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Journal Articles

A phase 1 clinical trial of NKTR-255 with CD19-22 CAR T-cell therapy for refractory B-cell acute lymphoblastic leukemia

Clinical Trials & Observations
Hrishikesh Srinagesh, Clayton Jackson, Parveen Shiraz, Nikeshan Jeyakumar, Mark Hamilton, Emily Egeler, Sharon Mavroukakis, Adam Kuo, Juancarlos Cancilla, Bita Sahaf, Neha Agarwal, Alyssa Kanegai, Anne Marijn Kramer, Sally Arai, Sushma Bharadwaj, Saurabh Dahiya, Hitomi Hosoya, Laura Johnston, Vanessa Kennedy, Michaela Liedtke, Robert Lowsky, Lekha Mikkilineni, Robert Negrin, Andrew Rezvani, Surbhi Sidana, Judith Shizuru, Melody Smith, Wen-Kai Weng, Steven Feldman, Matthew J. Frank, Zachary Lee, Mary Tagliaferri, A. Mario Marcondes, David Miklos, Crystal Mackall, Lori Muffly
Journal: Blood
Blood (2024) 144 (16): 1689–1698.
https://doi.org/10.1182/blood.2024024952
Published: 2024
Includes: Supplemental data
Journal Articles

CAR19 Therapy Drives Expansion of Clonal Hematopoiesis and Associated Cytopenias

Mark P. Hamilton, Brian J. Sworder, Stefan K. Alig, Zinaida Good, Jan Boegeholz, Joseph Schroers-Martin, John Tamaresis, Mohammad Shahrokh Esfahani, Ying Lu, Mari Olsen, Chih Long Liu, Zachary Ehlinger, Moksha Desai, Felicia Liu-Fei, Lori S. Muffly, Robert S. Negrin, Sally Arai, Laura Johnston, Robert Lowsky, Everett H. Meyer, Andrew R. Rezvani, Judith Shizuru, Wen-Kai Weng, Parveen Shiraz, Surbhi Sidana, Sushma Bharadwaj, Melody Smith, Saurabh Dahiya, Bita Sahaf, Maximilian Diehn, Matthew J. Frank, Crystal L. Mackall, David M. Kurtz, David B. Miklos, Ash A. Alizadeh
Journal: Blood
Blood (2023) 142 (Supplement 1): 360.
https://doi.org/10.1182/blood-2023-182522
Published: 2023
Journal Articles

Impact of Obesity on Efficacy, Safety, and Expansion Kinetics of Chimeric Antigen Receptor-T (CAR T) Therapy in Patients with Relapsed or Refractory Large B Cell Lymphoma (LBCL)

Anmol Goyal, Sushma Bharadwaj, Dasom Lee, Eric Lau, Mark P. Hamilton, Alexandria Jensen, Bita Sahaf, Shriya Syal, Sunita Patil, Juancarlos E Cancilla, Theresa Latchford, Wen-Kai Weng, Melody Smith, Matthew J. Frank, David B. Miklos, Saurabh Dahiya
Journal: Blood
Blood (2023) 142 (Supplement 1): 3783.
https://doi.org/10.1182/blood-2023-186828
Published: 2023
Journal Articles

Transcriptional Profiling Associated with CD22 CAR T Cell Clinical Response in LBCL

Anne Marijn Kramer, Mark P. Hamilton, Snehit Prabhu, Moksha Desai, Adam Kuo, Zachary Ehlinger, Neha Agarwal, Yi-Jiun Su, Nikolaos Gkitsas, Carley Fowler, Vimal Keerthi, Aidan Retherford, Dorota Klysz, Ramya Tunuguntla, Steven Feldman, Bita Sahaf, John H. Baird, Lori S. Muffly, Crystal L. Mackall, David B. Miklos, Zinaida Good, Matthew J. Frank
Journal: Blood
Blood (2023) 142 (Supplement 1): 2091.
https://doi.org/10.1182/blood-2023-187615
Published: 2023
Journal Articles

Manufacturing of a Subsequent Autologous CAR-T Product after Prior CAR-T Is Safe and Feasible

Yi-Jiun Su, Anne Marijn Kramer, Mark P. Hamilton, Neha Agarwal, Steven Feldman, Bita Sahaf, Adam Kuo, Crystal L. Mackall, Lori S. Muffly, David B. Miklos, Matthew J. Frank
Journal: Blood
Blood (2023) 142 (Supplement 1): 1037.
https://doi.org/10.1182/blood-2023-185413
Published: 2023
Journal Articles

CD22 CAR T Cell-Related IEC-HS Is Associated with an IFN-γ Cytokine Signature

Hrishikesh Srinagesh, John H. Baird, Neha Agarwal, Yi-Jiun Su, Anne Marijn Kramer, Agnes Reschke, Nikeshan Jeyakumar, Sushma Bharadwaj, Liora Michal Schultz, Sneha Ramakrishna, Kara L. Davis, Bita Sahaf, Steven Feldman, Crystal L. Mackall, David B. Miklos, Lori S. Muffly, Matthew J. Frank
Journal: Blood
Blood (2023) 142 (Supplement 1): 4839.
https://doi.org/10.1182/blood-2023-178283
Published: 2023
Journal Articles

Effective Prevention of Steroid-Requiring Chronic Graft-Vs.-Host Disease with B Cell Depletion: A Randomized, Placebo-Controlled Trial

Corey Cutler, Haesook T. Kim, Hassan El Banna, Elizabeth Halloran, Emily Matozel, Vincent Ho, John Koreth, Mahasweta Gooptu, Roman M. Shapiro, Amar H Kelkar, Christopher James Gibson, Carol Reynolds, Michela Ansuinelli, Rayuko Tamada, Chloe Au, Zachariah Defilipp, Areej El-Jawahri, Yi-Bin Chen, Najla H El Jurdi, Daniel Weisdorf, Daniel R. Couriel, Catherine J. Lee, Bita Sahaf, Juliana Craig, Kathleen Ji, Robert J. Soiffer, David B. Miklos, Joseph Antin, Jerome Ritz
Journal: Blood
Blood (2023) 142 (Supplement 1): 649.
https://doi.org/10.1182/blood-2023-180142
Published: 2023
Journal Articles

Analysis of PET-CT Derived Radiomic Biomarkers with Efficacy, Safety, and Expansion of Axicabtagene Ciloleucel (Axi-Cel) in Patients with Relapsed or Refractory Large B-Cell Lymphoma (LBCL)

Sushma Bharadwaj, Eric Lau, Ayesha Hashmi, Mark P. Hamilton, Alexandria Jensen, Anmol Goyal, Mallika Marar, Caroline Lee, Snegha Ananth, Bita Sahaf, Jayasindhu Mallampet, Zachary Ehlinger, Shriya Syal, Sunita Patil, Henry Guo, Melody Smith, Wen-Kai Weng, Matthew J. Frank, Michael S. Binkley, David B. Miklos, Saurabh Dahiya
Journal: Blood
Blood (2023) 142 (Supplement 1): 2125.
https://doi.org/10.1182/blood-2023-187617
Published: 2023
Journal Articles

Long-Term Efficacy and Immune Reconstitution with Bendamustine As a Lymphodepleting Agent for Axicabtagene Ciloleucel (Axi-Cel) in Patients with Refractory or Relapsed Large B-Cell Lymphoma (LBCL)

Sushma Bharadwaj, Eric Lau, Anmol Goyal, Mark P. Hamilton, Hrishikesh Srinagesh, Alexandria Jensen, Shriya Syal, Jayasindhu Mallampet, Theresa Latchford, Bita Sahaf, Wen-Kai Weng, Melody Smith, Holden T Maecker, Matthew J. Frank, David B. Miklos, Saurabh Dahiya
Journal: Blood
Blood (2023) 142 (Supplement 1): 4878.
https://doi.org/10.1182/blood-2023-188166
Published: 2023
Journal Articles

CD22 CAR T Cells Demonstrate Favorable Safety Profile and High Response Rates in Pediatric and Adult B-ALL: Results of a Phase 1b Study

Nikeshan Jeyakumar, Sneha Ramakrishna, Matthew J Frank, Bita Sahaf, Steven A. Feldman, David B. Miklos, Crystal L. Mackall, Kara L. Davis, Lori Muffly, Liora M. Schultz
Journal: Blood
Blood (2022) 140 (Supplement 1): 2374–2375.
https://doi.org/10.1182/blood-2022-164456
Published: 2022
Journal Articles

Long-Term Follow-up of CD19/22 CAR Therapy in Children and Young Adults with B-ALL Reveals Efficacy, Tolerability and High Survival Rates When Coupled with Hematopoietic Stem Cell Transplantation

Liora M. Schultz, Sneha Ramakrishna, Reema Baskar, Rebecca M Richards, Jennifer Moon, Christina Baggott, Michelle Fujimoto, Michael Kunicki, Amy Li, Sneha Jariwala, Courtney Erickson, Ashley Jacobs, Karen Yamabe, Valentin Barsan, Robbie G. Majzner, Emily L. Egeler, Sharon Mavroukakis, Zachary Ehlinger, Warren D. Reynolds, Bita Sahaf, Lori Muffly, Matthew J Frank, Anne-Louise Gramstrup, Harshini Chinnasamy, Shabnum Patel, David B. Miklos, Steven A. Feldman, Crystal L. Mackall, Kara L. Davis
Journal: Blood
Blood (2022) 140 (Supplement 1): 10300–10302.
https://doi.org/10.1182/blood-2022-167789
Published: 2022
Journal Articles

Higher Rates of Severe Infection and Persistent Cytopenias in Long-Term CAR19 Responders Than after Autologous HCT: A Single Institution Study of 139 Subjects

Mark P Hamilton, Felicia C Liu-Fei, Stefan K. Alig, John Tamaresis, Mohammad Shahrokh Esfahani, Zinaida Good, Brian Sworder, Joseph Schroers-Martin, Chih Long Liu, Freja Tang Severinsen, Paul J Hanson, Ying Lu, Robert Lowsky, Robert S. Negrin, Everett H Meyer, Melody Smith, Sushma Bharadwaj, Judith A Shizuru, Surbhi Sidana, Parveen Shiraz, Andrew R. Rezvani, Laura J. Johnston, Wen-Kai Weng, Sally Arai, Lori Muffly, Saurabh Dahiya, Maximilian Diehn, David M. Kurtz, Bita Sahaf, Crystal L. Mackall, Matthew J Frank, David B. Miklos, Ash A. Alizadeh
Journal: Blood
Blood (2022) 140 (Supplement 1): 7545–7547.
https://doi.org/10.1182/blood-2022-165600
Published: 2022
Journal Articles

Determinants of Resistance to Engineered T-Cell Therapies Targeting CD19 in Large B-Cell Lymphomas

Brian Sworder, David M. Kurtz, Stefan K. Alig, Matthew J Frank, Navika D. Shukla, Andrea Garofalo, Charles Macaulay, Mohammad Shahrokh Esfahani, Mari Olsen, James Hamilton, III, Hitomi Hosoya, Mark P Hamilton, Jay Y. Spiegel, John H. Baird, Mia Carleton, Alexander F.M. Craig, Sheren F. Younes, Bita Sahaf, Natasha Sheybani, Joseph Schroers-Martin, Chih Long Liu, Jean S Oak, Michael C. Jin, Sara Beygi, Andreas Hüttmann, Christine Hanoun, Ulrich Dührsen, Jason Westin, Michael S. Khodadoust, Yasodha Natkunam, Robbie G. Majzner, Crystal L. Mackall, Maximilian Diehn, David B. Miklos, Ash A. Alizadeh
Journal: Blood
Blood (2022) 140 (Supplement 1): 1301–1303.
https://doi.org/10.1182/blood-2022-165545
Published: 2022
Journal Articles

Analysis of Bendamustine Lymphodepletion, CD19 CART Expansion, Safety and Efficacy in Patients with Rel/Ref Non-Hodgkin Lymphoma

Sushma Bharadwaj, Mark P Hamilton, Bita Sahaf, John Tamaresis, Sunita Patil, Paul J Hanson, Theresa Latchford, Sally Arai, Laura J. Johnston, Robert Lowsky, Robert S. Negrin, Andrew R. Rezvani, Judith A Shizuru, Everett H Meyer, Parveen Shiraz, Surbhi Sidana, Melody Smith, Wen-Kai Weng, Lori Muffly, Crystal L. Mackall, Matthew J Frank, David B. Miklos, Saurabh Dahiya
Journal: Blood
Blood (2022) 140 (Supplement 1): 10371–10373.
https://doi.org/10.1182/blood-2022-170759
Published: 2022
Journal Articles

CD22-CAR T-Cell Therapy Mediates High Durable Remission Rates in Adults with Large B-Cell Lymphoma Who Have Relapsed after CD19-CAR T-Cell Therapy

Matthew J. Frank, John H. Baird, Shabnum Patel, Juliana Craig, Jay Y. Spiegel, Zachary Ehlinger, Harshini Chinnasamy, Sheren F. Younes, Jean S. Oak, Yasodha Natkunam, Warren D. Reynolds, Maria Iglesias, Emma Crawford, Hrishikesh K. Srinagesh, Emily L. Egeler, Sally Arai, Laura J. Johnston, Robert Lowsky, Robert S. Negrin, Andrew R. Rezvani, Parveen Shiraz, Surbhi Sidana, Wen-Kai Weng, Liora M. Schultz, Sneha Ramakrishna, Kara L. Davis, Bita Sahaf, Steven A. Feldman, Crystal L. Mackall, David B. Miklos, Lori Muffly
Journal: Blood
Blood (2021) 138 (Supplement 1): 741.
https://doi.org/10.1182/blood-2021-152145
Published: 2021
Journal Articles

Ikaros Mediates Antigen Escape Following CD19 CAR T Cell Therapy in r/r B-ALL

Pablo Domizi, Jolanda Sarno, Astraea Jager, Reema Baskar, Warren D. Reynolds, Bita Sahaf, Sean Bendall, Charles G. Mullighan, Allison Barz Leahy, Regina M. Myers, Stephan A. Grupp, Elena Sotillo, David Barrett, Kara L. Davis
Journal: Blood
Blood (2021) 138 (Supplement 1): 613.
https://doi.org/10.1182/blood-2021-151002
Published: 2021
Journal Articles

CD22-directed CAR T-cell therapy induces complete remissions in CD19-directed CAR–refractory large B-cell lymphoma

Clinical Trials & Observations Brief Report
John H. Baird, Matthew J. Frank, Juliana Craig, Shabnum Patel, Jay Y. Spiegel, Bita Sahaf, Jean S. Oak, Sheren F. Younes, Michael G. Ozawa, Eric Yang, Yasodha Natkunam, John Tamaresis, Zachary Ehlinger, Warren D. Reynolds, Sally Arai, Laura Johnston, Robert Lowsky, Everett Meyer, Robert S. Negrin, Andrew R. Rezvani, Parveen Shiraz, Surbhi Sidana, Wen-Kai Weng, Kara L. Davis, Sneha Ramakrishna, Liora Schultz, Chelsea Mullins, Allison Jacob, Ilan Kirsch, Steven A. Feldman, Crystal L. Mackall, David B. Miklos, Lori Muffly
Journal: Blood
Blood (2021) 137 (17): 2321–2325.
https://doi.org/10.1182/blood.2020009432
Published: 2021
Includes: Supplemental data
Journal Articles

CD22-Directed CAR T-Cell Therapy Mediates Durable Complete Responses in Adults with Relapsed or Refractory Large B-Cell Lymphoma after Failure of CD19-Directed CAR T-Cell Therapy and High Response Rates in Adults with Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia

John H. Baird, MD, Matthew J. Frank, MD PhD, Juliana Craig, BA, Shabnum Patel, PhD, Jay Y. Spiegel, MDFRCPC, Bita Sahaf, PhD, Sheren F. Younes, MD PhD, Jean S. Oak, MD PhD, Yasodha Natkunam, MD PhD, Zachary Ehlinger, MS, Warren D. Reynolds, BS, Sally Arai, MD MS, Laura J. Johnston, MD, Robert Lowsky, MD FRCP, Robert S. Negrin, MD, Andrew R. Rezvani, MD, Parveen Shiraz, MD, Surbhi Sidana, MD, Wen-Kai Weng, MD PhD, Liora M. Schultz, MD, Sneha Ramakrishna, MD, Kara L Davis, DO, Steven A. Feldman, PhD, Crystal L. Mackall, MD, David B. Miklos, MD PhD, Lori S. Muffly, MD MS
Journal: Blood
Blood (2020) 136 (Supplement 1): 28–29.
https://doi.org/10.1182/blood-2020-139087
Published: 2020
Journal Articles

Molecular Imaging of Chimeric Antigen Receptor T Cells By ICOS-Immunopet

Federico Simonetta, MD PhD, Israt S. Alam, PhD, Juliane K. Lohmeyer, MD, Bita Sahaf, PhD, Zinaida Good, PhD, Weiyu Chen, PhD, Zunyu Xiao, MD PhD, Toshihito Hirai, MD PhD, Lukas Scheller, MD, Pujan Engels, M.Sc., Ophir Vermesh, MD PhD, Elise Robinson, Tom Haywood, PhD, Ataya Sathirachindra, Jeanette Baker, Meena B. Malipatlolla, Liora M. Schultz, MD, Jay Y. Spiegel, MDFRCPC, Jason T. Lee, PhD, David B. Miklos, MD PhD, Crystal L. Mackall, MD, Sanjiv S. Gambhir, MD PhD, Robert S. Negrin, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 5–6.
https://doi.org/10.1182/blood-2020-136331
Published: 2020
Journal Articles

Circulating DNA for Molecular Response Prediction, Characterization of Resistance Mechanisms and Quantification of CAR T-Cells during Axicabtagene Ciloleucel Therapy

Brian Sworder, MD PhD, David M. Kurtz, MD PhD, Charles Macaulay, MSc, BA, Matthew J. Frank, MD PhD, Stefan Alig, MD, Andrea Garofalo, BS, BA, Bita Sahaf, PhD, Mohammad Shahrokh Esfahani, Jay Y. Spiegel, MDFRCPC, Jean Oak, MD PhD, Sara Beygi, MD, Michael C. Jin, BS, Jacob J Chabon, Michael S. Khodadoust, MD PhD, Robbie G. Majzner, MD, Crystal L. Mackall, MD, Maximilian Diehn, MD PhD, David B Miklos, MD PhD, Ash A. Alizadeh, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 550.
https://doi.org/10.1182/blood-2019-129015
Published: 2019