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Melody Smith
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Journal Articles

A phase 1 clinical trial of NKTR-255 with CD19-22 CAR T-cell therapy for refractory B-cell acute lymphoblastic leukemia

Clinical Trials & Observations
Hrishikesh Srinagesh, Clayton Jackson, Parveen Shiraz, Nikeshan Jeyakumar, Mark Hamilton, Emily Egeler, Sharon Mavroukakis, Adam Kuo, Juancarlos Cancilla, Bita Sahaf, Neha Agarwal, Alyssa Kanegai, Anne Marijn Kramer, Sally Arai, Sushma Bharadwaj, Saurabh Dahiya, Hitomi Hosoya, Laura Johnston, Vanessa Kennedy, Michaela Liedtke, Robert Lowsky, Lekha Mikkilineni, Robert Negrin, Andrew Rezvani, Surbhi Sidana, Judith Shizuru, Melody Smith, Wen-Kai Weng, Steven Feldman, Matthew J. Frank, Zachary Lee, Mary Tagliaferri, A. Mario Marcondes, David Miklos, Crystal Mackall, Lori Muffly
Journal: Blood
Blood (2024) 144 (16): 1689–1698.
https://doi.org/10.1182/blood.2024024952
Published: 2024
Includes: Supplemental data
Journal Articles

The intestinal microbiota and cellular therapy: implications for impact and mechanisms

Jiayi Xie, Melody Smith
Journal: Blood
Blood (2024) 144 (15): 1557–1569.
https://doi.org/10.1182/blood.2024024219
Published: 2024
Journal Articles

CAR19 Therapy Drives Expansion of Clonal Hematopoiesis and Associated Cytopenias

Mark P. Hamilton, Brian J. Sworder, Stefan K. Alig, Zinaida Good, Jan Boegeholz, Joseph Schroers-Martin, John Tamaresis, Mohammad Shahrokh Esfahani, Ying Lu, Mari Olsen, Chih Long Liu, Zachary Ehlinger, Moksha Desai, Felicia Liu-Fei, Lori S. Muffly, Robert S. Negrin, Sally Arai, Laura Johnston, Robert Lowsky, Everett H. Meyer, Andrew R. Rezvani, Judith Shizuru, Wen-Kai Weng, Parveen Shiraz, Surbhi Sidana, Sushma Bharadwaj, Melody Smith, Saurabh Dahiya, Bita Sahaf, Maximilian Diehn, Matthew J. Frank, Crystal L. Mackall, David M. Kurtz, David B. Miklos, Ash A. Alizadeh
Journal: Blood
Blood (2023) 142 (Supplement 1): 360.
https://doi.org/10.1182/blood-2023-182522
Published: 2023
Journal Articles

Impact of Obesity on Efficacy, Safety, and Expansion Kinetics of Chimeric Antigen Receptor-T (CAR T) Therapy in Patients with Relapsed or Refractory Large B Cell Lymphoma (LBCL)

Anmol Goyal, Sushma Bharadwaj, Dasom Lee, Eric Lau, Mark P. Hamilton, Alexandria Jensen, Bita Sahaf, Shriya Syal, Sunita Patil, Juancarlos E Cancilla, Theresa Latchford, Wen-Kai Weng, Melody Smith, Matthew J. Frank, David B. Miklos, Saurabh Dahiya
Journal: Blood
Blood (2023) 142 (Supplement 1): 3783.
https://doi.org/10.1182/blood-2023-186828
Published: 2023
Journal Articles

Post-CAR-T Minimal Residual Disease (MRD) Monitoring in Mantle Cell Lymphoma Enables Early Relapse Detection

Snegha Ananth, Yi-Jiun Su, Mark P. Hamilton, Neha Agarwal, Wen-Kai Weng, Saurabh Dahiya, Sushma Bharadwaj, Jayasindhu Mallampet, Melody Smith, Katherine Ann Kong, Abigail Twoy, David B. Miklos, Matthew J. Frank
Journal: Blood
Blood (2023) 142 (Supplement 1): 1673.
https://doi.org/10.1182/blood-2023-188338
Published: 2023
Journal Articles

Phase 1 Trial Results for Patients with Advanced Hematologic Malignancies Undergoing Reduced Intensity Allogeneic HCT with Orca-T Donor Cell Therapy Product and Single Agent Tacrolimus

Alejandro Villar-Prados, Everett H. Meyer, Katherine Sutherland, Robert S. Negrin, Sally Arai, Matthew J. Frank, Laura Johnston, Robert Lowsky, David B. Miklos, Lori S. Muffly, Saurabh Dahiya, Andrew R. Rezvani, Surbhi Sidana, Parveen Shiraz, Judith Shizuru, Wen-Kai Weng, Melody Smith, Sushma Bharadwaj, John Tamaresis, Anna Pavlova, Scott McClellan
Journal: Blood
Blood (2023) 142 (Supplement 1): 3560.
https://doi.org/10.1182/blood-2023-188162
Published: 2023
Journal Articles

Analysis of PET-CT Derived Radiomic Biomarkers with Efficacy, Safety, and Expansion of Axicabtagene Ciloleucel (Axi-Cel) in Patients with Relapsed or Refractory Large B-Cell Lymphoma (LBCL)

Sushma Bharadwaj, Eric Lau, Ayesha Hashmi, Mark P. Hamilton, Alexandria Jensen, Anmol Goyal, Mallika Marar, Caroline Lee, Snegha Ananth, Bita Sahaf, Jayasindhu Mallampet, Zachary Ehlinger, Shriya Syal, Sunita Patil, Henry Guo, Melody Smith, Wen-Kai Weng, Matthew J. Frank, Michael S. Binkley, David B. Miklos, Saurabh Dahiya
Journal: Blood
Blood (2023) 142 (Supplement 1): 2125.
https://doi.org/10.1182/blood-2023-187617
Published: 2023
Journal Articles

Long-Term Efficacy and Immune Reconstitution with Bendamustine As a Lymphodepleting Agent for Axicabtagene Ciloleucel (Axi-Cel) in Patients with Refractory or Relapsed Large B-Cell Lymphoma (LBCL)

Sushma Bharadwaj, Eric Lau, Anmol Goyal, Mark P. Hamilton, Hrishikesh Srinagesh, Alexandria Jensen, Shriya Syal, Jayasindhu Mallampet, Theresa Latchford, Bita Sahaf, Wen-Kai Weng, Melody Smith, Holden T Maecker, Matthew J. Frank, David B. Miklos, Saurabh Dahiya
Journal: Blood
Blood (2023) 142 (Supplement 1): 4878.
https://doi.org/10.1182/blood-2023-188166
Published: 2023
Journal Articles

Microbes matter in pediatric allo-HSCT

Melody Smith, Kate A. Markey
Journal: Blood
Blood (2023) 142 (16): 1335–1337.
https://doi.org/10.1182/blood.2023021608
Published: 2023
Journal Articles

How I treat refractory CRS and ICANS after CAR T-cell therapy

Clinical Trials & Observations
Michael D. Jain, Melody Smith, Nirali N. Shah
Journal: Blood
Blood (2023) 141 (20): 2430–2442.
https://doi.org/10.1182/blood.2022017414
Published: 2023
Journal Articles

Harnessing ADR T cells to enhance allo-HCT

Melody Smith
Journal: Blood
Blood (2023) 141 (10): 1101–1102.
https://doi.org/10.1182/blood.2022018182
Published: 2023
Journal Articles

Higher Rates of Severe Infection and Persistent Cytopenias in Long-Term CAR19 Responders Than after Autologous HCT: A Single Institution Study of 139 Subjects

Mark P Hamilton, Felicia C Liu-Fei, Stefan K. Alig, John Tamaresis, Mohammad Shahrokh Esfahani, Zinaida Good, Brian Sworder, Joseph Schroers-Martin, Chih Long Liu, Freja Tang Severinsen, Paul J Hanson, Ying Lu, Robert Lowsky, Robert S. Negrin, Everett H Meyer, Melody Smith, Sushma Bharadwaj, Judith A Shizuru, Surbhi Sidana, Parveen Shiraz, Andrew R. Rezvani, Laura J. Johnston, Wen-Kai Weng, Sally Arai, Lori Muffly, Saurabh Dahiya, Maximilian Diehn, David M. Kurtz, Bita Sahaf, Crystal L. Mackall, Matthew J Frank, David B. Miklos, Ash A. Alizadeh
Journal: Blood
Blood (2022) 140 (Supplement 1): 7545–7547.
https://doi.org/10.1182/blood-2022-165600
Published: 2022
Journal Articles

Outcomes for Acute Myeloid Leukemia Relapse after Allogeneic Hematopoietic Cell Transplantation Remain Poor in the Modern Era

Shona Philip, Robert Lowsky, Laura J. Johnston, Sally Arai, Everett H. Meyer, Robert S. Negrin, Andrew R. Rezvani, Parveen Shiraz, Judith A. Shizuru, Surbhi Sidana, Wen-Kai Weng, Sushma Bharadwaj, Matthew J. Frank, David B. Miklos, Melody Smith, Lori Muffly, Vaibhav Agrawal
Journal: Blood
Blood (2022) 140 (Supplement 1): 4825–4827.
https://doi.org/10.1182/blood-2022-168546
Published: 2022
Journal Articles

The Development of Carhlh after Axicabtagene Ciloleucel Is Associated with Poor Outcomes

Shona Philip, Hrishikesh K. Srinagesh, Mark P Hamilton, Cesar Gentille, Alain Mina, Sally Arai, Laura J. Johnston, Robert Lowsky, Everett H Meyer, Robert S. Negrin, Andrew R. Rezvani, Parveen Shiraz, Judith A Shizuru, Surbhi Sidana, Wen-Kai Weng, Sushma Bharadwaj, Saurabh Dahiya, Lori Muffly, Melody Smith, David B. Miklos, Matthew J Frank
Journal: Blood
Blood (2022) 140 (Supplement 1): 12775–12777.
https://doi.org/10.1182/blood-2022-170877
Published: 2022
Journal Articles

Microbial Bile Acid Metabolism Shapes Effector T Cell Responses during Inflammation in Mouse and Human

Sarah Lindner, Oriana Miltiadous, Ruben J Ramos, Anqi Dai, Anastasia Kousa, Gabriel K Armijo, Romina Ghale, Chi L Nguyen, Jenny Paredes Sanchez, Teng Fei, John W Frame V, Sebastien Monette, Emily Fontana, John Slingerland, Ying Taur, Marina D Burgos da Silva, Kate A Markey, Jonathan U Peled, Melody Smith, Sergio A Giralt, Miguel-Angel Perales, Justin R Cross, Clarissa Campbell, Marcel R M van den Brink
Journal: Blood
Blood (2022) 140 (Supplement 1): 1154–1156.
https://doi.org/10.1182/blood-2022-167809
Published: 2022
Journal Articles

Allogeneic Hematopoietic Cell Transplantation in Patients with Relapsed or Refractory Acute Leukemia

Shlomo Elias, Moneeza Walji, Samantha Brown, Sean M. Devlin, Esperanza B. Papadopoulos, Ann A Jakubowski, Doris M Ponce, James W. Young, Sergio A Giralt, Miguel-Angel Perales, Brian C. Shaffer, Parastoo B. Dahi, Richard J. Lin, Christina Cho, Roni Tamari, Melody Smith, Boglarka Gyurkocza
Journal: Blood
Blood (2022) 140 (Supplement 1): 10627–10628.
https://doi.org/10.1182/blood-2022-170088
Published: 2022
Journal Articles

Analysis of Bendamustine Lymphodepletion, CD19 CART Expansion, Safety and Efficacy in Patients with Rel/Ref Non-Hodgkin Lymphoma

Sushma Bharadwaj, Mark P Hamilton, Bita Sahaf, John Tamaresis, Sunita Patil, Paul J Hanson, Theresa Latchford, Sally Arai, Laura J. Johnston, Robert Lowsky, Robert S. Negrin, Andrew R. Rezvani, Judith A Shizuru, Everett H Meyer, Parveen Shiraz, Surbhi Sidana, Melody Smith, Wen-Kai Weng, Lori Muffly, Crystal L. Mackall, Matthew J Frank, David B. Miklos, Saurabh Dahiya
Journal: Blood
Blood (2022) 140 (Supplement 1): 10371–10373.
https://doi.org/10.1182/blood-2022-170759
Published: 2022
Journal Articles

Alloreactive T cells deficient of the short-chain fatty acid receptor GPR109A induce less graft-versus-host disease

Melissa D. Docampo, Marina B. da Silva, Amina Lazrak, Katherine B. Nichols, Sophia R. Lieberman, Ann E. Slingerland, Gabriel K. Armijo, Yusuke Shono, Chi Nguyen, Sebastien Monette, Emmanuel Dwomoh, Nicole Lee, Clair D. Geary, Suelen M. Perobelli, Melody Smith, Kate A. Markey, Santosha A. Vardhana, Anastasia I. Kousa, Eli Zamir, Itamar Greenfield, Joseph C. Sun, Justin R. Cross, Jonathan U. Peled, Robert R. Jenq, Christoph K. Stein-Thoeringer, Marcel R. M. van den Brink
Journal: Blood
Blood (2022) 139 (15): 2392–2405.
https://doi.org/10.1182/blood.2021010719
Published: 2022
Includes: Supplemental data
Journal Articles

Highly Selective Irreversible ITK Inhibitor Cpi-818 Reduces Acute Graft-Versus Host Disease

Sarah Lindner, Nicole Lee, Gabriel K Armijo, Marina D Burgos da Silva, Pamela S Herrera, Chi L Nguyen, Emmanuel A Dwomoh, Romina Ghale, Melody Smith, Miguel-Angel Perales, Kate A Markey, Joseph J Buggy, James W Janc, Marcel van den Brink
Journal: Blood
Blood (2021) 138 (Supplement 1): 3814.
https://doi.org/10.1182/blood-2021-153360
Published: 2021
Journal Articles

The Intestinal Microbiota Correlates with Response and Toxicity after CAR T Cell Therapy in Patients with B-Cell Malignancies

Melody Smith, Anqi Dai, Guido Ghilardi, Kimberly Amelsberg, Sean M Devlin, Raymone Pajarillo, John B Slingerland, Silvia Beghi, Pamela S Herrera, Paul A Giardina, Annelie Clurman, Emmanuel A Dwomoh, Gabriel K Armijo, Antonio L.C. Gomes, Eric R Littmann, Jonas Schluter, Emily Fontana, Ying Taur, Jae H Park, Maria Lia Palomba, Elizabeth Halton, Josel D Ruiz, Tania Jain, Martina Pennisi, Aishat Olaide Afuye, Miguel-Angel Perales, Craig W. Freyer, Alfred L Garfall, Shannon H Gier, Sunita Nasta, Daniel J Landsburg, James N Gerson, Jakub Svoboda, Justin Cross, Elise A Chong, Sergio A Giralt, Saar Gill, Isabelle Rivière, David L Porter, Stephen J Schuster, Michel Sadelain, Noelle V Frey, Renier J Brentjens, Carl H June, Eric G Pamer, Jonathan U Peled, Marco Ruella, Marcel van den Brink, Andrea Facciabene
Journal: Blood
Blood (2021) 138 (Supplement 1): 253.
https://doi.org/10.1182/blood-2021-153945
Published: 2021