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Journal Articles

Loss of CCAAT‐Enhancer Binding Protein Delta Promotes Acute Myeloid Leukemia Cell Proliferation and Survival By Upregulating Cyclin D1 Expression

Subhash Prajapati, Cem Meydan, Richard Dillon, Nicholas Dunham, Hao Fan, Jorge A Gandara, Tak Lee, Yaseswini Neelamraju, Caroline Sheridan, Zhenjia Wang, Paul Zumbo, Michael W. Becker, Lars Bullinger, Martin Carroll, Richard J D'Andrea, Ross L Levine, Christopher Mason, Ari M Melnick, Chongzhi Zang, Stefan Bekiranov, Francine E. Garrett-Bakelman
Journal: Blood
Blood (2023) 142 (Supplement 1): 1380.
https://doi.org/10.1182/blood-2023-181946
Published: 2023
Journal Articles

SWI/SNF Chromatin Remodeling Complex Orchestrates Sequential Binding of Key Transcription Factors in B Cells and Restricts Aggressive Lymphoma

Darko Barisic, Christopher Chin, Cem Meydan, Matthew Teater, Ioanna Tsialta, Coraline Mlynarczyk, Amy Chadburn, Min Xia, Christian Steidl, David W. Scott, Andrew P. Weng, Christopher Mason, Michael R. Green, Ari M Melnick
Journal: Blood
Blood (2023) 142 (Supplement 1): 718.
https://doi.org/10.1182/blood-2023-190494
Published: 2023
Journal Articles

Cooperative Super-Enhancer Inactivation through Loss of Crebbp and KMT2D Skews B Cell Fate Decisions and Yields T Cell-Depleted Lymphomas

Jie Li, Christopher Chin, Hsia-Yuan Ying, Cem Meydan, Matthew Teater, Min Xia, Pedro Farinha, Katsuyoshi Takata, Chi-Shuen Chu, Martin A Rivas, Amy Chadburn, Christian Steidl, David W. Scott, Robert G. Roeder, Christopher Mason, Wendy Béguelin, Ari M Melnick
Journal: Blood
Blood (2023) 142 (Supplement 1): 2776.
https://doi.org/10.1182/blood-2023-174501
Published: 2023
Journal Articles

PRMT5 supports multiple oncogenic pathways in mantle cell lymphoma

Shelby L. Sloan, Fiona Brown, Mackenzie Long, Christoph Weigel, Shirsha Koirala, Ji-Hyun Chung, Betsy Pray, Lynda Villagomez, Claire Hinterschied, Anuvrat Sircar, JoBeth Helmig-Mason, Alexander Prouty, Eric Brooks, Youssef Youssef, Walter Hanel, Samir Parekh, Wing Keung Chan, Zhengming Chen, Rosa Lapalombella, Lalit Sehgal, Kris Vaddi, Peggy Scherle, Selina Chen-Kiang, Maurizio Di Liberto, Olivier Elemento, Cem Meydan, Jonathan Foox, Daniel Butler, Christopher E. Mason, Robert A. Baiocchi, Lapo Alinari
Journal: Blood
Blood (2023) 142 (10): 887–902.
https://doi.org/10.1182/blood.2022019419
Published: 2023
Includes: Supplemental data
Journal Articles

Smarca4 (Brg1) Controls Germinal Center B-Cell Development and Is a Haploinsufficient Tumor Suppressor in Lymphoma

Qing Deng, Cem Meydan, Priya Lakra, Darko Barisic, Christopher R Chin, Estela Rojas-Neira, Vida Ravanmehr, Jared Henderson, Panhong Gou, Nader Kim El-Mallawany, Carl Allen, Branko Cuglievan, Francisco Vega, Christopher E Mason, Ari Melnick, Michael R Green
Journal: Blood
Blood (2022) 140 (Supplement 1): 1690–1691.
https://doi.org/10.1182/blood-2022-166258
Published: 2022
Journal Articles

Acquired Resistance to PRMT5 Inhibition in Mantle Cell Lymphoma Is Associated with Compensatory Activation of Multiple Signaling Pathways

Mackenzie Long, Shirsha Koirala, Shelby Sloan, Fiona Brown, Sheetal Tallada, Claire Hinterschied, Kara Corps, JoBeth Helmig-Mason, Ji Hyun Chung, Peggy Scherle, Kris Vaddi, Cem Meydan, Jonathan Foox, Daniel Butler, Christopher E Mason, Lapo Alinari, Bradley W Blaser, Robert A. Baiocchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 3103–3104.
https://doi.org/10.1182/blood-2022-164641
Published: 2022
Journal Articles

PRMT5 Inhibition Modulates E2F1 and P53 to Restore Cell Cycle Regulation and Drive DNA Damage Response in Ibrutinib-Resistant Mantle Cell Lymphoma

Shelby Sloan, Fiona Brown, Mackenzie Long, JoBeth Helmig-Mason, Stacey Beck, Ji Hyun Chung, Walter Hanel, Eric Brooks, Haley Klimazewski, Cem Meydan, Jonathan Foox, Daniel Butler, John C. Byrd, Rosa Lapalombella, Maurizio Di Liberto, Christopher Mason, Selina Chen-Kiang, Kris Vaddi, Peggy Scherle, Robert Baiocchi, Lapo Alinari
Journal: Blood
Blood (2021) 138 (Supplement 1): 787.
https://doi.org/10.1182/blood-2021-153992
Published: 2021
Journal Articles

BCL6 maintains survival and self-renewal of primary human acute myeloid leukemia cells

Kimihito C. Kawabata, Hongliang Zong, Cem Meydan, Sarah Wyman, Bas J. Wouters, Mayumi Sugita, Srinjoy Goswami, Michael Albert, Winnie Yip, Gail J. Roboz, Zhengming Chen, Ruud Delwel, Martin Carroll, Christopher E. Mason, Ari Melnick, Monica L. Guzman
Journal: Blood
Blood (2021) 137 (6): 812–825.
https://doi.org/10.1182/blood.2019001745
Published: 2021
Includes: Supplemental data
Journal Articles

Computational Systems Biology Models for the Identification of Metabolic Vulnerabilities in Multiple Myeloma

Luis Vitores V. Valcárcel, MSc, Raquel Ordoñez, PhD, Iñigo Apaolaza, MSc, Ana Valcárcel, Leire Garate, Cem Meydan, PhD, Bruno Paiva, PhD, Ari M Melnick, MD, Jesús San-Miguel, Francisco J. Planes, Xabier Agirre, PhD, Felipe Prosper, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3084.
https://doi.org/10.1182/blood-2019-123970
Published: 2019
Journal Articles

Characterization of Complete Lncrnas Transcriptome Reveals Expression of Lncrnas As a Prognostic Factor and Linc-Smilo As a Potential Therapeutic Target in Multiple Myeloma

Arantxa Carrasco, Teresa Ezponda, Cem Meydan, PhD, Luis Vitores Valcárcel, MSc, Raquel Ordoñez, PhD, Marta Kulis, PhD, Leire Garate, Estíbaliz Miranda, Victor Segura, PhD, Elizabeth Guruceaga, Amaia Vilas-Zornoza, PhD, Diego Alignani, PhD, Laura Castro, Marien Pascual, PhD, Ane Amundarain, Halima El Omri, Ruba Yasin, MBBS, MRCP, Maria Jose Calasanz, PhD BSc, Francisco J Planes, Bruno Paiva, PhD, Christopher Mason, PhD, Jesús San-Miguel, Inaki Martin Subero, PhD, Ari M Melnick, MD, Felipe Prosper, MD PhD, Xabier Agirre, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4323.
https://doi.org/10.1182/blood-2019-123008
Published: 2019
Journal Articles

EZH2 Gain-of-Function Mutations Generate a Lymphoma-Permissive Immune Niche

Wendy Béguelin, PhD, Matthew R Teater, PhD, Cem Meydan, PhD, Jude M Phillip, PhD, Ari Melnick, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2768.
https://doi.org/10.1182/blood-2019-132263
Published: 2019
Journal Articles

Therapeutic Targeting of the Ubiquitin Conjugating Enzyme UBE2N in Myeloid Malignancies

Laura Barreyro, PhD, Avery Sampson, BSc, Kathleen Hueneman, BSc, Lyndsey C Bolanos, BSc, Mario Pujato, PhD, Somchai Chutipongtanate, MD PhD, Michael Wyder, MS, Wendy Haffey, PhD, Kwangmin Choi, PhD, Yaseswini Neelamraju, MS, Molly A Smith, BSc, Madeline Niederkorn, BSc, Vighnesh Ramesh, Tomoya Muto, MD PhD, Eric O'Brien, BSc, Cem Meydan, PhD, Susanne Christie, BSc, Xiaona Liu, Francine Garret-Bakelman, MD PhD, Boris Bartholdy, PhD, Britta Will, PhD, Matthew T. Weirauch, PhD, Zartash Gul, MD, Stephen Medlin, MD, John Peter Perentesis, MD, Kenneth D Greis, PhD, William Seibel, PhD, Daniel T. Starczynowski, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4050.
https://doi.org/10.1182/blood-2018-99-115359
Published: 2018
Journal Articles

Genetically-Defined AML Subgroups Represent Diverse Epigenetic Heterogeneity Landscape

Sheng Li, PhD, Xiaowen Chen, PhD, Jihui Wang, MS, Cem Meydan, PhD, Jacob L Glass, MDPhD, Alan H. Shih, MD PhD, Peter J.M. Valk, PhD, Ruud Delwel, PhD, Ross L. Levine, MD, Christopher Mason, PhD, Ari Melnick, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 243.
https://doi.org/10.1182/blood.V130.Suppl_1.243.243
Published: 2017
Journal Articles

Aid is a key regulator of myeloid/erythroid differentiation and DNA methylation in hematopoietic stem/progenitor cells

Hiroyoshi Kunimoto, Anna Sophia McKenney, Cem Meydan, Kaitlyn Shank, Abbas Nazir, Franck Rapaport, Benjamin Durham, Francine E. Garrett-Bakelman, Elodie Pronier, Alan H. Shih, Ari Melnick, Jayanta Chaudhuri, Ross L. Levine
Journal: Blood
Blood (2017) 129 (13): 1779–1790.
https://doi.org/10.1182/blood-2016-06-721977
Published: 2017
Includes: Supplemental data
Journal Articles

Cooperative Epigenetic Remodeling By TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity

Hiroyoshi Kunimoto, MD PhD, Cem Meydan, PhD, Abbas Nazir, BS, Kaitlyn Shank, BS, Rebecca Maher, BA, Franck Rapaport, PhD, Elodie Pronier, PhD, Ari Melnick, MD, Ross L. Levine, MD, Alan H. Shih, MD PhD
Journal: Blood
Blood (2016) 128 (22): 433.
https://doi.org/10.1182/blood.V128.22.433.433
Published: 2016
Journal Articles

Long Non-Coding RNAs Annotation and Their Involvement in Multiple Myeloma

Arantxa Carrasco, Teresa Ezponda, Cem Meydan, PhD, Marta Kulis, Raquel Ordoñez, Leire Garate, Victor Segura, PhD, Diego Alignani, Bruno Paiva, PhD, Jesus San Miguel, MD PhD, José I. Martin Subero, PhD, Ari Melnick, MD, Felipe Prosper, MD, Xabier Agirre, PhD
Journal: Blood
Blood (2016) 128 (22): 4420.
https://doi.org/10.1182/blood.V128.22.4420.4420
Published: 2016
Journal Articles

Cooperative Gene Repression By DNA Methylation and LSD1-Mediated Enhancer Inactivation in Acute Myeloid Leukemia

Cihangir Duy, PhD, Matt Teater, M.S., Francine E. Garrett-Bakelman, MD PhD, Tak C Lee, M.S., Cem Meydan, PhD, Jacob Lowell Glass, MD PhD, Meng Li, PhD, Helai Mohammad, PhD, Kimberly Smitheman, Alan H. Shih, MD PhD, Omar Abdel-Wahab, MD, Elisabeth Paietta, PhD, Martin S. Tallman, MD, Monica L. Guzman, PhD, Ryan G. Kruger, PhD, Caretha L. Creasy, PhD, Ross L. Levine, MD, Martin Carroll, MD, Ari Melnick, MD
Journal: Blood
Blood (2016) 128 (22): 1048.
https://doi.org/10.1182/blood.V128.22.1048.1048
Published: 2016
Journal Articles

Targeting ß -Catenin Signaling in DLBCL with ICG-001 and PAM-1 Suppresses Cell Proliferation and Induces Apoptosis

Angela A. Fachel, PhD, Ashlesha Shrikant Muley, MS, Cem Meydan, PhD, Xabier Agirre, PhD, Leandro Cerchietti, MD, Ari Melnick, MD, Kristy L. Richards, PhD MD
Journal: Blood
Blood (2016) 128 (22): 5382.
https://doi.org/10.1182/blood.V128.22.5382.5382
Published: 2016
Journal Articles

Dose-Dependent Role of the Cohesin Complex in Normal and Malignant Hematopoiesis

Aaron D. Viny, MD MS, Christopher J. Ott, PhD, Barbara Spitzer, MD, Martin A Rivas, PhD, Cem Meydan, Efthymia Papalexi, Dana Yelin, MD, Kaitlyn Shank, BS, Jaime Reyes, April Chiu, MD, Swapna Thota, MD, Jaroslaw P Maciejewski, MD PhD FACP, Ari Melnick, MD, James E. Bradner, MD, Ross L. Levine, MD
Journal: Blood
Blood (2015) 126 (23): 435.
https://doi.org/10.1182/blood.V126.23.435.435
Published: 2015
Journal Articles

AG-221, a Small Molecule Mutant IDH2 Inhibitor, Remodels the Epigenetic State of IDH2-Mutant Cells and Induces Alterations in Self-Renewal/Differentiation in IDH2-Mutant AML Model in Vivo

Alan H. Shih, MDPhD, Kaitlyn R Shank, B.S., Cem Meydan, Andrew M. Intlekofer, MD PhD, Patrick Ward, Craig B. Thompson, MD, Ari M Melnick, MD, Jeremy Travins, Kim Straley, Camelia Gliser, Katherine Yen, Ross L Levine, MD
Journal: Blood
Blood (2014) 124 (21): 437.
https://doi.org/10.1182/blood.V124.21.437.437
Published: 2014