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Giada Bianchi
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Journal Articles

Loss of GABARAP mediates resistance to immunogenic chemotherapy in multiple myeloma

Annamaria Gulla, Eugenio Morelli, Megan Johnstone, Marcello Turi, Mehmet K. Samur, Cirino Botta, Selma Cifric, Pietro Folino, Delaney Vinaixa, Francesca Barello, Cole Clericuzio, Vanessa Katia Favasuli, Domenico Maisano, Srikanth Talluri, Rao Prabhala, Giada Bianchi, Mariateresa Fulciniti, Kenneth Wen, Keiji Kurata, Jiye Liu, Johany Penailillo, Alberto Bragoni, Anna Sapino, Paul G. Richardson, Dharminder Chauhan, Ruben D. Carrasco, Teru Hideshima, Nikhil C. Munshi, Kenneth C. Anderson
Journal: Blood
Blood (2024) 143 (25): 2612–2626.
https://doi.org/10.1182/blood.2023022777
Published: 2024
Includes: Supplemental data
Journal Articles

A SNAP23-Dependent SNARE Complex Mediates Free Light Chain Secretion in AL Amyloidosis and Multiple Myeloma and Its Blockade Triggers a Terminal Unfolded Protein Response and Massive Apoptosis

Emre Karayol, Maria Moscvin, Tianzeng Chen, Peter G. Czarnecki, Annamaria Gulla, Kenneth C. Anderson, Giada Bianchi
Journal: Blood
Blood (2023) 142 (Supplement 1): 4662.
https://doi.org/10.1182/blood-2023-177714
Published: 2023
Journal Articles

Prevalence, Characteristics, and Clinical Impact of Clonal Hematopoiesis of Indeterminate Potential in AL Amyloidosis

Paolo Lopedote, Alfredo Marchetti, Benjamin Evans, Tianzeng Chen, Maria Moscvin, Niccolò Bolli, Giada Bianchi
Journal: Blood
Blood (2023) 142 (Supplement 1): 2029.
https://doi.org/10.1182/blood-2023-190905
Published: 2023
Journal Articles

Selinexor, Ixazomib, Pomalidomide and Dexamethasone in Functionally High-Risk Multiple Myeloma: Results from the Myeloma Developing Regimens Using Genomics (MyDRUG) Sub-Protocol Y3

Joshua Richter, Jeffrey A. Zonder, Nitya Nathwani, Giada Bianchi, Craig C. Hofmeister, Ravi Vij, Matthew Pianko, Gurbakhash Kaur, Malin Hultcrantz, Katie Wozniak, Mercedes Martillo, Hearn Jay Cho, Shaji Kunnathu Kumar
Journal: Blood
Blood (2023) 142 (Supplement 1): 3387.
https://doi.org/10.1182/blood-2023-184949
Published: 2023
Journal Articles

Expansion, Persistence, and Characteristics of Autologous, Bhv-1100 Armored Memory-like NK Cells Infused Prior to Autologous Stem Cell Transplant in MRD+ Multiple Myeloma Patients: A First-in-Human Trial

Grace Caroline Birch, Juliana Vergara-Cadavid, Mohsin Maqbool, Alba Martini, Khanlinh Dinh, Roman M. Shapiro, Michela Ansuinelli, Tuyet Nguyen, Carol Reynolds, Im Soo Y, Hope Wei, Sarah Hogan, Elizabeth Kendricken, Adam S. Sperling, Omar Nadeem, Jacob Laubach, Alissa Rybicki, Steven Schnittman, Elyse Stock, Diego Hernandez Rodriguez, Heather Daley, Sarah Nikiforow, Jerome Ritz, Robert J. Soiffer, Giada Bianchi, Rizwan Romee
Journal: Blood
Blood (2023) 142 (Supplement 1): 2105.
https://doi.org/10.1182/blood-2023-180224
Published: 2023
Journal Articles

A MIR17HG-derived long noncoding RNA provides an essential chromatin scaffold for protein interaction and myeloma growth

Eugenio Morelli, Mariateresa Fulciniti, Mehmet K. Samur, Caroline F. Ribeiro, Leon Wert-Lamas, Jon E. Henninger, Annamaria Gullà, Anil Aktas-Samur, Katia Todoerti, Srikanth Talluri, Woojun D. Park, Cinzia Federico, Francesca Scionti, Nicola Amodio, Giada Bianchi, Megan Johnstone, Na Liu, Doriana Gramegna, Domenico Maisano, Nicola A. Russo, Charles Lin, Yu-Tzu Tai, Antonino Neri, Dharminder Chauhan, Teru Hideshima, Masood A. Shammas, Pierfrancesco Tassone, Sergei Gryaznov, Richard A. Young, Kenneth C. Anderson, Carl D. Novina, Massimo Loda, Nikhil C. Munshi
Journal: Blood
Blood (2023) 141 (4): 391–405.
https://doi.org/10.1182/blood.2022016892
Published: 2023
Includes: Supplemental data
Journal Articles

A Phase I/II Study of Twice Weekly Ixazomib Plus Pomalidomide and Dexamethasone in Relapsed and Refractory Multiple Myeloma

Omar Nadeem, Robert A. Redd, Trevor J. Bayliss, Peter Barth, Jacob Laubach, Clifton C. Mo, Giada Bianchi, Kelly Masone, Kyle Griffin, Lindsay Issokson, Anna Barrell, Randi Doherty, Deborah Mailand, Alexandra Distaso, Sarah Patches, Kathryn Goodrich, Kathleen Oneill, Vaishali Sanchorawala, Leyla O. Shune, Paul G. Richardson
Journal: Blood
Blood (2022) 140 (Supplement 1): 10180–10181.
https://doi.org/10.1182/blood-2022-165512
Published: 2022
Journal Articles

Targeting Autophagy to Overcome Resistance to Immunogenic Chemotherapy in High-Risk Multiple Myeloma

Annamaria Gulla, Eugenio Morelli, Mehmet K. Samur, Megan Johnstone, Cirino Botta, Delaney Vinaixa, Marcello Turi, Mariateresa Fulciniti, Kenneth Wen, Selma Cifric, Srikanth Talluri, Giada Bianchi, Rao Prabhala, Paul G. Richardson, Dharminder Chauhan, Ruben D. Carrasco, Teru Hideshima, Nikhil C Munshi, Kenneth C. Anderson
Journal: Blood
Blood (2022) 140 (Supplement 1): 7114–7115.
https://doi.org/10.1182/blood-2022-162653
Published: 2022
Journal Articles

Sustained minimal residual disease in myeloma

Clinical Trials & Observations
Giada Bianchi
Journal: Blood
Blood (2022) 139 (4): 469–471.
https://doi.org/10.1182/blood.2021013199
Published: 2022
Journal Articles

Gabarap Loss Mediates Immune Escape in High Risk Multiple Myeloma

Annamaria Gulla, Eugenio Morelli, Mehmet K. Samur, Cirino Botta, Megan Johnstone, Giada Bianchi, Mariateresa Fulciniti, Leona Yamamoto, Rao Prabhala, Kenneth Wen, Paul G. Richardson, Yu-Tzu Tai, Dharminder Chauhan, Teru Hideshima, Nikhil C. Munshi, Kenneth C. Anderson
Journal: Blood
Blood (2021) 138 (Supplement 1): 891.
https://doi.org/10.1182/blood-2021-148621
Published: 2021
Journal Articles

Mutations in the Alternative Complement Pathway in Multiple Myeloma Patients with Carfilzomib-Induced Thrombotic Microangiopathy

Maria Moscvin, Christine Ivy Liacos, Tianzeng Chen, Foteini Theodorakakou, Despina Fotiou, Eileen Regan, Efstathios Kastritis, Meletios A. Dimopoulos, Paul G. Richardson, Giada Bianchi
Journal: Blood
Blood (2021) 138 (Supplement 1): 2708.
https://doi.org/10.1182/blood-2021-153229
Published: 2021
Journal Articles

A Phase I/II Study of Twice Weekly Ixazomib Plus Pomalidomide and Dexamethasone in Relapsed and Refractory Multiple Myeloma

Omar Nadeem, Robert A. Redd, Peter Barth, Clifton C Mo, Jacob P. Laubach, Giada Bianchi, Trevor J. Bayliss, Vaishali Sanchorawala, Leyla Shune, Alexandra Distaso, Virginia Dalton, Mary McKenney, Sarah Patches, Isabella Hou, Lindsay Issokson, Anna Barrell, Kelly Masone, Adam S. Sperling, Nikhil C. Munshi, Irene M. Ghobrial, Kenneth C. Anderson, Paul G. Richardson
Journal: Blood
Blood (2021) 138 (Supplement 1): 1650.
https://doi.org/10.1182/blood-2021-146866
Published: 2021
Journal Articles

Targeting Free Light Chain Secretion Via Botulinum Neurotoxin Is a Novel Therapeutic Strategy in AL Amyloidosis By Inducing a Terminal Unfolded Protein Response

Maria Moscvin, Tianzeng Chen, Peter G. Czarnecki, Annamaria Gulla, Kenneth C. Anderson, Giada Bianchi
Journal: Blood
Blood (2021) 138 (Supplement 1): 1576.
https://doi.org/10.1182/blood-2021-149768
Published: 2021
Journal Articles

Specific targeting of the KRAS mutational landscape in myeloma as a tool to unveil the elicited antitumor activity

Antonio Sacco, Cinzia Federico, Katia Todoerti, Bachisio Ziccheddu, Valentina Palermo, Arianna Giacomini, Cosetta Ravelli, Federica Maccarinelli, Giada Bianchi, Angelo Belotti, Rossella Ribolla, Vanessa Favasuli, Alexey S. Revenko, A. Robert Macleod, Brandon Willis, Hongbo Cai, Joana Hauser, Claire Rooney, Sophie E. Willis, Philip Lloyd Martin, Anna Staniszewska, Helen Ambrose, Lyndsey Hanson, Chiara Cattaneo, Alessandra Tucci, Giuseppe Rossi, Roberto Ronca, Antonino Neri, Stefania Mitola, Niccolò Bolli, Marco Presta, Michele Moschetta, Sarah Ross, Aldo M. Roccaro
Journal: Blood
Blood (2021) 138 (18): 1705–1720.
https://doi.org/10.1182/blood.2020010572
Published: 2021
Includes: Supplemental data
Journal Articles

RNA Regulator of Lipogenesis (RROL) Is a Novel Lncrna Mediating Protein-Protein Interaction at Gene Regulatory Loci Driving Lipogenic Programs in Multiple Myeloma

Eugenio Morelli, MD, Mariateresa Fulciniti, PhD, Mehmet K. Samur, PhD, Caroline Ribeiro, PhD, Leon Wert-Lamas, PhD, Annamaria Gulla, MD, Anil Aktas-Samur, PhD, Katia Todoerti, PhD, Srikanth Talluri, PhD, Woojun Daniel Park, Jonathan E Henninger, Cinzia Federico, PhD, Giada Bianchi, MD, Francesca Scionti, PhD, Yao Yao, Nicola Amodio, PhD, Charles Y Lin, PhD, Yu-Tzu Tai, PhD, Pierfrancesco Tassone, MD, Antonino Neri, MD, Dharminder Chauhan, PhD, Teru Hideshima, MD PhD, Richard A. Young, PhD, Kenneth Anderson, MD, Carl D. Novina, MD PhD, Massimo Loda, MD, Nikhil C. Munshi, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 20–21.
https://doi.org/10.1182/blood-2020-142514
Published: 2020
Journal Articles

Bortezomib Induces Anti-Multiple Myeloma Immune Response Mediated By Cgas/Sting Pathway Activation, Type I Interferon Secretion, and Immunogenic Cell Death: Clinical Application

Annamaria Gulla, MD, Eugenio Morelli, MD, Mehmet Kemal Samur, PhD, Cirino Botta, MDPhD, Teru Hideshima, MD PhD, Giada Bianchi, MD, Mariateresa Fulciniti, PhD, Stefano Malvestiti, MD, Rao Prabhala, Srikanth Talluri, PhD, Yu-Tzu Tai, PhD, Kenneth Wen, Paul G. Richardson, MD, Ruben D. Carrasco, MD PhD, Dharminder Chauhan, PhD, Nikhil C. Munshi, MD, Kenneth Anderson, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 7–8.
https://doi.org/10.1182/blood-2020-140356
Published: 2020
Journal Articles

A Phase I/II Study of Twice Weekly Ixazomib Plus Pomalidomide and Dexamethasone in Relapsed and Refractory Multiple Myeloma: Results from Phase I Dose Escalation Cohorts

Omar Nadeem, MD, Clifton C Mo, MD, Jacob P. Laubach, MD, Giada Bianchi, MD, Robert Redd, Peter Barth, Trevor J. Bayliss, MD, Vaishali Sanchorawala, MD, Leyla Shune, MD, Alexandra Distaso, Virginia Dalton, MS, APRN, Adam S Sperling, MD PhD, Laura Amweg, Mary McKenney, NP, Kathleen Colson, BS,BSN,RN, Ella L Millard, Isabella Hou, Alexandra Savell, BS, Kelly Masone, BA, Nikhil C. Munshi, MD, Irene M. Ghobrial, MD, Kenneth Anderson, MD, Paul G. Richardson, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 1–2.
https://doi.org/10.1182/blood-2020-141549
Published: 2020
Journal Articles

YWHAE/14-3-3ε expression impacts the protein load, contributing to proteasome inhibitor sensitivity in multiple myeloma

Yan Xu, Mariateresa Fulciniti, Mehmet K. Samur, Matthew Ho, Shuhui Deng, Lanting Liu, Kenneth Wen, Tengteng Yu, Zuzana Chyra, Sanika Dereibal, Li Zhang, Yao Yao, Chandraditya Chakraborty, Eugenio Morelli, Na Li, Michael A. Lopez, Tommaso Perini, Shidai Mu, Gang An, Rafael Alonso, Giada Bianchi, Yu-Tzu Tai, Kenneth C. Anderson, Lugui Qiu, Nikhil C. Munshi
Journal: Blood
Blood (2020) 136 (4): 468–479.
https://doi.org/10.1182/blood.2019004147
Published: 2020
Includes: Supplemental data
Journal Articles

The Transmembrane Receptor Roundabout 1 (ROBO1) Is Necessary for Multiple Myeloma Proliferation and Homing to the Bone Marrow Niche

Giada Bianchi, MD, Peter G. Czarnecki, MD, Matthew Ho, PhD, Aldo M. Roccaro, MD PhD, Antonio Sacco, RN, Yawara Kawano, MD PhD, Anil Aktas Samur, PhD, Annamaria Gulla, MD, Tianzeng Chen, Kenneth Wen, Xinchen Wu, Yu-Tzu Tai, PhD, Gulden Camci-Unal, PhD, Irene M. Ghobrial, MD, Ruben D. Carrasco, MD PhD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 507.
https://doi.org/10.1182/blood-2019-128778
Published: 2019
Journal Articles

Phase II Trial of the Combination of Ixazomib, Lenalidomide, and Dexamethasone in High-Risk Smoldering Multiple Myeloma

Mark Bustoros, MD, Omar Nadeem, MD, Adam S Sperling, MD PhD, Giada Bianchi, MD, Lily Ardente, BS, Robert A. Redd, MS, Julia Prescott, NP, Erin Frey, RN, Kathleen Guimond, RN, Rachel Styles, BS, Kalvis Hornburg, BA, Alexandra Savell, BS, Nang Kham Su, BA, Govind Bindra, BA, Cody J Boehner, BS, Kaitlen Reyes, DNP, Houry Leblebjian, PharmD, Diane Warren, Nikhil C. Munshi, MD, Jacob P. Laubach, MD, Kenneth C. Anderson, MD, Paul G. Richardson, MD, Irene M. Ghobrial, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 580.
https://doi.org/10.1182/blood-2019-128519
Published: 2019