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Journal Articles

The Atpase Domain of LONP1 Is Necessary for Mitochondrial Protein Solubility and the Viability of Acute Myeloid Leukemia (AML) Cells

Matthew Tcheng, Aaron D. Schimmer, Marcela Gronda, Rose Hurren, Shahbaz Khan, Lan Xin Zhang, Chaitra Sarathy, Yongran Yan, Andrea Arruda, Thomas Kislinger, Mark D. Minden

Blood (2023) 142 (Supplement 1): 1420.

https://doi.org/10.1182/blood-2023-178399

Published: 2023

Journal Articles

Inflammatory Signatures Define a New High-Risk T-Lineage ALL Subtype

Blood (2023) 142 (Supplement 1): 2969.

https://doi.org/10.1182/blood-2023-182412

Published: 2023

Journal Articles

DNA Methylation Instability: A Novel Biomarker for Aging, Clonality, and Cancer

Salman Basrai, Robert Kridel, Mehran Bakhtiari, Dennis D. H. Kim, Fernando L. Scolari, Filio Billia, Andrea Arruda, Mark D. Minden, Sagi Abelson

Blood (2023) 142 (Supplement 1): 4059.

https://doi.org/10.1182/blood-2023-173489

Published: 2023

Journal Articles

Polyamines Are Required for AML LSC Function through Their Role in Regulating eIF5A Dependent Protein Synthesis

Vincent Rondeau, Rachel Culp-Hill, Julie A Reisz, Duhan Yendi, Aarushi Gupta, Jacob Berman, Cristiana O'Brien, Tianyi Ling, Aleksandra Bourdine, Mary Shi, Jonathan St-Germain, Soheil Jahangiri, Anastasia N. Tikhonova, Andrea Arruda, Mark D. Minden, Brian Raught, Angelo D'Alessandro, Courtney L Jones

Blood (2023) 142 (Supplement 1): 585.

https://doi.org/10.1182/blood-2023-187283

Published: 2023

Journal Articles

Functional Ex-Vivo Testing Combined with Machine Learning Predicts Clinical Response to Azacitidine+Venetoclax in AML

Blood (2023) 142 (Supplement 1): 2274.

https://doi.org/10.1182/blood-2023-187284

Published: 2023

Journal Articles

AML Drug Tolerant Persister (DTP) Cells Survive Chemotherapy By Transiently Altering Cellular Lipidomics to Increase Plasma Membrane Rigidity, but Also Increases Sensitivity to Immune Cell Killing

Yael Morgenstern, JongBok Lee, Yoosu Na, William Gwynne, Rose Hurren, Li Ma, Marcela Gronda, Chaitra Sarathy, Arvind Mer, Andrea Arruda, Avraham Frisch, Tsila Zuckerman, Yishai Ofran, Mark D. Minden, Li Zhang, Catherine O'Brien, J. Rafael Montenegro-Burke, Aaron D. Schimmer

Blood (2023) 142 (Supplement 1): 2806.

https://doi.org/10.1182/blood-2023-178995

Published: 2023

Journal Articles

Inhibiting Mitochondrial RNA Degradosome Complex SUV3 and PNPT1 Increases dsRNA in the Cytoplasm, Triggers Viral Mimicry Response and Sensitizes AML Cells to Immune Mediated Killing

Geethu Emily Thomas, Kazem Nouri, Jong Bok Lee, Rose Hurren, Yongran Yan, Neil Maclean, Yulia Jitkova, Li Ma, Xiaoming Wang, Chaitra Sarathy, Andrea Arruda, Mark D. Minden, Li Zhang, Vito Spadavecchio, Aaron D. Schimmer

Blood (2023) 142 (Supplement 1): 2742.

https://doi.org/10.1182/blood-2023-178696

Published: 2023

Journal Articles

Intracellular IL-23 Receptor (IL-23R) Is a Regulator of Mitotic Spindle and Centrosome Formation and Is Essential for AML Viability

Blood (2023) 142 (Supplement 1): 5694.

https://doi.org/10.1182/blood-2023-174536

Published: 2023

Journal Articles

Presence of Recurrent Somatic Mutations in Mesenchymal Stromal Cell Fractions Isolated from Acute Myeloid Leukemia As an Evidence of Clonality

Muzaffar Bhatti, Taehyung Kim, Jenny Warrington, Amirthagowri Ambalavanan, Sarah Zarabi, Anthea Travas, Jaeyoon John Kim, Danielle Pyne, Troy Ketela, Andrea Arruda, Mark D. Minden, Armand Keating, Dennis Dong Hwan Kim

Blood (2023) 142 (Supplement 1): 6042.

https://doi.org/10.1182/blood-2023-185149

Published: 2023

Journal Articles

Identification of Unexpected Responders to Gilteritinib in a Cohort of FLT3-WT AML Patients Using Ex-Vivo Testing

Blood (2023) 142 (Supplement 1): 7132.

https://doi.org/10.1182/blood-2023-181119

Published: 2023

Journal Articles

Ex-Vivo Testing Using Patient Micro Avatars (PMAs) Predicts Clinical Response in Acute Leukemias

Blood (2022) 140 (Supplement 1): 13027–13028.

https://doi.org/10.1182/blood-2022-164847

Published: 2022

Journal Articles

Intracellular IL-23 Receptor (IL-23R) Is Necessary for AML Viability and Regulates Mitotic Spindle and Centrosome Formation

Nathan Duong, Dilshad H. Khan, Geethu Emily Thomas, Rose Hurren, Jong Bok Lee, Jonathan St-Germain, Lily Drimmer, Yongran Yan, Neil MacLean, Marcela Gronda, Brandon D Brown, Brian Raught, Andrea Arruda, Mark D. Minden, Li Zhang, Steven M. Kornblau, Vito Spadevecchio, Aaron D. Schimmer

Blood (2022) 140 (Supplement 1): 3005–3006.

https://doi.org/10.1182/blood-2022-157626

Published: 2022

Journal Articles

The LSC17 Score Correlates with the ELN 2022 Classification of AML and Is an Independent Predictor of Detectable Measurable Residual Disease after Induction Chemotherapy

Blood (2022) 140 (Supplement 1): 9122–9124.

https://doi.org/10.1182/blood-2022-171107

Published: 2022

Journal Articles

Stem Cell-Derived Gene Expression Scores Predict Survival and Leukemic Transformation in Myelofibrosis

Jessie J.F. Medeiros, Andy G.X. Zeng, Michelle Chan-Seng-Yue, Tristan Woo, Jessica L McLeod, Andrea Arruda, Hubert Tsui, Burhan Goraya, Jaime O. Claudio, Jenny M. Ho, James A. Kennedy, Dawn Maze, Hassan Sibai, Mark D. Minden, Jean C.Y. Wang, John E. Dick, Vikas Gupta

Blood (2022) 140 (Supplement 1): 9681–9682.

https://doi.org/10.1182/blood-2022-163722

Published: 2022

Journal Articles

Inhibiting the Mitochondrial RNA Degradosome Complex SUV3 and Pnpase Increases dsRNA in the Cytoplasm, Triggers a Viral Mimicry Response and Kills AML Cells and Progenitors

Geethu Emily Thomas, Kazem Nouri, Rose Hurren, Yongran Yan, Neil MacLean, Yulia Jitkova, Li Ma, Xiaoming Wang, Chaitra Sarathy, Andrea Arruda, Mark D. Minden, Vito Spadevecchio, Aaron D. Schimmer

Blood (2022) 140 (Supplement 1): 8723–8724.

https://doi.org/10.1182/blood-2022-158326

Published: 2022

Journal Articles

Simultaneous Inhibition of SIRT3 and Cholesterol Homeostasis Targets AML Stem Cells By Perturbing Fatty Acid β-Oxidation and Inducing Lipotoxicity

Blood (2022) 140 (Supplement 1): 104–106.

https://doi.org/10.1182/blood-2022-157794

Published: 2022

Journal Articles

KDM6 Demethylases Integrate DNA Repair Gene Regulation: Loss of KDM6A Sensitizes AML to PARP Inhibition and Potentiates with BCL2 Blockade

Blood (2021) 138 (Supplement 1): 25.

https://doi.org/10.1182/blood-2021-145491

Published: 2021

Journal Articles

Proteomics and Phospho-Proteomics Reveal Predictive Signatures of Response and Mechanisms of Resistance to Midostaurin Plus Chemotherapy in FLT3 Mutant Positive Acute Myeloid Leukemia

Luis Miguel Veiga Veiga Nobre, Salvatore Federico Pedicona, Arran Dokal, Andrea Arruda, Ryan Smith, Calum Greenhalgh, Francesca Patella, Pedro Casado-Izquierdo, Bela Wrench, Jane Theaker, Andrew Thompson, Mark D. Minden, John G. Gribben, David James Britton, Pedro Cutillas

Blood (2021) 138 (Supplement 1): 3462.

https://doi.org/10.1182/blood-2021-152379

Published: 2021

Journal Articles

Sirtuin 3 Inhibition Targets AML Stem Cells through Perturbation of Fatty Acid Oxidation

Cristiana O'Brien, Jacob Berman, Rachel Culp-Hill, Julie Reisz, Tianyi Ling, Vincent Rondeau, Meng Li, Min Yang, Jun Young Hong, Hening Lin, Ari Melnick, Andrea Arruda, Mark D. Minden, Angelo D'Alessandro, Courtney L Jones

Blood (2021) 138 (Supplement 1): 2240.

https://doi.org/10.1182/blood-2021-148143

Published: 2021

Journal Articles

Clinical Features and Long-Term Outcomes in a Molecularly-Annotated Cohort of Adolescents and Young Adults with Myeloproliferative Neoplasms

James T. England, Rouslan Kotchetkov, Hubert Tsui, Jose-Mario Capo-Chichi, Andrea Arruda, Sarah Malik, Verna Cheung, Taylor Nye, Hassan Sibai, Vikas Gupta, Dawn Maze

Blood (2021) 138 (Supplement 1): 3648.

https://doi.org/10.1182/blood-2021-148706

Published: 2021

NARROW

The Atpase Domain of LONP1 Is Necessary for Mitochondrial Protein Solubility and the Viability of Acute Myeloid Leukemia (AML) Cells

Inflammatory Signatures Define a New High-Risk T-Lineage ALL Subtype

DNA Methylation Instability: A Novel Biomarker for Aging, Clonality, and Cancer

Polyamines Are Required for AML LSC Function through Their Role in Regulating eIF5A Dependent Protein Synthesis

Functional Ex-Vivo Testing Combined with Machine Learning Predicts Clinical Response to Azacitidine+Venetoclax in AML

AML Drug Tolerant Persister (DTP) Cells Survive Chemotherapy By Transiently Altering Cellular Lipidomics to Increase Plasma Membrane Rigidity, but Also Increases Sensitivity to Immune Cell Killing

Inhibiting Mitochondrial RNA Degradosome Complex SUV3 and PNPT1 Increases dsRNA in the Cytoplasm, Triggers Viral Mimicry Response and Sensitizes AML Cells to Immune Mediated Killing

Intracellular IL-23 Receptor (IL-23R) Is a Regulator of Mitotic Spindle and Centrosome Formation and Is Essential for AML Viability

Presence of Recurrent Somatic Mutations in Mesenchymal Stromal Cell Fractions Isolated from Acute Myeloid Leukemia As an Evidence of Clonality

Identification of Unexpected Responders to Gilteritinib in a Cohort of FLT3-WT AML Patients Using Ex-Vivo Testing

Ex-Vivo Testing Using Patient Micro Avatars (PMAs) Predicts Clinical Response in Acute Leukemias

Intracellular IL-23 Receptor (IL-23R) Is Necessary for AML Viability and Regulates Mitotic Spindle and Centrosome Formation

The LSC17 Score Correlates with the ELN 2022 Classification of AML and Is an Independent Predictor of Detectable Measurable Residual Disease after Induction Chemotherapy

Stem Cell-Derived Gene Expression Scores Predict Survival and Leukemic Transformation in Myelofibrosis

Inhibiting the Mitochondrial RNA Degradosome Complex SUV3 and Pnpase Increases dsRNA in the Cytoplasm, Triggers a Viral Mimicry Response and Kills AML Cells and Progenitors

Simultaneous Inhibition of SIRT3 and Cholesterol Homeostasis Targets AML Stem Cells By Perturbing Fatty Acid β-Oxidation and Inducing Lipotoxicity

KDM6 Demethylases Integrate DNA Repair Gene Regulation: Loss of KDM6A Sensitizes AML to PARP Inhibition and Potentiates with BCL2 Blockade

Proteomics and Phospho-Proteomics Reveal Predictive Signatures of Response and Mechanisms of Resistance to Midostaurin Plus Chemotherapy in FLT3 Mutant Positive Acute Myeloid Leukemia

Sirtuin 3 Inhibition Targets AML Stem Cells through Perturbation of Fatty Acid Oxidation

Clinical Features and Long-Term Outcomes in a Molecularly-Annotated Cohort of Adolescents and Young Adults with Myeloproliferative Neoplasms

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American Society of Hematology

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ASH Publications

American Society of Hematology

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