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Marc S. Raab
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Journal Articles

The biological and clinical impact of deletions before and after large chromosomal gains in multiple myeloma

Anthony M. Cirrincione, Alexandra M. Poos, Bachisio Ziccheddu, Marcella Kaddoura, Marc-Andrea Bärtsch, Kylee Maclachlan, Monika Chojnacka, Benjamin Diamond, Lukas John, Philipp Reichert, Stefanie Huhn, Patrick Blaney, Dylan Gagler, Karsten Rippe, Yanming Zhang, Ahmet Dogan, Alexander M. Lesokhin, Faith Davies, Hartmut Goldschmidt, Roland Fenk, Katja C. Weisel, Elias K. Mai, Neha Korde, Gareth J. Morgan, Saad Usmani, Ola Landgren, Marc S. Raab, Niels Weinhold, Francesco Maura
Journal: Blood
Blood (2024) 144 (7): 771–783.
https://doi.org/10.1182/blood.2024024299
Published: 2024
Includes: Supplemental data
Journal Articles

Venetoclax in myeloma: to B, or not to B

Marc S. Raab
Journal: Blood
Blood (2024) 143 (1): 4–5.
https://doi.org/10.1182/blood.2023022535
Published: 2024
Journal Articles

Resolving therapy resistance mechanisms in multiple myeloma by multiomics subclone analysis

Alexandra M. Poos, Nina Prokoph, Moritz J. Przybilla, Jan-Philipp Mallm, Simon Steiger, Isabelle Seufert, Lukas John, Stephan M. Tirier, Katharina Bauer, Anja Baumann, Jennifer Rohleder, Umair Munawar, Leo Rasche, K. Martin Kortüm, Nicola Giesen, Philipp Reichert, Stefanie Huhn, Carsten Müller-Tidow, Hartmut Goldschmidt, Oliver Stegle, Marc S. Raab, Karsten Rippe, Niels Weinhold
Journal: Blood
Blood (2023) 142 (19): 1633–1646.
https://doi.org/10.1182/blood.2023019758
Published: 2023
Includes: Supplemental data
Journal Articles

Hdp-101, an Anti-BCMA Antibody-Drug Conjugate with a Novel Payload Amanitin in Patients with Relapsed Multiple Myeloma, Initial Findings of the First in Human Study

Marc S. Raab, Jonathan L. Kaufman, Shambavi Richard, Sebastian Grosicki, Istvan Takacs, Andras Strassz, Andreas Martin Pahl, Thorsten Michael, Anette Last, Hajnalka Szaboki, Garrit Jentsch, Oliver Schönborn-Kellenberger, Robert Z. Orlowski
Journal: Blood
Blood (2023) 142 (Supplement 1): 3334.
https://doi.org/10.1182/blood-2023-182480
Published: 2023
Journal Articles

Real-World Analysis of Teclistamab in 115 RRMM Patients from Germany

Christine Riedhammer, Florian Bassermann, Britta Besemer, Moritz Bewarder, Franziska Brunner, Alexander Carpinteiro, Hermann Einsele, Josefine Faltin, Jan Frenking, Deniz Gezer, Sarah Goldman-Mazur, Mathias Hanel, Marion Hoegner, K. Martin Kortüm, Jan Krönke, Miriam Kull, Theo Leitner, Christoph Mann, Rabea Mecklenbrauck, Maximilian Merz, Anke Morgner, Axel Nogai, Marc S. Raab, Raphael Teipel, Ralph Wäsch, Leo Rasche
Journal: Blood
Blood (2023) 142 (Supplement 1): 3329.
https://doi.org/10.1182/blood-2023-180032
Published: 2023
Journal Articles

Immunological Subgroups Predicting Efficacy of Elotuzumab in Multiple Myeloma Patients: Insights from the GMMG-HD6 Clinical Trial

Gigi Nu Hoang Quy Ton, Katharina Kriegsmann, Mohamed H.S. Awwad, Axel Benner, Uta Bertsch, Britta Besemer, Mathias Hänel, Roland Fenk, Jana Schlenzka, Markus Munder, Jan Dürig, Igor Wolfgang Blau, Stefanie Huhn, Dirk Hose, Anna Jauch, Andreas Neubauer, Niels Weinhold, Christof Scheid, Roland Schroers, Ivana von Metzler, Aneta Schieferdecker, Jörg Thomalla, Peter Reimer, Rolf Mahlberg, Ullrich Graeven, Stephan Kremers, Uwe Martens, Christian Kunz, Manfred Hensel, Andrea Seidel-Glätzer, Katja Weisel, Hans Salwender, Carsten Müller-Tidow, Marc S. Raab, Hartmut Goldschmidt, Elias K. Mai, Michael Hundemer
Journal: Blood
Blood (2023) 142 (Supplement 1): 1991.
https://doi.org/10.1182/blood-2023-189169
Published: 2023
Journal Articles

The Phase 2 CARTITUDE-2 Trial: Updated Efficacy and Safety of Ciltacabtagene Autoleucel in Patients with Multiple Myeloma and 1-3 Prior Lines of Therapy (Cohort A) and with Early Relapse after First Line Treatment (Cohort B)

Jens Hillengass, Adam D. Cohen, Mounzer E Agha, Michel Delforge, Tessa Kerre, Wilfried Roeloffzen, Hermann Einsele, Hartmut Goldschmidt, Katja Weisel, Marc S. Raab, Christof Scheid, Sebastien Anguille, Pieter Sonneveld, Sonja Zweegman, Jordan M. Schecter, Kevin C De Braganca, Carolyn Chang Jackson, Philip Vlummens, Helen Varsos, Christina Corsale, Deepu Madduri, Tzu-min Yeh, Pankaj Mistry, Tito Roccia, Qingxuan Song, Muhammad Akram, Octavio Costa Filho, Dong Geng, Yael C. Cohen, Niels W.C.J. Van De Donk
Journal: Blood
Blood (2023) 142 (Supplement 1): 1021.
https://doi.org/10.1182/blood-2023-178882
Published: 2023
Journal Articles

Idecabtagene Vicleucel (ide-cel) Versus Standard (std) Regimens in Patients (pts) with Triple-Class-Exposed (TCE) Relapsed and Refractory Multiple Myeloma (RRMM): Analysis of Cytopenias and Infections in Pts from KarMMa-3

Rachid Baz, Paula Rodriguez Otero, Sikander Ailawadhi, Bertrand Arnulf, Krina K. Patel, Ajay K. Nooka, Luciano Costa, Noopur S. Raje, Ingerid Weum Abrahamsen, Michel Delforge, Usama Gergis, Douglas W. Sborov, Sergio A. Giralt, Marc S. Raab, Tadao Ishida, Asya Varshavsky-Yanovsky, Taewoong Choi, Larry D. Anderson, Jr., Anna Truppel-Hartmann, Rashmi Bhatnagar, Fan Wu, Julia Piasecki, Jasper Felten, Andrea Caia, Mark Cook, Yi Lin
Journal: Blood
Blood (2023) 142 (Supplement 1): 4879.
https://doi.org/10.1182/blood-2023-174477
Published: 2023
Journal Articles

Whole-Genome Sequencing Reveals Distinct Mutational Signatures in Multiple Myeloma Patients with African Ancestry Compared with Those of Non-African Ancestry

Kylee H Maclachlan, Patrick Blaney, Anthony Cirrincione, Timothy R. Chu, Alexandra Maria Poos, Elizabeth E. Brown, Elisabet E. Manasanch, Antje Hoering, Liming Hou, Dylan Gagler, Yubao Wang, Sanxiong Liu, Benjamin Diamond, Bachisio Ziccheddu, Marc S. Raab, Niels Weinhold, Ola Landgren, Nicolas Robine, Faith E. Davies, Alexander Lesokhin, Saad Z Usmani, Francesco Maura, Gareth J. Morgan
Journal: Blood
Blood (2023) 142 (Supplement 1): 3764.
https://doi.org/10.1182/blood-2023-190882
Published: 2023
Journal Articles

Salvage Autologous Transplant and Lenalidomide Maintenance Versus Continuous Lenalidomide/Dexamethasone for Relapsed Multiple Myeloma: Long Term Follow up Results of the Randomized GMMG Phase III Multicenter Trial Relapse

Marc-Andrea Baertsch, Jana Schlenzka, Thomas Hielscher, Marc S. Raab, Sandra Sauer, Maximilian Merz, Elias K. Mai, Carsten Müller-Tidow, Steffen Luntz, Anna Jauch, Peter Brossart, Martin Goerner, Stefan Klein, Bertram Glass, Peter Reimer, Ullrich Graeven, Roland Fenk, Mathias Hänel, Ivana von Metzler, Lindemann Hans W., Christof Scheid, Axel Nogai, Hans Salwender, Richard Noppeney, Britta Besemer, Katja Weisel, Hartmut Goldschmidt
Journal: Blood
Blood (2023) 142 (Supplement 1): 782.
https://doi.org/10.1182/blood-2023-178835
Published: 2023
Journal Articles

The Ig Superfamily Ligand B7H6 Subjects Activated T Cells to NK Cell Surveillance and Limits CAR T Cell Persistence

Mirco Julian Friedrich, Michael Kilian, Kevin Hai-Ning Lu, Selina Jansky, Julius Michel, Anna Keib, David Vonhören, Nicolaj Hackert, Markus Hahn, Adelheid Cerwenka, Felix Sahm, Frank Westermann, Peter Dreger, Marc S. Raab, Nadja M. Meindl-Beinker, Matthias Ebert, Lukas Bunse, Carsten Müller-Tidow, Michael Schmitt, Michael Platten
Journal: Blood
Blood (2023) 142 (Supplement 1): 4830.
https://doi.org/10.1182/blood-2023-190873
Published: 2023
Journal Articles

The Temporal Evolution of Chromosome 1q Gain and Hyperdiploidy and Its Impact on Clinical Outcomes in Multiple Myeloma

Francesco Maura, Marcella Kaddoura, Alexandra Maria Poos, Anthony Cirrincione, Benjamin Diamond, Kylee H Maclachlan, Bachisio Ziccheddu, Elias K. Mai, Hartmut Goldschmidt, Katja Weisel, Roland Fenk, Gareth J. Morgan, Saad Z Usmani, Ola Landgren, Marc S. Raab, Niels Weinhold
Journal: Blood
Blood (2023) 142 (Supplement 1): 638.
https://doi.org/10.1182/blood-2023-182267
Published: 2023
Journal Articles

Somatic Hypermutation in Enhancer Regions Shapes Non-Coding Myeloma Genome, Generating DNA Breaks and Driving Etiology through Mutation and Structural Variation

Patrick Blaney, Brian A. Walker, Aneta Mikulasova, Dylan Gagler, Bachisio Ziccheddu, Benjamin Diamond, Yubao Wang, Liming Hou, Sanxiong Liu, Alexandra Maria Poos, Anthony Cirrincione, Kylee H Maclachlan, Elias K. Mai, Hartmut Goldschmidt, Saad Z Usmani, Marc S. Raab, Niels Weinhold, Ola Landgren, Faith E. Davies, Francesco Maura, Gareth J. Morgan
Journal: Blood
Blood (2023) 142 (Supplement 1): 1401.
https://doi.org/10.1182/blood-2023-190473
Published: 2023
Journal Articles

Spatial Dissection of the Bone Marrow Microenvironment in Multiple Myeloma By High Dimensional Multiplex Tissue Imaging

Marc-Andrea Baertsch, Alexander Brobeil, John Hickey, Maximilian Haist, Alexandra Maria Poos, Guolan Lu, Wilson Kuswanto, Christian Schuerch, Harald Voehringer, Wolfgang Huber, Gunhild Mechtersheimer, Carsten Mueller-Tidow, Peter Schirmacher, Katja Weisel, Roland Fenk, Hartmut Goldschmidt, Yury Goltsev, Marc S. Raab, Niels Weinhold, Garry P. Nolan
Journal: Blood
Blood (2023) 142 (Supplement 1): 85.
https://doi.org/10.1182/blood-2023-189255
Published: 2023
Journal Articles

Initial Results from a Phase 1 Dose-Escalation Study of WVT078, a BCMA×CD3 Bispecific Antibody, in Combination with WHG626, a Gamma-Secretase (GS) Inhibitor, in Patients with Relapsed and/or Refractory Multiple Myeloma

Fredrik Schjesvold, Andrew Spencer, Yael C. Cohen, Enrique M Ocio, Jordi López-Pardo, Anna Maria Cafro, Natalie S. Callander, Jonathan L. Kaufman, Meera Mohan, Martin Wermke, Noriko Doki, Rebecca Kan, Karolina Kulec, Gina Trabucco, Stan Ye, Romain Sechaud, Cornelia Quadt, Raghav Chawla, Marc S. Raab
Journal: Blood
Blood (2023) 142 (Supplement 1): 4752.
https://doi.org/10.1182/blood-2023-177908
Published: 2023
Journal Articles

Tumor Reactive T Cells Reside in the Bone Marrow and Are Associated with Clinical Response to Hematological Malignancies

Tim Robin Wagner, Niklas Kehl, Simon Steiger, Michael Kilian, Kane Foster, Tamara Boschert, Gabrielle M. Hernandez, Jennifer Abelin, Katharina Lindner, Lilli Sophie Sester, Jan Frenking, Bruno Schönfelder, Daria Galas-Filipowicz, Evie Fitzsimons, Edward W. Green, Patrick Schmidt, Sebastian Uhrig, Lukas Bunse, Benny Chain, Hartmut Goldschmidt, Niels Weinhold, Stefan Fröhling, Carsten Müller-Tidow, Steven A. Carr, Kwee Yong, Karsten Rippe, Marc S. Raab, Michael Platten, Stefan B Eichmüller, Mirco Julian Friedrich
Journal: Blood
Blood (2023) 142 (Supplement 1): 4074.
https://doi.org/10.1182/blood-2023-189779
Published: 2023
Journal Articles

Genomic and Transcriptomic Landscape of Hyper-Apobec Multiple Myeloma

Marios Papadimitriou, Marilena Tauro, Bachisio Ziccheddu, Alexandra Maria Poos, Abdessamad Youssfi Alaoui, Mark B Meads, Kylee H Maclachlan, Saad Z Usmani, Marc S. Raab, Gareth J. Morgan, Niels Weinhold, Kenneth H. Shain, Ola Landgren, Francesco Maura
Journal: Blood
Blood (2023) 142 (Supplement 1): 639.
https://doi.org/10.1182/blood-2023-184784
Published: 2023
Journal Articles

Revealing Novel Mechanisms Underlying Inactivation of Tumor Suppressor Genes on Duplicated Chromosomes in Multiple Myeloma

Anthony Cirrincione, Marcella Kaddoura, Alexandra Maria Poos, Bachisio Ziccheddu, Kylee H Maclachlan, Monika Chojnacka, Benjamin Diamond, Patrick Blaney, Dylan Gagler, Yanming Zhang, Ahmet Dogan, Alexander Lesokhin, Faith E. Davies, Hartmut Goldschmidt, Katja Weisel, Roland Fenk, Elias K. Mai, Neha Korde, Gareth J. Morgan, Marc S. Raab, Saad Z Usmani, Ola Landgren, Niels Weinhold, Francesco Maura
Journal: Blood
Blood (2023) 142 (Supplement 1): 874.
https://doi.org/10.1182/blood-2023-186802
Published: 2023
Journal Articles

A phase 2 clinical trial of combined BRAF/MEK inhibition for BRAF V600E -mutated multiple myeloma

Clinical Trials & Observations Brief Report
Nicola Giesen, Manik Chatterjee, Christof Scheid, Alexandra M. Poos, Britta Besemer, Kaya Miah, Axel Benner, Nicole Becker, Thomas Moehler, Ivana Metzler, Cyrus Khandanpour, Andrea Seidel-Glaetzer, Karolin Trautmann-Grill, K. Martin Kortüm, Carsten Müller-Tidow, Gunhild Mechtersheimer, Benjamin Goeppert, Albrecht Stenzinger, Niels Weinhold, Hartmut Goldschmidt, Katja Weisel, Marc S. Raab
Journal: Blood
Blood (2023) 141 (14): 1685–1690.
https://doi.org/10.1182/blood.2022017789
Published: 2023
Includes: Supplemental data
Journal Articles

Bone Marrow Immune Signatures in Multiple Myeloma Are Linked to Tumor Heterogeneity and Treatment Outcome

Simon Steiger, Raphael Lutz, Nina Prokoph, Subarna Palit, Stephan M Tirier, Philipp Reichert, Anja Baumann, Nadine Hefner, Sabrina Schumacher, Dominik Vonficht, Florian Grünschläger, Alexandra M Poos, Lukas John, Laleh Haghverdi, Jan-Philipp Mallm, Elias K Mai, Mirco Friedrich, Katharina Kriegsmann, Mohamed H.S. Awwad, Anna Jauch, Uta Bertsch, Diana Tichy, Carsten Müller-Tidow, Roland Schroers, Hans Salwender, Britta Besemer, Roland Fenk, Katja Weisel, Hartmut Goldschmidt, Stefanie Huhn, Michael Hundemer, Karsten Rippe, Simon Haas, Niels Weinhold, Marc S Raab
Journal: Blood
Blood (2022) 140 (Supplement 1): 2083–2085.
https://doi.org/10.1182/blood-2022-168685
Published: 2022