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Journal Articles

Deconvoluting Clonal and Cellular Architecture in IDH -Mutant Acute Myeloid Leukemia

Blood (2023) 142 (Supplement 1): 1591.

https://doi.org/10.1182/blood-2023-186322

Published: 2023

Journal Articles

N/KRAS -Mutant AML LSCs Originate from Committed Myelomonocytic Progenitors and Drive Clinical Resistance to Venetoclax

Blood (2023) 142 (Supplement 1): 403.

https://doi.org/10.1182/blood-2023-187695

Published: 2023

Journal Articles

Comparison of Live Cell Enrichment Methods for Single-Cell Rnaseq

Brigita Meskauskaite Urben, Tobias Krause, Meril Takizawa, Catherine Snopkowski, Ignas Masilionis, Jan Remsik, Yollanda Parisotto, Chrysothemis Brown, Adrienne Boire, Dana Pe'er, Roshan Sharma, Ronan Chaligne

Blood (2023) 142 (Supplement 1): 7179.

https://doi.org/10.1182/blood-2023-190109

Published: 2023

Journal Articles

Single-Cell Multi-Omics Reveals That Pegylated Interferon-Alfa Treatment Differentially Redirects Mutated and Wildtype Hematopoietic Cell Differentiation Trajectories in CALR- mutated Essential Thrombocythemia (ET) Patients

Shira Rosenberg, Andrea Kubas-Meyer, Neelang Parghi, Nathaniel D. Omans, Neville Dusaj, Paulina Chamely, Eleni Mimitou, Amylou C. Dueck, Heidi E. Kosiorek, Rona Singer Weinberg, Peter Smibert, Ronan Chaligne, Dan A. Landau, Ronald Hoffman, Anna S Nam

Blood (2021) 138 (Supplement 1): 57.

https://doi.org/10.1182/blood-2021-150745

Published: 2021

Journal Articles

High Throughput Single-Cell Simultaneous Genotyping and Chromatin Accessibility Reveals Genotype to Phenotype Relationship in Human Myeloproliferation

Robert M. Myers, Franco Izzo, Tamara Prieto, Eleni Mimitou, Ramya Raviram, Ronan Chaligne, Ronald Hoffman, Maximilian Stahl, Omar Abdel-Wahab, Bridget Marcellino, Peter Smibert, Dan A. Landau

Blood (2021) 138 (Supplement 1): 678.

https://doi.org/10.1182/blood-2021-149226

Published: 2021

Journal Articles

Single-Cell Multi-Omics Defines the Cell-Type Specific Impact of SF3B1 Splicing Factor Mutations on Hematopoietic Differentiation in Human Clonal Hematopoiesis and Myelodysplastic Syndromes

Blood (2021) 138 (Supplement 1): 145.

https://doi.org/10.1182/blood-2021-147529

Published: 2021

Journal Articles

Single-Cell Multi-Omics in Human Clonal Hematopoiesis Reveals That DNMT3A R882 Mutations Perturb Early Progenitor States through Selective Hypomethylation

Anna S Nam, MD, Neville Dusaj, MS, Franco Izzo, PhD, Rekha Murali, MS, Tarek H Mouhieddine, MD, Robert M Myers, Jesus Sotelo, Salima Benbarche, PhD, Federico Gaiti, PhD, Sabrin Tahri, MD MSc, Omar Abdel-Wahab, MD, Irene M. Ghobrial, MD, Ronan Chaligne, PhD, Dan A. Landau, MD PhD

Blood (2020) 136 (Supplement 1): 1–2.

https://doi.org/10.1182/blood-2020-142574

Published: 2020

Journal Articles

Single-Cell Multi-Omics Reveals Distinct Paths to Survival of Admixed BTK C481 Mutant Vs. Wild-Type Cells in Clinically Progressing Chronic Lymphocytic Leukemia

Blood (2020) 136 (Supplement 1): 40–42.

https://doi.org/10.1182/blood-2020-138374

Published: 2020

Journal Articles

Robust Discovery of Candidate DNA Methylation Cancer Drivers

Heng Pan, PhD, Loïc Renaud, MD MSc, Ronan Chaligne, PhD, Johannes Bloehdorn, MD, Eugen Tausch, MD, Daniel Mertens, PhD, Anna-Maria Fink, MD, Kirsten Fischer, MD, Chao Zhang, PhD, Doron Betel, PhD, Andreas Gnirke, Marcin Imielinski, Jerome Moreaux, PhD, Michael Hallek, Alexander Meissner, PhD, Stephan Stilgenbauer, MD, Catherine J. Wu, MD, Olivier Elemento, PhD, Dan A. Landau, MD PhD

Blood (2020) 136 (Supplement 1): 33–34.

https://doi.org/10.1182/blood-2020-136830

Published: 2020

Journal Articles

High Throughput Droplet Single-Cell Genotyping of Transcriptomes (GoT) Reveals the Cell Identity Dependency of the Transcriptional Output of Somatic Mutations

Anna S Nam, MD, Kyu-Tae Kim, PhD, Ronan Chaligne, PhD, Franco Izzo, PhD, Chelston Ang, MS, Nathaniel Omans, MS, Alessandro Pastore, Justin Taylor, MD, Alicia Alonso, Wayne Tam, MD PhD, Ronald Hoffman, MD, Joseph Scandura, MDPhD, Raul Rabadan, PhD, Omar I Abdel-Wahab, MD, Peter Smibert, PhD, Dan A. Landau, MD PhD

Blood (2018) 132 (Supplement 1): 541.

https://doi.org/10.1182/blood-2018-99-119236

Published: 2018

Journal Articles

Multimodal Single-Cell Profiling Defines the Epigenetic Determinants of Chronic Lymphocytic Leukemia Evolution

Ronan Chaligne, PhD, Federico Gaiti, PhD, Franco Izzo, PhD, Steven Kothen-Hill, MS, Hongcang Gu, Kevin Huang, BS, Davide Risso, PhD, Rafael Schulman, BS, Ryan M Brand, Stanley C Lee, PhD, Asaf Poran, Kye-Tae Kim, PhD, Alessandro Pastore, Alicia Alonso, Andreas Gnirke, Catherine J. Wu, MD, Omar I Abdel-Wahab, MD, Alexander Meissner, PhD, Dan A. Landau, MD PhD

Blood (2018) 132 (Supplement 1): 1312.

https://doi.org/10.1182/blood-2018-99-115596

Published: 2018

Journal Articles

Single-Cell Joint Methylomics and Transcriptomics Define the Epigenetic Evolution and Lineage Histories of Chronic Lymphocytic Leukemia

Ronan Chaligne, PhD, Federico Gaiti, PhD, Steven Kothen-Hill, MS, Hongcang Gu, Kevin Huang, BS, Rafael Schulman, Kye-Tae Kim, PhD, Evan Biederstedt, Lili Wang, MD PhD, Martin J. Aryee, PhD, Andreas Gnirke, Catherine J. Wu, MD, Alexander Meissner, PhD, Dan A. Landau, MD

Blood (2017) 130 (Supplement 1): 55.

https://doi.org/10.1182/blood.V130.Suppl_1.55.55

Published: 2017

Journal Articles

Single-Cell Methylome and Transcriptome High-Resolution Maps Define the Effects of Epigenetic Modifiers on the Landscape of Hematopoietic Differentiation

Franco Izzo, PhD, Asaf Poran, Stanley Chun-Wei Lee, PhD, Ronan Chaligne, PhD, Federico Gaiti, PhD, Steven Kothen-Hill, MS, Rafael Schulman, BS, Michelle Ki, Kenigsberg Ephraim, PhD, Omar Abdel-Wahab, MD, Dan A. Landau, MD PhD

Blood (2017) 130 (Supplement 1): 559.

https://doi.org/10.1182/blood.V130.Suppl_1.559.559

Published: 2017

Journal Articles

Induction of myeloproliferative disorder and myelofibrosis by thrombopoietin receptor W515 mutants is mediated by cytosolic tyrosine 112 of the receptor

Christian Pecquet, Judith Staerk, Ronan Chaligné, Valerie Goss, Kimberly A. Lee, Xiaowu Zhang, John Rush, Joanne Van Hees, Hélène A. Poirel, Jean-Marie Scheiff, William Vainchenker, Stéphane Giraudier, Roberto D. Polakiewicz, Stefan N. Constantinescu

Blood (2010) 115 (5): 1037–1048.

https://doi.org/10.1182/blood-2008-10-183558

Published: 2010

Journal Articles

The hematopoietic stem cell compartment of JAK2V617F-positive myeloproliferative disorders is a reflection of disease heterogeneity

Chloe James, Frederic Mazurier, Sabrina Dupont, Ronan Chaligne, Isabelle Lamrissi-Garcia, Micheline Tulliez, Eric Lippert, François-Xavier Mahon, Jean-Max Pasquet, Gabriel Etienne, François Delhommeau, Stephane Giraudier, William Vainchenker, Hubert de Verneuil

Blood (2008) 112 (6): 2429–2438.

https://doi.org/10.1182/blood-2008-02-137877

Published: 2008

Journal Articles

The Hematopoietic Stem Cell Compartment Is Different in Polycythemia Vera and Idiopathic Myelofibrosis.

Chloe James, MD, Frederic Mazurier, PhD, Ronan Chaligne, Sabrina Dupont, Francois Delhommeau, MD, PhD, Stephane Giraudier, MD, PhD, William Vainchenker, MD, PhD, Hubert De Verneuil, MD, PhD

Blood (2007) 110 (11): 259.

https://doi.org/10.1182/blood.V110.11.259.259

Published: 2007

Journal Articles

Evidence for MPL W515L/K mutations in hematopoietic stem cells in primitive myelofibrosis

Ronan Chaligné, Chloé James, Carole Tonetti, Rodolphe Besancenot, Jean Pierre Le Couédic, Fanny Fava, Fréderic Mazurier, Isabelle Godin, Karim Maloum, Frédéric Larbret, Yann Lécluse, William Vainchenker, Stéphane Giraudier

Blood (2007) 110 (10): 3735–3743.

https://doi.org/10.1182/blood-2007-05-089003

Published: 2007

Journal Articles

Proteasome inhibitor bortezomib impairs both myelofibrosis and osteosclerosis induced by high thrombopoietin levels in mice

Orianne Wagner-Ballon, Didier F. Pisani, Thomas Gastinne, Micheline Tulliez, Ronan Chaligné, Catherine Lacout, Frédéric Auradé, Jean-Luc Villeval, Patrick Gonin, William Vainchenker, Stéphane Giraudier

Blood (2007) 110 (1): 345–353.

https://doi.org/10.1182/blood-2006-10-054502

Published: 2007

Journal Articles

Evidence That the MPL 515L and 515K Mutations Occur in a Lympho-Myeloid Progenitor in Idiopathic Myelofibrosis and Are Associated with TPO Hypersensitivity.

Ronan Chaligne, Jean-Pierre Le Couedic, sRA, Carole Tonetti, sRA, Rodolphe Besancenot, MD, Orianne Wagner-Ballon, MD, PhD, Najet Debili, PhD, William Vainchenker, MD, PhD, Stephane Giraudier, MD, PhD

Blood (2006) 108 (11): 117.

https://doi.org/10.1182/blood.V108.11.117.117

Published: 2006

NARROW

Deconvoluting Clonal and Cellular Architecture in IDH -Mutant Acute Myeloid Leukemia

N/KRAS -Mutant AML LSCs Originate from Committed Myelomonocytic Progenitors and Drive Clinical Resistance to Venetoclax

Comparison of Live Cell Enrichment Methods for Single-Cell Rnaseq

Single-Cell Multi-Omics Reveals That Pegylated Interferon-Alfa Treatment Differentially Redirects Mutated and Wildtype Hematopoietic Cell Differentiation Trajectories in CALR- mutated Essential Thrombocythemia (ET) Patients

High Throughput Single-Cell Simultaneous Genotyping and Chromatin Accessibility Reveals Genotype to Phenotype Relationship in Human Myeloproliferation

Single-Cell Multi-Omics Defines the Cell-Type Specific Impact of SF3B1 Splicing Factor Mutations on Hematopoietic Differentiation in Human Clonal Hematopoiesis and Myelodysplastic Syndromes

Single-Cell Multi-Omics in Human Clonal Hematopoiesis Reveals That DNMT3A R882 Mutations Perturb Early Progenitor States through Selective Hypomethylation

Single-Cell Multi-Omics Reveals Distinct Paths to Survival of Admixed BTK C481 Mutant Vs. Wild-Type Cells in Clinically Progressing Chronic Lymphocytic Leukemia

Robust Discovery of Candidate DNA Methylation Cancer Drivers

High Throughput Droplet Single-Cell Genotyping of Transcriptomes (GoT) Reveals the Cell Identity Dependency of the Transcriptional Output of Somatic Mutations

Multimodal Single-Cell Profiling Defines the Epigenetic Determinants of Chronic Lymphocytic Leukemia Evolution

Single-Cell Joint Methylomics and Transcriptomics Define the Epigenetic Evolution and Lineage Histories of Chronic Lymphocytic Leukemia

Single-Cell Methylome and Transcriptome High-Resolution Maps Define the Effects of Epigenetic Modifiers on the Landscape of Hematopoietic Differentiation

Induction of myeloproliferative disorder and myelofibrosis by thrombopoietin receptor W515 mutants is mediated by cytosolic tyrosine 112 of the receptor

The hematopoietic stem cell compartment of JAK2V617F-positive myeloproliferative disorders is a reflection of disease heterogeneity

The Hematopoietic Stem Cell Compartment Is Different in Polycythemia Vera and Idiopathic Myelofibrosis.

Evidence for MPL W515L/K mutations in hematopoietic stem cells in primitive myelofibrosis

Proteasome inhibitor bortezomib impairs both myelofibrosis and osteosclerosis induced by high thrombopoietin levels in mice

Evidence That the MPL 515L and 515K Mutations Occur in a Lympho-Myeloid Progenitor in Idiopathic Myelofibrosis and Are Associated with TPO Hypersensitivity.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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