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Journal Articles

Safety and efficacy of elranatamab + nirogacestat in patients with relapsed or refractory multiple myeloma: Results from the Phase 1b MagnetisMM-4 study

Free
Ola Landgren, Suzanne Trudel, Jacalyn Rosenblatt, Arleigh McCurdy, Sumit Madan, Syed Abbas Ali, Nizar Bahlis, Eli Gabayan, Robert Vescio, Melissa O'Gorman, Shinta Cheng, Sibo Jiang, Margaret Hoyle, Jay Cheng, Erik Vandendries, Noopur Raje
Journal: Blood
Blood (2025) 146 (Supplement 1): 4058.
https://doi.org/10.1182/blood-2025-4058
Published: 2025
Journal Articles

A randomized phase II study of daratumumab, lenalidomide, ixazomib, and dexamethasone in transplant-ineligible or deferred patients with newly diagnosed multiple myeloma: Alliance Foundation Trial 41 (AFT-41)

Free
Andrew Yee, Elizabeth O'Donnell, Omar Nadeem, Garth Nelson, Tanya Wildes, Tondre Buck, Sascha Tuchman, Krishna Ghimire, Sarah Sinclair, Catherine Stewart, Paul Richardson, Saad Usmani, Noopur Raje
Journal: Blood
Blood (2025) 146 (Supplement 1): 4053.
https://doi.org/10.1182/blood-2025-4053
Published: 2025
Journal Articles

Targeted deep sequencing of myeloma in a multi-institutional clinical workflow

Free
Parth Shah, Andrew Yee, Mehmet Samur, Adam Sperling, Vikas Gupta, Benjamin Barwick, Jeremiah Karrs, Rutu Vyas, Wahab Khan, Liam Donnelly, Kacthary Sanclemente, Diana Cirstea, Prabhjot Kaur, Sadhanshu Shukla, Yuxin Liu, Ajay Nooka, Nisha Joseph, Jonathan Kaufman, Craig Hofmeister, Nishi Shah, Richa Parikh, Hervé Avet-Loiseau, Nikhil Munshi, Sagar Lonial, Noopur Raje
Journal: Blood
Blood (2025) 146 (Supplement 1): 4026.
https://doi.org/10.1182/blood-2025-4026
Published: 2025
Journal Articles

Ruxolitinib for refractory immune effector cell enterocolitis following ciltacabtagene autoleucel CAR T-cell therapy for multiple myeloma

Free
Viktoria Blumenberg, Filippo Birocchi, Angela Shih, Giulia Escobar, Adele Mucci, Alexander Armstrong, Diana Cirstea, Deshea L Harris, David Bozym, Benjamin Puliafito, Richard Newcomb, Tejaswini Dhawale, Patrick Connor Johnson, Areej El-Jawahri, Richard Jeffrey, Alexis Barselau, Alex Li, Estelle Emmanuel-Alejandro, Daniella Cook, Kevin Lindell, Samantha Luk, Ryan Chaffee, Andrew Yee, Andrew Branagan, Noopur Raje, Charlotte Graham, Sarah Hammond, Frederic Bushman, Aoife Doto, Shanyan Reddy, Alexander McFarland, Yi-Bin Chen, Christopher Mount, Michael Dougan, Valentina Nardi, Aliyah Sohani, Kathleen ME Gallagher, Marcela Maus, Matthew Frigault, Mark Leick
Journal: Blood
Blood (2025) 146 (Supplement 1): 2392.
https://doi.org/10.1182/blood-2025-2392
Published: 2025
Journal Articles

Deepening responses and MRD-conversion in a phase II fixed-duration consolidation trial of elranatamab post-idecabtagene vicleucel CAR-T cell therapy (EPIC) in relapsed or refractory multiple myeloma

Free
Benjamin Puliafito, Matthew Lei, Andrew Yee, Diana Cirstea, Andrew Branagan, Emerentia Agyemang, Cynthia Harrington, Kacthary Sanclemente, Lisette Packer, Alexandra Wright, E. Bridget Kim, Brenna McCormick, Kareem Mosaheb, Julia Lin, Nora Horick, Eric Hua, Omar Nadeem, Matthew Frigault, Jacalyn Rosenblatt, Noopur Raje
Journal: Blood
Blood (2025) 146 (Supplement 1): 5824.
https://doi.org/10.1182/blood-2025-5824
Published: 2025
Journal Articles

Validation and refinement of the new high-risk multiple myeloma (HRMM) criteria in relapsed or refractory patients treated with BCMA CAR-T.

Free
Joshua Gustine, Narsis Attar, Benjamin Puliafito, Diana Cirstea, Andrew Branagan, Marcela Maus, Matthew Frigault, Andrew Yee, Noopur Raje
Journal: Blood
Blood (2025) 146 (Supplement 1): 2243.
https://doi.org/10.1182/blood-2025-2243
Published: 2025
Journal Articles

The impact of Duffy genotype on progression-free survival (PFS) with lenalidomide, Bortezomib, and dexamethasone (RVd) alone or RVd plus autologous stem cell transplantation (ASCT) and continuous R maintenance in patients (pts) with newly diagnosed multiple myeloma (NDMM): Updated subgroup analysis of the phase 3 DETERMINATION trial

Free
Lauren Merz, Rebecca Zon, Susanna Jacobus, Mehmet Samur, Jeffrey Zonder, Abdullah Khan, Hani Hassoun, Larry Anderson, Yvonne Efebera, Tondre Buck, Racquel Innis-Shelton, Monique Hartley-Brown, Sagar Lonial, Erica Campagnaro, Peter Voorhees, Robert Orlowski, Caitlin Costello, Noopur Raje, Eva Medvedova, Philip McCarthy, Carter Milner, Cristina Gasparetto, Mounzer Agha, Krisstina Gowin, Rammurti Kamble, Sundar Jagannath, Nitya Nathwani, Melissa Alsina, Sergio Giralt, Jacob Laubach, Omar Nadeem, Irene Ghobrial, Clifton Mo, Kenneth Anderson, Nikhil Munshi, Paul Richardson
Journal: Blood
Blood (2025) 146 (Supplement 1): 1033.
https://doi.org/10.1182/blood-2025-1033
Published: 2025
Journal Articles

In Vivo postnatal loss of mature osteoblasts creates an immunosuppressive bone marrow microenvironment to permit the engraftment and proliferation of myeloma cells

Free
Cristina Panaroni, Keertik Fulzele, Advait Joshi, Rie Matsubara, Allison Maebius, Chukwuamaka Onyewadume, Noopur Raje
Journal: Blood
Blood (2025) 146 (Supplement 1): 3957.
https://doi.org/10.1182/blood-2025-3957
Published: 2025
Journal Articles

Immune aging and macrophage inhibitory factor (MIF) – mediated stromal rewiring drives pre-malignant evolution in smoldering multiple myeloma

Free
Rajib Shome, Srikanth Talluri, Diana Cirstea, Rie Matsubara, Farah Rexha, Advait Joshi, Andrew Yee, Nikhil Munshi, Mehmet Samur, Noopur Raje
Journal: Blood
Blood (2025) 146 (Supplement 1): 3952.
https://doi.org/10.1182/blood-2025-3952
Published: 2025
Journal Articles

Deciphering the role of EP300 in maintaining the enhancer landscape and lineage-specific epigenetic vulnerability in multiple myeloma

Free
Rajib Shome, Mehmet Samur, Srikanth Talluri, Rie Matsubara, Advait Joshi, Farah Rexha, Diana Cirstea, Andrew Yee, Nikhil Munshi, Noopur Raje
Journal: Blood
Blood (2025) 146 (Supplement 1): 5735.
https://doi.org/10.1182/blood-2025-5735
Published: 2025
Journal Articles

First-in-human phase 1 trial of trimeric APRIL (TriPRIL) CAR T cells in relapsed or refractory multiple myeloma: Clinical outcomes and biological correlates of disease response and resistance

Free
Charlotte Graham, Benjamin Puliafito, Noopur Raje, Diana Cirstea, Andrew Branagan, Andrew Yee, Nora Horick, Daniella Cook, Kevin Lindell, Danielle Bernier, Alexis Barselau, Gabrielle Furman, Meaghan Ekstrom, Jaclyn Emmett, Maxx King, Md Raihan Chowdhury, Valentina Supper, Hannah Donner, Mark Leick, Viktoria Blumenberg, Aiyana Parker, Deshea L Harris, Won-Ho Lee, Kiana Graham, Hadley Wiggin, Pascal Schneider, Jerome Ritz, Sarah Nikiforow, Heather Daley, Myriam Armant, Lu Huang, Kathleen ME Gallagher, Matthew Frigault, Marcela Maus
Journal: Blood
Blood (2025) 146 (Supplement 1): 270.
https://doi.org/10.1182/blood-2025-270
Published: 2025
Journal Articles

The efficacy of cilta-cel after a prior BCMA-directed CAR T-cell therapy in relapsed/refractory multiple myeloma

Free
Narsis Attar, Rajib Shome, Mehmet Samur, Joshua Gustine, Charlotte Graham, Kathleen ME Gallagher, Agustin Busse, Deshea L Harris, Diana Cirstea, Andrew Yee, Andrew Branagan, Marcela Maus, Matthew Frigault, Nikhil Munshi, Adam Sperling, Noopur Raje
Journal: Blood
Blood (2025) 146 (Supplement 1): 5764.
https://doi.org/10.1182/blood-2025-5764
Published: 2025
Journal Articles

Patient perspectives and preferences for step-up dosing and treatment with teclistamab and talquetamab: Insights from a patient survey

Free
Jay Hydren, Rachel Jensen, Jorge Arturo Hurtado Martinez, Jennifer Ahlstrom, Mason Barnes, Caitlin Costello, Gurbakhash Kaur, Meera Mohan, Francesca Cottini, Douglas Sborov, Shaji Kumar, Noopur Raje, Philippe Moreau, Maithili Deshpande, Niodita Gupta-Werner, Tonya Le Blanc, Jessica Fowler, Rahul Banerjee
Journal: Blood
Blood (2025) 146 (Supplement 1): 6354.
https://doi.org/10.1182/blood-2025-6354
Published: 2025
Journal Articles

Risk score and survival outcomes for multiple myeloma patients with disease refractory to BCMA CAR-T.

Free
Joshua Gustine, Narsis Attar, Benjamin Puliafito, Diana Cirstea, Andrew Branagan, Marcela Maus, Matthew Frigault, Andrew Yee, Noopur Raje
Journal: Blood
Blood (2025) 146 (Supplement 1): 5792.
https://doi.org/10.1182/blood-2025-5792
Published: 2025
Journal Articles

Single-cell transcriptomics reveal mechanisms of efficacy and toxicity in anti-BCMA CAR-T cell therapies for multiple myeloma

Free
Xiaomeng Sun, Charlotte Graham, Aiyana Parker, Maria Dolaher, Kevin Lindell, Deshea L Harris, Won-Ho Lee, Kiana Graham, Hannah Nolan, Viktoria Blumenberg, David Bozym, Diana Cirstea, Andrew Branagan, Andrew Yee, Noopur Raje, Mark Leick, Matthew Frigault, Kathleen ME Gallagher, Nicholas Haradhvala, Gad Getz, Marcela Maus
Journal: Blood
Blood (2025) 146 (Supplement 1): 503.
https://doi.org/10.1182/blood-2025-503
Published: 2025
Journal Articles

Ide-cel vs standard regimens in triple-class–exposed relapsed and refractory multiple myeloma: updated KarMMa-3 analyses

Free
Clinical Trials & Observations
Sikander Ailawadhi, Bertrand Arnulf, Krina Patel, Michele Cavo, Ajay K. Nooka, Salomon Manier, Natalie Callander, Luciano J. Costa, Ravi Vij, Nizar J. Bahlis, Philippe Moreau, Scott Solomon, Ingerid Weum Abrahamsen, Rachid Baz, Annemiek Broijl, Christine Chen, Sundar Jagannath, Noopur Raje, Christof Scheid, Michel Delforge, Reuben Benjamin, Thomas Pabst, Shinsuke Iida, Jesús Berdeja, Sergio Giralt, Anna Truppel-Hartmann, Yanping Chen, Xiaobo Zhong, Fan Wu, Julia Piasecki, Laurie Eliason, Devender Dhanda, Jasper Felten, Andrea Caia, Mark Cook, Mihaela Popa McKiver, Paula Rodríguez-Otero
Journal: Blood
Blood (2024) 144 (23): 2389–2401.
https://doi.org/10.1182/blood.2024024582
Published: 2024
Includes: Supplemental data
Journal Articles

Outcomes of Patients By High-Risk Cytogenetic Abnormalities in a Phase II Study of Isatuximab, Weekly Carfilzomib, Lenalidomide, Dexamethasone in Newly Diagnosed, Multiple Myeloma (The SKylaRk Trial) Who Deferred Transplant

Free
Elizabeth K. O'Donnell, Clifton C. Mo, Omar Nadeem, Jacob Laubach, Jacalyn Rosenblatt, Nikhil C. Munshi, Shonali Midha, Diana Cirstea, Paul G. Richardson, Noopur Raje, Andrew J. Yee
Journal: Blood
Blood (2024) 144 (Supplement 1): 4747.
https://doi.org/10.1182/blood-2024-201768
Published: 2024
Journal Articles

Design and Methodological Considerations for Real World Data-Derived Progression-Free Survival in Multiple Myeloma

Free
Jocelyn R Wang, Jennifer Hayden, Yiyang Yue, Craig S Meyer, Ryan W Gan, Youyi Zhang, Benjamin Ackerman, Pranay Mohanty, James Roose, Jennifer L Lund, Sebastian Schneeweiss, Janick Weberpals, Omar Nadeem, Sikander Ailawadhi, Noopur Raje, Smith Giri, Juned Siddique, Laura Hester, Kelly Reid, Robin Carson, Khaled Sarsour, Ashita Batavia
Journal: Blood
Blood (2024) 144 (Supplement 1): 3763.
https://doi.org/10.1182/blood-2024-199224
Published: 2024
Journal Articles

Phase 1 Study of Anitocabtagene Autoleucel for the Treatment of Patients with Relapsed and/or Refractory Multiple Myeloma (RRMM): Efficacy and Safety with 34-Month Median Follow-up

Free
Michael R Bishop, Jacalyn Rosenblatt, Binod Dhakal, Noopur Raje, Daniella Cook, Mahmoud R. Gaballa, Estelle Emmanuel-Alejandro, Danielle Nissen, Kamalika Banerjee, Rebecca J Chan, Ana Kostic, Christopher R. Heery, Tim Welliver, David Avigan, Andrzej J Jakubowiak, Matthew Frigault
Journal: Blood
Blood (2024) 144 (Supplement 1): 4825.
https://doi.org/10.1182/blood-2024-201080
Published: 2024
Journal Articles

Biological Correlatives of Efficacy and Toxicity of BCMA Targeting CAR T Cell Therapy in a Real-World Setting

Free
Charlotte Graham, Aiyana Parker, Xiaomeng Sun, Nicholas J. Haradhvala, Maria Dolaher, Kevin Lindell, Deshea Harris, Won-Ho Lee, Kiana J Graham, Hannah K Nolan, Viktoria Blumenberg, David J Bozym, Alex Li, Hana Cho, Estelle Emmanuel-Alejandro, Arienne R Annati, Julianne Marie Gildea, Alexis Barselau, Diana Cirstea, Andrew R. Branagan, Andrew J. Yee, Noopur Raje, Gad Getz, Mark B Leick, Matthew Frigault, Kathleen Gallagher, Marcela V Maus
Journal: Blood
Blood (2024) 144 (Supplement 1): 7126.
https://doi.org/10.1182/blood-2024-194895
Published: 2024