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Jacob Laubach
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Journal Articles

Results of the Phase II d-PRISM study: Daratumumab in high-risk MGUS and low-risk smoldering myeloma

Free
Omar Nadeem, Michelle Aranha, Robert Redd, Michael Koontz, Jeffrey Matous, Andrew Yee, Jeffrey Zonder, Andrew Kin, Sophie Magidson, Elizabeth Lightbody, Ting Wu, Floris Chabrun, Jean-Baptiste Alberge, Ankit Dutta, Jacqueline Perry, Ashlee Sturtevant, Mahshid Rahmat, Junko Tsuji, Christine Davie, Caroline Ricciardi, Frances Arters, Marjorie Marto, Amy Goguen, Jacalyn Rosenblatt, Elizabeth O'Donnell, Jacob Laubach, Paul Richardson, Gad Getz, Lorenzo Trippa, Romanos Sklavenitis-Pistofidis, Irene Ghobrial
Journal: Blood
Blood (2025) 146 (Supplement 1): 1533.
https://doi.org/10.1182/blood-2025-1533
Published: 2025
Journal Articles

A phase I/II, open label, Study to evaluate safety, tolerability and efficacy of elranatamab in patients with relapsed or refractory AL amyloidosis: Interim report of phase I results

Free
Shahrier Hossain, Adam Sperling, Jacob Laubach, Shannon Miller, Pedro Vianna, Emily Simpson, Madison Chuma, Brendan Fink, Samantha Geberth, Emily Magnavita, Jack Khouri, James Hoffman, Jonathan Kaufman, Vaishali Sanchorawala, Raymond Comenzo, Giada Bianchi
Journal: Blood
Blood (2025) 146 (Supplement 1): 5808.
https://doi.org/10.1182/blood-2025-5808
Published: 2025
Journal Articles

The role of palliative care in the multidisciplinary treatment of immunoglobulin light chain amyloidosis

Free
Pedro Vianna, Joshua Lakin, Samantha Gelfand, Eilann Santo, Brigitte Durieux, Shannon Miller, Shahrier Hossain, Jacob Laubach, Giada Bianchi
Journal: Blood
Blood (2025) 146 (Supplement 1): 8152.
https://doi.org/10.1182/blood-2025-8152
Published: 2025
Journal Articles

The impact of Duffy genotype on progression-free survival (PFS) with lenalidomide, Bortezomib, and dexamethasone (RVd) alone or RVd plus autologous stem cell transplantation (ASCT) and continuous R maintenance in patients (pts) with newly diagnosed multiple myeloma (NDMM): Updated subgroup analysis of the phase 3 DETERMINATION trial

Free
Lauren Merz, Rebecca Zon, Susanna Jacobus, Mehmet Samur, Jeffrey Zonder, Abdullah Khan, Hani Hassoun, Larry Anderson, Yvonne Efebera, Tondre Buck, Racquel Innis-Shelton, Monique Hartley-Brown, Sagar Lonial, Erica Campagnaro, Peter Voorhees, Robert Orlowski, Caitlin Costello, Noopur Raje, Eva Medvedova, Philip McCarthy, Carter Milner, Cristina Gasparetto, Mounzer Agha, Krisstina Gowin, Rammurti Kamble, Sundar Jagannath, Nitya Nathwani, Melissa Alsina, Sergio Giralt, Jacob Laubach, Omar Nadeem, Irene Ghobrial, Clifton Mo, Kenneth Anderson, Nikhil Munshi, Paul Richardson
Journal: Blood
Blood (2025) 146 (Supplement 1): 1033.
https://doi.org/10.1182/blood-2025-1033
Published: 2025
Journal Articles

Identification of persister cells and evolution of tumor clones during immunotherapy and at minimal residual disease timepoints decoded by single-cell whole-genome sequencing in multiple myeloma

Free
Rosa Toenges, Jean-Baptiste Alberge, Tomoki Iemura, Francesco Corrado, Nayda Bidikian, David Cordas Dos Santos, Ankit Dutta, Romanos Sklavenitis-Pistofidis, Subear Hussein, Carlson Ketcham, Sophie Magidson, Shonali Midha, Elizabeth O'Donnell, Adam Sperling, Jacob Laubach, Kenneth Anderson, Eric Smith, Nikhil Munshi, Omar Nadeem, Gad Getz, Irene Ghobrial
Journal: Blood
Blood (2025) 146 (Supplement 1): 3930.
https://doi.org/10.1182/blood-2025-3930
Published: 2025
Journal Articles

Spatial proteomics of the bone marrow reveals distinct Tumor–Immune niches in smoldering and relapsed myeloma and their remodeling in response to bispecific antibody and CAR-T therapy

Free
David Cordas Dos Santos, Kane Foster, Daniel Heilpern-Mallory, Sophia Schroeder, Yoshinobu Konishi, Maria-Theresa Silverio, Jacqueline Perry, Sophie Magidson, Diego Vieyra, Rocio Montes De Oca, Daniel Zangrando, Nina Lane, Adam Sperling, Eric Smith, Jacob Laubach, Elizabeth O'Donnell, Nikhil Munshi, Kenneth Anderson, Shonali Midha, Gad Getz, Omar Nadeem, Irene Ghobrial
Journal: Blood
Blood (2025) 146 (Supplement 1): 3921.
https://doi.org/10.1182/blood-2025-3921
Published: 2025
Journal Articles

In depth characterization of autologous infused bhv-1100 armored memory-like NK cells in MRD+ multiple myeloma patients receiving autologous stem cell transplant

Free
Grace Birch, Juliana Vergara-Cadavid, Alba Martini, Maily Nguyen, Mubin Tarannum, Roman Shapiro, Carol Reynolds, Kathryn miles, Kathleen Pfaff, Mohsin Maqbool, Brendan Kineavy, Hope Wei, Sarah Hogan, Elizabeth Kendricken, Casey Welch, Adam Sperling, Omar Nadeem, Shonali Midha, Jacob Laubach, Anna Bunin, Steven schnittman, Elyse Stock, Heather Daley, Diego Hernandez rodriguez, Robert Soiffer, Sarah Nikiforow, Giada Bianchi, Rizwan Romee
Journal: Blood
Blood (2025) 146 (Supplement 1): 261.
https://doi.org/10.1182/blood-2025-261
Published: 2025
Journal Articles

Maintenance therapy following chimeric antigen receptor T-cell therapy in relapsed and refractory multiple myeloma: An exploratory case series evaluating feasibility and safety in a real-world setting

Free
Zohaib Ahmed, Walid Hamouche, Shonali Midha, Yuxin Liu, Adam Sperling, Clifton Mo, Jacob Laubach, Paul Richardson, Nikhil Munshi, Omar Nadeem
Journal: Blood
Blood (2025) 146 (Supplement 1): 7525.
https://doi.org/10.1182/blood-2025-7525
Published: 2025
Journal Articles

Isatuximab (Isa) plus lenalidomide (R), Bortezomib (V), and dexamethasone (d) (Isa-RVd) as induction therapy in transplant-eligible patients (pts) with newly diagnosed multiple myeloma (NDMM): Primary analysis of parallel phase 2 studies by the Dana-Farber Cancer Institute (DFCI) and Cancer Trials Ireland (CTI)

Free
Peter O'Gorman, Jacob Laubach, Ruth Clifford, Clifton Mo, Senthil Kumar, Omar Nadeem, Monique Hartley-Brown, Siobhan Glavey, Shonali Midha, Yuxin Liu, Maja Vase, Keith Pratz, Patrick Hayden, Jessica Liegel, Paul Dowling, Emily Benjamin, Vicky Donachie, Zahra Beers, Olivia McLoughlin, Layla Horwitz, Jacinta Marron, Emma Sueiro, Marc Nolan, David Poretsky, Anna Shevlin, Sarah Beaton, Charlotte Prior, Catherine Piper, Bindu Krishnanivas, Emily Simpson, Elizabeth Karimi, Marissa Davis, Lourdes McAlester, Alanna Allen, Paul Richardson
Journal: Blood
Blood (2025) 146 (Supplement 1): 4030.
https://doi.org/10.1182/blood-2025-4030
Published: 2025
Journal Articles

Tumor-Intrinsic and Immune Predictors of Response to Ixazomib, Lenalidomide, and Dexamethasone in High-Risk Smoldering Multiple Myeloma

Free
Michelle P. Aranha, Omar Nadeem, Robert A. Redd, Michael Timonian, Sophie Magidson, Elizabeth D. Lightbody, Jean-Baptiste Alberge, Ting Wu, Junko Tsuji, Luca Bertamini, Ankit K. Dutta, Habib El-Khoury, Mark Bustoros, Jacob Laubach, Giada Bianchi, Elizabeth K. O'Donnell, Kenneth C. Anderson, Gad Getz, Lorenzo Trippa, Paul G. Richardson, Romanos Sklavenitis-Pistofidis, Irene Ghobrial
Journal: Blood
Blood (2024) 144 (Supplement 1): 1928.
https://doi.org/10.1182/blood-2024-203684
Published: 2024
Journal Articles

Bone Marrow Spatial Signatures Predict Survival Outcomes and Toxicities after CAR-T Therapy in Patients with Relapsed/Refractory Multiple Myeloma

Free
Yoshinobu Konishi, David M. Cordas Dos Santos, Jacopo U. Verga, Patrick Costello, Sujal I. Shah, Qanber Raze, Liang S. Lim, Arnaldo G. Barican, David Howell, David King, Katherine Towle, Ruben D. Carrasco, Scott J. Rodig, Jon C. Aster, Adam S. Sperling, Eric L. Smith, Jacob Laubach, Nikhil C. Munshi, Kenneth C. Anderson, Omar Nadeem, Irene Ghobrial
Journal: Blood
Blood (2024) 144 (Supplement 1): 590.
https://doi.org/10.1182/blood-2024-204144
Published: 2024
Journal Articles

Outcomes of Patients By High-Risk Cytogenetic Abnormalities in a Phase II Study of Isatuximab, Weekly Carfilzomib, Lenalidomide, Dexamethasone in Newly Diagnosed, Multiple Myeloma (The SKylaRk Trial) Who Deferred Transplant

Free
Elizabeth K. O'Donnell, Clifton C. Mo, Omar Nadeem, Jacob Laubach, Jacalyn Rosenblatt, Nikhil C. Munshi, Shonali Midha, Diana Cirstea, Paul G. Richardson, Noopur Raje, Andrew J. Yee
Journal: Blood
Blood (2024) 144 (Supplement 1): 4747.
https://doi.org/10.1182/blood-2024-201768
Published: 2024
Journal Articles

A Phase II Study of Isatuximab, Once Weekly Carfilzomib, Lenalidomide, Dexamethasone, in Newly Diagnosed, Transplant-Eligible Multiple Myeloma (The SKylaRk Trial)

Free
Elizabeth K. O'Donnell, Clifton C. Mo, Andrew J. Yee, Omar Nadeem, Andrew R. Branagan, Jacob Laubach, Jacalyn Rosenblatt, Nora Horick, Paul G. Richardson, Noopur Raje, Diana Cirstea
Journal: Blood
Blood (2023) 142 (Supplement 1): 4671.
https://doi.org/10.1182/blood-2023-181019
Published: 2023
Journal Articles

Immuno-PRISM: A Randomized Phase II Platform Study of Bispecific Antibodies in High-Risk Smoldering Myeloma

Free
Omar Nadeem, Sophie Magidson, Shonali Midha, Elizabeth K. O'Donnell, Monique A Hartley-Brown, Adam S. Sperling, Robert A. Redd, Marjorie Marto, Christine Davie, Caroline Ricciardi, Dechen Choden, Ashlee Strutevant, Jillian Alberti, Clifton C. Mo, Jacob Laubach, Paul G. Richardson, Kenneth C. Anderson, Nikhil C Munshi, Lorenzo Trippa, Irene M. Ghobrial
Journal: Blood
Blood (2023) 142 (Supplement 1): 206.
https://doi.org/10.1182/blood-2023-177954
Published: 2023
Journal Articles

Venetoclax in Combination with Daratumumab and Dexamethasone Elicits Deep, Durable Responses in Patients with t(11;14) Relapsed/Refractory Multiple Myeloma: Updated Analyses of Minimal Residual Disease Negativity in Phase 1/2 Study

Free
Nizar J Bahlis, Hang Quach, Rachid Baz, Annette J. Vangsted, Shir-Jing Ho, Niels Abildgaard, Jacob Laubach, Vincent Ribrag, Peter M. Voorhees, Xifeng Wang, Orlando Bueno, Yan Luo, Jeremy A Ross, Jonathan L. Kaufman
Journal: Blood
Blood (2023) 142 (Supplement 1): 338.
https://doi.org/10.1182/blood-2023-180766
Published: 2023
Journal Articles

Expansion, Persistence, and Characteristics of Autologous, Bhv-1100 Armored Memory-like NK Cells Infused Prior to Autologous Stem Cell Transplant in MRD+ Multiple Myeloma Patients: A First-in-Human Trial

Free
Grace Caroline Birch, Juliana Vergara-Cadavid, Mohsin Maqbool, Alba Martini, Khanlinh Dinh, Roman M. Shapiro, Michela Ansuinelli, Tuyet Nguyen, Carol Reynolds, Im Soo Y, Hope Wei, Sarah Hogan, Elizabeth Kendricken, Adam S. Sperling, Omar Nadeem, Jacob Laubach, Alissa Rybicki, Steven Schnittman, Elyse Stock, Diego Hernandez Rodriguez, Heather Daley, Sarah Nikiforow, Jerome Ritz, Robert J. Soiffer, Giada Bianchi, Rizwan Romee
Journal: Blood
Blood (2023) 142 (Supplement 1): 2105.
https://doi.org/10.1182/blood-2023-180224
Published: 2023
Journal Articles

Phase II Trial of Daratumumab, Bortezomib, Lenalidomide and Dexamethasone in High-Risk Smoldering Multiple Myeloma

Free
Omar Nadeem, Sophie Magidson, Robert A. Redd, Jacob Laubach, Clifton C. Mo, Elizabeth K. O'Donnell, Adam S. Sperling, Monique A Hartley-Brown, Shonali Midha, Marjorie Marto, Christine Davie, Caroline Ricciardi, Dechen Choden, Ashlee Strutevant, Jillian Alberti, Lorenzo Trippa, Nikhil C Munshi, Kenneth C. Anderson, Paul G. Richardson, Irene M. Ghobrial
Journal: Blood
Blood (2023) 142 (Supplement 1): 3382.
https://doi.org/10.1182/blood-2023-177947
Published: 2023
Journal Articles

Keeping an Eye on Belantamab: Characterizing Ocular Toxicities

Free
Shahrier Hossain, Omar Marzouk, Houry Leblebjian, Robert A. Redd, Jacob Laubach
Journal: Blood
Blood (2022) 140 (Supplement 1): 13206–13207.
https://doi.org/10.1182/blood-2022-166720
Published: 2022
Journal Articles

A Phase II Study of Once Weekly Carfilzomib, Lenalidomide, Dexamethasone, and Isatuximab in Newly Diagnosed, Transplant-Eligible Multiple Myeloma (The SKylaRk Trial)

Free
Elizabeth K. O'Donnell, Clifton C Mo, Omar Nadeem, Andrew J. Yee, Andrew R. Branagan, Jacob Laubach, Marilyn T. Gammon, Kathleen J. Lively, Lisette Packer, Cynthia C. Harrington, Emerentia Agyemang, Jacalyn Rosenblatt, Nora K. Horick, Paul G. Richardson, Noopur Raje
Journal: Blood
Blood (2022) 140 (Supplement 1): 7282–7283.
https://doi.org/10.1182/blood-2022-156328
Published: 2022
Journal Articles

A Phase I/II Study of Twice Weekly Ixazomib Plus Pomalidomide and Dexamethasone in Relapsed and Refractory Multiple Myeloma

Free
Omar Nadeem, Robert A. Redd, Trevor J. Bayliss, Peter Barth, Jacob Laubach, Clifton C. Mo, Giada Bianchi, Kelly Masone, Kyle Griffin, Lindsay Issokson, Anna Barrell, Randi Doherty, Deborah Mailand, Alexandra Distaso, Sarah Patches, Kathryn Goodrich, Kathleen Oneill, Vaishali Sanchorawala, Leyla O. Shune, Paul G. Richardson
Journal: Blood
Blood (2022) 140 (Supplement 1): 10180–10181.
https://doi.org/10.1182/blood-2022-165512
Published: 2022