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Journal Articles

Multicenter phase 2 study of oral azacitidine (CC-486) plus CHOP as initial treatment for PTCL

Clinical Trials & Observations
Jia Ruan, Alison Moskowitz, Neha Mehta-Shah, Lubomir Sokol, Zhengming Chen, Nikita Kotlov, Grigorii Nos, Maria Sorokina, Vladislav Maksimov, Andrea Sboner, Michael Sigouros, Koen van Besien, Steven Horwitz, Sarah C. Rutherford, Erin Mulvey, Maria V. Revuelta, Jenny Xiang, Alicia Alonso, Ari Melnick, Olivier Elemento, Giorgio Inghirami, John P. Leonard, Leandro Cerchietti, Peter Martin
Journal: Blood
Blood (2023) 141 (18): 2194–2205.
https://doi.org/10.1182/blood.2022018254
Published: 2023
Includes: Supplemental data
Journal Articles

Smarca4 (Brg1) Controls Germinal Center B-Cell Development and Is a Haploinsufficient Tumor Suppressor in Lymphoma

Qing Deng, Cem Meydan, Priya Lakra, Darko Barisic, Christopher R Chin, Estela Rojas-Neira, Vida Ravanmehr, Jared Henderson, Panhong Gou, Nader Kim El-Mallawany, Carl Allen, Branko Cuglievan, Francisco Vega, Christopher E Mason, Ari Melnick, Michael R Green
Journal: Blood
Blood (2022) 140 (Supplement 1): 1690–1691.
https://doi.org/10.1182/blood-2022-166258
Published: 2022
Journal Articles

Simultaneous Inhibition of SIRT3 and Cholesterol Homeostasis Targets AML Stem Cells By Perturbing Fatty Acid β-Oxidation and Inducing Lipotoxicity

Cristiana O'Brien, Tianyi Ling, Jacob Berman, Rachel Culp-Hill, Julie A. Reisz, Vincent Rondeau, Soheil Jahangiri, Jonathan St-Germain, Vinitha Macwan, Audrey Astori, Andy G.X. Zeng, Jun Young Hong, Meng Li, Min Yang, Sadhan Jana, John E. Dick, Hening Lin, Ari Melnick, Anastasia N Tikhonova, Andrea Arruda, Mark D. Minden, Brian Raught, Angelo D'Alessandro, Courtney L Jones
Journal: Blood
Blood (2022) 140 (Supplement 1): 104–106.
https://doi.org/10.1182/blood-2022-157794
Published: 2022
Journal Articles

FGFR1 Is a Novel Therapeutic Target in Relapsed/Refractory Diffuse Large B Cell Lymphoma (RR-DLBCL)

Nicolas Di Siervi, Maria Victoria Revuelta, Maria Teresa Cacciapuoti, Nahuel Zamponi, Rossella Marullo, Ari Melnick, Giorgio Inghirami, Leandro Cerchietti
Journal: Blood
Blood (2022) 140 (Supplement 1): 1322.
https://doi.org/10.1182/blood-2022-169529
Published: 2022
Journal Articles

The Single-Cell Pathology Landscape of Diffuse Large B Cell Lymphoma

Dylan McNally, Andrew Lytle, Hiranmayi Ravichandran, Wayne Tam, Christian Steidl, David W. Scott, Ari Melnick, Olivier Elemento
Journal: Blood
Blood (2022) 140 (Supplement 1): 162–163.
https://doi.org/10.1182/blood-2022-169912
Published: 2022
Journal Articles

DTX1 Controls Germinal Center B-Cell Development and Lymphomagenesis

Atish Kizhakeyil, Sreejoyee Ghosh, Estela Rojas-Neira, Qing Deng, Jared Henderson, Jordan Showell, Ari Melnick, Wendy Beguelin, Francisco Vega, Loretta J. Nastoupil, Michael R Green
Journal: Blood
Blood (2022) 140 (Supplement 1): 1700–1701.
https://doi.org/10.1182/blood-2022-167086
Published: 2022
Journal Articles

A Predictive Endothelial-Leukemia Pre-Clinical Platform to Uncover Drug Vulnerabilities for Personalized Treatments

Luca Vincenzo Cappelli, Danilo Fiore, Jude M Phillip, Liron Yoffe, Filomena Di Giacomo, Yang Hu, Clarisse Kayembe, Michael Ginsberg, Lorena Consolino, José Gabriel Barcia Durán, Nahuel Zamponi, Ari Melnick, Francesco Boccalatte, Wayne Tam, Olivier Elemento, Sabina Chiaretti, Anna Guarini, Robin Foa, Leandro Cerchietti, Shahin Rafii, Giorgio Inghirami
Journal: Blood
Blood (2021) 138 (Supplement 1): 704.
https://doi.org/10.1182/blood-2021-153300
Published: 2021
Journal Articles

Complex Structural Variation Associated with Enhancer Hijacking and Loss of Tumor Suppressors in Mantle Cell Lymphoma

Prasath Pararajalingam, Laura K Hilton, Krysta M. Coyle, Kostiantyn Dreval, Barbara Meissner, Ari Melnick, Marco A. Marra, David W. Scott, Ryan D Morin
Journal: Blood
Blood (2021) 138 (Supplement 1): 675.
https://doi.org/10.1182/blood-2021-153162
Published: 2021
Journal Articles

MALT1 Degradation with a Proteolysis-Targeting Chimera for the Treatment of Activated B-Cell Type Diffuse Large B-Cell Lymphoma

Madhav R Seshadri, Lorena Fontan, Prasanna Sreevatsan, David Scott, John Hatcher, Guangyan Du, Min Xia, Ilkay Us, Nathanael Gray, Ari Melnick
Journal: Blood
Blood (2021) 138 (Supplement 1): 269.
https://doi.org/10.1182/blood-2021-153855
Published: 2021
Journal Articles

Sirtuin 3 Inhibition Targets AML Stem Cells through Perturbation of Fatty Acid Oxidation

Cristiana O'Brien, Jacob Berman, Rachel Culp-Hill, Julie Reisz, Tianyi Ling, Vincent Rondeau, Meng Li, Min Yang, Jun Young Hong, Hening Lin, Ari Melnick, Andrea Arruda, Mark D. Minden, Angelo D'Alessandro, Courtney L Jones
Journal: Blood
Blood (2021) 138 (Supplement 1): 2240.
https://doi.org/10.1182/blood-2021-148143
Published: 2021
Journal Articles

Single Cell ATAC Lineage Deconvolution Reveals Overlapping Subclones in Epigenetically Distinct AML Samples

Deepika Dilip, Richard Koche, Kamal Menghrajani, Ari Melnick, Olivier Elemento, Ross L. Levine, Jacob L Glass
Journal: Blood
Blood (2021) 138 (Supplement 1): 2381.
https://doi.org/10.1182/blood-2021-154517
Published: 2021
Journal Articles

Allogeneic Transplantation in Fit Older Adults Is Feasible and Encouragingly Efficacious. Post Remission Data from the Prospective ECOG-ACRIN (E2906) Clinical Study

Yishai Ofran, Zhuoxin Sun, Jacob M. Rowe, David F. Claxton, Martin S. Tallman, Daniel A. Arber, Ari Melnick, Ross L. Levine, Elisabeth Paietta, John E. Godwin, Hillard M Lazarus, Selina M. Luger, James M. Foran, Mark R. Litzow
Journal: Blood
Blood (2021) 138 (Supplement 1): 413.
https://doi.org/10.1182/blood-2021-149356
Published: 2021
Journal Articles

High Rates of Remission with the Initial Treatment of Oral Azacitidine Plus CHOP for Peripheral T-Cell Lymphoma (PTCL): Clinical Outcomes and Biomarker Analysis of a Multi-Center Phase II Study

Jia Ruan, Alison J. Moskowitz, Neha Mehta-Shah, Lubomir Sokol, Zhengming Chen, Riyaad Rahim, Wei Song, Nikita Kotlov, Grigorii Nos, Vladislav Maksimov, Maria Victoria Revuelta, Andrea Sboner, Michael Sigouros, Koen van Besien, Steven M. Horwitz, Sarah C. Rutherford, Erin C. Mulvey, Morton Coleman, Ari Melnick, Olivier Elemento, Giorgio Inghirami, John P. Leonard, Peter Martin, Leandro Cerchietti
Journal: Blood
Blood (2021) 138 (Supplement 1): 138.
https://doi.org/10.1182/blood-2021-145495
Published: 2021
Journal Articles

BTG1 Mutation Promotes Aggressive Lymphoma Development By Lowering the Threshold to MYC Activation and Generating "Super-Competitor" B Cells

Coraline Mlynarczyk, Matthew Teater, Juhee Pae, Theinmozhi Arulraj, Christopher R Chin, Ling Wang, Jonatan Ersching, Ekaterina Kots, Amy Chadburn, Ersilia Barin, Hui Xian Poh, Hannah M Isles, Chen Zhengming, Hao Shen, Arnab Bandyopadhyay, Kenneth B Hoehn, Diu T.T. Nguyen, Ashley S Doane, Huimin Geng, Muhammad H Rehman, Jonah Melnick, Wyatt Morgan, Olivier Elemento, Michael G Kharas, David W. Scott, Samie R Jaffrey, Michael Meyer-Hermann, George Khelashvili, Gabriel Victora, Ari Melnick
Journal: Blood
Blood (2021) 138 (Supplement 1): 359.
https://doi.org/10.1182/blood-2021-149921
Published: 2021
Journal Articles

Molecular classification improves risk assessment in adult BCR-ABL1– negative B-ALL

Elisabeth Paietta, Kathryn G. Roberts, Victoria Wang, Zhaohui Gu, Georgina A. N. Buck, Deqing Pei, Cheng Cheng, Ross L. Levine, Omar Abdel-Wahab, Zhongshan Cheng, Gang Wu, Chunxu Qu, Lei Shi, Stanley Pounds, Cheryl L. Willman, Richard Harvey, Janis Racevskis, Jan Barinka, Yanming Zhang, Gordon W. Dewald, Rhett P. Ketterling, David Alejos, Hillard M. Lazarus, Selina M. Luger, Letizia Foroni, Bela Patel, Adele K. Fielding, Ari Melnick, David I. Marks, Anthony V. Moorman, Peter H. Wiernik, Jacob M. Rowe, Martin S. Tallman, Anthony H. Goldstone, Charles G. Mullighan, Mark R. Litzow
Journal: Blood
Blood (2021) 138 (11): 948–958.
https://doi.org/10.1182/blood.2020010144
Published: 2021
Includes: Supplemental data
Journal Articles

KDM5 inhibition offers a novel therapeutic strategy for the treatment of KMT2D mutant lymphomas

James Heward, Lola Koniali, Annalisa D’Avola, Karina Close, Alison Yeomans, Martin Philpott, James Dunford, Tahrima Rahim, Ahad F. Al Seraihi, Jun Wang, Koorosh Korfi, Shamzah Araf, Sameena Iqbal, Findlay Bewicke-Copley, Emil Kumar, Darko Barisic, Maria Calaminici, Andrew Clear, John Gribben, Peter Johnson, Richard Neve, Pedro Cutillas, Jessica Okosun, Udo Oppermann, Ari Melnick, Graham Packham, Jude Fitzgibbon
Journal: Blood
Blood (2021) 138 (5): 370–381.
https://doi.org/10.1182/blood.2020008743
Published: 2021
Includes: Supplemental data
Journal Articles

BCL6 maintains survival and self-renewal of primary human acute myeloid leukemia cells

Kimihito C. Kawabata, Hongliang Zong, Cem Meydan, Sarah Wyman, Bas J. Wouters, Mayumi Sugita, Srinjoy Goswami, Michael Albert, Winnie Yip, Gail J. Roboz, Zhengming Chen, Ruud Delwel, Martin Carroll, Christopher E. Mason, Ari Melnick, Monica L. Guzman
Journal: Blood
Blood (2021) 137 (6): 812–825.
https://doi.org/10.1182/blood.2019001745
Published: 2021
Includes: Supplemental data
Journal Articles

Identification of MALT1 feedback mechanisms enables rational design of potent antilymphoma regimens for ABC-DLBCL

Lorena Fontan, Rebecca Goldstein, Gabriella Casalena, Matthew Durant, Matthew R. Teater, Jimmy Wilson, Jude Phillip, Min Xia, Shivem Shah, Ilkay Us, Himaly Shinglot, Ankur Singh, Giorgio Inghirami, Ari Melnick
Journal: Blood
Blood (2021) 137 (6): 788–800.
https://doi.org/10.1182/blood.2019004713
Published: 2021
Includes: Supplemental data
Journal Articles

BCL10 Gain-of-Function Mutations Aberrantly Induce Canonical and Non-Canonical NF-Kb Activation and Resistance to Ibrutinib in ABC-DLBCL

Min Xia, Liron David, PhD, Matthew Teater, PhD, Ozlem Onder, PhD MSc, Kojo S. J. Elenitoba-Johnson, MD, Lorena Fontan, PhD, Hao Wu, PhD, Ari Melnick, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 2–3.
https://doi.org/10.1182/blood-2020-141363
Published: 2020
Journal Articles

Multi-Center Phase II Study of Oral Azacitidine (CC-486) Plus CHOP As Initial Treatment for Peripheral T-Cell Lymphoma (PTCL)

Jia Ruan, MD PhD, Alison J. Moskowitz, MD, Neha Mehta-Shah, MD, Lubomir Sokol, MD PhD, Zhengming Chen, PhD MPH, MS, Riyaad Rahim, Wei Song, Koen Van Besien, MD PhD, Steven M. Horwitz, MD, Sarah C. Rutherford, MD, Morton Coleman, MD FACP, Ari Melnick, MD, Giorgio Inghirami, MD, Leandro Cerchietti, MD, John P. Leonard, MD, Peter Martin, FRCPC, MD MS
Journal: Blood
Blood (2020) 136 (Supplement 1): 33–34.
https://doi.org/10.1182/blood-2020-136023
Published: 2020