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Journal Articles

Zanubrutinib in Combination with Rituximab, Cyclophosphamide, Doxorubicin, Vincristine and Prednisone (R-CHOP) for Patients with Newly Diagnosed Diffuse Large B-Cell Lymphoma (DLBCL): Interim Results from a Phase 1b Clinical Trial

Yazeed Sawalha, Rina Li Welkie, Anna Krivenko, Brian Hess, Audrey M. Sigmund, Timothy Voorhees, Walter Hanel, David A. Bond, John C Reneau, Narendranath Epperla, Lapo Alinari, Jonathan E. Brammer, Beth Christian, Robert Baiocchi, Kami J. Maddocks
Journal: Blood
Blood (2023) 142 (Supplement 1): 6226.
https://doi.org/10.1182/blood-2023-182941
Published: 2023
Journal Articles

PRMT5 supports multiple oncogenic pathways in mantle cell lymphoma

Shelby L. Sloan, Fiona Brown, Mackenzie Long, Christoph Weigel, Shirsha Koirala, Ji-Hyun Chung, Betsy Pray, Lynda Villagomez, Claire Hinterschied, Anuvrat Sircar, JoBeth Helmig-Mason, Alexander Prouty, Eric Brooks, Youssef Youssef, Walter Hanel, Samir Parekh, Wing Keung Chan, Zhengming Chen, Rosa Lapalombella, Lalit Sehgal, Kris Vaddi, Peggy Scherle, Selina Chen-Kiang, Maurizio Di Liberto, Olivier Elemento, Cem Meydan, Jonathan Foox, Daniel Butler, Christopher E. Mason, Robert A. Baiocchi, Lapo Alinari
Journal: Blood
Blood (2023) 142 (10): 887–902.
https://doi.org/10.1182/blood.2022019419
Published: 2023
Includes: Supplemental data
Journal Articles

Nanochip Technology for Monitoring Chemotherapy Response Using Extracellular RNAs and Proteins in Patient Plasma with Diffuse Large B-Cell Lymphoma As Biomarkers

Narendranath Epperla, Xinyu Wang, Hong Li, David A. Bond, Yazeed Sawalha, John C. Reneau, Timothy J. Voorhees, Kami J. Maddocks, Beth Christian, Walter Hanel, Lapo Alinari, Lalit Sehgal, Robert A. Baiocchi, James L. Lee
Journal: Blood
Blood (2022) 140 (Supplement 1): 11873–11875.
https://doi.org/10.1182/blood-2022-164907
Published: 2022
Journal Articles

Impact of Circulating Lymphoma at Diagnosis on Outcomes in Patients with Diffuse Large B-Cell Lymphoma

Srichandhana Rajamouli, Eric McLaughlin, Walter Hanel, David A. Bond, Yazeed Sawalha, Timothy J. Voorhees, Lapo Alinari, Lalit Sehgal, Kami J. Maddocks, Beth Christian, Daniel Jones, Narendranath Epperla
Journal: Blood
Blood (2022) 140 (Supplement 1): 6659–6660.
https://doi.org/10.1182/blood-2022-166988
Published: 2022
Journal Articles

Dysregulation of PRMT5 in Chronic Lymphocytic Leukemia Supports Transformation to Diffuse Large B-Cell Lymphoma

Ethan Whipp, Zachary A Hing, Janek S. Walker, Steven Sher, Casey B. Cempre, Fiona Brown, Claudio Agostinelli, Stefano A Pileri, Katie Williams, Larry Beaver, Alexander Pan, Charles T. Gregory, Pearlly S. Yan, Peggy Scherle, Min Wang, Kris Vaddi, Selina Chen-Kiang, Jennifer A. Woyach, James S. Blachly, Lapo Alinari, Yiping Yang, Robert A. Baiocchi, Bradley W Blaser, Rosa Lapalombella
Journal: Blood
Blood (2022) 140 (Supplement 1): 8746–8747.
https://doi.org/10.1182/blood-2022-169949
Published: 2022
Journal Articles

A Phase I Clinical Trial of Point-of-Care Manufactured Fresh Anti-CD19/20/22 Chimeric Antigen Receptor T Cells for Treatment of Relapsed or Refractory Lymphoid Malignancies (Non-Hodgkin Lymphoma, Acute Lymphoblastic Leukemia, Chronic Lymphocytic Leukemia, B Prolymphocytic Leukemia)

Sumithira Vasu, Lapo Alinari, Nicole Szuminski, Dina Schneider, Nathan Denlinger, Wing Keung Chan, Khalid Parris, Nidhi Sharma, Hillary Bradbury, Beth Daneault, Lynn O'Donnell, Boro Dropulic, Marcos J.G. de Lima
Journal: Blood
Blood (2022) 140 (Supplement 1): 7474–7475.
https://doi.org/10.1182/blood-2022-167340
Published: 2022
Journal Articles

Targeting Sumoylation with Subasumstat (TAK-981), a Selective Inhibitor of SUMO-Activating Enzyme (SAE), Induces Mitochondrial Dysfunction in Preclinical Models of Non-Hodgkin Lymphoma (NHL)

Tingting Liu, Vi Lam, Elana Thieme, Olga Danilova, Nur Bruss, Lapo Alinari, Jeffrey W. Tyner, Stephen E. Kurtz, Zheng Xia, Alexey V Danilov
Journal: Blood
Blood (2022) 140 (Supplement 1): 6016–6017.
https://doi.org/10.1182/blood-2022-159691
Published: 2022
Journal Articles

Constitutive PRMT5 Expression Drives Spontaneous Lymphoblastic Lymphoma In Vivo

Lynda Villagomez, Porsha Smith, Fengting Yan, Victor Chen, Shelby Sloan, John T. Patton, Mackenzie Long, Fiona Brown, Elshafa H. Ahmed, Natarajan Muthusamy, Vincenzo Coppola, Anjali Mishra, Kris Vaddi, Peggy Scherle, Rosa Lapalombella, Lapo Alinari, Robert A. Baiocchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 6381–6382.
https://doi.org/10.1182/blood-2022-168160
Published: 2022
Journal Articles

Acquired Resistance to PRMT5 Inhibition in Mantle Cell Lymphoma Is Associated with Compensatory Activation of Multiple Signaling Pathways

Mackenzie Long, Shirsha Koirala, Shelby Sloan, Fiona Brown, Sheetal Tallada, Claire Hinterschied, Kara Corps, JoBeth Helmig-Mason, Ji Hyun Chung, Peggy Scherle, Kris Vaddi, Cem Meydan, Jonathan Foox, Daniel Butler, Christopher E Mason, Lapo Alinari, Bradley W Blaser, Robert A. Baiocchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 3103–3104.
https://doi.org/10.1182/blood-2022-164641
Published: 2022
Journal Articles

The FOXO1 TAD -p300-Mediated Lineage Survival Transcription Program Is a Targetable Dependency of Mantle Cell Lymphoma

Ja-Young Jang, Heng Pan, Maurizio Di Liberto, Lapo Alinari, Giorgio Inghirami, Robert A. Baiocchi, Olivier Elemento, Selina Chen-Kiang, Jihye Paik
Journal: Blood
Blood (2022) 140 (Supplement 1): 1692–1693.
https://doi.org/10.1182/blood-2022-165655
Published: 2022
Journal Articles

Genome-Wide CRISPR/Cas9 Knockout Screen Reveals Novel Gilteritinib Combinations Targeting Oxidative Phosphorylation and De-Novo Purine Biosynthesis Pathways for FLT3-ITD + Acute Myeloid Leukemia

Steven Sher, Pu Zhang, Lindsey Brinton, Mehdi Gharghabi, Katie Williams, Matthew Cannon, Janek S. Walker, Daniel Canfield, Larry Beaver, Casey B. Cempre, Hannah Phillips, Xuyong Chen, Pearlly S. Yan, Amy M. Lehman, Peggy Scherle, Min Wang, Kris Vaddi, Robert A. Baiocchi, Ruoning Wang, Deepa Sampath, Lapo Alinari, James S. Blachly, Rosa Lapalombella
Journal: Blood
Blood (2022) 140 (Supplement 1): 681–682.
https://doi.org/10.1182/blood-2022-165573
Published: 2022
Journal Articles

PRMT5 Inhibition Promotes FOXO1 Tumor Suppressor Activity to Drive a Pro-Apoptotic Program That Creates Vulnerability to Combination Treatment with Venetoclax in Mantle Cell Lymphoma

Fiona Brown, Inah Hwang, Shelby Sloan, Claire Hinterschied, JoBeth Helmig-Mason, Mackenzie Long, Youssef Youssef, Wing Keung Chan, Alexander Prouty, Ji Hyun Chung, Yang Zhang, Kris Vaddi, Selina Chen-Kiang, Maurizio Di Liberto, Olivier Elemento, Lalit Sehgal, Lapo Alinari, Peggy Scherle, Rosa Lapalombella, Jihye Paik, Robert Baiocchi
Journal: Blood
Blood (2021) 138 (Supplement 1): 681.
https://doi.org/10.1182/blood-2021-153733
Published: 2021
Journal Articles

TAK-981, a First-in-Class SUMO-Activating Enzyme Inhibitor, Combined with Rituximab in Adult Patients (Pts) with CD20-Positive Relapsed/Refractory (R/R) Non-Hodgkin Lymphoma (NHL): Phase 1 Data

Sarit Assouline, Amitkumar Mehta, Tycel Phillips, Lapo Alinari, Alexey V. Danilov, Stéphane Doucet, Steven I. Park, Deborah Berg, Alejandro Gomez-Pinillos, Alonzo Martinez, Bo Chao, Allison J Berger, John Gibbs, Sharon Friedlander, Christine K. Ward, Igor Proscurshim, Brenda W. Cooper, Paolo F Caimi
Journal: Blood
Blood (2021) 138 (Supplement 1): 2488.
https://doi.org/10.1182/blood-2021-152225
Published: 2021
Journal Articles

PRMT5 Inhibition Modulates E2F1 and P53 to Restore Cell Cycle Regulation and Drive DNA Damage Response in Ibrutinib-Resistant Mantle Cell Lymphoma

Shelby Sloan, Fiona Brown, Mackenzie Long, JoBeth Helmig-Mason, Stacey Beck, Ji Hyun Chung, Walter Hanel, Eric Brooks, Haley Klimazewski, Cem Meydan, Jonathan Foox, Daniel Butler, John C. Byrd, Rosa Lapalombella, Maurizio Di Liberto, Christopher Mason, Selina Chen-Kiang, Kris Vaddi, Peggy Scherle, Robert Baiocchi, Lapo Alinari
Journal: Blood
Blood (2021) 138 (Supplement 1): 787.
https://doi.org/10.1182/blood-2021-153992
Published: 2021
Journal Articles

Outcomes of Patients with Diffuse Large B Cell and High-Grade B Cell Lymphomas with Synchronous CNS and Systemic Involvement at Diagnosis Treated with High-Dose Methotrexate and R-CHOP: A Single-Center Retrospective Study

Megan Fleming, Ying Huang, Emily Dotson, David A. Bond, John C. Reneau, Narendranath Epperla, Jonathan E. Brammer, Beth Christian, Lapo Alinari, Robert Baiocchi, Kami J. Maddocks, Yazeed Sawalha
Journal: Blood
Blood (2021) 138 (Supplement 1): 1425.
https://doi.org/10.1182/blood-2021-148662
Published: 2021
Journal Articles

A Phase 2 Trial of Ibrutinib and Nivolumab in Patients with Relapsed or Refractory Classical Hodgkin's Lymphoma

Walter Hanel, MD, Beth A. Christian, MD, Kami J. Maddocks, MD, Narendranath Epperla, MDMS, Basem M. William, MDMRCP, Samantha Jaglowski, MD MPH, David A. Bond, MD, Yazeed Sawalha, MD, John C. Reneau, MDPhD, Jonathan E Brammer, MD, Robert Baiocchi, MD PhD, Kristie A. Blum, MD, Lapo Alinari, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 29.
https://doi.org/10.1182/blood-2020-141243
Published: 2020
Journal Articles

PRMT5 Inhibition Drives Therapeutic Vulnerability to BCL-2 Inhibition with Venetoclax and Provides Rationale for Combination Therapy in Mantle Cell Lymphoma

Fiona Brown, BS, Yang Zhang, PhD, Claire Hinterschied, Alexander Prouty, BS, Shelby Sloan, BS, JoBeth Helmig-Mason, Msc, Ji Hyun Chung, PhD, Kris Vaddi, PhD, Selina Chen-Kiang, PhD, Maurizio Di Liberto, PhD, Lapo Alinari, MD PhD, Peggy Scherle, PhD, Rosa Lapalombella, PhD, Jihye Paik, PhD, Robert A Baiocchi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 302.
https://doi.org/10.1182/blood-2019-130797
Published: 2019
Journal Articles

A Phase I Study of Nivolumab and Lenalidomide in Relapsed/ Refractory B Cell Lymphoma

David A. Bond, MD, Vedat Yildiz, Lai Wei, PhD, Lapo Alinari, MD PhD, Basem M. William, MRCP,MD, Jonathan E. Brammer, MD, Beth A. Christian, MD, Kristie A. Blum, MD, Kami J. Maddocks, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4091.
https://doi.org/10.1182/blood-2019-130539
Published: 2019
Journal Articles

Targeting Hypersumoylation in Mantle Cell Lymphoma

Walter Hanel, MD PhD, Liudmyla Tsyba, PhD, Dennis Huszar, PhD, Alex Prouty, Xiaoli Zhang, PhD, JoBeth Helmig-Mason, Msc, Bethany L Mundy-Bosse, PhD, Youssef Youssef, MD, Samir Parekh, MD, Kami J. Maddocks, MD, Robert A Baiocchi, MD PhD, Lapo Alinari, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4060.
https://doi.org/10.1182/blood-2019-127363
Published: 2019
Journal Articles

Brentuximab Vedotin (BV) and Lenalidomide (Len) in Relapsed and Refractory (r/r) Cutaneous (CTCL) and Peripheral (PTCL) T-Cell Lymphomas; A Planned Interim Analysis of Phase II Trial

Basem M. William, MRCP,MD, Ying Huang, MS, MA, Amy Johnson, MD, Jonathan E Brammer, MD, John C. Reneau, MD PhD, Joseph Maakaron, MD, Ruth Larbi, Cara Grantier, CNP, MPH, MS, Corinne Hoffman, MS, CNP, Sabarish Ayyappan, MBBS, Robert A Baiocchi, MD PhD, Narendranath Epperla, MDMS, Beth A. Christian, MD, Lapo Alinari, MD PhD, Kami J. Maddocks, MD, Catherine Chung, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2853.
https://doi.org/10.1182/blood-2019-123801
Published: 2019