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Journal Articles

A randomized phase 2 trial of oral vitamin A for graft-versus-host disease in children and young adults

Clinical Trials & Observations
Pooja Khandelwal, Lucille Langenberg, Nathan Luebbering, Kelly E. Lake, Abigail Butcher, Kylie Bota, Kristie N. Ramos, Cynthia Taggart, Hannah Choe, Sumithira Vasu, Ashley Teusink-Cross, Jane Koo, Gregory Wallace, Lindsey Romick-Rosendale, Miki Watanabe-Chailland, David B. Haslam, Adam Lane, Stella M. Davies
Journal: Blood
Blood (2024) 143 (12): 1181–1192.
https://doi.org/10.1182/blood.2023022865
Published: 2024
Includes: Supplemental data
Journal Articles

A Phase 1b/2 Trial of Liposomal Cytarabine and Daunorubicin (CPX-351) in Intermediate to High-Risk Acute Myeloid Leukemia for Patients Who Have Failed an Initial Cycle of Induction Chemotherapy

Corbin Pontious, Ramiro Garzon, James S. Blachly, Bradley Wayne Blaser, Hannah Choe, Nicole R. Grieselhuber, Meixiao Long, Sumithira Vasu, Sarah A Wall, Karilyn T. Larkin, Ann-Kathrin Eisfeld, Kristin L Koenig, Kieran D Sahasrabudhe, Gabriela Sanchez-Petitto, Ayman Saad, Bhavana Bhatnagar, Justin Lyberger, Uma M. Borate, Alice Mims, Brian A. Jonas, Gregory K Behbehani
Journal: Blood
Blood (2023) 142 (Supplement 1): 5946.
https://doi.org/10.1182/blood-2023-184344
Published: 2023
Journal Articles

Results of a Phase 1 Trial Testing the Novel Combination Therapy of Venetoclax and Ruxolitinib in Relapsed/Refractory Acute Myeloid Leukemia Patients

Uma M. Borate, Yazan F. Madanat, Cristina Tognon, Shikha Mishra, Andy Kaempf, Prapti A. Patel, Stephen E. Kurtz, Kara Johnson, Sumithira Vasu, Sharyn D. Baker, Bridget A Robinson, Tania Q Vu, Christopher A. Eide, Jessica Minnier, Yiqing Zhang, Peter Clement, Sammantha Avaylon, Thomas Jacob, Rachel Cook, Arpita Gandhi, Jessica T. Leonard, Brandon Hayes-Lattin, Laura F. Newell, Richard T Maziarz, Elie Traer, Ronan T. Swords, Jeffrey W Tyner, Brian J. Druker, Jennifer N. Saultz
Journal: Blood
Blood (2023) 142 (Supplement 1): 1515.
https://doi.org/10.1182/blood-2023-191166
Published: 2023
Journal Articles

Post-Hoc Analysis of Measurable Residual Disease from BMT-CTN 1506/Morpho: FLT3-ITD Variant Allele Frequency and Survival Are Highly Correlated

Mark J. Levis, Mehdi Hamadani, Brent R. Logan, Richard J. Jones, Anurag K. Singh, Mark R. Litzow, John R. Wingard, Esperanza B. Papadopoulos, Alexander Perl, Robert J. Soiffer, Celalettin Ustun, Masumi Ueda Oshima, Geoffrey L Uy, Edmund K. Waller, Sumithira Vasu, Melhem M. Solh, Asmita Mishra, Lori S. Muffly, Hee-Je Kim, Matthias Stelljes, Yuho Najima, Masahiro Onozawa, Kirsty Thomson, Arnon Nagler, Andrew H. Wei, Guido Marcucci, Nahla Hasabou, Mathew Rosales, Jason Hill, Stanley C. Gill, Rishita Nuthethi, Denise King, Heather Wittsack, Adam Mendizabel, Steven M. Devine, Mary M. Horowitz, Yi-Bin Chen
Journal: Blood
Blood (2023) 142 (Supplement 1): 973.
https://doi.org/10.1182/blood-2023-177929
Published: 2023
Journal Articles

Predictive Score for Utilization of Second Autologous Stem Cell Transplantation in Patients with Multiple Myeloma

Arti Vaishnav, Abdullah Khan, Qiuhong Zhao, Naresh Bumma, Francesca Cottini, Elvira Umyarova, Nidhi Sharma, Yvonne Efebera, Lynn O'Donnell, Ashley E Rosko, Sumithira Vasu, Marcos de Lima, Don Benson, Srinivas Devarakonda
Journal: Blood
Blood (2023) 142 (Supplement 1): 911.
https://doi.org/10.1182/blood-2023-184904
Published: 2023
Journal Articles

Post-Allograft Romidepsin Maintenance Mitigates Relapse Risk and Stimulates the Graft-Versus-Malignancy Effect through Enhanced NK-Cell Cytotoxicity in Patients with T-Cell Malignancies: Final Results of a Phase I/II Trial

Chitra Hosing, Zachary Braunstein, Eric McLaughlin, Benigno C. Valdez, Borje S. Andersson, Uday R. Popat, Sumithira Vasu, Evandro Bezzera, Gabriela Sanchez-Petitto, Sarah A Wall, Samantha M. Jaglowski, Sam Penza, Hannah Choe, Lai Wei, Robin Nakkula, Alex Cash, Richard E. Champlin, Marcos de Lima, Steven M. Devine, Dean Anthony Lee, Jonathan E. Brammer
Journal: Blood
Blood (2023) 142 (Supplement 1): 184.
https://doi.org/10.1182/blood-2023-190213
Published: 2023
Journal Articles

Maintenance Ruxolitinib Is Associated with Low Rates of Chronic Gvhd Requiring Systemic Treatment in Older Adults with AML/MDS Undergoing Allogeneic HCT: Results of a Phase II Multicenter Trial

Zachariah Defilipp, Haesook T. Kim, Laura Knight, Suzanne O'Connor, Meghan White, Bhagirathbhai Dholaria, Mark A. Schroeder, Sumithira Vasu, Sameem Abedin, Areej El-Jawahri, Steven McAfee, Yi-Bin Chen, Gabriela S. Hobbs
Journal: Blood
Blood (2023) 142 (Supplement 1): 653.
https://doi.org/10.1182/blood-2023-180423
Published: 2023
Journal Articles

North American Blastic Plasmacytoid Dendritic Cell Neoplasm Consortium: position on standards of care and areas of need

Naveen Pemmaraju, Hagop Kantarjian, Kendra Sweet, Eunice Wang, Jayastu Senapati, Nathaniel R. Wilson, Marina Konopleva, Arthur E. Frankel, Vikas Gupta, Ruben Mesa, Matthew Ulrickson, Edward Gorak, Sumeet Bhatia, Tulin Budak-Alpdogan, James Mason, Maria Teresa Garcia-Romero, Norma Lopez-Santiago, Gabriela Cesarman-Maus, Pankit Vachhani, Sangmin Lee, Vijaya Raj Bhatt, William Blum, Roland B. Walter, Dale Bixby, Ivana Gojo, Madeleine Duvic, Raajit K. Rampal, Marcos de Lima, James Foran, Amir T. Fathi, Aric Cameron Hall, Meagan A. Jacoby, Jeffrey Lancet, Gabriel Mannis, Anthony S. Stein, Alice Mims, David Rizzieri, Rebecca Olin, Alexander Perl, Gary Schiller, Paul Shami, Richard M. Stone, Stephen Strickland, Matthew J. Wieduwilt, Naval Daver, Farhad Ravandi, Sumithira Vasu, Monica Guzman, Gail J. Roboz, Joseph Khoury, Muzaffar Qazilbash, Phyu P. Aung, Branko Cuglievan, Yazan Madanat, Mohamed A. Kharfan-Dabaja, Anna Pawlowska, Justin Taylor, Martin Tallman, Prajwal Dhakal, Andrew A. Lane
Journal: Blood
Blood (2023) 141 (6): 567–578.
https://doi.org/10.1182/blood.2022017865
Published: 2023
Journal Articles

Tagraxofusp, an Anti-CD123 Therapy, in Patients with Blastic Plasmacytoid Dendritic Cell Neoplasm and Prior or Concomitant Hematologic Malignancies: Subgroup Analysis of a Pivotal Trial

Naveen Pemmaraju, Marina Konopleva, Kendra Sweet, Anthony S. Stein, Sumithira Vasu, David A Rizzieri, Eunice S. Wang, Hagop Kantarjian, Christopher L. Brooks, Carole Paley, Tariq I. Mughal, Andrew A. Lane
Journal: Blood
Blood (2022) 140 (Supplement 1): 6155–6157.
https://doi.org/10.1182/blood-2022-159970
Published: 2022
Journal Articles

Post-Allograft Romidepsin Maintenance Mitigates Relapse Risk and Stimulates the Graft-Versus-Malignancy Effect through Enhanced NK-Cell Cytotoxicity in Patients with Aggressive T-Cell Malignancies in a Phase I/II Trial

Chitra Hosing, Eric McLaughlin, Zachary Braunstein, Benigno C Valdez, Lai Wei, Uday R Popat, Borje S Andersson, Sumithira Vasu, Karilyn T. Larkin, Samantha Jaglowski, Sam Penza, Ayman Saad, Hannah Choe, Sarah A Wall, Alex Cash, Robin Nakkula, Richard E Champlin, Marcos J.G. de Lima, Dean Anthony Lee, Jonathan E Brammer
Journal: Blood
Blood (2022) 140 (Supplement 1): 1885–1886.
https://doi.org/10.1182/blood-2022-169336
Published: 2022
Journal Articles

A Phase I Clinical Trial of Point-of-Care Manufactured Fresh Anti-CD19/20/22 Chimeric Antigen Receptor T Cells for Treatment of Relapsed or Refractory Lymphoid Malignancies (Non-Hodgkin Lymphoma, Acute Lymphoblastic Leukemia, Chronic Lymphocytic Leukemia, B Prolymphocytic Leukemia)

Sumithira Vasu, Lapo Alinari, Nicole Szuminski, Dina Schneider, Nathan Denlinger, Wing Keung Chan, Khalid Parris, Nidhi Sharma, Hillary Bradbury, Beth Daneault, Lynn O'Donnell, Boro Dropulic, Marcos J.G. de Lima
Journal: Blood
Blood (2022) 140 (Supplement 1): 7474–7475.
https://doi.org/10.1182/blood-2022-167340
Published: 2022
Journal Articles

The Multi-CDK Inhibitor Dinaciclib Shows Synergistic Activity with the BET Inhibitor PLX51107 and Reverses BET Resistance through Inhibition of Canonical Wnt Signaling in Acute Myeloid Leukemia (AML)

Alexander Marr, Soumendrakrishna Karmahapatra, Dominique Corbin, Yerdanos Asemelash, Steven Sher, Shaneice Renee Mitchell, Bonnie K Harrington, Shelley Orwick, Larry Beaver, Ronni Wasmuth, Virginia Goettl, Alice S. Mims, Karilyn T. Larkin, Sumithira Vasu, Meixiao Long, James S. Blachly, Ramiro Garzon, John C. Byrd, Rosa Lapalombella, Nicole Grieselhuber
Journal: Blood
Blood (2022) 140 (Supplement 1): 3075–3076.
https://doi.org/10.1182/blood-2022-160277
Published: 2022
Journal Articles

Impact of diagnostic genetics on remission MRD and transplantation outcomes in older patients with AML

CME Clinical Trials & Observations
H. Moses Murdock, Haesook T. Kim, Nathan Denlinger, Pankit Vachhani, Bryan Hambley, Bryan S. Manning, Shannon Gier, Christina Cho, Harrison K. Tsai, Shannon McCurdy, Vincent T. Ho, John Koreth, Robert J. Soiffer, Jerome Ritz, Martin P. Carroll, Sumithira Vasu, Miguel-Angel Perales, Eunice S. Wang, Lukasz P. Gondek, Steven Devine, Edwin P. Alyea, III, R. Coleman Lindsley, Christopher J. Gibson
Journal: Blood
Blood (2022) 139 (24): 3546–3557.
https://doi.org/10.1182/blood.2021014520
Published: 2022
Includes: Supplemental data
Journal Articles

PP2A is a therapeutically targetable driver of cell fate decisions via a c-Myc/p21 axis in human and murine acute myeloid leukemia

Swagata Goswami, Rajeswaran Mani, Jessica Nunes, Chi-Ling Chiang, Kevan Zapolnik, Eileen Hu, Frank Frissora, Xiaokui Mo, Logan A. Walker, Pearlly Yan, Ralf Bundschuh, Larry Beaver, Raymond Devine, Yo-Ting Tsai, Ann Ventura, Zhiliang Xie, Min Chen, Rosa Lapalombella, Alison Walker, Alice Mims, Karilyn Larkin, Nicole Grieselhuber, Chad Bennett, Mitch Phelps, Erin Hertlein, Gregory Behbehani, Sumithira Vasu, John C. Byrd, Natarajan Muthusamy
Journal: Blood
Blood (2022) 139 (9): 1340–1358.
https://doi.org/10.1182/blood.2020010344
Published: 2022
Includes: Supplemental data
Journal Articles

Tagraxofusp, an Anti-CD123 Therapy, in Patients with Blastic Plasmacytoid Dendritic Cell Neoplasm: Subanalyses of a Pivotal Trial By Age and Baseline Disease Involvement

Naveen Pemmaraju, Marina Konopleva, Kendra Sweet, Anthony S. Stein, Sumithira Vasu, David A. Rizzieri, Eunice S. Wang, Hagop Kantarjian, Christopher L Brooks, Tariq I. Mughal, Andrew A. Lane
Journal: Blood
Blood (2021) 138 (Supplement 1): 874.
https://doi.org/10.1182/blood-2021-145109
Published: 2021
Journal Articles

Impact of Center Experience with Donor Type and Treatment Platform on Outcomes: A Secondary Analysis BMT CTN 1101

Claudio G. Brunstein, Paul V O'Donnell, Brent R. Logan, Luciano J. Costa, Corey Cutler, Michael Craig, William J Hogan, Mary M. Horowitz, Mitchell E. Horwitz, Chatchada Karanes, John M. Magenau, Adriana Malone, John M McCarty, Joseph P. McGuirk, Lawrence E Morris, Andrew R. Rezvani, Witold Rybka, Rachel Salit, Sumithira Vasu, Mary Eapen, Ephraim J. Fuchs
Journal: Blood
Blood (2021) 138 (Supplement 1): 3956.
https://doi.org/10.1182/blood-2021-145527
Published: 2021
Journal Articles

Utilizing Organ-Sparing Marrow Irradiation to Condition Patients Prior to Allogeneic Hematopoietic Cell Transplant with High-Risk Hematologic Malignancies: Results of a Pilot Study

Sumithira Vasu, Meghan Kromer, Qiuhong Zhao, Hannah Choe, Karilyn Larkin, Sarah A Wall, Samantha Jaglowski, Sam Penza, Jonathan E Brammer, Nidhi Sharma, Naduparambil Jacob, Marcos J.G. de Lima, Meng Welliver
Journal: Blood
Blood (2021) 138 (Supplement 1): 2856.
https://doi.org/10.1182/blood-2021-150948
Published: 2021
Journal Articles

A Phase I Clinical Trial Testing the Safety of IL-21-Expanded, Universally Alloreactive Donor-Derived Natural Killer Cells for Relapsed/Refractory Acute Myeloid Leukemia and Myelodysplastic Syndrome

Sumithira Vasu, Nidhi Sharma, Alison R. Walker, Sarah A Wall, James S. Blachly, Greg K. Behbehani, Hannah Choe, Aarohi Thakkar, Robin Nakkula, Ella Troy, Nicole Szuminski, Marcos J.G. de Lima, Lynn O'Donnell, Dean Anthony Lee
Journal: Blood
Blood (2021) 138 (Supplement 1): 1732.
https://doi.org/10.1182/blood-2021-150750
Published: 2021
Journal Articles

Phase 1/2 Study of Nexi-001 Donor-Derived Multi-Antigen Specific CD8+ T Cells for the Treatment of Relapsed Acute Myeloid Leukemia (AML) after Allogeneic Hematopoietic Transplantation

Monzr M. Al Malki, Sumithira Vasu, Dipenkumar Modi, Miguel-Angel Perales, Lucy Y Ghoda, Donna Bui, Vineetha Edavana, Emily Lu, Sojung Kim, Lauren Suarez, Mathias Oelke, Daniel Bednarik, Robert D Knight, Juan C. Varela
Journal: Blood
Blood (2021) 138 (Supplement 1): 4819.
https://doi.org/10.1182/blood-2021-152419
Published: 2021
Journal Articles

Effect of High Intensity Chemotherapy Vs Targeted Therapy on Survival in AML Patients Aged 60-75

Kieran D Sahasrabudhe, Melanie T Rebechi, Ying Huang, Greg K. Behbehani, Bhavana Bhatnagar, James S. Blachly, Bradley W Blaser, Uma Borate, Ramiro Garzon, Tamanna Haque, Karilyn Larkin, Meixiao Long, Alice S. Mims, Ayman Saad, Sumithira Vasu, Alison R. Walker, Sarah A Wall
Journal: Blood
Blood (2021) 138 (Supplement 1): 4125.
https://doi.org/10.1182/blood-2021-148676
Published: 2021