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Amanda Mitchell
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Journal Articles

Precise Single-Cell Transcriptomic Mapping of Leukemia Cell States Reveals Unconventional Lineage Priming in Acute Myeloid Leukemia

Andy G.X. Zeng, Ilaria Iacobucci, Sayyam Shah, Gordon Wong, Amanda Mitchell, Qingsong Gao, Hyerin Kim, Mark D. Minden, Torsten Haferlach, Charles G. Mullighan, John E. Dick
Journal: Blood
Blood (2023) 142 (Supplement 1): 1593.
https://doi.org/10.1182/blood-2023-189697
Published: 2023
Journal Articles

KDM6 Demethylases Integrate DNA Repair Gene Regulation: Loss of KDM6A Sensitizes AML to PARP Inhibition and Potentiates with BCL2 Blockade

Liberalis Debraj Boila, Liqing Jin, Alex Murison, Subham K. Bandyopadhyay, Subhadeep Ghosh, Siva Sai Naga Anurag Muddineni, Andy G.X. Zeng, Sayantani Sinha, Shankha Subhra Chatterjee, Mayukh Biswas, Nathan Mbong, Olga I. Gan, Andrea Arruda, Wasim Shaikh, Anwesha Bose, Satyaki Bhowmik, Sayan Chakraborty, James A. Kennedy, Amanda Mitchell, Eric R. Lechman, Debasis Banerjee, Michael Milyavsky, Mark D. Minden, John E. Dick, Amitava Sengupta
Journal: Blood
Blood (2021) 138 (Supplement 1): 25.
https://doi.org/10.1182/blood-2021-145491
Published: 2021
Journal Articles

Variation in Stem Cell Driven Hierarchies Underlies Clinical Outcome and Drug Response in AML

Andy G.X. Zeng, BSc, Amanda Mitchell, PhD, Oleksandr Galkin, PhD, Jean C.Y. Wang, MD PhD, James A. Kennedy, MDPhD, John E. Dick, PhD FRS
Journal: Blood
Blood (2020) 136 (Supplement 1): 27–28.
https://doi.org/10.1182/blood-2020-140895
Published: 2020
Journal Articles

HSCs Fated to Progress to Blast Phase Can be Detected in Myelofibrosis Patients Several Years Prior to Leukemic Transformation

Jenny M. Ho, MD, Jessie J.F. Medeiros, BSc, Michelle Chan-Seng-Yue, Lauren Hummel, BSc, Andrea Arruda, Amanda Mitchell, PhD, Caroline J McNamara, MBBS, James A Kennedy, MD PhD, Anne Tierens, MD PhD, Dawn Maze, MDFRCPC,MSc, Hubert Tsui, MD PhD, Mark D. Minden, MD PhD, Vikas Gupta, MD FRCP, FRCPath, John E. Dick, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1676.
https://doi.org/10.1182/blood-2019-130923
Published: 2019
Journal Articles

A stemness screen reveals C3orf54/INKA1 as a promoter of human leukemia stem cell latency

Kerstin B. Kaufmann, Laura Garcia-Prat, Qiang Liu, Stanley W. K. Ng, Shin-Ichiro Takayanagi, Amanda Mitchell, Erno Wienholds, Peter van Galen, Christian A. Cumbaa, Mike J. Tsay, Chiara Pastrello, Elvin Wagenblast, Gabriela Krivdova, Mark D. Minden, Eric R. Lechman, Sasan Zandi, Igor Jurisica, Jean C. Y. Wang, Stephanie Z. Xie, John E. Dick
Journal: Blood
Blood (2019) 133 (20): 2198–2211.
https://doi.org/10.1182/blood-2018-10-881441
Published: 2019
Includes: Supplemental data
Journal Articles

AML-Fated Clones Arise in Stem and Progenitor Cells in Myelofibrosis Patients Several Years Prior to AML Diagnosis

Jenny M. Ho, MD, Jessie James Franco Medeiros, BSc, Michelle Chan-Seng-Yue, Lauren Hummel, BSc, Andrea Arruda, Amanda Mitchell, PhD, Caroline J McNamara, MBBS, James Kennedy, MD PhD, Anne Tierens, MD PhD, Hubert Tsui, MD PhD, Mark D. Minden, MD PhD, Vikas Gupta, MD FRCP, FRCPath, John E. Dick, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4321.
https://doi.org/10.1182/blood-2018-99-118889
Published: 2018
Journal Articles

Myelofibrosis Is Initiated and Sustained By Rare Multipotent Stem Cells

Jessie J.F. Medeiros, BSc, Amanda Mitchell, PhD, Aaron Trotman-Grant, Tristan Woo, Jenny M. Ho, MD, Andrea Arruda, Mark D. Minden, MD PhD, John E. Dick, PhD, Vikas Gupta, MD FRCP, FRCPath, Liran I. Shlush, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1790.
https://doi.org/10.1182/blood-2018-99-119088
Published: 2018
Journal Articles

Identification of Gene Regulatory Networks Governing Stemness Properties of Human HSC and LSC

Stanley W.K. Ng, Stephanie Zhi-Juan Xie, PhD, Elvin Wagenblast, PhD, Naoya Takayama, MD PhD, Liqing Jin, MD, Nathan Mbong, Alex Murison, Schoof E Erwin, Amanda Mitchell, PhD, Peter Van Galen, PhD, Mathieu Lupien, PhD, Mark D. Minden, MD PhD, Jean C.Y. Wang, MD PhD, Peter W. Zandstra, PhD, John E. Dick
Journal: Blood
Blood (2018) 132 (Supplement 1): 3832.
https://doi.org/10.1182/blood-2018-99-114314
Published: 2018
Journal Articles

A Novel Predictor of Response to Gemtuzumab Ozogamicin Therapy in AML Provides Strategies for Sensitization of Leukemia Stem Cells in Individual Patients

Stanley W.K. Ng, Schoof E Erwin, Amanda Mitchell, PhD, Mark D. Minden, MD PhD, Lars Bullinger, MD, Hartmut Döhner, MD, Hervé Dombret, Claude Preudhomme, Meyling Cheok, BSPharm, PhD, John E. Dick, PhD, Jean C.Y. Wang, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2765.
https://doi.org/10.1182/blood-2018-99-114275
Published: 2018
Journal Articles

Long Term AML Survivors Have Increased Mortality and High Prevalence of Clonal Hematopoiesis

Noa Chapal Ilani, PhD, Elisabeth Niemeyer, MD, Netta Mendelson Cohen, PhD, Yoni Moskovitz, PhD, Barak Oron, Amanda Mitchell, PhD, Mark D. Minden, MD PhD, Amos Tanay, PhD, Ran Balicer, MD PhD, Tamir Biezuner, PhD, Daniela Cilloni, MD PhD, Klaus H. Metzeler, MD, Yishai Ofran, MD, Nathali Kaushansky, PhD, Liran I. Shlush, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1287.
https://doi.org/10.1182/blood-2018-99-116599
Published: 2018
Journal Articles

Leukemic Stem Cell Expression Signatures Identify Novel Therapeutics for Acute Myeloid Leukemia

Meaghan Boileau, BSc, Isabelle Laverdiere, BPharm, MSc, PhD, Amanda Mitchell, PhD, Stanley W.K. Ng, Jean Wang, MD PhD, Mark D. Minden, MD PhD, John E. Dick, PhD, Kolja Eppert, MSc, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3815.
https://doi.org/10.1182/blood.V130.Suppl_1.3815.3815
Published: 2017
Journal Articles

Simultaneous Identification and Stratification of Low Molecular Risk AML Patients Using a Single LSC17-Based Nanostring Assay at Diagnosis

Stanley W.K. Ng, Amanda Mitchell, PhD, Peter W. Zandstra, PhD, Mark D. Minden, MD PhD, John E. Dick, PhD, Jean C.Y. Wang
Journal: Blood
Blood (2017) 130 (Supplement 1): 28.
https://doi.org/10.1182/blood.V130.Suppl_1.28.28
Published: 2017
Journal Articles

CD200 Is a Marker of LSC Activity in Acute Myeloid Leukemia

Jenny M. Ho, MD, Stephanie M. Dobson, Jessica McLeod, Liqing Jin, MD PhD, Stanley W.K. Ng, MSc, Amanda Mitchell, PhD, Liran I. Shlush, MD PhD, Sasan Zandi, MD PhD, Kolja Eppert, PhD, Mark D. Minden, MD PhD, John E. Dick, PhD, Jean C.Y. Wang, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1705.
https://doi.org/10.1182/blood.V128.22.1705.1705
Published: 2016
Journal Articles

On the Origins of AML Relapse

Liran I. Shlush, MDPhD, Amanda Mitchell, PhD, Lawrence Heisler, PhD, Sagi Abelson, PhD, Monica Doedens, McLeod Jessica, Ms.C., John D. McPherson, PhD, Thomas Hudson, MD PhD, Jean C.Y. Wang, MDPhD, Mark D. Minden, MD PhD, John E. Dick, PhD
Journal: Blood
Blood (2015) 126 (23): 223.
https://doi.org/10.1182/blood.V126.23.223.223
Published: 2015
Journal Articles

Engraftment Patterns in NOD. SCID Mice Predict Outcome in Human AML

James A. Kennedy, MDPhD, Amanda Mitchell, PhD, Weihsu Claire Chen, PhD, Liqing Jin, MD, Stanley Wai-Kwong Ng, BASc, Liran I. Shlush, MDPhD, Sasan Zandi, MDPhD, Jessica McLeod, BSc, Andreea C. Popescu, BSc, Nathan Mbong, BSc, Andrea Arruda, MSc, Mark D Minden, MDPhD, John E. Dick, PhD, Jean C.Y. Wang, MDPhD
Journal: Blood
Blood (2014) 124 (21): 16.
https://doi.org/10.1182/blood.V124.21.16.16
Published: 2014
Journal Articles

Mir-126 Governs Human Leukemia Stem Cell Quiescence and Chemotherapy Resistance

Eric R. Lechman, PhD, Bernhard Gentner, MD, Peter van Galen, Stanley Wai-Kwong Ng, Kolja Eppert, PhD, Rene Marke, Liran Slush, MD, James A. Kennedy, MD PhD, Amanda Mitchell, PhD, Weihsu Claire Chen, PhD, Veronique Voisin, PhD, Gary Bader, PhD, Mark D. Minden, MD, PhD, Jun Lu, PhD, Jean C.Y. Wang, MD PhD, Luigi Naldini, John E. Dick, PhD
Journal: Blood
Blood (2013) 122 (21): 1647.
https://doi.org/10.1182/blood.V122.21.1647.1647
Published: 2013
Journal Articles

Functional and Phenotypic Characterization Of Acute Myeloid Leukemia By Analysis Of Diagnostic/Relapse Paired Samples

Jenny M. Ho, MD, Liran I. Shlush, MD, PhD, Amanda Mitchell, PhD, Rene Marke, Jessica McLeod, Mark D. Minden, MD PhD, John E. Dick, PhD, Jean C.Y. Wang, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 2595.
https://doi.org/10.1182/blood.V122.21.2595.2595
Published: 2013
Journal Articles

Leukemic Engraftment In NOD. SCID Mice Is Correlated With Clinical Parameters and Predicts Outcome In Human AML

James A. Kennedy, MD PhD, Amanda Mitchell, PhD, Weihsu Claire Chen, PhD, Jessica McLeod, Andreea C. Popescu, BSc, Andrea Arruda, MSc, Mark D. Minden, MD PhD, John E. Dick, PhD, Jean C.Y. Wang, MD PhD
Journal: Blood
Blood (2013) 122 (21): 50.
https://doi.org/10.1182/blood.V122.21.50.50
Published: 2013
Journal Articles

DNMT3a Mutations Define a Pre-Leukemic Stem Cell Reservoir In Human Acute Myeloid Leukemia

Liran I. Shlush, MD, PhD, Sasan Zandi, PhD, MD, Amanda Mitchell, PhD, Weihsu Claire Chen, PhD, McLeod Jessica, Monica Doedens, Medeiros Jessie, Marke Rene, McPherson J John, PhD, Thomas J Hudson, MD, Brown Andrew, PhD, Trinh M Quang, Lincoln D Stein, James A. Kennedy, MD PhD, Mark D. Minden, MD, PhD, Jean C.Y. Wang, MD PhD, John E Dick, PhD
Journal: Blood
Blood (2013) 122 (21): 487.
https://doi.org/10.1182/blood.V122.21.487.487
Published: 2013