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Mark D. Minden
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Journal Articles

Intracellular IL-23 Receptor (IL-23R) Is a Regulator of Mitotic Spindle and Centrosome Formation and Is Essential for AML Viability

Nathan Duong, Dilshad H. Khan, Geethu Emily Thomas, Rose Hurren, Jong Bok Lee, Jonathan St-Germain, Lily Drimmer, Yongran Yan, Neil Maclean, Marcela Gronda, Vincent Rondeau, Brandon D. Brown, Courtney L Jones, Hong Chang, Andrea Arruda, Mark D. Minden, Li Zhang, Steven M. Kornblau, Brian Raught, Vito Spadavecchio, Aaron D. Schimmer
Journal: Blood
Blood (2023) 142 (Supplement 1): 5694.
https://doi.org/10.1182/blood-2023-174536
Published: 2023
Journal Articles

Presence of Recurrent Somatic Mutations in Mesenchymal Stromal Cell Fractions Isolated from Acute Myeloid Leukemia As an Evidence of Clonality

Muzaffar Bhatti, Taehyung Kim, Jenny Warrington, Amirthagowri Ambalavanan, Sarah Zarabi, Anthea Travas, Jaeyoon John Kim, Danielle Pyne, Troy Ketela, Andrea Arruda, Mark D. Minden, Armand Keating, Dennis Dong Hwan Kim
Journal: Blood
Blood (2023) 142 (Supplement 1): 6042.
https://doi.org/10.1182/blood-2023-185149
Published: 2023
Journal Articles

Identification of Unexpected Responders to Gilteritinib in a Cohort of FLT3-WT AML Patients Using Ex-Vivo Testing

Alejandra Garcia, Laura Bertoldi, Paula Scaglia, Sofia Carbajosa, Natalia Cavallo, Agustina Garcia-Melani, Laura Guantay, Marisa Piaggio, Gimena Ferreira, Maria Sol Jarchum, Gustavo Jarchum, Miguel Arturo Pavlovsky, Isolda Isabel Fernandez, María Jose Mela Osorio, Carolina Pavlovsky, Blanca Rossi, Martín Alonso, Juan José García, Nicolás Cazap, Jorge Solimano, Silvina Palmer, Adriana Rinflerch, Erika Barbara Brulc, Paula González Hermida, Alberto Gimenez Conca, Emilio Sarkotic, Andrea Arruda, Mark D. Minden, Virginia García, Federico Molineris, Maximiliano Zeballos, Maria Laura Bernaschini, Diego Andino, Agustina Conrrero, María Rita Drocchi, Tarek Ali Zaki, Gerardo Gatti, Candelaria Llorens, Gaston Soria
Journal: Blood
Blood (2023) 142 (Supplement 1): 7132.
https://doi.org/10.1182/blood-2023-181119
Published: 2023
Journal Articles

The Atpase Domain of LONP1 Is Necessary for Mitochondrial Protein Solubility and the Viability of Acute Myeloid Leukemia (AML) Cells

Matthew Tcheng, Aaron D. Schimmer, Marcela Gronda, Rose Hurren, Shahbaz Khan, Lan Xin Zhang, Chaitra Sarathy, Yongran Yan, Andrea Arruda, Thomas Kislinger, Mark D. Minden
Journal: Blood
Blood (2023) 142 (Supplement 1): 1420.
https://doi.org/10.1182/blood-2023-178399
Published: 2023
Journal Articles

Inflammatory Signatures Define a New High-Risk T-Lineage ALL Subtype

Mark Gower, Ximing Li, Alicia Aguilar-Navarro, Brian Lin, Minerva Fernandez, Gibran Edun, Mursal Nader, Andrea Arruda, Anne Maria Tierens, Elvin Wagenblast, Lin Yang, Ho Seok Lee, Sanam Loghavi, John E. Dick, Mark D. Minden, Johann K. Hitzler, Courtney L Jones, Gregory Schwartz, Igor Dolgalev, Soheil Jahangiri, Anastasia N. Tikhonova
Journal: Blood
Blood (2023) 142 (Supplement 1): 2969.
https://doi.org/10.1182/blood-2023-182412
Published: 2023
Journal Articles

DNA Methylation Instability: A Novel Biomarker for Aging, Clonality, and Cancer

Salman Basrai, Robert Kridel, Mehran Bakhtiari, Dennis D. H. Kim, Fernando L. Scolari, Filio Billia, Andrea Arruda, Mark D. Minden, Sagi Abelson
Journal: Blood
Blood (2023) 142 (Supplement 1): 4059.
https://doi.org/10.1182/blood-2023-173489
Published: 2023
Journal Articles

AML Drug Tolerant Persister (DTP) Cells Survive Chemotherapy By Transiently Altering Cellular Lipidomics to Increase Plasma Membrane Rigidity, but Also Increases Sensitivity to Immune Cell Killing

Yael Morgenstern, JongBok Lee, Yoosu Na, William Gwynne, Rose Hurren, Li Ma, Marcela Gronda, Chaitra Sarathy, Arvind Mer, Andrea Arruda, Avraham Frisch, Tsila Zuckerman, Yishai Ofran, Mark D. Minden, Li Zhang, Catherine O'Brien, J. Rafael Montenegro-Burke, Aaron D. Schimmer
Journal: Blood
Blood (2023) 142 (Supplement 1): 2806.
https://doi.org/10.1182/blood-2023-178995
Published: 2023
Journal Articles

Prognostic Role of Multiparameter Flow Cytometry-Based Measurable Residual Disease Assessment in Acute Myeloid Leukemia Patients with FMS3-like Tyrosine Kinase-3 Internal Tandem Duplication (FLT3-ITD)

Josephine Anne Lucero, Aniket Bankar, Marta Beata Davidson, Guillaume Richard-Carpentier, Aaron D. Schimmer, Andre C. Schuh, Dawn C. Maze, Karen Yee, Mark D. Minden, Steven M. Chan, Jonas Mattsson, Rajat Kumar, Vikas Gupta, Jose-Mario Capo-Chichi, Tracy Stockley, Hassan Sibai, Anne Maria Tierens, Dennis Dong Hwan Kim
Journal: Blood
Blood (2023) 142 (Supplement 1): 1595.
https://doi.org/10.1182/blood-2023-190694
Published: 2023
Journal Articles

Final Results of the Phase Ib/II Study Evaluating Enasidenib in Combination with Venetoclax in Patients with IDH2 -Mutated Relapsed/Refractory Myeloid Malignancies

Guillaume Richard-Carpentier, Gopila Gupta, Charina Cameron, Severine Cathelin, Aniket Bankar, Marta Beata Davidson, Vikas Gupta, Dawn C. Maze, Mark D. Minden, Tracy Murphy, Aaron D. Schimmer, Andre C. Schuh, Hassan Sibai, Karen Yee, Courtney D. DiNardo, Joseph Brandwein, Caroline Jane McNamara, Steven M. Chan
Journal: Blood
Blood (2023) 142 (Supplement 1): 159.
https://doi.org/10.1182/blood-2023-188341
Published: 2023
Journal Articles

Inhibiting Mitochondrial RNA Degradosome Complex SUV3 and PNPT1 Increases dsRNA in the Cytoplasm, Triggers Viral Mimicry Response and Sensitizes AML Cells to Immune Mediated Killing

Geethu Emily Thomas, Kazem Nouri, Jong Bok Lee, Rose Hurren, Yongran Yan, Neil Maclean, Yulia Jitkova, Li Ma, Xiaoming Wang, Chaitra Sarathy, Andrea Arruda, Mark D. Minden, Li Zhang, Vito Spadavecchio, Aaron D. Schimmer
Journal: Blood
Blood (2023) 142 (Supplement 1): 2742.
https://doi.org/10.1182/blood-2023-178696
Published: 2023
Journal Articles

Identifying Stress Granules As Determinants of Leukemia Stem Cell Maintenance and Stress Adaptation

Amanda Tajik, Emily Tsao, Brendon Seale, Soheil Jahangiri, Belma Abidin, Lina Liu, Zaldy Balde, He Tian (Tony) Chen, Nicholas Wong, Ava Keyvani Chahi, Pratik Joshi, Steven Moreira, Curtis W. McCloskey, Shahbaz Khan, Helena Boutzen, Cassandra Wong, Suraj Bansal, Andy G.X. Zeng, Stefan Aigner, Yu Lu, John E. Dick, Thomas Kislinger, Rama Khokha, Mark D. Minden, Gene W. Yeo, Anne-Claude Gingras, Kristin J. Hope
Journal: Blood
Blood (2023) 142 (Supplement 1): 405.
https://doi.org/10.1182/blood-2023-180919
Published: 2023
Journal Articles

Precise Single-Cell Transcriptomic Mapping of Leukemia Cell States Reveals Unconventional Lineage Priming in Acute Myeloid Leukemia

Andy G.X. Zeng, Ilaria Iacobucci, Sayyam Shah, Gordon Wong, Amanda Mitchell, Qingsong Gao, Hyerin Kim, Mark D. Minden, Torsten Haferlach, Charles G. Mullighan, John E. Dick
Journal: Blood
Blood (2023) 142 (Supplement 1): 1593.
https://doi.org/10.1182/blood-2023-189697
Published: 2023
Journal Articles

Functional Ex-Vivo Testing Combined with Machine Learning Predicts Clinical Response to Azacitidine+Venetoclax in AML

Diego Andino, Maria Laura Bernaschini, Agustina Conrrero, María Rita Drocchi, Sofia Carbajosa, Alejandra Garcia, Isolda Isabel Fernandez, María Jose Mela Osorio, Miguel Arturo Pavlovsky, Carolina Pavlovsky, Silvina Palmer, Nicolás Cazap, Jorge Solimano, Adriana Rinflerch, Erika Barbara Brulc, Paula González Hermida, Andrea Arruda, Mark D. Minden, Gimena Ferreira, Marisa Piaggio, Tarek Ali Zaki, Gerardo Gatti, Candelaria Llorens, Gastón Soria
Journal: Blood
Blood (2023) 142 (Supplement 1): 2274.
https://doi.org/10.1182/blood-2023-187284
Published: 2023
Journal Articles

Aberrant Splicing of MBD1 Reshapes the Epigenome to Drive Convergent Myeloerythroid Defects in MDS

He Tian (Tony) Tony Chen, Pratik Joshi, Emily Tsao, Joshua Xu, Soheil Jahangiri, Yulin Mo, David Kealy, Dylan Gowlett-Park, Katarina Czibere, Alexandra Misura, Olga Bigun, Renato Sasso, Dianne Chadwick, Sila Usta, Tina Khazaee, Signy Chow, Hubert Tsui, Mark D. Minden, Katherine S Bridge, Gang Zheng, Kristin J. Hope
Journal: Blood
Blood (2023) 142 (Supplement 1): 317.
https://doi.org/10.1182/blood-2023-180889
Published: 2023
Journal Articles

Polyamines Are Required for AML LSC Function through Their Role in Regulating eIF5A Dependent Protein Synthesis

Vincent Rondeau, Rachel Culp-Hill, Julie A Reisz, Duhan Yendi, Aarushi Gupta, Jacob Berman, Cristiana O'Brien, Tianyi Ling, Aleksandra Bourdine, Mary Shi, Jonathan St-Germain, Soheil Jahangiri, Anastasia N. Tikhonova, Andrea Arruda, Mark D. Minden, Brian Raught, Angelo D'Alessandro, Courtney L Jones
Journal: Blood
Blood (2023) 142 (Supplement 1): 585.
https://doi.org/10.1182/blood-2023-187283
Published: 2023
Journal Articles

Clinical Outcomes in De Novo Versus Secondary NPM1 -Mutated AML

Elliot C. Smith, Eshetu G. Atenafu, Aniket Bankar, Steven M. Chan, Marta B. Davidson, Vikas Gupta, Mark D. Minden, Guillaume Richard-Carpentier, Aaron D. Schimmer, Andre C. Schuh, Hassan Sibai, Karen Yee, Dawn Maze
Journal: Blood
Blood (2022) 140 (Supplement 1): 8952–8953.
https://doi.org/10.1182/blood-2022-166939
Published: 2022
Journal Articles

Acute Lymphoblastic Leukemia in Patients 60 Years and Older Treated with Pediatric-Inspired Protocols, 20 Years of Follow-up

Maria Agustina Perusini, Eshetu G. Atenafu, Aniket Bankar, Vikas Gupta, Mark D. Minden, Jad Sibai, Dawn Maze, Marta B. Davidson, Steven M. Chan, Fernando Binder, Guillaume Richard-Carpentier, Salman Alharbi, Claire Andrews, Karen Yee, Andre C. Schuh, Hassan Sibai
Journal: Blood
Blood (2022) 140 (Supplement 1): 3176–3177.
https://doi.org/10.1182/blood-2022-170121
Published: 2022
Journal Articles

Do Adult Philadelphia-Positive Acute Lymphoblastic Leukemia (Ph+ ALL) Patients Require Allogeneic Transplant in First Remission (CR1)?

Fatima M Khadadah, Claire Andrews, Eshetu G. Atenafu, Andre C. Schuh, Dawn Maze, Karen Yee, Osamah Jamal S. Jarallah, Mark D. Minden, Aaron D. Schimmer, Steven M. Chan, Vikas Gupta, Dennis Dong Hwan Kim, Hassan Sibai
Journal: Blood
Blood (2022) 140 (Supplement 1): 3169–3171.
https://doi.org/10.1182/blood-2022-169342
Published: 2022
Journal Articles

Intracellular IL-23 Receptor (IL-23R) Is Necessary for AML Viability and Regulates Mitotic Spindle and Centrosome Formation

Nathan Duong, Dilshad H. Khan, Geethu Emily Thomas, Rose Hurren, Jong Bok Lee, Jonathan St-Germain, Lily Drimmer, Yongran Yan, Neil MacLean, Marcela Gronda, Brandon D Brown, Brian Raught, Andrea Arruda, Mark D. Minden, Li Zhang, Steven M. Kornblau, Vito Spadevecchio, Aaron D. Schimmer
Journal: Blood
Blood (2022) 140 (Supplement 1): 3005–3006.
https://doi.org/10.1182/blood-2022-157626
Published: 2022
Journal Articles

The LSC17 Score Correlates with the ELN 2022 Classification of AML and Is an Independent Predictor of Detectable Measurable Residual Disease after Induction Chemotherapy

Tracy Murphy, Stanley W.K. Ng, Ian King, Tong Zhang, Andrea Arruda, Jaime Claudio, Kristele Pan, Chantal Rockwell, Zhibin Lu, Natalie Stickle, Carl Virtanen, Vikas Gupta, Dawn Maze, Caroline McNamara, Aaron D. Schimmer, Andre C. Schuh, Hassan Sibai, Karen Yee, Dina Khalaf, Brian Leber, Mitchell Sabloff, Anne Tierens, Mark D. Minden, Tracy L. Stockley, Steven Chan, Jean C.Y. Wang
Journal: Blood
Blood (2022) 140 (Supplement 1): 9122–9124.
https://doi.org/10.1182/blood-2022-171107
Published: 2022