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Gabriela Krivdova
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Journal Articles

Adaptation to ex vivo culture reduces human hematopoietic stem cell activity independently of the cell cycle

Carys S. Johnson, Matthew Williams, Kendig Sham, Serena Belluschi, Wenjuan Ma, Xiaonan Wang, Winnie W. Y. Lau, Kerstin B. Kaufmann, Gabriela Krivdova, Emily F. Calderbank, Nicole Mende, Jessica McLeod, Giovanna Mantica, Juan Li, Charlotte Grey-Wilson, Michael Drakopoulos, Shaaezmeen Basheer, Shubhankar Sinha, Evangelia Diamanti, Christina Basford, Nicola K. Wilson, Steven J. Howe, John E. Dick, Berthold Göttgens, Anthony R. Green, Natalie Francis, Elisa Laurenti
Journal: Blood
Blood (2024) 144 (7): 729–741.
https://doi.org/10.1182/blood.2023021426
Published: 2024
Includes: Supplemental data
Journal Articles

Identification of Global miRNA Targetomes within Human Hematopoietic Progenitors and Acute Myeloid Leukemia Uncovers Unique Molecular Networks Centered on Mitochondria Function in Leukemic Stem Cells

Gabriela Krivdova, Brian Yee, Stefan Aigner, Martino Gabra, Alexander Shishkin, Long Nguyen, Jessica L McLeod, Leah Carley, Leonardo Salmena, Lorien Shakib, Mark D. Minden, Eric L Van Nostrand, Gene W. Yeo, Eric R. Lechman, John E. Dick
Journal: Blood
Blood (2022) 140 (Supplement 1): 8684–8685.
https://doi.org/10.1182/blood-2022-169849
Published: 2022
Journal Articles

PLAG1 dampens protein synthesis to promote human hematopoietic stem cell self-renewal

Ava Keyvani Chahi, Muluken S. Belew, Joshua Xu, He Tian Tony Chen, Stefan Rentas, Veronique Voisin, Gabriela Krivdova, Eric Lechman, Sajid A. Marhon, Daniel D. De Carvalho, John E. Dick, Gary D. Bader, Kristin J. Hope
Journal: Blood
Blood (2022) 140 (9): 992–1008.
https://doi.org/10.1182/blood.2021014698
Published: 2022
Includes: Supplemental data
Journal Articles

PLAGL2 Independently Drives Aberrant Erythropoiesis and Initiation of Preleukemic State

Joshua Xu, Tony Chen, Ava Keyvani Chahi, Gabriela Krivdova, Sajid Marhon, Ana Vujovic, Nicholas Wong, John E. Dick, Kristin Hope
Journal: Blood
Blood (2021) 138 (Supplement 1): 3663.
https://doi.org/10.1182/blood-2021-153098
Published: 2021
Journal Articles

Mir-125b Regulates the Self-Renewal of Acute Myeloid Leukemia Stem Cells through PTPN18 and GSK3

Qiang Liu, PhD BSc, Olga I. Gan, PhD, Gabriela Krivdova, BSc, Aaron Trotman-Grant, Stephanie M. Dobson, PhD, Karin G. Hermans, Mark D. Minden, Shai Izraeli, MD, John E. Dick, PhD FRS, Jean C.Y. Wang, MD PhD, Eric R. Lechman,, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 16–17.
https://doi.org/10.1182/blood-2020-141733
Published: 2020
Journal Articles

Functional Investigation of the Argonaute Proteins in Human Hematopoietic Stem and Progenitor Cells

Gordon G. L. Wong, BS, Gabriela Krivdova, BSc, Olga I. Gan, PhD, Jessica L. McLeod, John E. Dick, PhD FRS, Eric R. Lechman, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 32.
https://doi.org/10.1182/blood-2020-142963
Published: 2020
Journal Articles

A Human Model of Down Syndrome Associated Leukemia Reveals Different Cell of Origins for Initiation and Progression

Elvin Wagenblast, PhD, Joana Araújo, MD, Olga I. Gan, PhD, Sarah K Cutting, Alex Murison, Jessica L. McLeod, Gabriela Krivdova, BSc, Maria Azkanaz, Sabrina A Smith, Johann K Hitzler, MD, John E. Dick, PhD FRS, Eric R Lechman, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 11–12.
https://doi.org/10.1182/blood-2020-135867
Published: 2020
Journal Articles

Elevated Expression of Mir-130a in t(8,21) AML Reinforces the Aberrant Molecular Program of AML1-ETO

Gabriela Krivdova, BSc, Veronique Voisin, PhD, Sajid Marhon, Schoof E Erwin, Martino Gabra, Jessica L. McLeod, Leonardo Salmena, Mark D. Minden, Eric R. Lechman,, PhD, John E. Dick, PhD FRS
Journal: Blood
Blood (2020) 136 (Supplement 1): 41–42.
https://doi.org/10.1182/blood-2020-142652
Published: 2020
Journal Articles

Understanding Pre-Leukemia in Trisomy 21 Human HSC and Modeling Progression Towards Down Syndrome Associated Leukemia Using CRISPR/Cas9 at Single Cell Resolution

Elvin Wagenblast, PhD, Olga I. Gan, PhD, Maria Azkanaz, Sabrina A. Smith, Joana Araújo, MD, Lorien Shakib, Jessica L. McLeod, Gabriela Krivdova, Johann K. Hitzler, MD, Eric R. Lechman, PhD, John E. Dick, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2531.
https://doi.org/10.1182/blood-2019-129259
Published: 2019
Journal Articles

A stemness screen reveals C3orf54/INKA1 as a promoter of human leukemia stem cell latency

Kerstin B. Kaufmann, Laura Garcia-Prat, Qiang Liu, Stanley W. K. Ng, Shin-Ichiro Takayanagi, Amanda Mitchell, Erno Wienholds, Peter van Galen, Christian A. Cumbaa, Mike J. Tsay, Chiara Pastrello, Elvin Wagenblast, Gabriela Krivdova, Mark D. Minden, Eric R. Lechman, Sasan Zandi, Igor Jurisica, Jean C. Y. Wang, Stephanie Z. Xie, John E. Dick
Journal: Blood
Blood (2019) 133 (20): 2198–2211.
https://doi.org/10.1182/blood-2018-10-881441
Published: 2019
Includes: Supplemental data
Journal Articles

Modeling the Initiation and Evolution of Down Syndrome Associated Leukemia Using CRISPR/Cas9

Elvin Wagenblast, PhD, Gabriela Krivdova, BSc, MSc, Lorien Shakib, Maria Azkanaz, Olga I. Gan, Eric R. Lechman,, PhD MSC, John E. Dick
Journal: Blood
Blood (2018) 132 (Supplement 1): 3891.
https://doi.org/10.1182/blood-2018-99-110363
Published: 2018
Journal Articles

The Integrated Stress Response Activity Marks Stem Cells in Normal Hematopoiesis and Leukemia

Nathan Mbong, John E. Dick, Peter Van Galen, PhD, Antonija Kreso, MD PhD, Elvin Wagenblast, PhD, Gabriela Krivdova, BSc, MSc, Ng Stanley, Schoof E Erwin
Journal: Blood
Blood (2018) 132 (Supplement 1): 1276.
https://doi.org/10.1182/blood-2018-99-110819
Published: 2018
Journal Articles

Functional and Molecular Consequences of Trisomy 21 on Human Fetal Hematopoiesis

Elvin Wagenblast, PhD, Gabriela Krivdova, BSc, MSc, Olga I. Gan, PhD, Johann K. Hitzler, MD, John E. Dick, PhD, Eric R. Lechman, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1317.
https://doi.org/10.1182/blood-2018-99-119734
Published: 2018
Journal Articles

Microrna-130a Regulates Hematopoietic Stem Cell Self-Renewal By Repressing Chromatin Modifiers and Shaping the Accessible Chromatin Landscape

Gabriela Krivdova, BSc, MSc, Schoof E Erwin, Veronique Voisin, PhD, Alex Murison, Karin G. Hermans, Laura Garcia Prat, Olga I. Gan, Elvin Wagenblast, PhD, Aaron Trotman-Grant, Eric R. Lechman,, PhD MSC, Mark D. Minden, MD PhD, John E. Dick, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3824.
https://doi.org/10.1182/blood-2018-99-116866
Published: 2018
Journal Articles

Mir-125a Confers Multi-Lineage Long-Term Repopulating Stem Cell Activity to Human Hematopoietic Committed Progenitors

Eric R. Lechman, PhD, Karin G. Hermans, PhD, Erwin M. Schoof, PhD, Aaron Trotman-Grant, BS, Stephanie M Dobson, MSc, Gabriela Krivdova, MS, Janneke J. Elzinga, James A. Kennedy, MDPhD, Olga I Gan, PhD, John E Dick, PhD
Journal: Blood
Blood (2015) 126 (23): 900.
https://doi.org/10.1182/blood.V126.23.900.900
Published: 2015