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Journal Articles

Mezigdomide Treatment in Relapsed-Refractory Myeloma Patients Shifts Bone Marrow NK and T Cell Populations from Exhaustion to Activation

Lucia Y Chen, Oliver Van Oekelen, Michael Amatangelo, Tracy T. Chow, Bhaskar Upadhyaya, Alessandro Lagana, Geoffrey Kelly, Seunghee Kim-Schulze, Adolfo Aleman, Antonina Kurtova, Sarah Gooding, Sundar Jagannath, Erin Flynt, Anita K. Gandhi, Udo Oppermann, Anjan Thakurta, Samir Parekh
Journal: Blood
Blood (2023) 142 (Supplement 1): 4686.
https://doi.org/10.1182/blood-2023-187748
Published: 2023
Journal Articles

Emergence of Highly-Plastic B Cell States Cooperates with Early Immune Microenvironment Remodeling to Drive Follicular Lymphomagenesis

Gabriel Brisou, Sabrina Baaklini, Noushin Mossadegh-Keller, Alicia Beyou, Manon Zala, Laurine Gil, Camille Soun, Caroline Huber, Iñaki Cervera-Marzal, Agnés Bru, Delphine Potier, Stéphanie Gon, Lionel Chasson, Asier Antoranz, Jon Pey Perez, Anita K. Gandhi, Yumi Nakayama, Patrick R Hagner, Pierre Milpied, Bertrand Nadel, Sandrine Roulland
Journal: Blood
Blood (2023) 142 (Supplement 1): 717.
https://doi.org/10.1182/blood-2023-185829
Published: 2023
Journal Articles

Iberdomide Enhances Dara Mediated Cytotoxicity through Upregulation of CDC Activity and Elevated NK Cell Mediated ADCC

Peilin Ma, Vinidhra Sridharan, Krista Wollerman, Debjani Dutta, Ram Kumar Singh, Sambuddo Mukherjee, Chad C. Bjorklund, Patrick R Hagner, Michael Amatangelo, Anita K. Gandhi
Journal: Blood
Blood (2023) 142 (Supplement 1): 3289.
https://doi.org/10.1182/blood-2023-189423
Published: 2023
Journal Articles

Pharmacodynamic Biomarkers and CtDNA Support the Mechanism of Action and Clinical Efficacy of Golcadomide (CC-99282) Combined with R-CHOP in Previously Untreated Aggressive B-Cell Lymphoma

Mark Kaplan, Tara Basavanhally, Yumi Nakayama, Charalampos Kyriakopoulos, Arnaud Amzallag, Argyrios Gkasiamis, Arpankumar Patel, Akshay Sudhindra, Grzegorz S. Nowakowski, Jason Westin, Anita K. Gandhi
Journal: Blood
Blood (2023) 142 (Supplement 1): 1631.
https://doi.org/10.1182/blood-2023-180231
Published: 2023
Journal Articles

Molecular Classification of Relapsed DLBCL Reveals Novel Biologic Subgroups

Kerstin Wenzl, Matthew E Stokes, Joseph P. Novak, Allison M. Bock, Melissa A. Hopper, Jordan Krull, Abigail R. Dropik, Janek S. Walker, Miranda S. Laverty, Vivekananda Sarangi, Raphael Mwangi, Maria Ortiz, Nicholas Stong, C. Chris Huang, Matthew J. Maurer, Lisa M. Rimsza, Brian K. Link, Rebecca King, Stephen M Ansell, Thomas M. Habermann, Thomas E. Witzig, Grzegorz S. Nowakowski, James R. Cerhan, Anita K. Gandhi, Anne J. Novak
Journal: Blood
Blood (2023) 142 (Supplement 1): 2770.
https://doi.org/10.1182/blood-2023-180949
Published: 2023
Journal Articles

RRMM and Post-BCMA Treated Subjects from the CC-220-MM-001 Study Show Increased Genomic Aberrations Associated with High-Risk and Significant Dysfunction in CD4+ T-Cell Compartment Compared to NDMM Subjects

Michael Amatangelo, Erin Flynt, Nicholas Stong, Maria Ortiz, Pradipta Ray, Maria Wang, Niels W.C.J. van de Donk, Sagar Lonial, Aparna Raval, Anita K. Gandhi
Journal: Blood
Blood (2023) 142 (Supplement 1): 4665.
https://doi.org/10.1182/blood-2023-178912
Published: 2023
Journal Articles

Fedratinib Overcomes Ruxolitinib Resistance through Inhibition of the Interferon Signaling Pathway

Danny Jeyaraju, Ann Polonskaia, Chih-Chao Hsu, Patrick R Hagner, Anita K. Gandhi
Journal: Blood
Blood (2023) 142 (Supplement 1): 1434.
https://doi.org/10.1182/blood-2023-181898
Published: 2023
Journal Articles

An Integrated Single Cell Immunogenomic Atlas Reveals Pathways of Clonal Expansion, Inflammation and Dyserythropoiesis in Low and High-Risk Clonal Haematopoiesis

Xuesen Zheng, Amandine Tan, Maria del Pilar Casares Alaez, Garry Mallett, Deniz Ece Kaya, Nogayhan Seymen, Marta Rzepkowska, Sarah Mackie, Prodromos Chatzikyriakou, Laarni Bogaanay, Jen Lewis, Maroof Hasan, Rajasekhar N.V.S. Suragani, James Carmichael, Ghulam Mufti, Anita K. Gandhi, Giorgio Napolitani, Lynn Quek
Journal: Blood
Blood (2023) 142 (Supplement 1): 812.
https://doi.org/10.1182/blood-2023-174947
Published: 2023
Journal Articles

Preclinical and Translational Biomarker Analyses to Inform Clinical Development of Mezigdomide (CC-92480) in Combination with Dexamethasone and Daratumumab in Multiple Myeloma

Tracy T. Chow, Michael Amatangelo, Peilin Ma, Chad C. Bjorklund, Krista Wollerman, Tiziana Civardi, Phillip Koo, Yue Zhu, Paulo Maciag, Jessica Katz, Aparna Raval, Albert Oriol, Robert Z. Orlowski, Darrell White, Paul G. Richardson, Anita K. Gandhi
Journal: Blood
Blood (2023) 142 (Supplement 1): 3318.
https://doi.org/10.1182/blood-2023-178881
Published: 2023
Journal Articles

Clonal Hematopoiesis-Related Mutations Are Associated with Favorable Clinical Benefit Following Luspatercept Treatment in Patients with Lower-Risk Myelodysplastic Syndromes: A Subgroup Analysis from the Phase 3 COMMANDS Trial

Maroof Hasan, Sadanand Vodala, Sheida Hayati, Guillermo Garcia-Manero, Anita K. Gandhi, Rajasekhar N.V.S. Suragani
Journal: Blood
Blood (2023) 142 (Supplement 1): 3214.
https://doi.org/10.1182/blood-2023-178666
Published: 2023
Journal Articles

Clonal Dynamics of Gene Mutations during Oral Azacitidine Maintenance Therapy in Patients with Acute Myeloid Leukemia (AML): Outcomes from the QUAZAR AML-001 Trial

Daniel Lopes De Menezes, Manuel Ugidos Guerrero, Arnaud Amzallag, Wendy L. See, Alberto Risueno, Charalampos Kyriakopoulos, Rajasekhar N.V.S. Suragani, Barry S. Skikne, C.L. Beach, Thomas Prebet, Maria Teresa Voso, Andre C. Schuh, Gail J. Roboz, Hartmut Döhner, Andrew H. Wei, Anita K. Gandhi
Journal: Blood
Blood (2023) 142 (Supplement 1): 1582.
https://doi.org/10.1182/blood-2023-187651
Published: 2023
Journal Articles

Mezigdomide Reverses T-Cell Exhaustion through Degradation of Aiolos/Ikaros and Reinvigoration of Cytokine Production Pathways

Hsiling Chiu, Junfei Zhao, Maria Ortiz Estevez, Patrick R Hagner, Anita K. Gandhi
Journal: Blood
Blood (2023) 142 (Supplement 1): 335.
https://doi.org/10.1182/blood-2023-189445
Published: 2023
Journal Articles

Celmod Induced Disruption of Granulopoiesis Continuum Identified Using Humanized Cereblon Mice

Ajit Dhadve, Neelam Kumari, Amrutha Y, Riddhita Deb, Gobinathan Rengarasu, Ramya V, Swetha Muralidhar, Shwetank Verma, Patrick R Hagner, Sambuddo Mukherjee, Anita K. Gandhi
Journal: Blood
Blood (2023) 142 (Supplement 1): 5586.
https://doi.org/10.1182/blood-2023-189539
Published: 2023
Journal Articles

Investigation of the Synergistic Combination of a Novel Celmod (CC-99282) and BET Inhibitors in Preclinical DLBCL

Chih-Chao Hsu, Hsiling Chiu, Chad C. Bjorklund, Patrick R Hagner, Anita K. Gandhi
Journal: Blood
Blood (2023) 142 (Supplement 1): 5719.
https://doi.org/10.1182/blood-2023-189191
Published: 2023
Journal Articles

High Deletion Burden Identified By Whole Genome Sequencing Is Associated with Enhanced Risk in del17p CLL Patients

Preeti Trisal, Esteban Braggio, Nicholas Stong, Kay L. Medina, Sameer A. Parikh, Daniel L. Van Dyke, Kari G. Rabe, Zhiquan Wang, C. Chris Huang, Anita K. Gandhi, Neil E. Kay
Journal: Blood
Blood (2023) 142 (Supplement 1): 6509.
https://doi.org/10.1182/blood-2023-173881
Published: 2023
Journal Articles

A Multiomic Single-Cell Atlas of Human Myelopoiesis Reveals Cellular and Molecular Drivers of Immunomodulatory Drug-Induced Neutropenia

Christina Simoglou Karali, Simone Riva, Sally-Ann Clark, Sean Wen, Nikolaos Sousos, Eleni Louka, E. Ravza Gür, Nawshad Hayder, William E. Pierceall, Anjan Thakurta, Anita K. Gandhi, Patrick R Hagner, Jim Hughes, Adam J Mead
Journal: Blood
Blood (2023) 142 (Supplement 1): 935.
https://doi.org/10.1182/blood-2023-182041
Published: 2023
Journal Articles

Tumor Mutational Burden As a Prognostic Factor in Diffuse Large B-Cell Lymphoma

Rosalie Griffin, Kerstin Wenzl, Vivekananda Sarangi, Lisa M. Rimsza, Rebecca King, Andrew L. Feldman, Matthew J. Maurer, Grzegorz S. Nowakowski, Brian K. Link, Thomas M. Habermann, Nicholas Stong, C. Chris Huang, Anita K. Gandhi, Susan L. Slager, Anne J. Novak, James R. Cerhan
Journal: Blood
Blood (2023) 142 (Supplement 1): 1633.
https://doi.org/10.1182/blood-2023-182291
Published: 2023
Journal Articles

Differential Chromatin Organization between t(4;14) and Non-t(4;14) Multiple Myeloma Driven By the Histone Methyltransferase NSD2

Chad C. Bjorklund, Junfei Zhao, Gaurav Jain, Natasha Shtraizent, Maria Ortiz, Sambuddo Mukherjee, Patrick R Hagner, Anita K. Gandhi
Journal: Blood
Blood (2023) 142 (Supplement 1): 3295.
https://doi.org/10.1182/blood-2023-190137
Published: 2023
Journal Articles

Fedratinib Treatment Reduces the Inflammatory Cytokine Profile and Decreases Exhausted T Cells Correlating with Clinical Response in Patients with Myelofibrosis: Biomarker Analysis from the Phase 3 FREEDOM2 Trial

Danny Jeyaraju, Sheida Hayati, Jia Wang, Claire N Harrison, Jean-Jacques Kiladjian, Christopher Hernandez, Patrick Brown, Daniel Lopes De Menezes, Anita K. Gandhi, Rajasekhar N.V.S. Suragani
Journal: Blood
Blood (2023) 142 (Supplement 1): 4526.
https://doi.org/10.1182/blood-2023-180419
Published: 2023
Journal Articles

A Single Cell Atlas of Diffuse Large B Cell Lymphomas Reveals Distinct Cellular States Predictive of Outcomes

Sabrina Baaklini, Alexandre Sarrabay, Camille Barthelemy, Laila Dahbi, Laurine Gil, Noushin Mossadegh-Keller, Jean-Marc Navarro, Caroline Huber, Romain Fenouil, Bertrand Escaliere, Romane Trombetta, Marine Pujol, Philippe Gaulard, Benjamin Riviere, Peggy Dartigues, Francesco Llamas Gutierrez, Celine Pangault, Fabrice Jardin, Francois Lemonnier, Gabriel Brisou, Corinne Haioun, Pauline Gravelle, Camille Laurent, Lionel Spinelli, C Chris Huang, Matthew E Stokes, Sahil Seth, Maria Ortiz, Anita K. Gandhi, Bertrand Nadel, Pierre Milpied, Sandrine Roulland
Journal: Blood
Blood (2023) 142 (Supplement 1): 848.
https://doi.org/10.1182/blood-2023-173929
Published: 2023