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Parveen Shiraz
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Journal Articles

Evaluating thymic stromal lymphopoietin (TSLP) as a biomarker in acute graft versus host disease

Free
Parveen Shiraz, Ioannis Louloudis, Joanna Liliental, Shailja Patel, Alexandria Jensen, Sonia Fonseca, Kathy Le, Binta Diallo, Anna Pavlova, Sally Arai, Robert Negrin, Andrew Rezvani, Laura Johnston, Wen-Kai Weng, Robert Lowsky, Lori Muffly, David Miklos, Vanessa Kennedy, Everett Meyer, John Levine, James Ferrara, Judith Shizuru
Journal: Blood
Blood (2025) 146 (Supplement 1): 586.
https://doi.org/10.1182/blood-2025-586
Published: 2025
Journal Articles

Allogeneic HSC and regulatory T cell  (Orca-T) engineered cell therapy following reduced intensity conditioning: Results of a single center Phase 1 study

Free
Alejandro Villar-Prados, Paige Kim, Katherine Sutherland, Robert Negrin, Sally Arai, Matthew Frank, Laura Johnston, Robert Lowsky, David Miklos, Lori Muffly, Saurabh Dahiya, Andrew Rezvani, Surbhi Sidana, Parveen Shiraz, Judith Shizuru, Wen-Kai Weng, Melody Smith, Sushma Bharadwaj, John Tamaresis, Anna Pavlova, J. Scott McClellan, Everett Meyer
Journal: Blood
Blood (2025) 146 (Supplement 1): 111.
https://doi.org/10.1182/blood-2025-111
Published: 2025
Journal Articles

CD22-directed CAR-T cells induce complete remissions in high-risk follicular and Mantle Cell Lymphoma with limited neurotoxicity

Free
Hrishikesh Srinagesh, Anne Marijn Kramer, Mark Hamilton, Yi-Jiun Su, Kendall Kozy, LaTesha Jackson, Annie Brown, Kimi DeNoble, Sharon Mavroukakis, Claire Lohman, Kristen Cunanan, Neha Agarwal, Sushma Bharadwaj, Warren Reynolds, Sally Arai, Laura Johnston, Robert Lowsky, Everett Meyer, Robert Negrin, Andrew Rezvani, Judith Shizuru, Lekha Mikkilineni, Hitomi Hosoya, Parveen Shiraz, Surbhi Sidana, Wen-Kai Weng, Vanessa Kennedy, Melody Smith, Saurabh Dahiya, Kara Davis, Sneha Ramakrishna, Liora Schultz, Ramya Tunuguntla, Lori Muffly, Crystal Mackall, David Miklos, Matthew Frank
Journal: Blood
Blood (2025) 146 (Supplement 1): 4159.
https://doi.org/10.1182/blood-2025-4159
Published: 2025
Journal Articles

Superior efficacy and persistence of Orca-T-allogeneic CAR19/22 versus autologous CAR19/22 in high-risk adult B-ALL

Free
Alfonso Molina, Parveen Shiraz, Alyssa Kanegai, Ayesha Fraser, Diana Kordek, Caroline Wagner, Hrishikesh Srinagesh, Lindsay Danley, Arvind Ramakrishnan, Hossein Daghagh, Ying-Wen Huang, Gaurav Dhapola, Aman Siddiqui, Sally Arai, Sushma Bharadwaj, Saurabh Dahiya, Hany Elmariah, Matthew Frank, Hitomi Hosoya, Vanessa Kennedy, Laura Johnston, Everett Meyer, Lekha Mikkilineni, Robert Lowsky, Robert Negrin, Andrew Rezvani, Judith Shizuru, Surbhi Sidana, Wen-Kai Weng, Catherine McIntyre, Steven Feldman, Bita Sahaf, Crystal Mackall, David Miklos, Lori Muffly, Melody Smith
Journal: Blood
Blood (2025) 146 (Supplement 1): 514.
https://doi.org/10.1182/blood-2025-514
Published: 2025
Journal Articles

Non-response to bridging therapy prior to CAR-T is associated with increased toxicity and adverse outcomes in Relapsed/Refractory multiple myeloma (RRMM)

Free
Masooma Rana, Alexandria Jensen, Arash Velayati, Vanna Hovanky, Lori Muffly, Bita Sahaf, David Iberri, Michaela Liedtke, Sushma Bharadwaj, Vanessa Kennedy, Sally Arai, Parveen Shiraz, Wen-Kai Weng, Melody Smith, Matthew Frank, David Miklos, Saurabh Dahiya, Hitomi Hosoya, Lekha Mikkilineni, Surbhi Sidana
Journal: Blood
Blood (2025) 146 (Supplement 1): 4586.
https://doi.org/10.1182/blood-2025-4586
Published: 2025
Journal Articles

Donor regulatory T-cell therapy to prevent graft-versus-host disease

Available to Purchase
Clinical Trials & Observations
Everett H. Meyer, Anna Pavlova, Alejandro Villar-Prados, Cameron Bader, Bryan Xie, Lori Muffly, Paige Kim, Katherine Sutherland, Sushma Bharadwaj, Saurabh Dahiya, Matthew Frank, Sally Arai, Laura Johnston, David Miklos, Andrew Rezvani, Parveen Shiraz, Surbhi Sidana, Judy Shizuru, Wen-Kai Weng, Vaibhav Agrawal, Amy Putnam, Nathaniel Fernhoff, John Tamarisis, Ying Lu, Rahul D. Pawar, J. Scott McClellan, Robert Lowsky, Robert S. Negrin
Journal: Blood
Blood (2025) 145 (18): 2012–2024.
https://doi.org/10.1182/blood.2024026446
Published: 2025
Includes: Supplemental data
Journal Articles

Safety and Efficacy of Chimeric Antigen Receptor T-Cell Therapy in Octogenarian Patients (Aged ≥ 80) with Relapsed or Refractory (R/R) Large B-Cell Lymphoma (LBCL)

Free
Dasom Lee, Sushma Bharadwaj, Masooma S Rana, Alexandria Jensen, William Wang, Nima Ghalehsari, Bita Sahaf, Jayasindhu Mallampet, Sarah Elkordy, Theresa Latchford, Sally Arai, Laura Johnston, Hitomi Hosoya, Robert Lowsky, Robert S. Negrin, Andrew R. Rezvani, Judith Shizuru, Everett H. Meyer, Parveen Shiraz, Lekha Mikkilineni, Wen-Kai Weng, Lauren S. Maeda, Melody Smith, Surbhi Sidana, Lori Muffly, Matthew J. Frank, David B. Miklos, Saurabh Dahiya
Journal: Blood
Blood (2024) 144 (Supplement 1): 386.
https://doi.org/10.1182/blood-2024-201822
Published: 2024
Journal Articles

Anti-BCMA CAR T-Cell Expansion and Its Association with Response and Toxicity in Multiple Myeloma

Free
Hitomi Hosoya, Alexandria Jensen, Vanna Hovanky, Sylvester Homsy, Juancarlos E Cancilla, Sunita Patil, Vanessa E. Kennedy, Sushma Bharadwaj, Melody Smith, Parveen Shiraz, Matthew J. Frank, Saurabh Dahiya, Sally Arai, Wen-Kai Weng, Lori Muffly, Bita Sahaf, Crystal L. Mackall, David B. Miklos, Lekha Mikkilineni, Surbhi Sidana
Journal: Blood
Blood (2024) 144 (Supplement 1): 2006.
https://doi.org/10.1182/blood-2024-211128
Published: 2024
Journal Articles

CD22-Directed CAR T-Cell Therapy Achieves Complete Remission in CD19-Directed CAR T-Cell Refractory Follicular and Mantle Cell Lymphoma

Free
Anne Marijn Kramer, Hrishikesh Srinagesh, Yi-Jiun Su, Mark P. Hamilton, Kendall Levine, Eleonora Migliore, Kimi DeNoble, Annie K. Brown, Kristen Cunanan, Neha Agarwal, Claire Lohman, Sharon Mavroukakis, Sushma Bharadwaj, Sally Arai, Laura Johnston, Robert Lowsky, Everett H. Meyer, Robert S. Negrin, Andrew R. Rezvani, Judith Shizuru, Lekha Mikkilineni, Hitomi Hosoya, Parveen Shiraz, Surbhi Sidana, Wen-Kai Weng, Vanessa E. Kennedy, Melody Smith, Saurabh Dahiya, Kara L. Davis, Sneha Ramakrishna, Liora Michal Schultz, Ramya Tunuguntla, Steven A. Feldman, Lori Muffly, Crystal L. Mackall, David B. Miklos, Matthew J. Frank
Journal: Blood
Blood (2024) 144 (Supplement 1): 2064.
https://doi.org/10.1182/blood-2024-198489
Published: 2024
Journal Articles

Safe and Effective Combination of Donor-Derived, Allogeneic CD19/CD22-CAR T Cells with Myeloablative Graft-Engineered Allo-HCT for High-Risk B-ALL

Free
Lori Muffly, Snegha Ananth, Lindsay Danley, Caroline Wagner, Diana Kordek, Kimi DeNoble, Ayesha Fraser, Emily Egeler, Alfonso Molina, Zachary Ehlinger, Moksha Desai, Hossein Daghagh, Ramya Tunuguntla, Annie K. Brown, Raquel Ibañez, Anne Marijn Kramer, Zinaida Good, Sally Arai, Laura Johnston, Robert Lowsky, Andrew R. Rezvani, Judith Shizuru, Lekha Mikkilineni, Parveen Shiraz, Surbhi Sidana, Wen-Kai Weng, Vanessa E. Kennedy, Sushma Bharadwaj, Saurabh Dahiya, Matthew J. Frank, Everett H. Meyer, Robert S. Negrin, Steven A. Feldman, Crystal L. Mackall, Bita Sahaf, David B. Miklos, Melody Smith
Journal: Blood
Blood (2024) 144 (Supplement 1): 679.
https://doi.org/10.1182/blood-2024-211959
Published: 2024
Journal Articles

CD22-Directed CAR T-Cell Therapy for Large B-Cell Lymphomas Progressing after CD19-Directed CAR T-Cell Therapy: Continued Durable Remissions at 3-Year Follow-up

Free
Anne Marijn Kramer, John H. Baird, Hrishikesh Srinagesh, Emily Egeler, Kendall Levine, Annie K. Brown, Sharon Mavroukakis, Kristen Cunanan, Yi-Jiun Su, Neha Agarwal, Mark P. Hamilton, Sushma Bharadwaj, Sally Arai, Laura Johnston, Robert Lowsky, Everett H. Meyer, Robert S. Negrin, Andrew R. Rezvani, Judith Shizuru, Lekha Mikkilineni, Hitomi Hosoya, Parveen Shiraz, Surbhi Sidana, Wen-Kai Weng, Vanessa E. Kennedy, Melody Smith, Saurabh Dahiya, Kara L. Davis, Sneha Ramakrishna, Liora Michal Schultz, Ramya Tunuguntla, Steven A. Feldman, Lori Muffly, Crystal L. Mackall, David B. Miklos, Matthew J. Frank
Journal: Blood
Blood (2024) 144 (Supplement 1): 69.
https://doi.org/10.1182/blood-2024-198544
Published: 2024
Journal Articles

Single Institution Analysis of Lymphoma Treatment Related Post-CAR Myeloid Neoplasms

Free
Mark Hamilton, Nick Phillips, Dasom Lee, Zachary Ehlinger, Anne Marijn Kramer, Hrishikesh Srinagesh, Zinaida Good, Xiaoman Kang, Mari Olsen, Chih Long Liu, Feng Tian, Brian J. Sworder, Hitomi Hosoya, Joseph G. Schroers-Martin, Sushma Bharadwaj, Sally Arai, Laura Johnston, Robert Lowsky, Everett H. Meyer, Robert S. Negrin, Andrew R. Rezvani, Judith Shizuru, Lekha Mikkilineni, Parveen Shiraz, Surbhi Sidana, Wen-Kai Weng, Vanessa E. Kennedy, Melody Smith, Lori Muffly, David Kurtz, Saurabh Dahiya, Matthew J. Frank, Crystal L. Mackall, Bita Sahaf, David B. Miklos, Ash A. Alizadeh
Journal: Blood
Blood (2024) 144 (Supplement 1): 96.
https://doi.org/10.1182/blood-2024-205378
Published: 2024
Journal Articles

A phase 1 clinical trial of NKTR-255 with CD19-22 CAR T-cell therapy for refractory B-cell acute lymphoblastic leukemia

Free
Clinical Trials & Observations
Hrishikesh Srinagesh, Clayton Jackson, Parveen Shiraz, Nikeshan Jeyakumar, Mark Hamilton, Emily Egeler, Sharon Mavroukakis, Adam Kuo, Juancarlos Cancilla, Bita Sahaf, Neha Agarwal, Alyssa Kanegai, Anne Marijn Kramer, Sally Arai, Sushma Bharadwaj, Saurabh Dahiya, Hitomi Hosoya, Laura Johnston, Vanessa Kennedy, Michaela Liedtke, Robert Lowsky, Lekha Mikkilineni, Robert Negrin, Andrew Rezvani, Surbhi Sidana, Judith Shizuru, Melody Smith, Wen-Kai Weng, Steven Feldman, Matthew J. Frank, Zachary Lee, Mary Tagliaferri, A. Mario Marcondes, David Miklos, Crystal Mackall, Lori Muffly
Journal: Blood
Blood (2024) 144 (16): 1689–1698.
https://doi.org/10.1182/blood.2024024952
Published: 2024
Includes: Supplemental data
Journal Articles

Phase 1 Trial Results for Patients with Advanced Hematologic Malignancies Undergoing Reduced Intensity Allogeneic HCT with Orca-T Donor Cell Therapy Product and Single Agent Tacrolimus

Free
Alejandro Villar-Prados, Everett H. Meyer, Katherine Sutherland, Robert S. Negrin, Sally Arai, Matthew J. Frank, Laura Johnston, Robert Lowsky, David B. Miklos, Lori S. Muffly, Saurabh Dahiya, Andrew R. Rezvani, Surbhi Sidana, Parveen Shiraz, Judith Shizuru, Wen-Kai Weng, Melody Smith, Sushma Bharadwaj, John Tamaresis, Anna Pavlova, Scott McClellan
Journal: Blood
Blood (2023) 142 (Supplement 1): 3560.
https://doi.org/10.1182/blood-2023-188162
Published: 2023
Journal Articles

CAR19 Therapy Drives Expansion of Clonal Hematopoiesis and Associated Cytopenias

Free
Mark P. Hamilton, Brian J. Sworder, Stefan K. Alig, Zinaida Good, Jan Boegeholz, Joseph Schroers-Martin, John Tamaresis, Mohammad Shahrokh Esfahani, Ying Lu, Mari Olsen, Chih Long Liu, Zachary Ehlinger, Moksha Desai, Felicia Liu-Fei, Lori S. Muffly, Robert S. Negrin, Sally Arai, Laura Johnston, Robert Lowsky, Everett H. Meyer, Andrew R. Rezvani, Judith Shizuru, Wen-Kai Weng, Parveen Shiraz, Surbhi Sidana, Sushma Bharadwaj, Melody Smith, Saurabh Dahiya, Bita Sahaf, Maximilian Diehn, Matthew J. Frank, Crystal L. Mackall, David M. Kurtz, David B. Miklos, Ash A. Alizadeh
Journal: Blood
Blood (2023) 142 (Supplement 1): 360.
https://doi.org/10.1182/blood-2023-182522
Published: 2023
Journal Articles

Improved outcomes for relapsed/refractory Hodgkin lymphoma after autologous transplantation in the era of novel agents

Free
Clinical Trials & Observations
Michael A. Spinner, R. A. Sica, John S. Tamaresis, Ying Lu, Cheryl Chang, Robert Lowsky, Matthew J. Frank, Laura J. Johnston, David B. Miklos, Lori S. Muffly, Robert S. Negrin, Andrew R. Rezvani, Parveen Shiraz, Judith A. Shizuru, Wen-Kai Weng, Michael S. Binkley, Richard T. Hoppe, Ranjana H. Advani, Sally Arai
Journal: Blood
Blood (2023) 141 (22): 2727–2737.
https://doi.org/10.1182/blood.2022018827
Published: 2023
Includes: Supplemental data
Journal Articles

Belumosudil Combination Therapy in Refractory Chronic Graft-Versus-Host Disease

Free
Michelle Chin, Judith A. Shizuru, Lori Muffly, Parveen Shiraz, Laura J. Johnston, Robert Lowsky, Andrew R. Rezvani, Matthew J. Frank, Sushma Bharadwaj, Wen-Kai Weng, Robert S. Negrin, David B. Miklos, Sally Arai
Journal: Blood
Blood (2022) 140 (Supplement 1): 4788–4789.
https://doi.org/10.1182/blood-2022-165547
Published: 2022
Journal Articles

Ultra-Sensitive Next-Generation Sequencing Establishes the Prognostic Value of Very Low MRD in Adults with Acute Lymphoblastic Leukemia Undergoing Hematopoietic Cell Transplantation

Free
Emily C. Liang, Simone E. Dekker, Jean M.G. Sabile, Stefan Torelli, Amy Zhang, Katharine Miller, Parveen Shiraz, Brandon Hayes-Lattin, Jessica Leonard, Lori Muffly
Journal: Blood
Blood (2022) 140 (Supplement 1): 1732–1733.
https://doi.org/10.1182/blood-2022-157442
Published: 2022
Journal Articles

Higher Rates of Severe Infection and Persistent Cytopenias in Long-Term CAR19 Responders Than after Autologous HCT: A Single Institution Study of 139 Subjects

Free
Mark P Hamilton, Felicia C Liu-Fei, Stefan K. Alig, John Tamaresis, Mohammad Shahrokh Esfahani, Zinaida Good, Brian Sworder, Joseph Schroers-Martin, Chih Long Liu, Freja Tang Severinsen, Paul J Hanson, Ying Lu, Robert Lowsky, Robert S. Negrin, Everett H Meyer, Melody Smith, Sushma Bharadwaj, Judith A Shizuru, Surbhi Sidana, Parveen Shiraz, Andrew R. Rezvani, Laura J. Johnston, Wen-Kai Weng, Sally Arai, Lori Muffly, Saurabh Dahiya, Maximilian Diehn, David M. Kurtz, Bita Sahaf, Crystal L. Mackall, Matthew J Frank, David B. Miklos, Ash A. Alizadeh
Journal: Blood
Blood (2022) 140 (Supplement 1): 7545–7547.
https://doi.org/10.1182/blood-2022-165600
Published: 2022
Journal Articles

Outcomes for Acute Myeloid Leukemia Relapse after Allogeneic Hematopoietic Cell Transplantation Remain Poor in the Modern Era

Free
Shona Philip, Robert Lowsky, Laura J. Johnston, Sally Arai, Everett H. Meyer, Robert S. Negrin, Andrew R. Rezvani, Parveen Shiraz, Judith A. Shizuru, Surbhi Sidana, Wen-Kai Weng, Sushma Bharadwaj, Matthew J. Frank, David B. Miklos, Melody Smith, Lori Muffly, Vaibhav Agrawal
Journal: Blood
Blood (2022) 140 (Supplement 1): 4825–4827.
https://doi.org/10.1182/blood-2022-168546
Published: 2022