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Journal Articles

Final Results of the Phase Ib/II Study Evaluating Enasidenib in Combination with Venetoclax in Patients with IDH2 -Mutated Relapsed/Refractory Myeloid Malignancies

Guillaume Richard-Carpentier, Gopila Gupta, Charina Cameron, Severine Cathelin, Aniket Bankar, Marta Beata Davidson, Vikas Gupta, Dawn C. Maze, Mark D. Minden, Tracy Murphy, Aaron D. Schimmer, Andre C. Schuh, Hassan Sibai, Karen Yee, Courtney D. DiNardo, Joseph Brandwein, Caroline Jane McNamara, Steven M. Chan
Journal: Blood
Blood (2023) 142 (Supplement 1): 159.
https://doi.org/10.1182/blood-2023-188341
Published: 2023
Journal Articles

Metformin Treatment Abrogates the Competitive Advantage of Dnmt3a R878H HSPCs By Enhancing DNA Methylation Activity

Mohsen Hosseini, Severine Cathelin, Alex Liu, Yitong Yang, Amit Subedi, Dhanoop Manikoth Ayyathan, Shraddha Pai, Steven M. Chan
Journal: Blood
Blood (2022) 140 (Supplement 1): 977–978.
https://doi.org/10.1182/blood-2022-170366
Published: 2022
Journal Articles

Enasidenib in Combination with Venetoclax in IDH2 -Mutated Myeloid Malignancies: Preliminary Results of the Phase Ib/II Enaven-AML Trial

Steven M Chan, Charina Cameron, Severine Cathelin, Vikas Gupta, Dawn Maze, Mark D. Minden, Tracy Murphy, Aaron D Schimmer, Andre C. Schuh, Hassan Sibai, Karen Yee, Courtney D. DiNardo, Caroline J McNamara
Journal: Blood
Blood (2021) 138 (Supplement 1): 1263.
https://doi.org/10.1182/blood-2021-153660
Published: 2021
Journal Articles

Inhibition of PINK1-Dependent Mitochondrial Quality Control Pathways Induces Senescence of Acute Myeloid Leukemia Stem Cells

Dhanoop Manikoth Ayyathan, David Sharon, Severine Cathelin, Steven M Chan
Journal: Blood
Blood (2021) 138 (Supplement 1): 2225.
https://doi.org/10.1182/blood-2021-153847
Published: 2021
Journal Articles

STAT5 Signaling Promotes Resistance to Ivosidenib in IDH1 -Mutated AML

Alex Liu, Severine Cathelin, Steven M Chan
Journal: Blood
Blood (2021) 138 (Supplement 1): 210.
https://doi.org/10.1182/blood-2021-154278
Published: 2021
Journal Articles

Nicotinamide Phosphoribosyltransferase Inhibitors Induce Apoptosis of AML Stem Cells through Dysregulation of Lipid Metabolism

Amit Subedi, PhD, Qiang Liu, PhD BSc, David Sharon, PhD, Severine Cathelin, PhD, Gary D Bader, Changjiang Xu, Veronique Voisin, PhD, Angelo D'Alessandro, PhD, Eric R Lechman, PhD, John E. Dick, PhD FRS, Mark D. Minden, Jean C.Y. Wang, MD, Steven M Chan, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 25–26.
https://doi.org/10.1182/blood-2020-142404
Published: 2020
Journal Articles

Combination of Enasidenib and Venetoclax Shows Superior Anti-Leukemic Activity Against IDH2 Mutated AML in Patient-Derived Xenograft Models

Severine Cathelin, PhD, David Sharon, PhD, Amit Subedi, PhD, Dan Cojocari, PhD BSc, Darren C. Phillips, PhD, Joel D. Leverson, PhD, Kyle MacBeth, PhD, Brandon Nicolay, Rohini Narayanaswamy, Sebastien Ronseaux, Guowen Liu, PhD, Steven M Chan, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 562.
https://doi.org/10.1182/blood-2018-99-119688
Published: 2018
Journal Articles

The Origin and Functional Impact of Mitochondrial DNA Mutations in Acute Myeloid Leukemia

Severine Cathelin, PhD, David Sharon, PhD, Michael Ryan Corces-Zimmerman, PhD, Bruno C Medeiros, MD, Ravi Majeti, MD PhD, Steven M. Chan, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2496.
https://doi.org/10.1182/blood.V130.Suppl_1.2496.2496
Published: 2017
Journal Articles

Targeting Mitochondrial Translation Overcomes Venetoclax Resistance in Acute Myeloid Leukemia (AML) through Activation of the Integrated Stress Response

David Sharon, PhD, Severine Cathelin, PhD, Amit Subedi, PhD, Ryan Williams, Mariana Benicio, PhD, Troy Ketela, Steven M. Chan, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 297.
https://doi.org/10.1182/blood.V130.Suppl_1.297.297
Published: 2017
Journal Articles

cIAP1-dependent TRAF2 degradation regulates the differentiation of monocytes into macrophages and their response to CD40 ligand

Alban Dupoux, Jessy Cartier, Séverine Cathelin, Rodolphe Filomenko, Eric Solary, Laurence Dubrez-Daloz
Journal: Blood
Blood (2009) 113 (1): 175–185.
https://doi.org/10.1182/blood-2008-02-137919
Published: 2009
Includes: Supplemental data