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Jennifer A. Woyach
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Journal Articles

International Consensus Statement on Diagnosis, Evaluation, and Research of Richter Transformation: the ERIC Recommendations

Free
Adam S Kittai, Monia Marchetti, Othman Al-Sawaf, Ohad Benjamini, Alexey V Danilov, Matthew S. Davids, Barbara F. Eichhorst, Toby A. Eyre, Anna Maria Frustaci, Michael J Hallek, Paul Joseph Hampel, Yair Herishanu, Rodney John Hicks, Arnon P. Kater, Rebecca L. King, José-Ignacio Ignacio Martín-Subero, Carolyn Owen, Erin M. Parry, Maurilio Ponzoni, Davide Rossi, Tanya Siddiqi, Stephan Stilgenbauer, Constantine S. Tam, Elisa ten Hacken, Philip A Thompson, William G. Wierda, Gianluca Gaidano, Jennifer A. Woyach, Paolo Ghia
Journal: Blood
Blood blood.2024028064.
https://doi.org/10.1182/blood.2024028064
Published: 2025
Includes: Supplemental data
Journal Articles

Acalabrutinib-Obinutuzumab Improves Survival vs Chemoimmunotherapy in treatment-naive CLL in the 6-year Follow-up of ELEVATE-TN

Open Access
Clinical Trials & Observations
Jeff P. Sharman, Miklos Egyed, Wojciech Jurczak, Alan P Skarbnik, Krish Patel, Ian W. Flinn, Manali Kamdar, Talha Munir, Renata Walewska, Marie Hughes, Laura Maria Fogliato, Yair Herishanu, Versha Banerji, George A. Follows, Patricia A Walker, Paolo Ghia, Ann MH Janssens, John C Byrd, Emmanuelle France Ferrant, Alessandra Ferrajoli, William G. Wierda, Catherine Wangui Wachira, Batul T. Suterwala, Paulo A Palhares de Miranda, Veerendra Munugalavadla, Chuan-Chuan Wun, Jennifer A. Woyach
Journal: Blood
Blood blood.2024024476.
https://doi.org/10.1182/blood.2024024476
Published: 2025
Includes: Supplemental data
Journal Articles

Targeting WDR5/ATAD2 signaling by the CK2/IKAROS axis demonstrates therapeutic efficacy in T-ALL

Open Access
Qi Han, Yan Gu, Huimin Xiang, Linyao Zhang, Yan Wang, Chan Yang, Jun Li, Chelsea Steiner, Rosa Lapalombella, Jennifer A. Woyach, Yiping Yang, Sinisa Dovat, Chunhua Song, Zheng Ge
Journal: Blood
Blood (2025) 145 (13): 1407–1421.
https://doi.org/10.1182/blood.2024024130
Published: 2025
Includes: Supplemental data
Journal Articles

Mutations in the Bruton Tyrosine Kinase ( BTK ) Gene in Patients with Chronic Lymphocytic Leukemia (CLL) Receiving BTK Inhibitors (BTKis)

Free
Alan P Skarbnik, Alexey V. Danilov, Marc Hoffmann, Farrukh T. Awan, Frank Scarpa, Caryn Davies, Todd Oakland, Marina Kovach, Jenna Lilyquist, Veerendra Munugalavadla, Alan SM Yong, Vikram Shetty, John N. Allan, Jennifer A. Woyach
Journal: Blood
Blood (2024) 144 (Supplement 1): 4623.
https://doi.org/10.1182/blood-2024-209590
Published: 2024
Journal Articles

LP-168 (Rocbrutinib), a Novel Covalent and Non-Covalent Next-Generation Inhibitor of Bruton's Tyrosine Kinase: Updates on the Phase 1 Trial and Initial Results of the CLL Gatekeeper Mutation Cohort

Free
Jennifer A. Woyach, Danielle M. Brander, Boyu Hu, Kerry A. Rogers, Zulfa Omer, Deborah M. Stephens, Andrea Sitlinger, Fenlai Tan, Yi Chen, Stephen P. Anthony, Yu Chen, Kewei Shang, John C. Byrd
Journal: Blood
Blood (2024) 144 (Supplement 1): 4622.
https://doi.org/10.1182/blood-2024-205775
Published: 2024
Journal Articles

Outcomes of Patients with Chronic Lymphocytic Leukemia Discontinuing Bruton Tyrosine Kinase Inhibitors Due to Adverse Effects

Free
Anthony G Mansour, Ying Huang, Aseel Alsouqi, Adam S Kittai, John C. Byrd, Michael R. Grever, Cecelia Miller, Gerard Lozanski, Mollie Moran, Margaret S. Lucas, Swetha Suresh, Cara Grantier, Corinne Hoffman, Mark Reid, Kerry A. Rogers, Seema A Bhat, Jennifer A. Woyach
Journal: Blood
Blood (2024) 144 (Supplement 1): 4629.
https://doi.org/10.1182/blood-2024-199676
Published: 2024
Journal Articles

Genome-Wide CRISPR/Cas9 Knockout Screen Reveals Novel LP-168 (Rocbrutinib) Combinations Targeting BCL-2 Protein Members for Chronic Lymphocytic Leukemia

Free
Britten K. Gordon, Ethan C. Whipp, Lianbo Yu, Samon Benrashid, Andrew D. Mitchell, Alexander He, Jazmin Urrutia, Shrilekha Misra, Alexander R. Marr, Tzung-Huei Lai, Naina Karnati, Shanmugapriya Thangavadivel, Kerry A. Rogers, Seema A. Bhat, Nicole R. Grieselhuber, Yi Chen, Fenlai Tan, Stephen P. Anthony, Yu Chen, Deepa Sampath, Rosa Lapalombella, Jennifer A. Woyach
Journal: Blood
Blood (2024) 144 (Supplement 1): 3587.
https://doi.org/10.1182/blood-2024-203522
Published: 2024
Journal Articles

CELESTIAL-TNCLL: An Ongoing, Open-Label, Multiregional, Phase 3 Study of Sonrotoclax (BGB-11417) + Zanubrutinib vs Venetoclax + Obinutuzumab for Treatment-Naive CLL

Free
Piers E.M. Patten, Arnon P. Kater, Jennifer A. Woyach, Jianyong Li, Talha Munir, Tommi Salmi, Patrick Phuong, Tian Tian, Mazyar Shadman
Journal: Blood
Blood (2024) 144 (Supplement 1): 3257.1.
https://doi.org/10.1182/blood-2024-198737
Published: 2024
Journal Articles

BRAVE: A Phase 2 Trial Evaluating the Efficacy and Safety of Venetoclax in Combination with Bruton's Tyrosine Kinase Inhibitors in Patients with First-Line Chronic Lymphocytic Leukemia

Free
Matthew S. Davids, John M. Burke, Jennifer A. Woyach, Mina Shahkarami, Katherine Eakle, Jinnie Ko, Vivek S. Chopra, Weize Huang, Rona Farighi, Richard H. Ko, Jeff P. Sharman, William G. Wierda
Journal: Blood
Blood (2024) 144 (Supplement 1): 3257.2.
https://doi.org/10.1182/blood-2024-201555
Published: 2024
Journal Articles

Prospective Randomized Phase 2 Study of Acalabrutinib + Obinutuzumab or Venetoclax in Previously Untreated CLL

Free
Adam S Kittai, Ying Huang, Seema A Bhat, Michael R. Grever, Swetha Suresh, Gerard Lozanski, Mollie Moran, Megan Nussbaum, Jennifer A. Woyach, Kerry A. Rogers
Journal: Blood
Blood (2024) 144 (Supplement 1): 4634.1.
https://doi.org/10.1182/blood-2024-199561
Published: 2024
Journal Articles

Hodgkin Lymphoma Transformation in Patients Who Received No Prior Chemotherapy for CLL/SLL: Outcomes from a Multicenter Retrospective Study in the Modern Era of Therapy

Free
Paul J. Hampel, Ying Huang, Sarah Miller, John N. Allan, Seema A Bhat, David A. Bond, Danielle M. Brander, John C. Byrd, Julio C. Chavez, Elise A. Chong, Alexey Danilov, Matthew S. Davids, Kaitlyn M. Dvorak-Kornaus, Hannah Freedman, Nikita Malakhov, Matthew Matasar, Cecelia Miller, Sameer A. Parikh, Erin M. Parry, Kari G. Rabe, Phil Raess, Manoj Rai, Joanna M. Rhodes, Kerry A. Rogers, Aditi Saha, Jake Schade, Geoffrey Shouse, Stephen E Spurgeon, Deborah M. Stephens, Yucai Wang, Jennifer A. Woyach, Max Yano, Omer Zulfa, Adam S Kittai
Journal: Blood
Blood (2024) 144 (Supplement 1): 5099.
https://doi.org/10.1182/blood-2024-198742
Published: 2024
Journal Articles

Clinical Characteristics and Outcome in a Cohort of CLL Patients with BTK T474 Gatekeeper Mutation

Free
Zulfa Omer, Max Yano, Jayesh Rai, Joyce Chen, Jennifer A. Woyach, Seema A. Bhat, Michael R. Grever, Dan Jones, Kerry A. Rogers, John C. Byrd
Journal: Blood
Blood (2024) 144 (Supplement 1): 1875.
https://doi.org/10.1182/blood-2024-209336
Published: 2024
Journal Articles

Protein Degrader WH25244 Eliminates Venetoclax Resistance Factors: Mutant or Hyperphosphorylated BCL2, and BCL-XL

Free
Daisy Y. Diaz Rohena, Andrew D. Mitchell, Jing Wang, Stephanie Chamberlain, Chaomei Liu, John R. Sanchez, II, Charmelle D. Williams, Trisha K. Wathan, Bailey Slawin, Kevin Bowman, Yaxia Yuan, Peiyi Zhang, Wanyi Hu, Guangrong Zheng, William G. Wierda, Nitin Jain, Matthew S. Davids, Daohong Zhou, Jennifer A. Woyach, Deepa Sampath
Journal: Blood
Blood (2024) 144 (Supplement 1): 2786.
https://doi.org/10.1182/blood-2024-208159
Published: 2024
Journal Articles

Outcomes of Therapies Following Discontinuation of Non-Covalent Bruton's Tyrosine Kinase Inhibitors for Patients with Chronic Lymphocytic Leukemia and Richter Transformation: Results from an International, Multicenter Study

Free
Meghan C. Thompson, Seema A. Bhat, Wojciech Jurczak, Krish Patel, Nirav N. Shah, Jennifer A. Woyach, Catherine C. Coombs, Toby A. Eyre, Michal Danecki, Monika Dlugosz-Danecka, Neil Bailey, Joanna M. Rhodes, Nicole Lamanna, Andrew H. Lipsky, Jeffrey Jensen, Adam Kidwell, Eytan M. Stein, Monica Shah, Jennifer R. Brown, Andriy Derkach, Anthony R. Mato, Lindsey Roeker
Journal: Blood
Blood (2024) 144 (Supplement 1): 1870.
https://doi.org/10.1182/blood-2024-194748
Published: 2024
Journal Articles

A Multi-Center Retrospective Study on Complex Karyotype in Patients with Richter Transformation Who Received No Chemoimmunotherapy for Their CLL

Free
Cecelia Miller, Ying Huang, John N. Allan, Seema A. Bhat, David A. Bond, Danielle M. Brander, John C. Byrd, Julio C. Chavez, Elise A. Chong, Alexey Danilov, Mark R Dowling, Kaitlyn M. Dvorak-Kornaus, Paul J. Hampel, Carrie I Ho, Prioty Islam, Nikita Malakhov, Matthew Matasar, Sarah Miller, Sameer A. Parikh, Kari G. Rabe, Joanna M. Rhodes, Lindsey Roeker, Kerry A. Rogers, Aditi Saha, Alan P Skarbnik, Hamish W Scott, Jake Schade, Mazyar Shadman, Geoffrey Shouse, Deborah M. Stephens, Meghan C. Thompson, Philip A. Thompson, Yucai Wang, Jennifer A. Woyach, Max Yano, Zulfa Omer, Adam S Kittai
Journal: Blood
Blood (2024) 144 (Supplement 1): 3245.
https://doi.org/10.1182/blood-2024-205668
Published: 2024
Journal Articles

The Effects of an Online Curriculum Based Approach to CME on Hematologist/Oncologists' Ability to Treat Patients with BTK Inhibitors for Chronic Lymphocytic Leukemia and Mantle Cell Lymphoma

Free
Victoria Harvey-Jones, Sarah E. Bomba, Sanneke Koekkoek, Ahmad Sarris, Haleh Kadkhoda, Lauren Berger, Jennifer A. Woyach
Journal: Blood
Blood (2024) 144 (Supplement 1): 2446.
https://doi.org/10.1182/blood-2024-209529
Published: 2024
Journal Articles

Temporally Controlled MYC Overexpression in Chronic Lymphocytic Leukemia Accelerates Progression and Promotes Large B Cell Lymphoma Transformation

Free
Ethan C. Whipp, Krithik Tella, Aidan Macaskill, Steven Sher, Casey Cempre, Jean Truxall, Mehdi Gharghabi, Fang Hao, Alexander R. Marr, Madeline Halpin, Pearlly S. Yan, Jennifer A. Woyach, Rosa Lapalombella
Journal: Blood
Blood (2024) 144 (Supplement 1): 2978.
https://doi.org/10.1182/blood-2024-210328
Published: 2024
Journal Articles

Topic Modeling of Genotyping of Transcriptomes Reveals Collaboration between BTK C481S -Mutant and Wild Type Cells in Btki-Resistant Chronic Lymphocytic Leukemia

Free
Ramon Massoni-Badosa, Joshua S. Schiffman, Barun Pradhan, Rebecca M. Murray, Andrew H. Lipsky, Debra Van Egeren, Danny Luan, Shirley Chen, Ronan Chaligne, Kai Beattie, Alyssa Indart, Nada Chraiki, Neville Dusaj, Erica B. Bhavsar, Chelston Ang, Anna S. Nam, Federico Gaiti, Paulina Chamely, Nathaniel D. Omans, Preeti Trisal, Anita K. Gandhi, Kyu-Tae Kim, Rafael Schulman, Franco Izzo, Gavriel Mullokandov, Chingiz Underbayev, Jan A. Burger, Adrian Wiestner, Elisa Ten Hacken, John N. Allan, Jennifer A. Woyach, Richard R. Furman, Dan A. Landau
Journal: Blood
Blood (2024) 144 (Supplement 1): 4610.
https://doi.org/10.1182/blood-2024-205727
Published: 2024
Journal Articles

Targeting Inflammation in Tet2 Mutant Clonal Hematopoiesis Via Inhibition of Brd4 Demonstrates Activity in Both Murine and Human Models

Free
Alexander R. Marr, Madeline Halpin, Dominique L. Corbin, Britten K. Gordon, Samon Benrashid, Ethan C. Whipp, Jean Truxall, Olivia Cahn, Bethany L. Mundy-Bosse, Julia Cooper, Marina Beltrami Moreira, James S. Blachly, Uma Borate, Jennifer A. Woyach, Rosa Lapalombella, Nicole R. Grieselhuber
Journal: Blood
Blood (2024) 144 (Supplement 1): 2661.
https://doi.org/10.1182/blood-2024-203526
Published: 2024
Journal Articles

TP53 Gain-of-Function Mutants Display Unique Transcriptional Profiles in Chronic Lymphocytic Leukemia

Free
Charmelle D. Williams, Suresh Satpati, Janani Ravikrishnan, Bailey Slawin, Daisy Y. Diaz Rohena, Palaniraja Thandapani, Kerry A. Rogers, Seema A. Bhat, Kunal Rai, Jennifer A. Woyach, Deepa Sampath
Journal: Blood
Blood (2024) 144 (Supplement 1): 6757.
https://doi.org/10.1182/blood-2024-199814
Published: 2024