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Dakai Ling
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Journal Articles

Ribosome biogenesis and its regulation by the exportin, CSE1L, are targetable vulnerabilities in childhood and young adult Acute Myeloid Leukemia

Free
Grace Egan, Amit Kumar, Veronique Voisin, Rose Hurren, Ali Chegini, Dakai Ling, Geethu Thomas, Yongran Yan, Yue Feng, Nathan Duong, Dilshad Khan, Chaitra Sarathy, Suraj Bansal, Andy Zeng, Fieke Hoff, Steven Kornblau, John Dick, Johann Hitzler, Aaron Schimmer
Journal: Blood
Blood (2025) 146 (Supplement 1): 1452.
https://doi.org/10.1182/blood-2025-1452
Published: 2025
Journal Articles

The mitochondrial protease YME1L regulates type 1 interferon signaling via the cgas-sting pathway in AML

Free
Yihe Zhang, Geethu Thomas, Rose Hurren, Yongran Yan, Dakai Ling, Marcela Gronda, Andrea Arruda, Mark Minden, Aaron Schimmer
Journal: Blood
Blood (2025) 146 (Supplement 1): 6765.
https://doi.org/10.1182/blood-2025-6765
Published: 2025
Journal Articles

The Exportin, CSE1L, Regulates Ribosome Biogenesis and Is a Selective Dependency in Childhood and Young Adult Acute Myeloid Leukemia

Free
Grace Egan, Amit Kumar, Veronique Voisin, Rose Hurren, Ali Chegini, Dakai Ling, Geethu Emily Thomas, Youngran Yan, Yue Feng, Suraj Bansal, Andy G.X. Zeng, Andrea Arruda, John Edgar Dick, Gary D Bader, Mark D. Minden, Aaron D Schimmer
Journal: Blood
Blood (2024) 144 (Supplement 1): 2724.
https://doi.org/10.1182/blood-2024-200148
Published: 2024
Journal Articles

The Mitochondrial Unfolded Protein Response (UPR mt) Is Upregulated in Acute Myeloid Leukemia (AML) and Inhibiting the UPR mt Protease, LONP1, Leads to Mitochondrial Protein Aggregation and Cell Death Selectively in AML

Free
Matthew Tcheng, Veronique Voisin, Marcela Gronda, Rose Hurren, Dakai Ling, Yongran Yan, Lan Xin Zhang, Yue Feng, Zaynab Mamai, Yulia Jitkova, Chaitra Sarathy, Andrea Arruda, Steven M. Kornblau, Mark D. Minden, Aaron D Schimmer
Journal: Blood
Blood (2024) 144 (Supplement 1): 2778.
https://doi.org/10.1182/blood-2024-205308
Published: 2024