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Journal Articles

Antigen escape as a shared mechanism of resistance to BCMA-directed therapies in multiple myeloma

Brief Report
Ross S. Firestone, Nicholas D. Socci, Tala Shekarkhand, Menglei Zhu, Wei Ge Qin, Malin Hultcrantz, Sham Mailankody, Carlyn Rose Tan, Neha Korde, Alexander M. Lesokhin, Hani Hassoun, Urvi Shah, Kylee H. Maclachlan, Sridevi Rajeeve, Heather J. Landau, Michael Scordo, Gunjan L. Shah, Oscar B. Lahoud, Sergio Giralt, Kazunori Murata, Saad Z. Usmani, David J. Chung
Journal: Blood
Blood (2024) 144 (4): 402–407.
https://doi.org/10.1182/blood.2023023557
Published: 2024
Includes: Supplemental data
Journal Articles

Clinical Outcomes Associated with Del(17p) in Newly Diagnosed Multiple Myeloma Treated with Triplet and Daratumumab-Based Quadruplet Induction Regimens

Eric Jurgens, Ross Firestone, Kylee H Maclachlan, David Nemirovsky, Andriy Derkach, Malin Hultcrantz, Hani Hassoun, Sham Mailankody, Urvi A Shah, Sridevi Rajeeve, Dhwani Patel, Tala Shekarkhand, Colin Rueda, Yanming Zhang, Oscar Boutros Lahoud, Gunjan L. Shah, Michael Scordo, David Chung, Heather Landau, Sergio A. Giralt, Alexander Lesokhin, Neha Korde, Saad Z Usmani, Carlyn Tan
Journal: Blood
Blood (2023) 142 (Supplement 1): 2024.
https://doi.org/10.1182/blood-2023-190728
Published: 2023
Journal Articles

Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone (DVRd) and Daratumumab, Carfilzomib, Lenalidomide and Dexamethasone (DKRd) As Induction Therapy in Newly Diagnosed Multiple Myeloma

Carlyn Tan, Kylee H Maclachlan, David Nemirovsky, Andriy Derkach, Malin Hultcrantz, Hani Hassoun, Sham Mailankody, Urvi A Shah, Sridevi Rajeeve, Dhwani Patel, Tala Shekarkhand, Colin Rueda, Oscar Boutros Lahoud, Gunjan L. Shah, Michael Scordo, David Chung, Heather Landau, Sergio A. Giralt, Alexander Lesokhin, Saad Z Usmani, Neha Korde
Journal: Blood
Blood (2023) 142 (Supplement 1): 4744.
https://doi.org/10.1182/blood-2023-181868
Published: 2023
Journal Articles

A Whole Foods Plant-Based Weight Loss Intervention Improves Quality of Life, Metabolic, Microbiome and Immune Profile in MGUS/SMM As Well As Progression Trajectory in a Subset - the Nutrivention Trial

Urvi A Shah, Francesca Castro, Andriy Derkach, Teng Fei, Kinga K Hosszu, Devin McAvoy, Susan DeWolf, Justin Cross, Ana Gradissimo, Alexis Nwankwo, Aishwarya Anuraj, Miranda Burge, Blaslov Jenna, Elizabeth Raynor, Jenna Wosleger, Peter Adintori, Michael Pollak, Jenny Paredes Sanchez, Thomas Atkinson, Kylee H Maclachlan, Sham Mailankody, Neha Korde, Carlyn Tan, Malin Hultcrantz, Hani Hassoun, Jonathan U. Peled, Gunjan L. Shah, Michael Scordo, Oscar Boutros Lahoud, David Chung, Heather Landau, Anita D'Souza, Ola Landgren, Sergio A. Giralt, Neil M. Iyengar, Saad Z Usmani, Alexander Lesokhin, Marcel R.M. van den Brink
Journal: Blood
Blood (2023) 142 (Supplement 1): 4771.
https://doi.org/10.1182/blood-2023-182878
Published: 2023
Journal Articles

Revised Definition of Free Light Chains in Serum and Light Chain Monoclonal Gammopathy of Undetermined Significance: Results of the Istopmm Study

Thorir Einarsson Long, Sæmundur Rögnvaldsson, Sigrun Thorsteinsdottir, Ingigerdur Sverrisdottir, Elias Eythorsson, Olafur Indridason, Runolfur Palsson, Thor Aspelund, Brynjar Vidarsson, Pall T. Onundarson, Bjarni Agnarsson, Margret Sigurdardottir, Ingunn Thorsteinsdottir, Isleifur Olafsson, Asdis Rosa Thordardottir, Asbjorn Jonsson, Gauti Gislason, Andri Olafsson, Malin Hultcrantz, Brian GM Durie, Stephen J. Harding, Thorvardur Jon Love, Ola Landgren, Sigurdur Y. Kristinsson
Journal: Blood
Blood (2023) 142 (Supplement 1): 535.
https://doi.org/10.1182/blood-2023-188547
Published: 2023
Journal Articles

A Comparative Analysis of Infectious Complications in Patients with Multiple Myeloma Treated with BCMA-Targeted Bispecific Antibodies and CAR T-Cell Therapy

Karthik Nath, Tala Shekarkhand, Bruno Almeida Costa, David Nemirovsky, Andriy Derkach, Noriko Nishimura, Tasmin Farzana, Colin Rueda, David Chung, Heather Landau, Oscar Boutros Lahoud, Michael Scordo, Gunjan L. Shah, Hani Hassoun, Kylee H Maclachlan, Neha Korde, Urvi A Shah, Carlyn Rose Tan, Malin Hultcrantz, Sergio A. Giralt, Saad Z Usmani, Zainab Shahid, Sham Mailankody, Alexander Lesokhin
Journal: Blood
Blood (2023) 142 (Supplement 1): 1957.
https://doi.org/10.1182/blood-2023-179413
Published: 2023
Journal Articles

Carfilzomib, Lenalidomide and Dexamethasone (KRd) As Induction Therapy in High-Risk Newly Diagnosed Multiple Myeloma

Carlyn Tan, Neha Korde, Andriy Derkach, Malin Hultcrantz, Kylee H Maclachlan, Hani Hassoun, Sham Mailankody, Urvi A Shah, Sridevi Rajeeve, Dhwani Patel, Alexander Lesokhin, Oscar Boutros Lahoud, Gunjan L. Shah, Michael Scordo, David Chung, Heather Landau, Sergio A. Giralt, Craig C. Hofmeister, Jonathan L. Kaufman, Ajay K. Nooka, Saad Z Usmani, Sagar Lonial, Nisha S. Joseph
Journal: Blood
Blood (2023) 142 (Supplement 1): 1996.
https://doi.org/10.1182/blood-2023-190279
Published: 2023
Journal Articles

The Early Benefits and Psychological Effects of Screening for Monoclonal Gammopathy of Undetermined Significance: Results of the Istopmm Study

Sæmundur Rögnvaldsson, Sigrun Thorsteinsdottir, Jon Oskarsson, Elias Eythorsson, Gudrun Asta Sigurdardottir, Brynjar Vidarsson, Pall T. Onundarson, Bjarni Agnarsson, Margret Sigurdardottir, Isleifur Olafsson, Ingunn Thorsteinsdottir, Andri Steinthor Bjornsson, Inga Dröfn Wessman, Gauti Gislason, Jon Kristinn Sigurdsson, Andri Olafsson, Ingigerdur Sverrisdottir, Thorir E. Long, Robert Palmason, Signy Vala Sveinsdottir, Fridbjorn Sigurdsson, Asdis Rosa Thordardottir, Asbjorn Jonsson, Runolfur Palsson, Olafur Indridason, Elin Ruth Reed, Gudlaug Katrin Hakonardottir, Hlif Steingrimsdottir, Malin Hultcrantz, Brian GM Durie, Stephen J. Harding, Thor Aspelund, Ola Landgren, Thorvardur Jon Love, Sigurdur Y. Kristinsson
Journal: Blood
Blood (2023) 142 (Supplement 1): 214.
https://doi.org/10.1182/blood-2023-186397
Published: 2023
Journal Articles

Patterns of Cytokine Release Syndrome with Teclistamab in Relapsed/Refractory Multiple Myeloma with or without Prior T-Cell Redirection Therapy

Issam S. Hamadeh, Tala Shekarkhand, Colin Rueda, Ross Firestone, Alice Wang, Neha Korde, Malin Hultcrantz, Alexander Lesokhin, Sham Mailankody, Hani Hassoun, Urvi A Shah, Kylee H Maclachlan, Dhwani Patel, Gunjan L. Shah, Michael Scordo, Oscar Boutros Lahoud, David Chung, Heather Landau, Sergio A. Giralt, Saad Z Usmani, Carlyn Rose Tan
Journal: Blood
Blood (2023) 142 (Supplement 1): 1961.
https://doi.org/10.1182/blood-2023-180283
Published: 2023
Journal Articles

Evaluating the Effect of Evolving Changes in Serum Biomarkers on the Risk of Progression in Smoldering Multiple Myeloma

Theresia Akhlaghi, David Nemirovsky, Kylee H Maclachlan, Neha Korde, Sham Mailankody, Alexander Lesokhin, Hani Hassoun, Dhwani Patel, Urvi A Shah, Carlyn Tan, Oscar Boutros Lahoud, Heather Landau, Gunjan L. Shah, Michael Scordo, David Chung, Ola Landgren, Sergio A. Giralt, Saad Z Usmani, Andriy Derkach, Malin Hultcrantz
Journal: Blood
Blood (2023) 142 (Supplement 1): 877.
https://doi.org/10.1182/blood-2023-180315
Published: 2023
Journal Articles

Monoclonal Gammopathy of Undetermined Significance and the Risk of Thrombotic Events: Results from Istopmm, a Population-Based Screening Study in Iceland

Sæmundur Rögnvaldsson, Alessandro Gasparini, Sigrun Thorsteinsdottir, Ingigerdur Sverrisdottir, Elias Eythorsson, Thorir E. Long, Brynjar Vidarsson, Pall T. Onundarson, Bjarni Agnarsson, Margret Sigurdardottir, Isleifur Olafsson, Ingunn Thorsteinsdottir, Jon Oskarsson, Robert Palmason, Signy Vala Sveinsdottir, Asdis Rosa Thordardottir, Asbjorn Jonsson, Runolfur Palsson, Olafur Indridason, Thor Aspelund, Gauti Gislason, Andri Olafsson, Jon Kristinn Sigurdsson, Malin Hultcrantz, Brian GM Durie, Stephen J. Harding, Ola Landgren, Thorvardur Jon Love, Sigurdur Y. Kristinsson
Journal: Blood
Blood (2023) 142 (Supplement 1): 216.
https://doi.org/10.1182/blood-2023-186098
Published: 2023
Journal Articles

Sars-Cov-2 Infection Does Not Lead to Progression of Monoclonal Gammopathy of Undetermined Significance: Results from the Population-Based Istopmm Screening Study

Robert Palmason, Sara Ekberg, Elias Eythorsson, Sæmundur Rögnvaldsson, Sigrun Thorsteinsdottir, Michael Crowther, Elin Ruth Reed, Jon Oskarsson, Gudrun Asta Sigurdardottir, Thor Aspelund, Brynjar Vidarsson, Pall T. Onundarson, Bjarni Agnarsson, Margret Sigurdardottir, Ingunn Thorsteinsdottir, Signy Vala Sveinsdottir, Isleifur Olafsson, Asdis Rosa Thordardottir, Asbjorn Jonsson, Olafur Indridason, Gauti Gislason, Andri Olafsson, Jon Kristinn Sigurdsson, Hlif Steingrimsdottir, Thorir E. Long, Malin Hultcrantz, Brian GM Durie, Stephen J. Harding, Ola Landgren, Runolfur Palsson, Thorvardur Jon Love, Sigurdur Y. Kristinsson
Journal: Blood
Blood (2023) 142 (Supplement 1): 4766.
https://doi.org/10.1182/blood-2023-173078
Published: 2023
Journal Articles

Evaluating Tumor-Intrinsic and Patient-Specific Mechanisms of Resistance to Teclistamab in Anti-BCMA Exposed and Naïve Multiple Myeloma

Ross Firestone, Devin McAvoy, Tala Shekarkhand, Edith Serrano, Issam S. Hamadeh, Alice Wang, Menglei Zhu, Dhwani Patel, Carlyn Tan, Malin Hultcrantz, Sham Mailankody, Hani Hassoun, Urvi A Shah, Neha Korde, Kylee H Maclachlan, Heather Landau, Michael Scordo, Gunjan L. Shah, Oscar Boutros Lahoud, Sergio A. Giralt, Kinga K Hosszu, David Chung, Alexander Lesokhin, Saad Z Usmani
Journal: Blood
Blood (2023) 142 (Supplement 1): 333.
https://doi.org/10.1182/blood-2023-187467
Published: 2023
Journal Articles

Identifying Causes of Unscheduled Healthcare Interactions and Changes to Patient Disposition in Individuals Receiving Outpatient Commercial Bispecific Antibody Therapy in Relapsed/Refractory Multiple Myeloma (RRMM)

Anna J Howard, Tala Shekarkhand, Issam S. Hamadeh, Alice Wang, Dhwani Patel, Carlyn Tan, Malin Hultcrantz, Sham Mailankody, Hani Hassoun, Urvi A Shah, Neha Korde, Kylee H Maclachlan, Heather Landau, Michael Scordo, Gunjan L. Shah, Oscar Boutros Lahoud, Sergio A. Giralt, David Chung, Alexander Lesokhin, Saad Z Usmani, Ross Firestone
Journal: Blood
Blood (2023) 142 (Supplement 1): 3707.
https://doi.org/10.1182/blood-2023-187889
Published: 2023
Journal Articles

Stem Cell Utilization in the Era of Novel Therapies for Multiple Myeloma

Noriko Nishimura, David Nemirovsky, Sean M. Devlin, Parastoo B. Dahi, Heather Landau, Oscar Boutros Lahoud, Michael Scordo, Gunjan L. Shah, Sham Mailankody, Hani Hassoun, Kylee H Maclachlan, Malin Hultcrantz, Neha Korde, Alexander Lesokhin, Urvi A Shah, Carlyn Tan, Gaurav Gupta, Elena Maryamchik, Rugved Pattarkine, Grace Linder, Saad Z Usmani, Sergio A. Giralt, David Chung
Journal: Blood
Blood (2023) 142 (Supplement 1): 2219.
https://doi.org/10.1182/blood-2023-188103
Published: 2023
Journal Articles

The Complex Structural Variant Chromothripsis Can be Defined on Targeted Sequencing Panels, Allowing Direct Clinical Translation in Order to Improve Multiple Myeloma Prognostication

Kylee H Maclachlan, Bachisio Ziccheddu, Carlyn Tan, Tala Shekarkhand, Colin Rueda, Edith Serrano, Benjamin Diamond, Hani Hassoun, Sham Mailankody, Urvi A Shah, Malin Hultcrantz, Sergio A. Giralt, David Chung, Heather Landau, Oscar Boutros Lahoud, Michael Scordo, Gunjan L. Shah, Yanming Zhang, Robert Cimera, Maria E. Arcila, Ola Landgren, Alexander Lesokhin, Neha Korde, Francesco Maura, Saad Z Usmani
Journal: Blood
Blood (2023) 142 (Supplement 1): 3343.
https://doi.org/10.1182/blood-2023-189316
Published: 2023
Journal Articles

Selinexor, Ixazomib, Pomalidomide and Dexamethasone in Functionally High-Risk Multiple Myeloma: Results from the Myeloma Developing Regimens Using Genomics (MyDRUG) Sub-Protocol Y3

Joshua Richter, Jeffrey A. Zonder, Nitya Nathwani, Giada Bianchi, Craig C. Hofmeister, Ravi Vij, Matthew Pianko, Gurbakhash Kaur, Malin Hultcrantz, Katie Wozniak, Mercedes Martillo, Hearn Jay Cho, Shaji Kunnathu Kumar
Journal: Blood
Blood (2023) 142 (Supplement 1): 3387.
https://doi.org/10.1182/blood-2023-184949
Published: 2023
Journal Articles

Comprehensive Genomic Characterization of Response and Resistance to Daratumumab-Based Quadruplet Induction in Newly Diagnosed Multiple Myeloma Patients

Kylee H Maclachlan, Carlyn Rose Tan, Tala Shekarkhand, Colin Rueda, Edith Serrano, David Nemirovsky, Andriy Derkach, Andrew McPherson, Benjamin Diamond, Bachisio Ziccheddu, Eileen Boyle, Hani Hassoun, Sham Mailankody, Urvi A Shah, Malin Hultcrantz, Sergio A. Giralt, David Chung, Heather Landau, Oscar Boutros Lahoud, Michael Scordo, Gunjan L. Shah, Yanming Zhang, Robert Cimera, Maria E. Arcila, Ahmet Dogan, Alexander Lesokhin, Gareth J. Morgan, Ola Landgren, Francesco Maura, Neha Korde, Saad Z Usmani
Journal: Blood
Blood (2023) 142 (Supplement 1): 3370.
https://doi.org/10.1182/blood-2023-187891
Published: 2023
Journal Articles

Risk Factors of Smoldering Multiple Myeloma: Results from the Screened Istopmm Study

Sigrun Thorsteinsdottir, Ingigerdur Sverrisdottir, Sæmundur Rögnvaldsson, Sara Ekberg, Malin Hultcrantz, Brynjar Vidarsson, Pall T. Onundarson, Bjarni Agnarsson, Margret Sigurdardottir, Ingunn Thorsteinsdottir, Isleifur Olafsson, Asdis Rosa Thordardottir, Jon Thorir Oskarsson, Gudrun Asta Sigurdardottir, Elias Eythorsson, Asbjorn Jonsson, Gauti Gislason, Andri Olafsson, Jon Kristinn Sigurdsson, Thorir Einarsson Long, Brian GM Durie, Stephen J. Harding, Ola Landgren, Thorvardur Jon Love, Sigurdur Y. Kristinsson
Journal: Blood
Blood (2023) 142 (Supplement 1): 3397.
https://doi.org/10.1182/blood-2023-188469
Published: 2023
Journal Articles

T-Cell Exhaustion Signature Predicts Early Relapse after Autologous Stem Cell Transplant for Multiple Myeloma: BMT CTN 0702 Secondary Immune Analysis

Nezar Mehanna, Andriy Derkach, Billel Gasmi, Theodora Anagnostou, Heather Landau, Oscar Boutros Lahoud, Michael Scordo, Gunjan L. Shah, Hani Hassoun, Kylee H Maclachlan, Malin Hultcrantz, Neha Korde, Sham Mailankody, Urvi A Shah, Carlyn Rose Tan, Saad Z Usmani, Sergio A. Giralt, Alexander Lesokhin, David Chung
Journal: Blood
Blood (2023) 142 (Supplement 1): 3326.
https://doi.org/10.1182/blood-2023-177960
Published: 2023