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Journal Articles

A phase 1 clinical trial of NKTR-255 with CD19-22 CAR T-cell therapy for refractory B-cell acute lymphoblastic leukemia

Clinical Trials & Observations
Hrishikesh Srinagesh, Clayton Jackson, Parveen Shiraz, Nikeshan Jeyakumar, Mark Hamilton, Emily Egeler, Sharon Mavroukakis, Adam Kuo, Juancarlos Cancilla, Bita Sahaf, Neha Agarwal, Alyssa Kanegai, Anne Marijn Kramer, Sally Arai, Sushma Bharadwaj, Saurabh Dahiya, Hitomi Hosoya, Laura Johnston, Vanessa Kennedy, Michaela Liedtke, Robert Lowsky, Lekha Mikkilineni, Robert Negrin, Andrew Rezvani, Surbhi Sidana, Judith Shizuru, Melody Smith, Wen-Kai Weng, Steven Feldman, Matthew J. Frank, Zachary Lee, Mary Tagliaferri, A. Mario Marcondes, David Miklos, Crystal Mackall, Lori Muffly
Journal: Blood
Blood (2024) 144 (16): 1689–1698.
https://doi.org/10.1182/blood.2024024952
Published: 2024
Includes: Supplemental data
Journal Articles

CAR19 Therapy Drives Expansion of Clonal Hematopoiesis and Associated Cytopenias

Mark P. Hamilton, Brian J. Sworder, Stefan K. Alig, Zinaida Good, Jan Boegeholz, Joseph Schroers-Martin, John Tamaresis, Mohammad Shahrokh Esfahani, Ying Lu, Mari Olsen, Chih Long Liu, Zachary Ehlinger, Moksha Desai, Felicia Liu-Fei, Lori S. Muffly, Robert S. Negrin, Sally Arai, Laura Johnston, Robert Lowsky, Everett H. Meyer, Andrew R. Rezvani, Judith Shizuru, Wen-Kai Weng, Parveen Shiraz, Surbhi Sidana, Sushma Bharadwaj, Melody Smith, Saurabh Dahiya, Bita Sahaf, Maximilian Diehn, Matthew J. Frank, Crystal L. Mackall, David M. Kurtz, David B. Miklos, Ash A. Alizadeh
Journal: Blood
Blood (2023) 142 (Supplement 1): 360.
https://doi.org/10.1182/blood-2023-182522
Published: 2023
Journal Articles

Safety and Efficacy of Orca-Q with Haploidentical Donors for the Treatment of Advanced Hematologic Malignancies without the Use of Post-Transplant Cyclophosphamide

Samer A. Srour, Amandeep Salhotra, Robert Lowsky, Rasmus T. Hoeg, Edmund K. Waller, Anna Pavlova, J. Scott McClellan, Nathaniel B. Fernhoff, Everett H. Meyer, Mehrdad Abedi
Journal: Blood
Blood (2023) 142 (Supplement 1): 773.
https://doi.org/10.1182/blood-2023-189534
Published: 2023
Journal Articles

One Year Follow-up on the First Patient Treated with Nula-Cel: An Autologous CRISPR/Cas9 Gene Corrected CD34+ Cell Product to Treat Sickle Cell Disease

David C Shyr, Robert Lowsky, Weston Miller, Mark A. Schroeder, Tonia Buchholz, Kirstin Dougall, Allison Intondi, Alexandra Charles, Josh Lehrer, Ali Bouge, Stacey Wolf, Blair MacDonald, Hena Din, Alana Lerner, Manal Amoury, Sebastien Treusch, Glen Chew, Brian Silva, Haider Mashhedi, Vincent Siu, Ian Perrone, Twaritha Vijay, Aayami Jain, Kristina Krassovsky, William Matern, Premanjali Lahiri, Ryan Rodriguez, Jason Skowronski, Arpit Batish, Dana Margittai, Prachi Wani, Timothy Van Horn, Claudia Flautero, Rosalva Flores, Jade Lee, Keri Tate, Maria-Grazia Roncarolo, Steven Feldman, John DiPersio, Matthew Porteus
Journal: Blood
Blood (2023) 142 (Supplement 1): 5000.
https://doi.org/10.1182/blood-2023-188963
Published: 2023
Journal Articles

Optimizing Outcomes with Myeloablative Conditioning in Older Patients: Efficacy and Safety of Precision Engineered Orca-T in Patients > 55 Years Old with Hematologic Malignancies

Caspian H. Oliai, Jeremy M. Pantin, Rasmus T. Hoeg, Lori S. Muffly, Sagar S. Patel, Arpita Gandhi, Robert Lowsky, Amandeep Salhotra, Bhagirathbhai Dholaria, Edmund K. Waller, Samer A. Srour, Anna Pavlova, Nathaniel B. Fernhoff, Irene Agodoa, J. Scott McClellan, Mehrdad Abedi, Robert S. Negrin, Everett H. Meyer
Journal: Blood
Blood (2023) 142 (Supplement 1): 230.
https://doi.org/10.1182/blood-2023-186749
Published: 2023
Journal Articles

Phase 1 Trial Results for Patients with Advanced Hematologic Malignancies Undergoing Reduced Intensity Allogeneic HCT with Orca-T Donor Cell Therapy Product and Single Agent Tacrolimus

Alejandro Villar-Prados, Everett H. Meyer, Katherine Sutherland, Robert S. Negrin, Sally Arai, Matthew J. Frank, Laura Johnston, Robert Lowsky, David B. Miklos, Lori S. Muffly, Saurabh Dahiya, Andrew R. Rezvani, Surbhi Sidana, Parveen Shiraz, Judith Shizuru, Wen-Kai Weng, Melody Smith, Sushma Bharadwaj, John Tamaresis, Anna Pavlova, Scott McClellan
Journal: Blood
Blood (2023) 142 (Supplement 1): 3560.
https://doi.org/10.1182/blood-2023-188162
Published: 2023
Journal Articles

Improved outcomes for relapsed/refractory Hodgkin lymphoma after autologous transplantation in the era of novel agents

Clinical Trials & Observations
Michael A. Spinner, R. A. Sica, John S. Tamaresis, Ying Lu, Cheryl Chang, Robert Lowsky, Matthew J. Frank, Laura J. Johnston, David B. Miklos, Lori S. Muffly, Robert S. Negrin, Andrew R. Rezvani, Parveen Shiraz, Judith A. Shizuru, Wen-Kai Weng, Michael S. Binkley, Richard T. Hoppe, Ranjana H. Advani, Sally Arai
Journal: Blood
Blood (2023) 141 (22): 2727–2737.
https://doi.org/10.1182/blood.2022018827
Published: 2023
Includes: Supplemental data
Journal Articles

Orca-Q Demonstrates Favorable GvHD-and-Relapse-Free Survival in Haploidentical Transplants without Post-Transplant Cyclophosphamide

Amandeep Salhotra, Samer A Srour, Rasmus T Hoeg, Ayman Saad, Everett H Meyer, Anna Pavlova, Edmund K. Waller, Mwe Mwe Chao, J Scott McClellan, Nathaniel B Fernhoff, Robert Lowsky, Mehrdad Abedi
Journal: Blood
Blood (2022) 140 (Supplement 1): 1865–1866.
https://doi.org/10.1182/blood-2022-170459
Published: 2022
Journal Articles

Higher Rates of Severe Infection and Persistent Cytopenias in Long-Term CAR19 Responders Than after Autologous HCT: A Single Institution Study of 139 Subjects

Mark P Hamilton, Felicia C Liu-Fei, Stefan K. Alig, John Tamaresis, Mohammad Shahrokh Esfahani, Zinaida Good, Brian Sworder, Joseph Schroers-Martin, Chih Long Liu, Freja Tang Severinsen, Paul J Hanson, Ying Lu, Robert Lowsky, Robert S. Negrin, Everett H Meyer, Melody Smith, Sushma Bharadwaj, Judith A Shizuru, Surbhi Sidana, Parveen Shiraz, Andrew R. Rezvani, Laura J. Johnston, Wen-Kai Weng, Sally Arai, Lori Muffly, Saurabh Dahiya, Maximilian Diehn, David M. Kurtz, Bita Sahaf, Crystal L. Mackall, Matthew J Frank, David B. Miklos, Ash A. Alizadeh
Journal: Blood
Blood (2022) 140 (Supplement 1): 7545–7547.
https://doi.org/10.1182/blood-2022-165600
Published: 2022
Journal Articles

Outcomes for Acute Myeloid Leukemia Relapse after Allogeneic Hematopoietic Cell Transplantation Remain Poor in the Modern Era

Shona Philip, Robert Lowsky, Laura J. Johnston, Sally Arai, Everett H. Meyer, Robert S. Negrin, Andrew R. Rezvani, Parveen Shiraz, Judith A. Shizuru, Surbhi Sidana, Wen-Kai Weng, Sushma Bharadwaj, Matthew J. Frank, David B. Miklos, Melody Smith, Lori Muffly, Vaibhav Agrawal
Journal: Blood
Blood (2022) 140 (Supplement 1): 4825–4827.
https://doi.org/10.1182/blood-2022-168546
Published: 2022
Journal Articles

The Development of Carhlh after Axicabtagene Ciloleucel Is Associated with Poor Outcomes

Shona Philip, Hrishikesh K. Srinagesh, Mark P Hamilton, Cesar Gentille, Alain Mina, Sally Arai, Laura J. Johnston, Robert Lowsky, Everett H Meyer, Robert S. Negrin, Andrew R. Rezvani, Parveen Shiraz, Judith A Shizuru, Surbhi Sidana, Wen-Kai Weng, Sushma Bharadwaj, Saurabh Dahiya, Lori Muffly, Melody Smith, David B. Miklos, Matthew J Frank
Journal: Blood
Blood (2022) 140 (Supplement 1): 12775–12777.
https://doi.org/10.1182/blood-2022-170877
Published: 2022
Journal Articles

Precision-Engineered Cell Therapy Orca-T Demonstrates High Relapse-Free Survival at 1 Year While Reducing Graft-Versus-Host Disease and Toxicity

Caspian Oliai, Rasmus T Hoeg, Anna Pavlova, Arpita Gandhi, Lori Muffly, Rohtesh S. Mehta, Samer A Srour, Edmund K. Waller, Robert Lowsky, Sagar S. Patel, Bhagirathbhai Dholaria, Carlos Bachier, Jeremy M. Pantin, Amandeep Salhotra, Joseph P. McGuirk, Nathaniel B Fernhoff, J Scott McClellan, Mehrdad Abedi, Robert S. Negrin, Everett H Meyer
Journal: Blood
Blood (2022) 140 (Supplement 1): 654–656.
https://doi.org/10.1182/blood-2022-165654
Published: 2022
Journal Articles

Analysis of Bendamustine Lymphodepletion, CD19 CART Expansion, Safety and Efficacy in Patients with Rel/Ref Non-Hodgkin Lymphoma

Sushma Bharadwaj, Mark P Hamilton, Bita Sahaf, John Tamaresis, Sunita Patil, Paul J Hanson, Theresa Latchford, Sally Arai, Laura J. Johnston, Robert Lowsky, Robert S. Negrin, Andrew R. Rezvani, Judith A Shizuru, Everett H Meyer, Parveen Shiraz, Surbhi Sidana, Melody Smith, Wen-Kai Weng, Lori Muffly, Crystal L. Mackall, Matthew J Frank, David B. Miklos, Saurabh Dahiya
Journal: Blood
Blood (2022) 140 (Supplement 1): 10371–10373.
https://doi.org/10.1182/blood-2022-170759
Published: 2022
Journal Articles

Belumosudil Combination Therapy in Refractory Chronic Graft-Versus-Host Disease

Michelle Chin, Judith A. Shizuru, Lori Muffly, Parveen Shiraz, Laura J. Johnston, Robert Lowsky, Andrew R. Rezvani, Matthew J. Frank, Sushma Bharadwaj, Wen-Kai Weng, Robert S. Negrin, David B. Miklos, Sally Arai
Journal: Blood
Blood (2022) 140 (Supplement 1): 4788–4789.
https://doi.org/10.1182/blood-2022-165547
Published: 2022
Journal Articles

Mgta-145 + Plerixafor Provides GCSF-Free Rapid and Reliable Hematopoietic Stem Cell Mobilization for Autologous Stem Cell Transplant in Patients with Multiple Myeloma: A Phase 2 Study

Surbhi Sidana, Andriyana K Bankova, Hitomi Hosoya, Shaji Kumar, John Tamaresis, Anne Le, Lori Muffly, Laura J. Johnston, Sally Arai, Robert Lowsky, Everett H Meyer, Andrew R. Rezvani, Wen-Kai Weng, Matthew J. Frank, Parveen Shiraz, Douglas Girgenti, Kevin A. Goncalves, Veit Schmelmer, John C. Davis, Jr., Ying Lu, Judith A Shizuru, David B. Miklos
Journal: Blood
Blood (2021) 138 (Supplement 1): 3885.
https://doi.org/10.1182/blood-2021-149306
Published: 2021
Journal Articles

CD22-CAR T-Cell Therapy Mediates High Durable Remission Rates in Adults with Large B-Cell Lymphoma Who Have Relapsed after CD19-CAR T-Cell Therapy

Matthew J. Frank, John H. Baird, Shabnum Patel, Juliana Craig, Jay Y. Spiegel, Zachary Ehlinger, Harshini Chinnasamy, Sheren F. Younes, Jean S. Oak, Yasodha Natkunam, Warren D. Reynolds, Maria Iglesias, Emma Crawford, Hrishikesh K. Srinagesh, Emily L. Egeler, Sally Arai, Laura J. Johnston, Robert Lowsky, Robert S. Negrin, Andrew R. Rezvani, Parveen Shiraz, Surbhi Sidana, Wen-Kai Weng, Liora M. Schultz, Sneha Ramakrishna, Kara L. Davis, Bita Sahaf, Steven A. Feldman, Crystal L. Mackall, David B. Miklos, Lori Muffly
Journal: Blood
Blood (2021) 138 (Supplement 1): 741.
https://doi.org/10.1182/blood-2021-152145
Published: 2021
Journal Articles

Orca-T Results in High Gvhd-Free and Relapse-Free Survival Following Myeloablative Conditioning for Hematological Malignancies: Results of a Single Center Phase 2 and a Multicenter Phase 1b Study

Rasmus T. Hoeg, Anna Moroz, Arpita Gandhi, Lori Muffly, Parveen Shiraz, Caspian Oliai, Rohtesh S. Mehta, Samer A. Srour, Joseph P. McGuirk, Edmund K. Waller, Sally Arai, Laura J. Johnston, Robert Lowsky, Andrew R. Rezvani, Wen-Kai Weng, David B. Miklos, Matthew J. Frank, John Tamaresis, Ying Lu, Vaibhav Agrawal, Nathaniel B Fernhoff, Gerhard Bauer, Amy Putnam, J Scott McClellan, Bronwen E. Shaw, Mehrdad Abedi, Robert S. Negrin, Everett H Meyer
Journal: Blood
Blood (2021) 138 (Supplement 1): 98.
https://doi.org/10.1182/blood-2021-154191
Published: 2021
Journal Articles

CD22-directed CAR T-cell therapy induces complete remissions in CD19-directed CAR–refractory large B-cell lymphoma

Clinical Trials & Observations Brief Report
John H. Baird, Matthew J. Frank, Juliana Craig, Shabnum Patel, Jay Y. Spiegel, Bita Sahaf, Jean S. Oak, Sheren F. Younes, Michael G. Ozawa, Eric Yang, Yasodha Natkunam, John Tamaresis, Zachary Ehlinger, Warren D. Reynolds, Sally Arai, Laura Johnston, Robert Lowsky, Everett Meyer, Robert S. Negrin, Andrew R. Rezvani, Parveen Shiraz, Surbhi Sidana, Wen-Kai Weng, Kara L. Davis, Sneha Ramakrishna, Liora Schultz, Chelsea Mullins, Allison Jacob, Ilan Kirsch, Steven A. Feldman, Crystal L. Mackall, David B. Miklos, Lori Muffly
Journal: Blood
Blood (2021) 137 (17): 2321–2325.
https://doi.org/10.1182/blood.2020009432
Published: 2021
Includes: Supplemental data
Journal Articles

Orca-T, a Precision Treg-Engineered Donor Product, Prevents Acute Gvhd with Less Immunosuppression in an Early Multicenter Experience with Myeloablative HLA-Matched Transplants

Everett H Meyer, MD PhD, Rasmus Hoeg, MD, Anna Moroz, MD PhD, Bryan Xei, BS, Hsin-Hsu Wu, MD, Rahul Pawar, Kartoosh Heydari, MD, David B. Miklos, MD PhD, Parveen Shiraz, MD, Lori S. Muffly, MD MS, Sally Arai, MD MS, Laura J. Johnston, MD, Robert Lowsky, MD FRCP, Andrew R. Rezvani, MD, Judith A Shizuru, MD PhD, Wen-Kai Weng, MD PhD, Nathaniel Fernhoff, PhD, Gerhard Bauer, Arpita Gandhi, MD MS, Amy Putnam, J. Scott Scott McClellan, MDPhD, Bronwen E. Shaw, PhD MRCP, FRCPath, Joseph P. McGuirk, DO, Mehrdad Abedi, MD, Robert S. Negrin, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 47–48.
https://doi.org/10.1182/blood-2020-142974
Published: 2020
Journal Articles

Monitoring Measurable Residual Disease Using Peripheral Blood in Acute Lymphoblastic Leukemia: Results of a Prospective, Observational Study

Lori S. Muffly, MD MS, Vandana Sundaram, MPH, Connie Chen, Ilana Yurkiewicz, MD BS, Eric Kuo, Sarah Burnash, Jay Y. Spiegel, MDFRCPC, Kelly Chyan, Sally Arai, MD MS, Matthew J. Frank, MD PhD, Laura J. Johnston, MD, Robert Lowsky, MD FRCP, Everett H Meyer, MD PhD, Robert S. Negrin, MD, Andrew R. Rezvani, MD, Surbhi Sidana, MD, Parveen Shiraz, MD, Judith A Shizuru, MD PhD, Wen-Kai Weng, MD PhD, Michaela Liedtke, MD, Hyma T. Vempaty, MD, David B. Miklos, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 22–23.
https://doi.org/10.1182/blood-2020-138988
Published: 2020