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Zachariah DeFilipp
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Journal Articles

Vitamin A keeps the GVHD away?

Zachariah DeFilipp
Journal: Blood
Blood (2024) 143 (12): 1067.
https://doi.org/10.1182/blood.2024023828
Published: 2024
Journal Articles

Spatial transcriptomics reveals distinct tissue niches linked with steroid responsiveness in acute gastrointestinal GVHD

Bidish K. Patel, Michael J. Raabe, Evan R. Lang, Yuhui Song, Chenyue Lu, Vikram Deshpande, Linda T. Nieman, Martin J. Aryee, Yi-Bin Chen, David T. Ting, Zachariah DeFilipp
Journal: Blood
Blood (2023) 142 (21): 1831–1844.
https://doi.org/10.1182/blood.2023020644
Published: 2023
Includes: Supplemental data
Journal Articles

The MAGIC Algorithm Probability Predicts Long-Term Outcomes and Treatment Response to Second-Line Therapy for Acute Gvhd

Zachariah Defilipp, Haesook T. Kim, Nikolaos Spyrou, Steven Kowalyk, Gilbert Eng, Rahnuma Beheshti, Janna Baez, Francis A. Ayuk, Hannah Choe, Aaron Etra, Stephan Grupp, Elizabeth O Hexner, William J. Hogan, Carrie L. Kitko, Muna Qayed, Ran Reshef, Ingrid Vasova, Robert Zeiser, Rachel Young, James L.M. Ferrara, Ryotaro Nakamura, John Levine, Yi-Bin Chen
Journal: Blood
Blood (2023) 142 (Supplement 1): 3576.
https://doi.org/10.1182/blood-2023-182300
Published: 2023
Journal Articles

Prediction of Graft-Versus-Host Disease (GVHD) in Recipients of Hematopoietic Cell Transplant(alloHCT) from a Single Mismatched Unrelated Donor Using a Highly Multiplexed Proteomics Assay: MHC-Pepseq

Karamjeet S. Sandhu, John Altin, Tao Wang, Jakob Devos, Medhat Askar, Zachariah DeFilipp, Ketevan Gendzekhadze, Carrie L. Kitko, Stephanie J. Lee, Margaret L. MacMillan, Stephen R. Spellman, Ryotaro Nakamura
Journal: Blood
Blood (2023) 142 (Supplement 1): 4930.
https://doi.org/10.1182/blood-2023-186724
Published: 2023
Journal Articles

Preliminary Safety Results of the Open-Label Phase of a 2-Part Phase 1b Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of an Investigational Microbiome Therapeutic, SER-155, in Adults Undergoing Hematopoietic Cell Transplantation

Doris M. Ponce, Satyajit Kosuri, Nandita Khera, Zachariah Defilipp, David I Lichter, Jonathan U Peled, Marcel R.M. van den Brink, Kelly Brady, Matthew D Puhl, Gabrielle Glick, Brooke Hasson, Barbara H McGovern, Lisa von Moltke, Bina Tejura
Journal: Blood
Blood (2023) 142 (Supplement 1): 6994.
https://doi.org/10.1182/blood-2023-180119
Published: 2023
Journal Articles

Impact of Investigational Microbiome Therapeutic SER-155 on Pathogen Domination: Initial Results from a Phase 1b Study in Adults Undergoing Allogeneic Hematopoietic Cell Transplantation (HCT)

Jonathan U. Peled, Marcel R.M. van den Brink, Doris M. Ponce, Satyajit Kosuri, Nandita Khera, Zachariah DeFilipp, Bina Tejura, David I Lichter, Mary-Jane Lombardo, Meghan Chafee, Jennifer R Wortman, Timothy Straub, Emily Walsh, Augustus Ge, David Lyttle, Brooke Hasson, Christopher Ford, Lisa von Moltke, Matthew Henn
Journal: Blood
Blood (2023) 142 (Supplement 1): 2198.
https://doi.org/10.1182/blood-2023-188885
Published: 2023
Journal Articles

Safety and Efficacy of Axatilimab at 3 Different Doses in Patients with Chronic Graft-Versus-Host Disease (AGAVE-201)

Daniel Wolff, Corey Cutler, Stephanie J. Lee, Iskra Pusic, Henrique Bittencourt, Jennifer White, Mehdi Hamadani, Sally Arai, Amandeep Salhotra, Jose A. Pérez-Simón, Amin Alousi, Hannah Choe, Mi Kwon, Arancha Bermúdez, Inho Kim, Gerard Socié, Vedran Radojcic, Timothy O'Toole, Chuan Tian, Peter Ordentlich, Zachariah DeFilipp, Carrie L. Kitko
Journal: Blood
Blood (2023) 142 (Supplement 1): 1.
https://doi.org/10.1182/blood-2023-186963
Published: 2023
Journal Articles

A Phase II Multicenter Trial of Ruxolitinib to Treat Bronchiolitis Obliterans Syndrome after Allogeneic Hematopoietic Cell Transplantation

Zachariah Defilipp, Haesook T. Kim, Guang-Shing Cheng, Saurabh Chhabra, Mehdi Hamadani, Karamjeet S. Sandhu, Betty K. Hamilton, Lia Perez, Catherine J. Lee, Timothy L Brennan, Cassandra Garrelts, Bergin M Brown, Kathleen Gallagher, Areej El-Jawahri, Yi-Bin Chen
Journal: Blood
Blood (2023) 142 (Supplement 1): 775.
https://doi.org/10.1182/blood-2023-179365
Published: 2023
Journal Articles

Multi-Site Randomized Trial of Inpatient Palliative Care for Hospitalized Patients Undergoing Hematopoietic Stem Cell Transplantation

Areej El-Jawahri, Thomas W LeBlanc, Alison Kavanaugh, Jason Webb, James Fausto, Lara Traeger, Joseph Greer, Vicki Jackson, Nora Horick, Zachariah Defilipp, Yi-Bin Chen, Stephanie J. Lee, Jennifer Temel
Journal: Blood
Blood (2023) 142 (Supplement 1): 913.
https://doi.org/10.1182/blood-2023-185735
Published: 2023
Journal Articles

A Day 14 Endpoint for Acute Gvhd Clinical Trials

Nikolaos Spyrou, Yu Akahoshi, Steven Kowalyk, George Morales, Rahnuma Beheshti, Paibel Aguayo-Hiraldo, MHD Monzr Al Malki, Francis Ayuketang Ayuk, Peter Bader, Janna Baez, Alexandra Capellini, Hannah Choe, Zachariah Defilipp, Matthias Eder, Gilbert Eng, Aaron Etra, Sigrun Gleich, Stephan Grupp, Elizabeth Hexner, Matthias Hoepting, William J. Hogan, Stelios Kasikis, Nikolaos Katsivelos, Carrie L. Kitko, Sabrina Kraus, Deukwoo Kwon, Pietro Merli, Joseph Portelli, Muna Qayed, Ran Reshef, Tal Schechter-Finkelstein, Ingrid Vasova, Matthias Woelfl, Kitsada Wudhikarn, Rachel Young, Ernst Holler, Yi-Bin Chen, Ryotaro Nakamura, John Levine, James L.M. Ferrara
Journal: Blood
Blood (2023) 142 (Supplement 1): 779.
https://doi.org/10.1182/blood-2023-172955
Published: 2023
Journal Articles

Effective Prevention of Steroid-Requiring Chronic Graft-Vs.-Host Disease with B Cell Depletion: A Randomized, Placebo-Controlled Trial

Corey Cutler, Haesook T. Kim, Hassan El Banna, Elizabeth Halloran, Emily Matozel, Vincent Ho, John Koreth, Mahasweta Gooptu, Roman M. Shapiro, Amar H Kelkar, Christopher James Gibson, Carol Reynolds, Michela Ansuinelli, Rayuko Tamada, Chloe Au, Zachariah Defilipp, Areej El-Jawahri, Yi-Bin Chen, Najla H El Jurdi, Daniel Weisdorf, Daniel R. Couriel, Catherine J. Lee, Bita Sahaf, Juliana Craig, Kathleen Ji, Robert J. Soiffer, David B. Miklos, Joseph Antin, Jerome Ritz
Journal: Blood
Blood (2023) 142 (Supplement 1): 649.
https://doi.org/10.1182/blood-2023-180142
Published: 2023
Journal Articles

Multimodal Mobile Application to Address Sexual Dysfunction in Hematopoietic Stem Cell Transplant (HCT) Survivors

Areej El-Jawahri, Jennifer Reese, Lara Traeger, Don Dizon, Sharon Bober, Julie Vanderklish, Richard Newcomb, Zachariah Defilipp, Yi-Bin Chen, Jennifer Temel
Journal: Blood
Blood (2023) 142 (Supplement 1): 5142.
https://doi.org/10.1182/blood-2023-185776
Published: 2023
Journal Articles

Maintenance Ruxolitinib Is Associated with Low Rates of Chronic Gvhd Requiring Systemic Treatment in Older Adults with AML/MDS Undergoing Allogeneic HCT: Results of a Phase II Multicenter Trial

Zachariah Defilipp, Haesook T. Kim, Laura Knight, Suzanne O'Connor, Meghan White, Bhagirathbhai Dholaria, Mark A. Schroeder, Sumithira Vasu, Sameem Abedin, Areej El-Jawahri, Steven McAfee, Yi-Bin Chen, Gabriela S. Hobbs
Journal: Blood
Blood (2023) 142 (Supplement 1): 653.
https://doi.org/10.1182/blood-2023-180423
Published: 2023
Journal Articles

Updated Findings of a Phase II Study of Ruxolitinib Pre-, during- and Post-Hematopoietic Stem Cell Transplantation for Patients with Primary or Secondary Myelofibrosis

Gabriela S. Hobbs, Haesook T. Kim, Suzanne O'Connor, Mark A. Schroeder, Roni Tamari, Sarah A Wall, Areej El-Jawahri, Steven McAfee, Jessica Hem, Patricia Lozano, Jonas S. Jutzi, Ann Mullally, Yi-Bin Chen, Zachariah Defilipp
Journal: Blood
Blood (2023) 142 (Supplement 1): 2103.
https://doi.org/10.1182/blood-2023-178645
Published: 2023
Journal Articles

A phase 2 study of pembrolizumab after autologous stem cell transplantation in patients with T-cell non-Hodgkin lymphoma

Clinical Trials & Observations
Mwanasha H. Merrill, Parastoo B. Dahi, Robert A. Redd, Mikaela M. McDonough, Yi-Bin Chen, Zachariah DeFilipp, Alex F. Herrera, David C. Fisher, Ann S. LaCasce, Oreofe O. Odejide, Samuel Y. Ng, Caron A. Jacobson, Reid W. Merryman, Austin I. Kim, Yago L. Nieto, Craig S. Sauter, Gunjan L. Shah, Jasmine M. Zain, Philippe Armand, Eric D. Jacobsen
Journal: Blood
Blood (2023) 142 (7): 621–628.
https://doi.org/10.1182/blood.2023020244
Published: 2023
Journal Articles

Effective treatment of low-risk acute GVHD with itacitinib monotherapy

Clinical Trials & Observations
Aaron Etra, Alexandra Capellini, Amin Alousi, Monzr M. Al Malki, Hannah Choe, Zachariah DeFilipp, William J. Hogan, Carrie L. Kitko, Francis Ayuk, Janna Baez, Isha Gandhi, Stelios Kasikis, Sigrun Gleich, Elizabeth Hexner, Matthias Hoepting, Urvi Kapoor, Steven Kowalyk, Deukwoo Kwon, Amelia Langston, Marco Mielcarek, George Morales, Umut Özbek, Muna Qayed, Ran Reshef, Wolf Rösler, Nikolaos Spyrou, Rachel Young, Yi-Bin Chen, James L. M. Ferrara, John E. Levine
Journal: Blood
Blood (2023) 141 (5): 481–489.
https://doi.org/10.1182/blood.2022017442
Published: 2023
Includes: Supplemental data
Journal Articles

How I treat with maintenance therapy after allogeneic HCT

Zachariah DeFilipp, Yi-Bin Chen
Journal: Blood
Blood (2023) 141 (1): 39–48.
https://doi.org/10.1182/blood.2021012412
Published: 2023
Journal Articles

Effective Treatment of Low Risk Acute Gvhd with Itacitinib Monotherapy

Alexandra Capellini, Aaron Etra, Amin M Alousi, Monzr M. Al Malki, Hannah Choe, Zachariah Defilipp, William J. Hogan, Carrie Lynn Kitko, Francis A. Ayuk, Janna Baez, Isha Gandhi, Stelios Kasikis, Sigrun Gleich, Elizabeth O. Hexner, Matthias Hoepting, Urvi Kapoor, Steven Kowalyk, Deukwoo Kwon, Amelia Langston, Marco Mielcarek, George Morales, Umut Ozbek, Muna Qayed, Ran Reshef, Wolf Roesler, Nikolaos Spyrou, Rachel Young, Yi-Bin Chen, James L.M. Ferrara, John E. Levine
Journal: Blood
Blood (2022) 140 (Supplement 1): 1867–1869.
https://doi.org/10.1182/blood-2022-156000
Published: 2022
Journal Articles

Spatial Transcriptomics of Tissue-Based Immune Response to Acute Graft-Versus-Host Disease of the Lower Gastrointestinal Tract

Bidesh Kumar Patel, Michael J Raabe, Vikram Deshpande, David T Ting, Yi-Bin Chen, Zachariah Defilipp
Journal: Blood
Blood (2022) 140 (Supplement 1): 1385–1386.
https://doi.org/10.1182/blood-2022-162847
Published: 2022
Journal Articles

A Phase 1b Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of an Investigational Microbiome Therapeutic, SER-155, in Adults Undergoing Hematopoietic Stem Cell Transplantation

Doris M Ponce, Jonathan U Peled, Bindu Tejura, Christopher Ford, Marcel R M van den Brink, Mary Jane Lombardo, Satyajit Kosuri, Nandita Khera, Zachariah Defilipp, Lisa von Moltke
Journal: Blood
Blood (2022) 140 (Supplement 1): 10532–10533.
https://doi.org/10.1182/blood-2022-162386
Published: 2022