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Rui Lu
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Journal Articles

Epigenetic regulation of noncanonical menin targets modulates menin inhibitor response in acute myeloid leukemia

Xinyue Zhou, Lixia Zhang, Sajesan Aryal, Virginia Veasey, Amanda Tajik, Cecilia Restelli, Steven Moreira, Pengcheng Zhang, Yanfeng Zhang, Kristin J. Hope, Yang Zhou, Changde Cheng, Ravi Bhatia, Rui Lu
Journal: Blood
Blood (2024) 144 (19): 2018–2032.
https://doi.org/10.1182/blood.2023023644
Published: 2024
Includes: Supplemental data
Journal Articles

A Mouse Model of Zhu-Tokita-Takenouchi-Kim Syndrome Reveals Indispensable Son Functions in Myeloid-Lymphoid Lineage Balance and Terminal Differentiation

Leah Gehrs, Lana Vukadin, Mostafa Mohamed, Bohye Park, Huashi Li, Amr Elkholy, Hyung-Gyoon Kim, Xinyue Zhou, Sajesan Aryal, Steve Lim, Rui Lu, Erin Ahn
Journal: Blood
Blood (2023) 142 (Supplement 1): 1301.
https://doi.org/10.1182/blood-2023-190317
Published: 2023
Journal Articles

Decoding the Epigenetic Drivers of Menin-MLL Inhibitor Resistance in KMT2A-Rearranged Acute Myeloid Leukemia

Xinyue Zhou, Lixia Zhang, Sajesan Aryal, Steven Moreira, Virginia Veasey, Kristin J. Hope, Rui Lu
Journal: Blood
Blood (2023) 142 (Supplement 1): 587.
https://doi.org/10.1182/blood-2023-185353
Published: 2023
Journal Articles

Functional Interrogation of Clinically Associated Venetoclax-Sensitive Genes Identifies an Essential Role of Transcription Factor ZNF740 in Therapeutic Response

Lixia Zhang, Rui Lu
Journal: Blood
Blood (2023) 142 (Supplement 1): 5748.
https://doi.org/10.1182/blood-2023-180074
Published: 2023
Journal Articles

Multi-Omics Analysis Reveals That TET2 Loss Epigenetically Primes Monocytes for Inflammatory Responses Via AP-1 Signaling

Matthew Jenkins, Yunli Chu, Sajesan Aryal, Xinyue Zhou, Kirsten Dickerson, Rebecca Dubin, Chad R Potts, Valeriya Kuznetsova, Alana Franceski, Paran Goel, Stanley C Lee, Rui Lu, Robert Welner, P. Brent Ferrell, Jr.
Journal: Blood
Blood (2023) 142 (Supplement 1): 4061.
https://doi.org/10.1182/blood-2023-182278
Published: 2023
Journal Articles

Metabolic adaptation to tyrosine kinase inhibition in leukemia stem cells

Shaowei Qiu, Vipul Sheth, Chengcheng Yan, Juan Liu, Balu K. Chacko, Hui Li, David K. Crossman, Seth D. Fortmann, Sajesan Aryal, Ashley Rennhack, Maria B. Grant, Robert S. Welner, Andrew J. Paterson, Adam R. Wende, Victor M. Darley-Usmar, Rui Lu, Jason W. Locasale, Ravi Bhatia
Journal: Blood
Blood (2023) 142 (6): 574–588.
https://doi.org/10.1182/blood.2022018196
Published: 2023
Includes: Supplemental data
Journal Articles

Metabolic Adaptation to Tyrosine Kinase Inhibition in Chronic Myelogenous Leukemia Stem Cells

Shaowei Qiu, Vipul Sheth, Chengcheng Yan, Juan Liu, Balu K. Chacko, Hui Li, David Crossman, Seth D. Fortmann, Sajesan Aryal, Maria B. Grant, Robert S. Welner, Andrew J. Paterson, Adam R. Wende, Victor M Darley-Usmar, Rui Lu, Jason W. Locasale, Ravi Bhatia
Journal: Blood
Blood (2022) 140 (Supplement 1): 3874–3875.
https://doi.org/10.1182/blood-2022-156631
Published: 2022
Journal Articles

PRMT5 Inhibition Enhances Elimination of FLT3-ITD AML Stem Cells in Combination with TKI Treatment

Harish Kumar, Aditi Dhir, Andrew J. Paterson, Nick R Anderson, Shaowei Qiu, Xinyang Zhao, Rui Lu, Ravi Bhatia
Journal: Blood
Blood (2022) 140 (Supplement 1): 3073–3074.
https://doi.org/10.1182/blood-2022-168326
Published: 2022
Journal Articles

Activating a Non-Genetic MYC-Regulating Pathway Sensitizes Acute Myeloid Leukemia to Bromodomain Inhibition

Xinyue Zhou, Steven Moreira, Hong Wang, Pengcheng Zhang, Yang Zhou, Ravi Bhatia, Chunliang Li, Kristin Hope, Rui Lu
Journal: Blood
Blood (2022) 140 (Supplement 1): 8735.
https://doi.org/10.1182/blood-2022-167049
Published: 2022
Journal Articles

Interrogating Novel Bromodomain Inhibition Resistance Mechanism in Mllr Leukemia

Chunliang Li, Shaela Wright, Jianzhong Hu, Yang Zhang, Judith Hyle, Rui Lu
Journal: Blood
Blood (2021) 138 (Supplement 1): 26.
https://doi.org/10.1182/blood-2021-147003
Published: 2021
Journal Articles

Essential Roles of Transcription Factor MEF2D in the Maintenance of MLL-Rearranged Acute Myeloid Leukemia

Pengcheng Zhang, Lianzhong Zhao, Shaowei Qiu, Ravi Bhatia, Rui Lu
Journal: Blood
Blood (2021) 138 (Supplement 1): 2218.
https://doi.org/10.1182/blood-2021-149232
Published: 2021
Journal Articles

E2A-PBX1 functions as a coactivator for RUNX1 in acute lymphoblastic leukemia

Wen-Chieh Pi, Jun Wang, Miho Shimada, Jia-Wei Lin, Huimin Geng, Yu-Ling Lee, Rui Lu, Dongxu Li, Gang Greg Wang, Robert G. Roeder, Wei-Yi Chen
Journal: Blood
Blood (2020) 136 (1): 11–23.
https://doi.org/10.1182/blood.2019003312
Published: 2020
Includes: Supplemental data
Journal Articles

Role of Autophagy in Resistance of FLT3-ITD AML Stem Cells to FLT3 TKI Treatment

Shaowei Qiu, MD, Chengcheng Yan, MD, Andrew J Paterson, PhD, Hui Li, BS, Nick Anderson, BS, Ajay Abraham, PhD, Jianbo He, MD, Mansi Shah, PhD, Puneet Agarwal, Jing Yang, PhD, Min Xie, MD, Rui Lu, PhD, Rob S. Welner, PhD, Ravi Bhatia, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2548.
https://doi.org/10.1182/blood-2019-124948
Published: 2019
Journal Articles

A New Valuable Technique in Diagnosis and Treatment Monitoring of Myeloproliferative Neoplasms

Yiqian Hu, Sanyun Wu, Yanan Liu, Mengxiao Zhang, Yingying Wang, Liang Shao, Bei Xiong, Xiaoyan Liu, Yicheng Zhang, Rui Lu, Yalan Yu, Ping Luo, Xuelan Zuo
Journal: Blood
Blood (2019) 134 (Supplement_1): 5377.
https://doi.org/10.1182/blood-2019-128709
Published: 2019
Journal Articles

Epigenetic Reprogramming of Cis-Regulatory Sites By R882 -Mutated DNMT3A Potentiates Aberrant Stem Cell Gene Program and Acute Leukemia Development

Rui Lu, PhD, Ping Wang, PhD, Trevor Parton, Deyou Zheng, PhD, Gang Greg Wang, PhD
Journal: Blood
Blood (2015) 126 (23): 2430.
https://doi.org/10.1182/blood.V126.23.2430.2430
Published: 2015