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Kristin J. Hope
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Journal Articles

Epigenetic regulation of noncanonical menin targets modulates menin inhibitor response in acute myeloid leukemia

Xinyue Zhou, Lixia Zhang, Sajesan Aryal, Virginia Veasey, Amanda Tajik, Cecilia Restelli, Steven Moreira, Pengcheng Zhang, Yanfeng Zhang, Kristin J. Hope, Yang Zhou, Changde Cheng, Ravi Bhatia, Rui Lu
Journal: Blood
Blood (2024) 144 (19): 2018–2032.
https://doi.org/10.1182/blood.2023023644
Published: 2024
Includes: Supplemental data
Journal Articles

Identifying Stress Granules As Determinants of Leukemia Stem Cell Maintenance and Stress Adaptation

Amanda Tajik, Emily Tsao, Brendon Seale, Soheil Jahangiri, Belma Abidin, Lina Liu, Zaldy Balde, He Tian (Tony) Chen, Nicholas Wong, Ava Keyvani Chahi, Pratik Joshi, Steven Moreira, Curtis W. McCloskey, Shahbaz Khan, Helena Boutzen, Cassandra Wong, Suraj Bansal, Andy G.X. Zeng, Stefan Aigner, Yu Lu, John E. Dick, Thomas Kislinger, Rama Khokha, Mark D. Minden, Gene W. Yeo, Anne-Claude Gingras, Kristin J. Hope
Journal: Blood
Blood (2023) 142 (Supplement 1): 405.
https://doi.org/10.1182/blood-2023-180919
Published: 2023
Journal Articles

Aberrant Splicing of MBD1 Reshapes the Epigenome to Drive Convergent Myeloerythroid Defects in MDS

He Tian (Tony) Tony Chen, Pratik Joshi, Emily Tsao, Joshua Xu, Soheil Jahangiri, Yulin Mo, David Kealy, Dylan Gowlett-Park, Katarina Czibere, Alexandra Misura, Olga Bigun, Renato Sasso, Dianne Chadwick, Sila Usta, Tina Khazaee, Signy Chow, Hubert Tsui, Mark D. Minden, Katherine S Bridge, Gang Zheng, Kristin J. Hope
Journal: Blood
Blood (2023) 142 (Supplement 1): 317.
https://doi.org/10.1182/blood-2023-180889
Published: 2023
Journal Articles

Decoding the Epigenetic Drivers of Menin-MLL Inhibitor Resistance in KMT2A-Rearranged Acute Myeloid Leukemia

Xinyue Zhou, Lixia Zhang, Sajesan Aryal, Steven Moreira, Virginia Veasey, Kristin J. Hope, Rui Lu
Journal: Blood
Blood (2023) 142 (Supplement 1): 587.
https://doi.org/10.1182/blood-2023-185353
Published: 2023
Journal Articles

PLAG1 dampens protein synthesis to promote human hematopoietic stem cell self-renewal

Ava Keyvani Chahi, Muluken S. Belew, Joshua Xu, He Tian Tony Chen, Stefan Rentas, Veronique Voisin, Gabriela Krivdova, Eric Lechman, Sajid A. Marhon, Daniel D. De Carvalho, John E. Dick, Gary D. Bader, Kristin J. Hope
Journal: Blood
Blood (2022) 140 (9): 992–1008.
https://doi.org/10.1182/blood.2021014698
Published: 2022
Includes: Supplemental data
Journal Articles

Making a bet on RET for hematopoietic stem cell expansion

Kristin J. Hope
Journal: Blood
Blood (2020) 136 (22): 2484–2486.
https://doi.org/10.1182/blood.2020007667
Published: 2020
Journal Articles

PLAG1 and USF2 Regulate Primitive Hematopoietic Expression of Musashi-2

Muluken S Belew, MS, Stefan Rentas, MS, Laura de Rooij, MS, Kristin J Hope, PhD
Journal: Blood
Blood (2015) 126 (23): 3583.
https://doi.org/10.1182/blood.V126.23.3583.3583
Published: 2015
Journal Articles

RNAi screen identifies Jarid1b as a major regulator of mouse HSC activity

Sonia Cellot, Kristin J. Hope, Jalila Chagraoui, Martin Sauvageau, Éric Deneault, Tara MacRae, Nadine Mayotte, Brian T. Wilhelm, Josette R. Landry, Stephen B. Ting, Jana Krosl, Keith Humphries, Alexander Thompson, Guy Sauvageau
Journal: Blood
Blood (2013) 122 (9): 1545–1555.
https://doi.org/10.1182/blood-2013-04-496281
Published: 2013
Includes: Supplemental data
Journal Articles

A Functional In Vivo RNAi screen Involving Jumonji C Domain Containing Candidates Unravels Kdm5b As a Negative Modulator of Hematopoietic Stem Cell Self-Renewal

Sonia Cellot, MD, Kristin J Hope, PhD, Martin Sauvageau, PhD, Jalila Chagraoui, PhD, Eric Deneault, PhD, Tara MacRae, Nadine Mayotte, Guy Sauvageau, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 385.
https://doi.org/10.1182/blood.V118.21.385.385
Published: 2011
Journal Articles

Enriched MicroRNA-126 Bioactivity Marks the Primitive Compartment In AML and Regulates LSC Numbers

Eric Lechman, PhD, Bernhard Gentner, MD, Hidefumi Hiramatsu, MD, Kristin J Hope, PhD, Katsuto Takenaka, MD, Kolja Eppert, PhD, Mark D. Minden, MD, PhD, Luigi Naldini, MD, PhD, John E. Dick, PhD
Journal: Blood
Blood (2010) 116 (21): 94.
https://doi.org/10.1182/blood.V116.21.94.94
Published: 2010
Journal Articles

Gpx3 Determines Competitiveness of Normal and Leukemic Stem Cells.

Olivier Herault, MD, PhD, Kristin J Hope, PhD, Eric Deneault, PhD, Matthias Trost, PhD, Nadine Mayotte, Jalila Chagraoui, PhD, Brian T Wilhelm, PhD, Sonia Cellot, MD, PhD, Martin Sauvageau, PhD, Pierre Thibault, PhD, Guy Sauvageau, MD, PhD, FRCPC
Journal: Blood
Blood (2010) 116 (21): 1587.
https://doi.org/10.1182/blood.V116.21.1587.1587
Published: 2010
Journal Articles

An RNA Interference Screen Identifies the Cell Fate Determinants Msi2 and Prox1 as Novel Regulators of Hematopoietic Stem Cell Self-Renewal.

Kristin J Hope, Ph.D., Sonia Cellot, MD, Stephen Ting, MD, PhD, Guy Sauvageau, M.D., Ph.D
Journal: Blood
Blood (2009) 114 (22): 394.
https://doi.org/10.1182/blood.V114.22.394.394
Published: 2009
Journal Articles

Histone Demethylases as Modulators of Hematopoietic Cell Fate.

Sonia Cellot, MD, Kristin J Hope, Ph.D., Martin Sauvageau, Guy Sauvageau, M.D., Ph.D
Journal: Blood
Blood (2009) 114 (22): 393.
https://doi.org/10.1182/blood.V114.22.393.393
Published: 2009
Journal Articles

An RNA Interference Screen Reveals Fate Determinants Implicated in Asymmetric Cell Division as Potential Regulators of Hematopoietic Stem Cell Self-Renewal

Kristin J Hope, Ph.D., Sonia Cellot, MD, Stephen Ting, MD, PhD, Guy Sauvageau, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 2462.
https://doi.org/10.1182/blood.V112.11.2462.2462
Published: 2008
Journal Articles

MicroRNA Expression Profiling in Sorted AML Subpopulations: A Possible Role for miR-155/BIC in Stem Cell Maintenance and Leukemogenesis.

Eric R. Lechman, PhD, Kristin J. Hope, B.S., Fernando J. Suarez Saiz, MD, Katsuto Takenaka, MD, Carlo M. Croce, MD, Mark D. Minden, MD, PhD, John E. Dick, Ph.D
Journal: Blood
Blood (2005) 106 (11): 466.
https://doi.org/10.1182/blood.V106.11.466.466
Published: 2005