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Diana Cirstea
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Journal Articles

Single-cell transcriptomics reveal mechanisms of efficacy and toxicity in anti-BCMA CAR-T cell therapies for multiple myeloma

Free
Xiaomeng Sun, Charlotte Graham, Aiyana Parker, Maria Dolaher, Kevin Lindell, Deshea L Harris, Won-Ho Lee, Kiana Graham, Hannah Nolan, Viktoria Blumenberg, David Bozym, Diana Cirstea, Andrew Branagan, Andrew Yee, Noopur Raje, Mark Leick, Matthew Frigault, Kathleen ME Gallagher, Nicholas Haradhvala, Gad Getz, Marcela Maus
Journal: Blood
Blood (2025) 146 (Supplement 1): 503.
https://doi.org/10.1182/blood-2025-503
Published: 2025
Journal Articles

Ruxolitinib for refractory immune effector cell enterocolitis following ciltacabtagene autoleucel CAR T-cell therapy for multiple myeloma

Free
Viktoria Blumenberg, Filippo Birocchi, Angela Shih, Giulia Escobar, Adele Mucci, Alexander Armstrong, Diana Cirstea, Deshea L Harris, David Bozym, Benjamin Puliafito, Richard Newcomb, Tejaswini Dhawale, Patrick Connor Johnson, Areej El-Jawahri, Richard Jeffrey, Alexis Barselau, Alex Li, Estelle Emmanuel-Alejandro, Daniella Cook, Kevin Lindell, Samantha Luk, Ryan Chaffee, Andrew Yee, Andrew Branagan, Noopur Raje, Charlotte Graham, Sarah Hammond, Frederic Bushman, Aoife Doto, Shanyan Reddy, Alexander McFarland, Yi-Bin Chen, Christopher Mount, Michael Dougan, Valentina Nardi, Aliyah Sohani, Kathleen ME Gallagher, Marcela Maus, Matthew Frigault, Mark Leick
Journal: Blood
Blood (2025) 146 (Supplement 1): 2392.
https://doi.org/10.1182/blood-2025-2392
Published: 2025
Journal Articles

Deepening responses and MRD-conversion in a phase II fixed-duration consolidation trial of elranatamab post-idecabtagene vicleucel CAR-T cell therapy (EPIC) in relapsed or refractory multiple myeloma

Free
Benjamin Puliafito, Matthew Lei, Andrew Yee, Diana Cirstea, Andrew Branagan, Emerentia Agyemang, Cynthia Harrington, Kacthary Sanclemente, Lisette Packer, Alexandra Wright, E. Bridget Kim, Brenna McCormick, Kareem Mosaheb, Julia Lin, Nora Horick, Eric Hua, Omar Nadeem, Matthew Frigault, Jacalyn Rosenblatt, Noopur Raje
Journal: Blood
Blood (2025) 146 (Supplement 1): 5824.
https://doi.org/10.1182/blood-2025-5824
Published: 2025
Journal Articles

Validation and refinement of the new high-risk multiple myeloma (HRMM) criteria in relapsed or refractory patients treated with BCMA CAR-T.

Free
Joshua Gustine, Narsis Attar, Benjamin Puliafito, Diana Cirstea, Andrew Branagan, Marcela Maus, Matthew Frigault, Andrew Yee, Noopur Raje
Journal: Blood
Blood (2025) 146 (Supplement 1): 2243.
https://doi.org/10.1182/blood-2025-2243
Published: 2025
Journal Articles

Immune aging and macrophage inhibitory factor (MIF) – mediated stromal rewiring drives pre-malignant evolution in smoldering multiple myeloma

Free
Rajib Shome, Srikanth Talluri, Diana Cirstea, Rie Matsubara, Farah Rexha, Advait Joshi, Andrew Yee, Nikhil Munshi, Mehmet Samur, Noopur Raje
Journal: Blood
Blood (2025) 146 (Supplement 1): 3952.
https://doi.org/10.1182/blood-2025-3952
Published: 2025
Journal Articles

Deciphering the role of EP300 in maintaining the enhancer landscape and lineage-specific epigenetic vulnerability in multiple myeloma

Free
Rajib Shome, Mehmet Samur, Srikanth Talluri, Rie Matsubara, Advait Joshi, Farah Rexha, Diana Cirstea, Andrew Yee, Nikhil Munshi, Noopur Raje
Journal: Blood
Blood (2025) 146 (Supplement 1): 5735.
https://doi.org/10.1182/blood-2025-5735
Published: 2025
Journal Articles

First-in-human phase 1 trial of trimeric APRIL (TriPRIL) CAR T cells in relapsed or refractory multiple myeloma: Clinical outcomes and biological correlates of disease response and resistance

Free
Charlotte Graham, Benjamin Puliafito, Noopur Raje, Diana Cirstea, Andrew Branagan, Andrew Yee, Nora Horick, Daniella Cook, Kevin Lindell, Danielle Bernier, Alexis Barselau, Gabrielle Furman, Meaghan Ekstrom, Jaclyn Emmett, Maxx King, Md Raihan Chowdhury, Valentina Supper, Hannah Donner, Mark Leick, Viktoria Blumenberg, Aiyana Parker, Deshea L Harris, Won-Ho Lee, Kiana Graham, Hadley Wiggin, Pascal Schneider, Jerome Ritz, Sarah Nikiforow, Heather Daley, Myriam Armant, Lu Huang, Kathleen ME Gallagher, Matthew Frigault, Marcela Maus
Journal: Blood
Blood (2025) 146 (Supplement 1): 270.
https://doi.org/10.1182/blood-2025-270
Published: 2025
Journal Articles

Targeted deep sequencing of myeloma in a multi-institutional clinical workflow

Free
Parth Shah, Andrew Yee, Mehmet Samur, Adam Sperling, Vikas Gupta, Benjamin Barwick, Jeremiah Karrs, Rutu Vyas, Wahab Khan, Liam Donnelly, Kacthary Sanclemente, Diana Cirstea, Prabhjot Kaur, Sadhanshu Shukla, Yuxin Liu, Ajay Nooka, Nisha Joseph, Jonathan Kaufman, Craig Hofmeister, Nishi Shah, Richa Parikh, Hervé Avet-Loiseau, Nikhil Munshi, Sagar Lonial, Noopur Raje
Journal: Blood
Blood (2025) 146 (Supplement 1): 4026.
https://doi.org/10.1182/blood-2025-4026
Published: 2025
Journal Articles

The efficacy of cilta-cel after a prior BCMA-directed CAR T-cell therapy in relapsed/refractory multiple myeloma

Free
Narsis Attar, Rajib Shome, Mehmet Samur, Joshua Gustine, Charlotte Graham, Kathleen ME Gallagher, Agustin Busse, Deshea L Harris, Diana Cirstea, Andrew Yee, Andrew Branagan, Marcela Maus, Matthew Frigault, Nikhil Munshi, Adam Sperling, Noopur Raje
Journal: Blood
Blood (2025) 146 (Supplement 1): 5764.
https://doi.org/10.1182/blood-2025-5764
Published: 2025
Journal Articles

Risk score and survival outcomes for multiple myeloma patients with disease refractory to BCMA CAR-T.

Free
Joshua Gustine, Narsis Attar, Benjamin Puliafito, Diana Cirstea, Andrew Branagan, Marcela Maus, Matthew Frigault, Andrew Yee, Noopur Raje
Journal: Blood
Blood (2025) 146 (Supplement 1): 5792.
https://doi.org/10.1182/blood-2025-5792
Published: 2025
Journal Articles

Cyclophosphamide mitigates non-ICANS neurotoxicities following ciltacabtagene autoleucel treatment

Available to Purchase
Clinical Trials & Observations
Viktoria Blumenberg, Benjamin R. Puliafito, Charlotte E. Graham, Mark B. Leick, Md. Raihan Chowdhury, Maxx King, Deshea L. Harris, Noopur S. Raje, Andrew R. Branagan, Andrew J. Yee, Diana Cirstea, Kathleen M. E. Gallagher, Jörg Dietrich, Marcela V. Maus, Matthew J. Frigault
Journal: Blood
Blood (2025) 145 (23): 2788–2793.
https://doi.org/10.1182/blood.2024028172
Published: 2025
Includes: Supplemental data
Journal Articles

Biological Correlatives of Efficacy and Toxicity of BCMA Targeting CAR T Cell Therapy in a Real-World Setting

Free
Charlotte Graham, Aiyana Parker, Xiaomeng Sun, Nicholas J. Haradhvala, Maria Dolaher, Kevin Lindell, Deshea Harris, Won-Ho Lee, Kiana J Graham, Hannah K Nolan, Viktoria Blumenberg, David J Bozym, Alex Li, Hana Cho, Estelle Emmanuel-Alejandro, Arienne R Annati, Julianne Marie Gildea, Alexis Barselau, Diana Cirstea, Andrew R. Branagan, Andrew J. Yee, Noopur Raje, Gad Getz, Mark B Leick, Matthew Frigault, Kathleen Gallagher, Marcela V Maus
Journal: Blood
Blood (2024) 144 (Supplement 1): 7126.
https://doi.org/10.1182/blood-2024-194895
Published: 2024
Journal Articles

Previous HDM/ASCT Adversely Impacts PFS with BCMA-Directed CAR T-Cell Therapy in Multiple Myeloma

Free
Joshua Gustine, Diana Cirstea, Andrew R. Branagan, Andrew J. Yee, Marcela Maus, Matthew J. Frigault, Noopur Raje
Journal: Blood
Blood (2024) 144 (Supplement 1): 79.
https://doi.org/10.1182/blood-2024-212135
Published: 2024
Journal Articles

Clonal Hematopoiesis of Indeterminate Potential Does Not Impact Overall Survival in Multiple Myeloma

Free
Farah Rexha, Joshua Gustine, Ryan Han, Rie Nakamoto-Matsubara, Cristina Panaroni, Rajib Shome, Valentina Nardi, Andrew R. Branagan, Diana Cirstea, Andrew J. Yee, Noopur Raje
Journal: Blood
Blood (2024) 144 (Supplement 1): 3339.
https://doi.org/10.1182/blood-2024-211622
Published: 2024
Journal Articles

Outcomes of Patients By High-Risk Cytogenetic Abnormalities in a Phase II Study of Isatuximab, Weekly Carfilzomib, Lenalidomide, Dexamethasone in Newly Diagnosed, Multiple Myeloma (The SKylaRk Trial) Who Deferred Transplant

Free
Elizabeth K. O'Donnell, Clifton C. Mo, Omar Nadeem, Jacob Laubach, Jacalyn Rosenblatt, Nikhil C. Munshi, Shonali Midha, Diana Cirstea, Paul G. Richardson, Noopur Raje, Andrew J. Yee
Journal: Blood
Blood (2024) 144 (Supplement 1): 4747.
https://doi.org/10.1182/blood-2024-201768
Published: 2024
Journal Articles

Use of Cilta-Cel CAR T Cells Following Previous Use of a BCMA-Directed CAR T-Cell Product in Heavily Treated Patients with Relapsed/Refractory Multiple Myeloma: A Single Institution Case Series

Free
Narsis Attar, Diana Cirstea, Andrew R. Branagan, Andrew J. Yee, Matthew J. Frigault, Noopur Raje
Journal: Blood
Blood (2023) 142 (Supplement 1): 6924.
https://doi.org/10.1182/blood-2023-182212
Published: 2023
Journal Articles

A Phase II Study of Isatuximab, Once Weekly Carfilzomib, Lenalidomide, Dexamethasone, in Newly Diagnosed, Transplant-Eligible Multiple Myeloma (The SKylaRk Trial)

Free
Elizabeth K. O'Donnell, Clifton C. Mo, Andrew J. Yee, Omar Nadeem, Andrew R. Branagan, Jacob Laubach, Jacalyn Rosenblatt, Nora Horick, Paul G. Richardson, Noopur Raje, Diana Cirstea
Journal: Blood
Blood (2023) 142 (Supplement 1): 4671.
https://doi.org/10.1182/blood-2023-181019
Published: 2023
Journal Articles

Immune Profiling and Responses of Smoldering Multiple Myeloma Patients Treated in a Phase Ib Study of Pvx-410 Vaccine Targeting XBP1/CD138/CS1 Antigens, and Citarinostat, a Histone Deacetylase Inhibitor (HDACi) with and without Lenalidomide

Free
Diana Cirstea, Rajib Shome, Joseph James Connolly, Emilie Duvallet, Amanda N. R. Joyce, Victor Moyo, Kathleen Lively, Gina Basinsky, Andrew J. Yee, Cristiana Costa Chase, Ehsan Malek, Ruben Niesvizky, Paul G. Richardson, Noopur S. Raje
Journal: Blood
Blood (2023) 142 (Supplement 1): 2017.
https://doi.org/10.1182/blood-2023-189332
Published: 2023
Journal Articles

With Equal Access, African Americans with Non-del17p Multiple Myeloma Have Superior Overall Survival, but del17p Still Carries Poor Prognosis across Race: A VA Study

Free
Anusha Munjuluri, MSc, Nathanael Fillmore, PhD, Diana Cirstea, MD, Hassan Yameen, MD, Sarvari Venkata Yellapragada, MD, Ifeorah Chizoba, MPH, Nhan Do, MD, Mary Brophy, MD MPH, Nikhil C. Munshi, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4388.
https://doi.org/10.1182/blood-2019-131247
Published: 2019
Journal Articles

With equal access, African American patients have superior survival compared to white patients with multiple myeloma: a VA study

Free
Clinical Trials & Observations
Nathanael R. Fillmore, Sarvari V. Yellapragada, Chizoba Ifeorah, Ansh Mehta, Diana Cirstea, Paul S. White, Gustavo Rivero, Andrew Zimolzak, Saiju Pyarajan, Nhan Do, Mary Brophy, Nikhil C. Munshi
Journal: Blood
Blood (2019) 133 (24): 2615–2618.
https://doi.org/10.1182/blood.2019000406
Published: 2019