecabtagene Vicleucel (Ide-Cel, bb2121) in a Real-World (RW) Setting: A Single-Center Experience

Lauren C. Peres, Pallavi Patwardhan, David Huggar, Gabriel De Avila, Laura B. Oswald, Ariel F. Grajales-Cruz, Brandon Blue, Julieta Abraham Miranda, Kayla Reid, Hien Liu, Taiga Nishihori, Kenneth H. Shain, Rachid Baz, Melissa Alsina, Omar Castaneda, Frederick L. Locke, Ciara Louise L. Freeman, Simrandeep Tiwana, Afraim Botros, Doris K. Hansen
Journal: Blood
Blood (2023) 142 (Supplement 1): 5081.
https://doi.org/10.1182/blood-2023-173812
Published: 2023
Journal Articles

Ex Vivo Mathematical Myeloma Advisor (EMMA) - a Clinical, Molecular, and Phenotypic Platform to Tailor Personalized Therapeutic Strategies for Multiple Myeloma

Rafael Renatino-Canevarolo, Maria Silva, Mark B Meads, Xiaohong Zhao, Alexandra Achille, David Noyes, Praneeth Reddy Sudalagunta, Raghunandan Reddy Alugubelli, Daniel Lastorino, Leticia Tordesillas, Miguel Gomez Fontela, Oliver Hampton, Daniel Abate-Daga, Kenneth H. Shain, Ariosto Siqueira Silva
Journal: Blood
Blood (2023) 142 (Supplement 1): 2280.
https://doi.org/10.1182/blood-2023-190479
Published: 2023
Journal Articles

Outcomes of Patients with Relapsed/Refractory Lymphoplasmacytic Lymphoma Treated with Venetoclax: A Multicenter Retrospective Analysis

Yazeed Sawalha, Shayna R Sarosiek, Rina Li Welkie, Sherif Seif, Shrinjaya Thapa, Saurabh Zanwar, Kirk Cahill, Rachel Treitman, Haikoo Shah, Shagun Arora, Georgios Pongas, Allison Winter, Ajay Major, Peter A. Riedell, Maria Lia Palomba, Prashant Kapoor, Ariel F. Grajales-Cruz, Kenneth H. Shain, Sheeba K. Thomas, Jorge J. Castillo
Journal: Blood
Blood (2023) 142 (Supplement 1): 3045.
https://doi.org/10.1182/blood-2023-187237
Published: 2023
Journal Articles

Sarcopenia Prevalence and Influence on the Development of Toxicity and Length of Stay in Patients with Relapsed and Refractory Myeloma Treated with Commercial Anti-BCMA CART Cells

Nathan Parker, Karnav Modi, Ricardo Villanueva, Lawrence Skelson, Ashley Scotto, Margaret Booth-Jones, Gabriel De Avila, Michael D. Jain, Asmita Mishra, Rawan Faramand, Othman Salim Akhtar, Jason Brayer, Omar Castaneda-Puglianini, Ariel F. Grajales-Cruz, Rachid C. Baz, Brandon J. Blue, Kenneth H. Shain, Melissa Alsina, Hien D. Liu, Taiga Nishihori, Frederick L. Locke, Doris K. Hansen, Ciara L. Freeman
Journal: Blood
Blood (2022) 140 (Supplement 1): 4688–4690.
https://doi.org/10.1182/blood-2022-168071
Published: 2022
Journal Articles

High Metabolic Tumor Volume Is Associated with Higher Toxicity and Decreased Efficacy of BCMA CAR-T Cell Therapy in Multiple Myeloma

Ricardo Villanueva, Doris K. Hansen, Rolf Petter Tonseth, Kenneth L Gage, Zhouping Wei, Gabriel De Avila, Rachid C. Baz, Ariel F Grajales-Cruz, Omar Castaneda-Puglianini, Brandon J. Blue, Jason Brayer, Kenneth H. Shain, Melissa Alsina, Hien D. Liu, Taiga Nishihori, Meghan A Menges, Frederick L. Locke, Yoganand Balagurunathan, Ciara L. Freeman
Journal: Blood
Blood (2022) 140 (Supplement 1): 10402–10404.
https://doi.org/10.1182/blood-2022-167804
Published: 2022
Journal Articles

Heightened Endoplasmic-Reticulum Stress Is a Targetable Vulnerability of Malignant Plasma Cells in Multiple Myeloma

Danai Dima, Metis Hasipek, Divya Jyoti Singh, Dongxu Jiang, Anand D. Tiwari, Dale Grabowski, Yvonne Parker, Daniel J. Lindner, Jianjun Zhao, Kenneth H. Shain, Jack Khouri, Jaroslaw P. Maciejewski, Babal K. Jha
Journal: Blood
Blood (2022) 140 (Supplement 1): 7100–7101.
https://doi.org/10.1182/blood-2022-169516
Published: 2022
Journal Articles

Patterns of Relapse and Clinical Outcomes in Multiple Myeloma Patients after Anti-BCMA CAR T-Cell Therapy: Implications for Patient's Monitoring after CAR T-Cell Therapy

Omar Alexis Castaneda Puglianini, Lauren C. Peres, Doris K. Hansen, Taiga Nishihori, Ariel F Grajales-Cruz, Brandon J. Blue, Jason Brayer, Ciara L. Freeman, Kenneth H. Shain, Hien D. Liu, Jose Ochoa, Frederick L. Locke, Rachid C. Baz, Melissa Alsina
Journal: Blood
Blood (2022) 140 (Supplement 1): 7538–7539.
https://doi.org/10.1182/blood-2022-170135
Published: 2022
Journal Articles

A Multiomic Approach to Reversing Therapy Resistance in Multiple Myeloma Using Paired Ex Vivo Drug Sensitivity Measures and RNA Sequencing Data

Praneeth Reddy Sudalagunta, Mark B. Meads, Rafael Renatino-Canevarolo, Maria L. Coelho Siqueira Silva, Xiaohong Zhao, Rhett Waldron, Christopher Cubitt, Raghunandan Reddy Alugubelli, Gabriel De Avila, Oliver Hampton, Robert Gatenby, Rachid C. Baz, Kenneth H. Shain, Ariosto Siqueira Silva
Journal: Blood
Blood (2022) 140 (Supplement 1): 4245–4246.
https://doi.org/10.1182/blood-2022-162454
Published: 2022
Journal Articles

Similar Benefits of High-Dose Melphalan Based Conditioning Regimens Followed By Autologous Hematopoietic Cell Transplantation in Elderly Myeloma Population Compared to the Younger Group: Single Center Experience

Taiga Nishihori, Ciara L. Freeman, Doris K. Hansen, Brandon J. Blue, Omar Alexis Castaneda Puglianini, Jongphil Kim, Ariel F. Grajales-Cruz, Jason Brayer, Jose Ochoa, Hien D. Liu, Kenneth H. Shain, Rachid C. Baz, Frederick L. Locke, Melissa Alsina
Journal: Blood
Blood (2022) 140 (Supplement 1): 4856–4858.
https://doi.org/10.1182/blood-2022-168888
Published: 2022
Journal Articles

Multiple Myeloma Evolution Is Characterized By Dynamic Epigenetic Landscapes

Rafael Renatino-Canevarolo, Mark B. Meads, Maria L. Coelho Siqueira Silva, Praneeth Reddy Sudalagunta, Christopher Cubitt, Gabriel De Avila, Raghunandan Reddy Alugubelli, Amit Kulkarni, Qi Zhang, Oliver Hampton, Rachid C. Baz, Kenneth H. Shain, Ariosto Siqueira Silva
Journal: Blood
Blood (2022) 140 (Supplement 1): 3036–3037.
https://doi.org/10.1182/blood-2022-163511
Published: 2022
Journal Articles

Daratumumab Plus Lenalidomide, Bortezomib, and Dexamethasone (D-RVd) in Transplant-Eligible Newly Diagnosed Multiple Myeloma (NDMM) Patients (Pts): Final Analysis of Griffin Among Clinically Relevant Subgroups

Ajai Chari, Jonathan L. Kaufman, Jacob P Laubach, Douglas W Sborov, Brandi Reeves, Cesar Rodriguez, Rebecca Silbermann, Luciano J. Costa, Larry D. Anderson, Jr., Nitya Nathwani, Nina Shah, Naresh Bumma, Sarah A. Holstein, Caitlin Costello, Andrzej Jakubowiak, Tanya M. Wildes, Robert Z. Orlowski, Kenneth H. Shain, Andrew J. Cowan, Huiling Pei, Annelore Cortoos, Sharmila Patel, Thomas S. Lin, Paul G. Richardson, Saad Usmani, Peter M. Voorhees
Journal: Blood
Blood (2022) 140 (Supplement 1): 7278–7281.
https://doi.org/10.1182/blood-2022-162339
Published: 2022
Journal Articles

Health-Related Quality of Life in Transplant-Eligible Patients with Newly Diagnosed Multiple Myeloma Treated with Daratumumab, Lenalidomide, Bortezomib, and Dexamethasone: Patient Reported Outcomes from GRIFFIN

Rebecca Silbermann, Jacob Laubach, Jonathan L. Kaufman, Douglas W. Sborov, Brandi Reeves, Cesar Rodriguez, Ajai Chari, Luciano J. Costa, Larry D. Anderson, Jr., Nitya Nathwani, Nina Shah, Naresh Bumma, Sarah A. Holstein, Caitlin Costello, Andrzej Jakubowiak, Robert Z. Orlowski, Kenneth H. Shain, Andrew J. Cowan, Katharine S. Gries, Huiling Pei, Annelore Cortoos, Sharmila Patel, Thomas S. Lin, Paul G. Richardson, Saad Usmani, Peter M. Voorhees
Journal: Blood
Blood (2022) 140 (Supplement 1): 1146–1149.
https://doi.org/10.1182/blood-2022-162313
Published: 2022
Journal Articles

Comparing Outcomes of Outpatient Vs. Inpatient High-Dose Melphalan Based Conditioning Regimens Followed By Autologous Hematopoietic Cell Transplantation in Myeloma

Taiga Nishihori, Doris K. Hansen, Hien D. Liu, Omar Alexis Castaneda Puglianini, Ciara L. Freeman, Brandon J. Blue, Jason Brayer, Jongphil Kim, Ariel F Grajales-Cruz, Jose Ochoa, Rachid C. Baz, Kenneth H. Shain, Frederick L. Locke, Melissa Alsina
Journal: Blood
Blood (2022) 140 (Supplement 1): 5174–5176.
https://doi.org/10.1182/blood-2022-171117
Published: 2022
Journal Articles

Daratumumab Based Response Adapted Therapy for Older Adults with Newly Diagnosed Multiple Myeloma: Interim Analysis of Phase II Study

Rachid C. Baz, Jongphil Kim, Christine Sam, Brandon J. Blue, Sonila Toska, Aaron Collier, Jason Brayer, Ariel F Grajales-Cruz, Melissa Alsina, Ariosto Siqueira Silva, Kenneth H. Shain
Journal: Blood
Blood (2022) 140 (Supplement 1): 7313–7314.
https://doi.org/10.1182/blood-2022-159164
Published: 2022
Journal Articles

Acid Ceramidase (ASAH1) Is a Key Mediator of Drug Resistance in Refractory Multiple Myeloma

Ryan T Bishop, Tao Li, Raghunandan Reddy Alugubelli, Mark Meads, Bin Fang, Gabriel De Avila, Oliver Hampton, Steven Grant, John M. Koomen, Ariosto Siqueira Silva, Kenneth H. Shain, Conor Lynch
Journal: Blood
Blood (2022) 140 (Supplement 1): 5977–5978.
https://doi.org/10.1182/blood-2022-170103
Published: 2022