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Journal Articles

Monoclonal gammopathy of indeterminate potential (MGIP) as a stable premalignant entity preceding hematologic malignancy

Free
Sungjae Kim, Sabine Allam, Yoshinobu Konishi, Floris Chabrun, Jean-Baptiste Alberge, Luca Bertamini, Habib El-Khoury, Junko Tsuji, Romanos Sklavenitis-Pistofidis, Rosa Toenges, Elizabeth Lightbody, Michael Timonian, Uday Aditya Sarkar, Michelle Aranha, Jacqueline Perry, Ting Wu, Grace Fleming, Joseph Flinn, Mendy Miller, Nikhil Munshi, Kenneth Anderson, Omar Nadeem, Catherine Marinac, Jennifer Brown, Paolo Ghia, Gad Getz, Irene Ghobrial
Journal: Blood
Blood (2025) 146 (Supplement 1): 582.
https://doi.org/10.1182/blood-2025-582
Published: 2025
Journal Articles

Results of the promise study from ~30,000 individuals screened for monoclonal gammopathies

Free
Sabine Allam, Sungjae Kim, Jean-Baptiste Alberge, Habib El-Khoury, Floris Chabrun, Jacqueline Perry, Katherine Padgett, Julia Colchie, Joseph Flinn, Grace Fleming, Rachel Choi, Kaitlin Bondi, Ciara Murphy, Sofia Wallin, Luca Bertamini, David Lee, Derek Troske, Dhananjay Sakrikar, David Barnidge, Stephen Harding, David Cordas Dos Santos, Romanos Sklavenitis-Pistofidis, Meletios Dimopoulos, Efstathios Kastritis, Irit Avivi, Wenlong Chen, Maureen Joffe, Elizabeth Karlson, Elizabeth O'Donnell, Omar Nadeem, Lorenzo Trippa, Catherine Marinac, Gad Getz, Irene Ghobrial
Journal: Blood
Blood (2025) 146 (Supplement 1): 403.
https://doi.org/10.1182/blood-2025-403
Published: 2025
Journal Articles

Characterization of the plasma proteome of multiple myeloma and its precursor conditions and identification of a prognostic high-risk signature of progression

Free
Elizabeth Lightbody, D. R. Mani, Hasmik Keshishian, Romanos Sklavenitis-Pistofidis, Ankit Dutta, Esperanza Martin-Sanchez, Elise Rees, Christine-Ivy Liacos, Nayda Bidikian, Habib El-Khoury, Hadley Barr, Ting Wu, Junko Tsuji, Sarah Nersesian, Nang Kham Su, Cody Boehner, Michael Agius, Michelle Aranha, Sabrin Tahri, Laura Hevenor, Katherine Towle, Erica Horowitz, Jacqueline Perry, Maya Davis, Kelly Walsh, John Ready, Catherine Marinac, Kwee Yong, Gad Getz, Efstathios Kastritis, Meletios Dimopoulos, Bruno Paiva, Namrata Udeshi, Michael Gillette, Steven Carr, Irene Ghobrial
Journal: Blood
Blood (2025) 146 (Supplement 1): 2168.
https://doi.org/10.1182/blood-2025-2168
Published: 2025
Journal Articles

Prospective analysis and clinical implications of therapy-related clonal hematopoiesis in adolescent and young adult survivors of acute lymphoblastic leukemia

Free
Habib El-Khoury, Ella Postich, Diren Arda Karaoglu, Aishwarya Atmakuri, Hamed Rahmani Youshalouei, Adam Duvall, Wendy Stock, Tara Henderson, Caner Saygin
Journal: Blood
Blood (2025) 146 (Supplement 1): 3319.
https://doi.org/10.1182/blood-2025-3319
Published: 2025
Journal Articles

Serum free light chains in a racially diverse population including African Americans and populations from South Africa

Available to Purchase
Luca Bertamini, Jean-Baptiste Alberge, David J. Lee, Habib El-Khoury, Sungjae Kim, Grace Fleming, Ciara Murphy, Julia Colchie, Maya I. Davis, Jacqueline Perry, Elizabeth D. Lightbody, Sabine Allam, Lindokuhle N. Goqwana, Vinitha Philip, Natalie Smyth, Dhananjay Sakrikar, Mark Perkins, Stephen Harding, Derek Troske, Gad Getz, Elizabeth W. Karlson, Nikhil Munshi, Kenneth C. Anderson, Lorenzo Trippa, Catherine R. Marinac, Wenlong C. Chen, Maureen Joffe, Irene M. Ghobrial
Journal: Blood
Blood (2025) 145 (8): 840–849.
https://doi.org/10.1182/blood.2024026078
Published: 2025
Includes: Supplemental data
Journal Articles

Early Serum Protein Clonal Dynamics Preceding Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma Years before Diagnosis

Free
Sabine Allam, Floris Chabrun, Jean-Baptiste Alberge, Grace Fleming, Sungjae Kim, Yoshinobu Konishi, Habib El-Khoury, Luca Bertamini, Sofia Wallin, Joseph Casey Flinn, Dhananjay Sakrikar, Derek Troske, David Barnidge, Mark C Perkins, Stephen J. Harding, Romanos Sklavenitis-Pistofidis, Paolo Ghia, Catherine R. Marinac, Gad Getz, Irene Ghobrial
Journal: Blood
Blood (2024) 144 (Supplement 1): 3279.
https://doi.org/10.1182/blood-2024-203937
Published: 2024
Journal Articles

Comprehensive Characterization of the Plasma Proteome of Multiple Myeloma and Its Precursor Conditions and Identification of a Proteomic Signature to Improve Risk Prediction of Disease Progression

Free
Elizabeth D. Lightbody, D. R. Mani, Hasmik Keshishian, Namrata Udeshi, Romanos Sklavenitis-Pistofidis, Ankit K. Dutta, Ting Wu, Junko Tsuji, Habib El-Khoury, Hadley Barr, Sarah Nersesian, Nang Kham Su, Cody J. Boehner, Michael P. Agius, Michelle P. Aranha, Laura Hevenor, Katherine Towle, Grace Fleming, Christian Cea-Curry, Daniel Heilpern-Mallory, Erica M. Horowitz, Jacqueline F Perry, Maya Davis, Kelly Walsh, Annie Cowan, John E. Ready, Catherine R. Marinac, Gad Getz, Michael Gillette, Steven A. Carr, Irene Ghobrial
Journal: Blood
Blood (2024) 144 (Supplement 1): 1903.
https://doi.org/10.1182/blood-2024-209286
Published: 2024
Journal Articles

Clinical Implications of Treatment-Related Clonal Hematopoiesis in Adolescent and Young Adult Survivors of Acute Lymphoblastic Leukemia

Free
Habib El-Khoury, Ella Postich, Diren Arda Karaoglu, Aishwarya Atmakuri, Hamed Rahmani Youshalouei, Syed Shah, Wendy Stock, Tara O. Henderson, Adam Duvall, Caner Saygin
Journal: Blood
Blood (2024) 144 (Supplement 1): 1429.
https://doi.org/10.1182/blood-2024-211655
Published: 2024
Journal Articles

Deep Learning Unveils Characteristics of Immune B Cell Aging in >17,000 Samples and Identifies Changes in the Immunoglobulin Repertoire Distribution and the Development of Monoclonal Gammopathy

Free
Floris Chabrun, Jean-Baptiste Alberge, Sabine Allam, Jacqueline F Perry, Habib El-Khoury, David J Lee, Michael Timonian, Luca Bertamini, Hadley Barr, Grace Fleming, Joseph Casey Flinn, Ciara Murphy, Sofia Wallin, Hiba Hussain, Elizabeth D. Lightbody, Sungjae Kim, Mark C Perkins, Stephen J. Harding, Dhananjay Sakrikar, Romanos Sklavenitis Pistofidis, Kenneth C. Anderson, Omar Nadeem, Elizabeth K. O'Donnell, Yuxin Liu, Wenlong Chen, Maureen Joffe, Benjamin Levine Ebert, Catherine R. Marinac, Gad Getz, Irene Ghobrial
Journal: Blood
Blood (2024) 144 (Supplement 1): 4984.
https://doi.org/10.1182/blood-2024-194368
Published: 2024
Journal Articles

Tumor-Intrinsic and Immune Predictors of Response to Ixazomib, Lenalidomide, and Dexamethasone in High-Risk Smoldering Multiple Myeloma

Free
Michelle P. Aranha, Omar Nadeem, Robert A. Redd, Michael Timonian, Sophie Magidson, Elizabeth D. Lightbody, Jean-Baptiste Alberge, Ting Wu, Junko Tsuji, Luca Bertamini, Ankit K. Dutta, Habib El-Khoury, Mark Bustoros, Jacob Laubach, Giada Bianchi, Elizabeth K. O'Donnell, Kenneth C. Anderson, Gad Getz, Lorenzo Trippa, Paul G. Richardson, Romanos Sklavenitis-Pistofidis, Irene Ghobrial
Journal: Blood
Blood (2024) 144 (Supplement 1): 1928.
https://doi.org/10.1182/blood-2024-203684
Published: 2024
Journal Articles

Improved Risk Stratification of Smoldering Multiple Myeloma (SMM) Using Trajectory Data in the Pangea 2.0 Model: A Multicenter Study in 1,431 Participants

Free
Floris Chabrun, Daniel Schwartz, Susanna Gentile, Tulika R Gupta, Noelia Collado Gisbert, Esperanza Martín-Sánchez, Rosalinda Termini, Jacqueline F Perry, Annie Cowan, Federico Ferrari, Samuel Freeman, Robert A. Redd, Vidhi Patel, Patrick Costello, Catherine Tobia, Romanos Sklavenitis-Pistofidis, Habib El-Khoury, Michael Timonian, David J Lee, Elizabeth D. Lightbody, Hadley Barr, Priya Kaur, Katelyn Downey, Sally Phan, Maya Patel, Jennifer Lamb, Nana Ama Boadi-Acheampong, Foteini Theodorakakou, Despina Fotiou, Christine-Ivy Liacos, Selina J Chavda, Louise Ainley, Elizabeth K. O'Donnell, Catherine R. Marinac, Gad Getz, Omar Nadeem, Kwee Yong, Efstathios Kastritis, Meletios Dimopoulos, Jesús F. San-Miguel, Bruno Paiva, Lorenzo Trippa, Irene Ghobrial
Journal: Blood
Blood (2024) 144 (Supplement 1): 1017.
https://doi.org/10.1182/blood-2024-205705
Published: 2024
Journal Articles

Single-Cell RNA Sequencing of Circulating Tumor Cells in Precursor Myeloma Patients Reveals Mechanisms of Disease Dissemination

Free
Elizabeth D. Lightbody, Romanos Sklavenitis-Pistofidis, Danielle T. Firer, Junko Tsuji, Mike P. Agius, Ankit K. Dutta, Ting Wu, Hadley Barr, Sungjae Kim, Tim Coorens, Jean-Baptiste Alberge, Michelle P. Aranha, Nicholas J Haradhvala, Nang Kham Su, Cody J. Boehner, Kelly Walsh, Mahshid Rahmat, Yoshinobu Konishi, Laura Hevenor, Katherine Towle, Erica M. Horowitz, Jacqueline Perry, Grace Fleming, Habib El-Khoury, Michael Vinyard, Annie Cowan, Daniel Auclair, John E. Ready, Catherine R. Marinac, Gad Getz, Irene M. Ghobrial
Journal: Blood
Blood (2023) 142 (Supplement 1): 872.
https://doi.org/10.1182/blood-2023-189760
Published: 2023
Journal Articles

High-Throughput Plasma Proteomics to Define the Precursor Multiple Myeloma Proteome and Identify Candidate High-Risk Disease Biomarkers of Progression

Free
Elizabeth D. Lightbody, D. R. Mani, Hasmik Keshishian, Habib El-Khoury, Ankit K. Dutta, Hadley Barr, Namrata Udeshi, Luca Bertamini, Nang Kham Su, Cody J. Boehner, Laura Hevenor, Katherine Towle, Grace Fleming, Christian Cea-Curry, Jacqueline Perry, Erica M. Horowitz, Maya Davis, Annie Cowan, Catherine R. Marinac, Michael Gillette, Steven A. Carr, Irene M. Ghobrial
Journal: Blood
Blood (2023) 142 (Supplement 1): 334.
https://doi.org/10.1182/blood-2023-189091
Published: 2023
Journal Articles

Multi-Center Clinical Validation of a Mass Spectrometry Immunoassay for the Diagnosis and Monitoring of Multiple Myeloma and Associated Disorders

Free
Oscar Berlanga, Jane Birtwistle, Syreeta Allen, Gemma Malin, Cristina Simion, Habib El-Khoury, Julia Colchie, Luca Bertamini, Grace Fleming, Erica M. Horowitz, Irene M. Ghobrial, Kaleb B McLendon, John Roback, Andrew S Neish, Sarah K Grewal, Gabriella Lakos
Journal: Blood
Blood (2023) 142 (Supplement 1): 3667.
https://doi.org/10.1182/blood-2023-189050
Published: 2023
Journal Articles

Prevalence of Monoclonal Gammopathies Detected By Mass Spectrometry and Their Risk Factors Among Black Africans in South Africa

Free
David J. Lee, Habib El-Khoury, Luca Bertamini, Jean-Baptiste Alberge, Maya I. Davis, Jacqueline Perry, Dhananjay Sakrikar, David Barnidge, Mark C. Perkins, Stephen Harding, Derek Troske, Audrey Pentz, Thulisile Hlubi, Natalie Smyth, Anna Cowan, Angela C. Tramontano, Gad Getz, Timothy R. Rebbeck, Maureen Joffe, Wenlong Carl Chen, Catherine R. Marinac, Irene Ghobrial
Journal: Blood
Blood (2022) 140 (Supplement 1): 7228–7229.
https://doi.org/10.1182/blood-2022-167268
Published: 2022
Journal Articles

High-Throughput Plasma Proteomic Profiling to Identify Candidate High-Risk Disease Biomarkers in Precursor Multiple Myeloma Patients

Free
Elizabeth D. Lightbody, Hasmik Keshishian, Habib El-Khoury, Ankit K. Dutta, Hadley Barr, Jes Barbagallo, Namrata Udeshi, Michael P. Agius, Nang Kham Su, Cody J. Boehner, Laura Hevenor, Katherine Towle, Christian J. Cea-Curry, Jacqueline Perry, Erica Horowitz, Maya I. Davis, Anna Cowan, Evan Mills, Marijana Rucevic, DR Mani, Daniel Auclair, Catherine R. Marinac, Michael A Gillette, Steven A Carr, Irene Ghobrial
Journal: Blood
Blood (2022) 140 (Supplement 1): 4303–4304.
https://doi.org/10.1182/blood-2022-170346
Published: 2022
Journal Articles

Abnormal Free Light Chains in Individuals with African Ancestry Screened for Monoclonal Gammopathy: Definition of New Reference Range Accounting for Renal Function and Race

Free
Luca Bertamini, Jean-Baptiste Alberge, Habib El-Khoury, David J. Lee, Ciara Murphy, Grace Fleming, Maya I. Davis, Jacqueline Perry, Christian J. Cea-Curry, Audrey Pentz, Thulisile Hlubi, Natalie Smyth, D.J. Sakrikar, Mark C. Perkins, Stephen Harding, Derek Troske, Gad Getz, Timothy R. Rebbeck, Maureen Joffe, Catherine R. Marinac, Nelson Leung, Carl Wenlong Chen, Irene Ghobrial
Journal: Blood
Blood (2022) 140 (Supplement 1): 10005–10006.
https://doi.org/10.1182/blood-2022-164436
Published: 2022
Journal Articles

Single-Cell RNA Sequencing of Rare Circulating Tumor Cells in Precursor Myeloma Patients Reveals Molecular Underpinnings of Tumor Cell Circulation

Free
Elizabeth D. Lightbody, Danielle T. Firer, Romanos Sklavenitis-Pistofidis, Junko Tsuji, Michael P. Agius, Ankit K. Dutta, Ting Wu, Hadley Barr, Mahshid Rahmat, Yoshinobu Konishi, Michelle P. Aranha, Michael Vinyard, Jean-Baptiste Alberge, Nang Kham Su, Cody J. Boehner, Laura Hevenor, Habib El-Khoury, Katherine Towle, Christian J. Cea-Curry, Erica Horowitz, Jacqueline Perry, Anna Cowan, Anna V. Justis, Daniel Auclair, Catherine R. Marinac, Gad Getz, Irene Ghobrial
Journal: Blood
Blood (2022) 140 (Supplement 1): 602–603.
https://doi.org/10.1182/blood-2022-162851
Published: 2022
Journal Articles

Persistence of Monoclonal Gammopathies in Serial Samples from a US Population-Based Screening Study

Free
Habib El-Khoury, Luca Bertamini, Jean-Baptiste Alberge, David J. Lee, Ciara Murphy, Grace Fleming, Christian J. Cea-Curry, Maya I. Davis, Jacqueline Perry, Elizabeth D. Lightbody, Dhananjay Sakrikar, Derek Troske, David Barnidge, Mark C. Perkins, Stephen Harding, Gad Getz, Catherine R. Marinac, Irene Ghobrial
Journal: Blood
Blood (2022) 140 (Supplement 1): 10101–10103.
https://doi.org/10.1182/blood-2022-169380
Published: 2022
Journal Articles

Clonal Hematopoiesis Is Associated with Increased Risk of Progression of Asymptomatic Waldenström Macroglobulinemia

Free
Sabrin Tahri, Tarek H Mouhieddine, Robert A. Redd, Luisa Maria Lampe, Katarina Nillson, Nang Kham Su, Habib El-Khoury, Amin H Nassar, Elio Adib, Govind Bindra, Sarah Abou Alaiwi, Lorenzo Trippa, David P. Steensma, Jorge J. Castillo, Steven P. Treon, Irene M. Ghobrial, Adam S. Sperling
Journal: Blood
Blood (2021) 138 (Supplement 1): 2678.
https://doi.org/10.1182/blood-2021-149711
Published: 2021