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Mark B. Meads
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Journal Articles

Single Cell RNA Sequencing of Sequential Samples before and after BCMA-Directed CAR-T Reveal Features Associated with Non-Durable Response, Exhausted T-Cells and Decreased Expression of Genes Encoding Key Surface Targets in Particular in Patients with Extramedullary Disease

Ciara Louise L. Freeman, Xiaohong Zhao, Mark B Meads, Jerald Noble, Raghunandan Reddy Alugubelli, Rafael Renatino-Canevarolo, Oliver Hampton, Praneeth Reddy Sudalagunta, Ariosto Siqueira Silva, Rachid Baz, Melissa Alsina, Doris K. Hansen, Xiaofei Song, Kenneth H. Shain
Journal: Blood
Blood (2023) 142 (Supplement 1): 3304.
https://doi.org/10.1182/blood-2023-191013
Published: 2023
Journal Articles

Selinexor Disrupts Epigenetic Programing and Modulates Immunogenicity in Multiple Myeloma

Praneeth Reddy Sudalagunta, Rafael Renatino-Canevarolo, Mark B Meads, David Noyes, Alexandra Achille, Maria Silva, Xiaohong Zhao, Raghunandan Reddy Alugubelli, Daniel Lastorino, Oliver Hampton, Ciara Louise L. Freeman, Stephen Wu, Andrea Ellero, Lauren C. Peres, Doris K. Hansen, Tomer Mark, Christopher J. Walker, Pietro Taverna, Rachid Baz, Kenneth Shain, Ariosto Siqueira Silva
Journal: Blood
Blood (2023) 142 (Supplement 1): 3301.
https://doi.org/10.1182/blood-2023-190658
Published: 2023
Journal Articles

Genomic and Transcriptomic Landscape of Hyper-Apobec Multiple Myeloma

Marios Papadimitriou, Marilena Tauro, Bachisio Ziccheddu, Alexandra Maria Poos, Abdessamad Youssfi Alaoui, Mark B Meads, Kylee H Maclachlan, Saad Z Usmani, Marc S. Raab, Gareth J. Morgan, Niels Weinhold, Kenneth H. Shain, Ola Landgren, Francesco Maura
Journal: Blood
Blood (2023) 142 (Supplement 1): 639.
https://doi.org/10.1182/blood-2023-184784
Published: 2023
Journal Articles

Expression of Cell Surface Immunotherapy Targets across the Multiple Myeloma Disease Spectrum: Implications for Sequencing and Multi-Target Strategies

Ciara Louise L. Freeman, Meghan Menges, Jerald Noble, Raghunandan Reddy Alugubelli, Rafael Renatino-Canevarolo, Oliver Hampton, Praneeth Reddy Sudalagunta, Salvatore Corallo, Ariosto Siqueira Silva, Mark B Meads, Rachid Baz, Melissa Alsina, Doris K. Hansen, Taiga Nishihori, Omar Castaneda, Brandon Blue, Ariel F. Grajales-Cruz, Yunfei Wang, Patrick Hwu, John Koomen, Kenneth H. Shain, Frederick L. Locke
Journal: Blood
Blood (2023) 142 (Supplement 1): 4678.
https://doi.org/10.1182/blood-2023-185930
Published: 2023
Journal Articles

Ex Vivo Mathematical Myeloma Advisor (EMMA) - a Clinical, Molecular, and Phenotypic Platform to Tailor Personalized Therapeutic Strategies for Multiple Myeloma

Rafael Renatino-Canevarolo, Maria Silva, Mark B Meads, Xiaohong Zhao, Alexandra Achille, David Noyes, Praneeth Reddy Sudalagunta, Raghunandan Reddy Alugubelli, Daniel Lastorino, Leticia Tordesillas, Miguel Gomez Fontela, Oliver Hampton, Daniel Abate-Daga, Kenneth H. Shain, Ariosto Siqueira Silva
Journal: Blood
Blood (2023) 142 (Supplement 1): 2280.
https://doi.org/10.1182/blood-2023-190479
Published: 2023
Journal Articles

A Multiomic Approach to Reversing Therapy Resistance in Multiple Myeloma Using Paired Ex Vivo Drug Sensitivity Measures and RNA Sequencing Data

Praneeth Reddy Sudalagunta, Mark B. Meads, Rafael Renatino-Canevarolo, Maria L. Coelho Siqueira Silva, Xiaohong Zhao, Rhett Waldron, Christopher Cubitt, Raghunandan Reddy Alugubelli, Gabriel De Avila, Oliver Hampton, Robert Gatenby, Rachid C. Baz, Kenneth H. Shain, Ariosto Siqueira Silva
Journal: Blood
Blood (2022) 140 (Supplement 1): 4245–4246.
https://doi.org/10.1182/blood-2022-162454
Published: 2022
Journal Articles

Multiple Myeloma Evolution Is Characterized By Dynamic Epigenetic Landscapes

Rafael Renatino-Canevarolo, Mark B. Meads, Maria L. Coelho Siqueira Silva, Praneeth Reddy Sudalagunta, Christopher Cubitt, Gabriel De Avila, Raghunandan Reddy Alugubelli, Amit Kulkarni, Qi Zhang, Oliver Hampton, Rachid C. Baz, Kenneth H. Shain, Ariosto Siqueira Silva
Journal: Blood
Blood (2022) 140 (Supplement 1): 3036–3037.
https://doi.org/10.1182/blood-2022-163511
Published: 2022
Journal Articles

Characterization of Synergistic Selinexor Combinations of Dexamethasone, Pomalidomide, Elotuzumab and Daratumumab in Primary MM Samples Ex Vivo

Kenneth H. Shain, MD PhD, Rafael Renatino-Canevarolo, PhD, Mark B. Meads, PhD, Praneeth Reddy Sudalagunta, PhD, Maria D Coelho Siqueira Silva, MSc, Christopher Cubitt, Gabriel De Avila, BS, Raghunandan Reddy Alugubelli, Amit Kulkarni, PhD, Qi Zhang, PhD, Oliver Hampton, Constantine Logothetis, MD, Christian Argueta, PhD, Yosef Landesman, PhD, Ariosto Siqueira Silva, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 29–30.
https://doi.org/10.1182/blood-2020-140485
Published: 2020
Journal Articles

Dynamic Epigenetic Landscapes Define Multiple Myeloma Progression and Drug Resistance

Rafael Renatino-Canevarolo, PhD, Mark B. Meads, PhD, Maria Silva, Praneeth Reddy Sudalagunta, PhD, Christopher Cubitt, Gabriel De Avila, BS, Raghunandan R Alugubelli, MS, Amit Kulkarni, PhD, Qi Zhang, PhD, Oliver Hampton, Kenneth H. Shain, MD PhD, Ariosto Siqueira Silva, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 32–33.
https://doi.org/10.1182/blood-2020-142872
Published: 2020
Journal Articles

Ex Vivo Drug Sensitivity and Functional Genomics Platform Identifies Novel Combinations Targeting Intrinsic and Extrinsic Apoptotic Signaling Pathways in Multiple Myeloma

Ariosto Siqueira Silva, PhD, Rafael Renatino-Canevarolo, PhD, Mark B. Meads, PhD, Maria D Coelho Siqueira Silva, MSc, Praneeth Reddy Sudalagunta, PhD, Christopher Cubitt, Gabriel De Avila, BS, Raghunandan Reddy Alugubelli, Amit Kulkarni, PhD, Melissa Mitchell, Hongyue Dai, Qi Zhang, PhD, Oliver Hampton, Xin Lu, Dimple A. Modi, PhD, Monica Motwani, PhD, Jason Harb, PhD, Jeremy A. Ross, Kenneth H. Shain, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 49–50.
https://doi.org/10.1182/blood-2020-134924
Published: 2020
Journal Articles

Composition of Immune Subpopulations Influence Multiple Myeloma Disease Progression

Rupal Ramakrishnan, Alexandra Achille, Tuan Nyugen, Ian Taylor, BS, Gabriel De Avila, BS, Raghunandanreddy Alugubelli, MS, Mark B. Meads, PhD, Ariosto Siqueira Silva, PhD, Kenneth H. Shain, MD PhD, Jason B. Brayer, PhDMD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4392.
https://doi.org/10.1182/blood-2019-131966
Published: 2019
Journal Articles

Re-Constructing and Exploiting Transcriptional Regulatory Networks in Multiple Myeloma Drug Resistance

Rafael Renatino-Canevarolo, PhD, Praneeth Reddy Sudalagunta, PhD, Maria D Coelho Siqueira Silva, MSc, Mark B. Meads, PhD, Alexandre Tungesvik, MD, Gabriel De Avila, Alugubelli Raghunandan Reddy, Minerva Nong, Jamie Teer, PhD, Eric A. Welsh, PhD, Tint Lwin, MD PhD, Amit Kulkarni, PhD, Hongyue Dai, PhD, William S. Dalton, PhDMD, Kenneth H. Shain, MD PhD, Ariosto Siqueira Silva, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5544.
https://doi.org/10.1182/blood-2019-128442
Published: 2019
Journal Articles

Integrated Multi-Level Omics to Characterize Bortezomib Resistance in Multiple Myeloma

David C. Koomen, BS, Mark B. Meads, PhD, Dario M. Magaletti, Joy D. Guingab, PhD, Paula S. Oliveira, Bin Fang, PhD, Victoria Izumi, MS, Rafael Renatino-Canevarolo, PhD, Praneeth Reddy Sudalagunta, PhD, Maria Silva, Raghunandanreddy Alugubelli, MS, Gabe De Avilla, Alex Tungeskiv, Eric A. Welsh, PhD, Laurel E. Meke, Wei Zhang, PhD, Steven A. Eschrich, PhD, Timothy J. Garrett, PhD, Ariosto Siqueira Silva, PhD, John M. Koomen, PhD, Kenneth H. Shain, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5534.
https://doi.org/10.1182/blood-2019-132001
Published: 2019
Journal Articles

A CK1δ/CK1ε Regulated Metabolic Circuit Is a Therapeutic Vulnerability for Multiple Myeloma

Karen L Burger, PhD, Mark B. Meads, PhD, Anders Berglund, Paula S. Oliveira, Allison Distler, Praneeth Reddy Sudalagunta, PhD, Timothy Jacobson, Jamie Teer, PhD, Eric A. Welsh, PhD, Hongyue Dai, PhD, John M. Koomen, PhD, Alugubelli Raghunandan Reddy, Gabriel De Avila, Alexandre Tungesvik, MD, William Roush, PhD, Ariosto Siqueira Silva, PhD, Kenneth H. Shain, MD PhD, John Cleveland, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5537.
https://doi.org/10.1182/blood-2019-130830
Published: 2019
Journal Articles

Systems Biology Analysis Identifies Targetable Vulnerability Networks to Proteasome Inhibitors in Multiple Myeloma

Mark B. Meads, PhD, Rafael Renatino Canevarolo, PhD, Praneeth Reddy Sudalagunta, PhD, Paula S. Oliveira, Dario M. Magaletti, Bin Fang, PhD, Maria D Coelho Siqueira Silva, MSc, Amit Kulkarni, PhD, Hongyue Dai, PhD, William S. Dalton, PhDMD, Ion Petre, PhD, John M. Koomen, PhD, Ariosto Siqueira Silva, PhD, Kenneth H. Shain, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 950.
https://doi.org/10.1182/blood-2018-99-120269
Published: 2018
Journal Articles

A Systems Biology Approach to Identify Mechanisms of Therapy Resistance in Multiple Myeloma

Rafael Renatino Canevarolo, PhD, Praneeth Reddy Sudalagunta, PhD, Maria D Coelho Siqueira Silva, MSc, Mark B. Meads, PhD, Priscilla Granados, Anders Berglund, Amit Kulkarni, PhD, Hongyue Dai, PhD, William S. Dalton, PhDMD, Ion Petre, PhD, Kenneth H. Shain, MD PhD, Ariosto Siqueira Silva, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3266.
https://doi.org/10.1182/blood-2018-99-118784
Published: 2018
Journal Articles

Proteometabolomics of Melphalan Resistance in Multiple Myeloma

David C. Koomen, BS, Joy D. Guingab, PhD, Paula S. Oliveira, Bin Fang, PhD, Min Liu, PhD, Eric A. Welsh, PhD, Mark B. Meads, PhD, Tuan Nguyen, Laurel E. Meke, Steven A. Eschrich, PhD, Timothy J. Garrett, PhD, John M. Koomen, PhD, Kenneth H. Shain, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5619.
https://doi.org/10.1182/blood-2018-99-117747
Published: 2018
Journal Articles

Functional Analysis of HDAC11 in Plasma Cell Development and Multiple Myeloma Survival

AGM Mostofa, PhD, Allison Distler, Mark B. Meads, PhD, Eva Sahakian, PhD, John J. Powers, BS, Tuan Nguyen, Melissa Alsina, MD, Taiga Nishihori, MD, Rachid Baz, MD, Javier Pinilla Ibarz, MD, Eduardo Sotomayor, MD, Kenneth H. Shain, MD PhD, Jason B. Brayer, PhD MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3223.
https://doi.org/10.1182/blood-2018-99-119119
Published: 2018
Journal Articles

Pharmacodynamical Modeling of Two-Way Synergistic Effect for High-Throughput Drug Combination Screening in an Ex Vivo Reconstruction of Bone Marrow Using Primary Multiple Myeloma Cells

Praneeth Reddy Sudalagunta, PhD, Rafael Renatino Canevarolo, PhD, Maria D Coelho Siqueira Silva, MSc, Mark B. Meads, PhD, Alex Tungesvik, MD, Gabriel De Avila, Kenneth H. Shain, MD PhD, Ariosto Siqueira Silva, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1919.
https://doi.org/10.1182/blood-2018-99-118978
Published: 2018
Journal Articles

A CK1δ/CK1ε-to-β-Catenin Circuit Is a Therapeutic Vulnerability for Primary and Drug Resistant Multiple Myeloma

Karen L Burger, PhD, Mark B. Meads, PhD, Ariosto Siqueira Silva, PhD, Paula Oliveira, Tuan Nguyen, Allison Distler, Maria Coelho Siqueira Silva, Timothy Jacobson, Jamie Teer, PhD, Hongyue Dai, PhD, William Roush, PhD, John Cleveland, PhD, Kenneth H Shain, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 591.
https://doi.org/10.1182/blood.V130.Suppl_1.591.591
Published: 2017