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Robert Negrin
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Journal Articles

Post-transplant cyclophosphamide vs tacrolimus/methotrexate: Improved GRFS, reduced NRM, and less severe GVHD in myeloablative HLA-matched allogeneic transplantation

Free
Alfonso Molina, Quenton Bubb, Ryan Yee, Sally Arai, Sushma Bharadwaj, Saurabh Dahiya, Hany Elmariah, Matthew Frank, Hitomi Hosoya, Laura Johnston, Everett Meyer, Lekha Mikkilineni, Robert Lowsky, Robert Negrin, Andrew Rezvani, Judith Shizuru, Surbhi Sidana, Melody Smith, Wen-Kai Weng, David Miklos, Lori Muffly, Vanessa Kennedy
Journal: Blood
Blood (2025) 146 (Supplement 1): 2494.
https://doi.org/10.1182/blood-2025-2494
Published: 2025
Journal Articles

Superior efficacy and persistence of Orca-T-allogeneic CAR19/22 versus autologous CAR19/22 in high-risk adult B-ALL

Free
Alfonso Molina, Parveen Shiraz, Alyssa Kanegai, Ayesha Fraser, Diana Kordek, Caroline Wagner, Hrishikesh Srinagesh, Lindsay Danley, Arvind Ramakrishnan, Hossein Daghagh, Ying-Wen Huang, Gaurav Dhapola, Aman Siddiqui, Sally Arai, Sushma Bharadwaj, Saurabh Dahiya, Hany Elmariah, Matthew Frank, Hitomi Hosoya, Vanessa Kennedy, Laura Johnston, Everett Meyer, Lekha Mikkilineni, Robert Lowsky, Robert Negrin, Andrew Rezvani, Judith Shizuru, Surbhi Sidana, Wen-Kai Weng, Catherine McIntyre, Steven Feldman, Bita Sahaf, Crystal Mackall, David Miklos, Lori Muffly, Melody Smith
Journal: Blood
Blood (2025) 146 (Supplement 1): 514.
https://doi.org/10.1182/blood-2025-514
Published: 2025
Journal Articles

FOXP3 and helios expressing CD4+ T conventional cells are a regulatory-like subset that is induced after orca-T allogeneic immunotherapy

Free
Cameron Bader, Scott Killian, Bettina Iliopoulou, Pin-I Chen, Shiva Pathak, Xuhuai Ji, Nate Fernhoff, Kent Jensen, Robert Negrin, Everett Meyer
Journal: Blood
Blood (2025) 146 (Supplement 1): 822.
https://doi.org/10.1182/blood-2025-822
Published: 2025
Journal Articles

Allogeneic HSC and regulatory T cell  (Orca-T) engineered cell therapy following reduced intensity conditioning: Results of a single center Phase 1 study

Free
Alejandro Villar-Prados, Paige Kim, Katherine Sutherland, Robert Negrin, Sally Arai, Matthew Frank, Laura Johnston, Robert Lowsky, David Miklos, Lori Muffly, Saurabh Dahiya, Andrew Rezvani, Surbhi Sidana, Parveen Shiraz, Judith Shizuru, Wen-Kai Weng, Melody Smith, Sushma Bharadwaj, John Tamaresis, Anna Pavlova, J. Scott McClellan, Everett Meyer
Journal: Blood
Blood (2025) 146 (Supplement 1): 111.
https://doi.org/10.1182/blood-2025-111
Published: 2025
Journal Articles

Patients with TP53-mutated AML/MDS without complex or monosomal karyotype can achieve durable survival benefits with allogeneic HCT

Free
Nikeshan Jeyakumar, Nancy Torres, Suneeta Godbole, Fiona Yamamoto, Bing Zhang, Sally Arai, Sushma Bharadwaj, Saurabh Dahiya, Hany Elmariah, Matthew Frank, Hitomi Hosoya, Laura Johnston, Everett Meyer, Lekha Mikkilineni, Robert Lowsky, Robert Negrin, Andrew Rezvani, Judith Shizuru, Surbhi Sidana, Melody Smith, Wen-Kai Weng, David Miklos, Matthew Schwede, Gabriel Mannis, Tian Zhang, Lori Muffly, Vanessa Kennedy
Journal: Blood
Blood (2025) 146 (Supplement 1): 2525.
https://doi.org/10.1182/blood-2025-2525
Published: 2025
Journal Articles

Targeting CD117 with engineered invariant natural killer T cells (iNKT Cells) as a novel approach for acute myeloid leukemia treatment

Free
Chaiyaporn Boonchalermvichian, Hao Yan, Jeanette Baker, Quenton Bubb, Biki Gupta, Agnieszka Czechowicz, Robert Negrin
Journal: Blood
Blood (2025) 146 (Supplement 1): 7662.
https://doi.org/10.1182/blood-2025-7662
Published: 2025
Journal Articles

Double-dose axicabtagene ciloleucel (Axi-Cel-2) as second-line therapy for high-risk relapsed or refractory large B-cell lymphoma (r/rLBCL): Interim results from a Phase 1b study

Free
Dasom (Caroline) Lee, Kameron Rodrigues, Masooma Rana, Kendall Kozy, Sunny Salazar, Alexandria Jensen, Moksha Desai, Jayasindhu Mallampet, Claire Lohman, Ying-Wen Huang, Xiaoman Kang, Feng Tian, Jurik Mutter, Nick Phillips, Colleen Schweitzer, Faisal Cheema, Lekha Mikkilineni, Andrew Rezvani, Laura Johnston, Judith Shizuru, Everett Meyer, Robert Lowsky, Wen-Kai Weng, Melody Smith, Sushma Bharadwaj, Robert Negrin, Surbhi Sidana, Lori Muffly, Bita Sahaf, Yasodha Natkunam, Rhine Shen, Matthew Frank, Crystal Mackall, Zinaida Good, Ash Alizadeh, David Miklos, Saurabh Dahiya
Journal: Blood
Blood (2025) 146 (Supplement 1): 671.
https://doi.org/10.1182/blood-2025-671
Published: 2025
Journal Articles

CD22-directed CAR-T cells induce complete remissions in high-risk follicular and Mantle Cell Lymphoma with limited neurotoxicity

Free
Hrishikesh Srinagesh, Anne Marijn Kramer, Mark Hamilton, Yi-Jiun Su, Kendall Kozy, LaTesha Jackson, Annie Brown, Kimi DeNoble, Sharon Mavroukakis, Claire Lohman, Kristen Cunanan, Neha Agarwal, Sushma Bharadwaj, Warren Reynolds, Sally Arai, Laura Johnston, Robert Lowsky, Everett Meyer, Robert Negrin, Andrew Rezvani, Judith Shizuru, Lekha Mikkilineni, Hitomi Hosoya, Parveen Shiraz, Surbhi Sidana, Wen-Kai Weng, Vanessa Kennedy, Melody Smith, Saurabh Dahiya, Kara Davis, Sneha Ramakrishna, Liora Schultz, Ramya Tunuguntla, Lori Muffly, Crystal Mackall, David Miklos, Matthew Frank
Journal: Blood
Blood (2025) 146 (Supplement 1): 4159.
https://doi.org/10.1182/blood-2025-4159
Published: 2025
Journal Articles

Orca-T improves chronic graph-versus-host disease free in patients with a broad range of demographic and clinical variables: Results of randomized, Phase 3 trial

Free
Everett Meyer, Amandeep Salhotra, Arpita Gandhi, Jeremy Pantin, Rasmus Hoeg, Alexandra Gomez-Arteaga, Rawan Faramand, Roni Tamari, Edmund Waller, Satyajit Kosuri, Antonio Jimenez Jimenez, Jennifer Holter-Chakrabarty, Bhagirathbhai Dholaria, Yi-Bin Chen, Betty K. Hamilton, John Magenau, Alireza Eghtedar, Anna Pavlova, Nate Fernhoff, J. Scott McClellan, Scott Killian, Caspian Oliai, Robert Negrin, Sagar Patel
Journal: Blood
Blood (2025) 146 (Supplement 1): 2477.
https://doi.org/10.1182/blood-2025-2477
Published: 2025
Journal Articles

Inhibition of DRP1–FIS1–Mediated mitochondrial fission as a novel strategy to prevent gvhd

Free
Hao Yan, Vijith Vijayan, Chun-Hsien Chiang, Xiaobin Zheng, Ivan Lopez, Kaylin Prentiss, Jeanette Baker, Daria Mochly-Rosen, Robert Negrin, Kenneth Weinberg, Bereketeab Haileselassie
Journal: Blood
Blood (2025) 146 (Supplement 1): 2310.
https://doi.org/10.1182/blood-2025-2310
Published: 2025
Journal Articles

Observational comparison of orca-T to registry-based post-transplant cyclophosphamide patients using matched unrelated donors

Free
Roni Tamari, Caspian Oliai, Rasmus Hoeg, Arpita Gandhi, Edmund Waller, Sagar Patel, Bhagirathbhai Dholaria, Jeremy Pantin, Amandeep Salhotra, Steven Devine, Alexandra Gomez-Arteaga, Rawan Faramand, Jennifer Holter-Chakrabarty, Betty K. Hamilton, Antonio Jimenez Jimenez, Satyajit Kosuri, Yi-Bin Chen, John Magenau, Alireza Eghtedar, Anna Pavlova, Nate Fernhoff, J. Scott McClellan, Scott Killian, Robert Negrin, Everett Meyer
Journal: Blood
Blood (2025) 146 (Supplement 1): 6029.
https://doi.org/10.1182/blood-2025-6029
Published: 2025
Journal Articles

Off-the-shelf CD117 CAR-iNKT cells as a safe and effective allogeneic immunotherapy targeting AML and its immunosuppressive microenvironment

Free
Hao Yan, Chaiyaporn Boonchalermvichian, Biki Gupta, Jeanette Baker, Jiayan Zhou, Sisi Wang, Cameron Bader, Federico Simonetta, Robert Negrin
Journal: Blood
Blood (2025) 146 (Supplement 1): 5888.
https://doi.org/10.1182/blood-2025-5888
Published: 2025
Journal Articles

Evaluating thymic stromal lymphopoietin (TSLP) as a biomarker in acute graft versus host disease

Free
Parveen Shiraz, Ioannis Louloudis, Joanna Liliental, Shailja Patel, Alexandria Jensen, Sonia Fonseca, Kathy Le, Binta Diallo, Anna Pavlova, Sally Arai, Robert Negrin, Andrew Rezvani, Laura Johnston, Wen-Kai Weng, Robert Lowsky, Lori Muffly, David Miklos, Vanessa Kennedy, Everett Meyer, John Levine, James Ferrara, Judith Shizuru
Journal: Blood
Blood (2025) 146 (Supplement 1): 586.
https://doi.org/10.1182/blood-2025-586
Published: 2025
Journal Articles

A phase 1 clinical trial of NKTR-255 with CD19-22 CAR T-cell therapy for refractory B-cell acute lymphoblastic leukemia

Free
Clinical Trials & Observations
Hrishikesh Srinagesh, Clayton Jackson, Parveen Shiraz, Nikeshan Jeyakumar, Mark Hamilton, Emily Egeler, Sharon Mavroukakis, Adam Kuo, Juancarlos Cancilla, Bita Sahaf, Neha Agarwal, Alyssa Kanegai, Anne Marijn Kramer, Sally Arai, Sushma Bharadwaj, Saurabh Dahiya, Hitomi Hosoya, Laura Johnston, Vanessa Kennedy, Michaela Liedtke, Robert Lowsky, Lekha Mikkilineni, Robert Negrin, Andrew Rezvani, Surbhi Sidana, Judith Shizuru, Melody Smith, Wen-Kai Weng, Steven Feldman, Matthew J. Frank, Zachary Lee, Mary Tagliaferri, A. Mario Marcondes, David Miklos, Crystal Mackall, Lori Muffly
Journal: Blood
Blood (2024) 144 (16): 1689–1698.
https://doi.org/10.1182/blood.2024024952
Published: 2024
Includes: Supplemental data
Journal Articles

Donor-Derived CIK Cell Infusion As Consolidative Therapy after Non-Myeloablative Allogeneic Transplant in Patients with Myeloid Neoplasms

Free
Rupa Narayan, MD, Jonathan Benjamin, MD PhD, Ginna Laport, MD, Lu Tian, PhD, Keri Tate, PhD, Linda Elder, Leah Galvez, RN, Randall Armstrong, Kevin Sheehan, PhD, Robert Lowsky, MD, Sally Arai, MD, Laura Johnston, MD, David Miklos, MD PhD, Lori S. Muffly, MD, Andrew R. Rezvani, MD, Judith Shizuru, MD PhD, Wen-Kai Weng, MD PhD, Samuel Strober, MD, Robert Negrin, MD, Everett Meyer, MD PhD
Journal: Blood
Blood (2015) 126 (23): 3232.
https://doi.org/10.1182/blood.V126.23.3232.3232
Published: 2015
Journal Articles

Expanded CD4+Foxp3+ Regulatory T Cells through DR3 Signaling Have a Distinct Immunophenotype and Abrogate the Lethal Acute-Graft and Host Disease after Allogeneic Transplantation

Free
Hidekazu Nishikii, MD, PhD, Byung-Su Kim, MD, Yasuhisa Yokoyama, MD,PhD, Jeanette Baker, PhD, Antonio Pierini, MD, Maite Alvarez, PhD, Yuqiong Pan, MD, PhD, Yan Chen, MD, Dominik Schneidawind, MD, Shigeru Chiba, MD, PhD, Robert Negrin, MD
Journal: Blood
Blood (2015) 126 (23): 1876.
https://doi.org/10.1182/blood.V126.23.1876.1876
Published: 2015
Journal Articles

TNF-Alpha Priming Enhances CD4 + FoxP3 + Regulatory T Cell Suppressive Function in GvHD Prevention and Treatment

Free
Antonio Pierini, MD, Caitlin Moffett, Dominik Schneidawind, MD, Jeanette Baker, PhD, Hidekazu Nishikii, MD PhD, Yuqiong Pan, MD, PhD, Maite Alvarez, PhD, Everett Meyer, MD PhD, Robert Negrin, MD
Journal: Blood
Blood (2015) 126 (23): 1885.
https://doi.org/10.1182/blood.V126.23.1885.1885
Published: 2015
Journal Articles

Increased Activity in the T Cell Effector Phase and Enhanced T Cell Repertoire Target-Tissue Stability Distinguish Alloreactivity Across Major Versus Minor Histocompatibility Barriers

Free
Pingping Zheng, PhD, Adrianne E Vasey, Jeanette Baker, Bettina Iliopoulou, PhD, Dennis B Leveson-Gower, PhD, Antonio Pierini, Dominik Schneidawind, MD, Xiaoqing You, PhD, Katie Hsu, Robert Negrin, MD, Everett Meyer, MD PhD
Journal: Blood
Blood (2015) 126 (23): 4284.
https://doi.org/10.1182/blood.V126.23.4284.4284
Published: 2015
Journal Articles

Treatment of Corticosteroid-Refractory Graft-Versus-Host Disease with Ruxolitinib in 95 Patients

Free
Robert Zeiser, MD, Andreas Burchert, MD, Claudia Lengerke, MD, Mareike Verbeek, Kristina Maas-Bauer, MD, Stephan Metzelder, MD, Silvia Spoerl, MD, Markus Ditschkowski, MD, Matyas Ecsedi, MD, Katja Sockel, MD, Francis Ayuk, MD, Salem Ajib, MD, Flore Sicre de Fontbrune, MD, Il-Kang Na, MD, Livius Penter, MD, Udo Holtick, MD PhD, Dominik Wolf, MD, Esther Schuler, MD, Everett Meyer, MD PhD, Petya Apostolova, MD, Hartmut Bertz, MD, Reinhard Marks, Michael Luebbert, MD, Ralph M. Waesch, MD PhD, Christof Scheid, MD PhD, Friedrich Stölzel, MD, Rainer Ordemann, MD, Gesine Bug, MD, Guido Kobbe, MD, Robert Negrin, MD, Mats L Brune, Alexandros Spyridonidis, Annette Schmitt-Graeff, MD, Walter van der Velden, MD, Gerwin Huls, MD PhD, Stephan Mielke, MD, Goetz Ulrich Grigoleit, MD, Jurgen Kuball, MDPhD, Ryan P Flynn, PhD, Gabriele Ihorst, PhD, Jing Du, Bruce R. Blazar, MD, Renate Arnold, MD, Nicolaus Kröger, MD, Joerg Halter, MD, Gerard Socie, Dietrich Beelen, MD, Christian Peschel, MD, Andreas Neubauer, MD, Juergen Finke, MD, Justus Duyster, MD PhD, Nikolas von Bubnoff, MD
Journal: Blood
Blood (2015) 126 (23): 858.
https://doi.org/10.1182/blood.V126.23.858.858
Published: 2015
Journal Articles

Phase I/II Clinical Trial of CpG-Activated Whole Cell Vaccine in Mantle Cell Lymphoma (MCL): Results in Safety and Efficacy from Planned Interim Analysis

Free
Michael P. Chu, MD, Joshua Brody, MD, Holbrook E Kohrt, MD PhD, Matthew J. Frank, MD PhD, Michael Khodadoust, MD PhD, Sunil Reddy, MD, Ranjana H Advani, MD, Neel K. Gupta, MD, Ginna Laport, MD, Lauren S Maeda, MD, Everett Meyer, MD PhD, David B. Miklos, MD PhD, Robert Negrin, MD, Andrew R. Rezvani, MD, Wen-Kai Weng, MD PhD, Kevin Sheehan, PhD, Malek Faham, MD PhD, Debra K Czerwinski, Ami Okada, PhD, Ronald Levy, MD
Journal: Blood
Blood (2015) 126 (23): 1536.
https://doi.org/10.1182/blood.V126.23.1536.1536
Published: 2015