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Journal Articles

A Novel Role for PLK1 in Leukemia Stem Cell Function in Acute Myeloid Leukemia

Qiang Liu, Alex Murison, Andy G.X. Zeng, Changjiang Xu, Veronique Voisin, Faith Yeung, Amit Subedi, Steven M. Chan, Brian Raught, Gary D Bader, John E. Dick, Jean C.Y. Wang
Journal: Blood
Blood (2022) 140 (Supplement 1): 5920–5921.
https://doi.org/10.1182/blood-2022-169732
Published: 2022
Journal Articles

Nicotinamide Phosphoribosyltransferase Inhibitors Induce Apoptosis of AML Stem Cells through Dysregulation of Lipid Metabolism

Amit Subedi, PhD, Qiang Liu, PhD BSc, David Sharon, PhD, Severine Cathelin, PhD, Gary D Bader, Changjiang Xu, Veronique Voisin, PhD, Angelo D'Alessandro, PhD, Eric R Lechman, PhD, John E. Dick, PhD FRS, Mark D. Minden, Jean C.Y. Wang, MD, Steven M Chan, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 25–26.
https://doi.org/10.1182/blood-2020-142404
Published: 2020
Journal Articles

IPO11 Regulates the Nuclear Import of BZW1/2 and Is Necessary for AML Cells and Stem Cells

Boaz Nachmias, MDPhD, Veronique Voisin, PhD, Geethu Emily Thomas, PhDMSc,BSc, Dilshad H. Khan, Rose Hurren, BSc, Aaron Botham, Xiaoming Wang, Neil Maclean, Ayesh K Seneviratne, BSc, MSc, Changjiang Xu, Jonathan St-Germain, Andrea Arruda, MSc, Elias Orouji, Liran I. Shlush, MD, Mark D. Minden, Brian Raught, Gary D Bader, Aaron D Schimmer, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 22–23.
https://doi.org/10.1182/blood-2020-134787
Published: 2020
Journal Articles

A Stemness-Based Screen Identifies PLK1 Inhibitors for Targeting Leukemia Stem Cells in AML

Qiang Liu, PhD BSc, Amit Subedi, PhD, Samantha Yao, Changjiang Xu, Veronique Voisin, PhD, Gary D Bader, Steven M Chan, MD PhD, Jean C.Y. Wang, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 34–35.
https://doi.org/10.1182/blood-2020-141740
Published: 2020
Journal Articles

IPO11 Is Upregulated in Relapsed AML and Supports Survival of Leukemic Stem Cells

Boaz Nachmias, MD PhD, Veronique Voisin, PhD, Rose Hurren, BSc, Xioaming Wang, Neil Maclean, G. Wei Xu, Ayesh K Seneviratne, BSc, MSc, Changjiang Xu, Gary D Bader, Liran I. Shlush, MD, Aaron D Schimmer, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2530.
https://doi.org/10.1182/blood-2019-122284
Published: 2019
Journal Articles

The Mitochondrial Protease, Neurolysin (NLN), Regulates Respiratory Chain Complex and Supercomplex Formation and Is Necessary for AML Viability

Sara Mirali, BSc, Botham Aaron, Veronique Voisin, PhD, Changjiang Xu, Jonathan St-Germain, David Sharon, PhD, Fieke W Hoff, BSc, Yihua Qiu, Rose Hurren, BSc, Marcela Gronda, MSc, Yulia Jitkova, PhD, G Wei Xu, Boaz Nachmias, MD PhD, Neil MacLean, Xiaoming Wang, Andrea Arruda, Mark D. Minden, MD PhD, Terzah M Horton, MD PhD, Steven M. Kornblau, MD, Steven M Chan, MD PhD, Gary D Bader, Brian Raught, Aaron D Schimmer, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 729.
https://doi.org/10.1182/blood-2019-122784
Published: 2019
Journal Articles

Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT) Activity Selectively Targets Human Acute Myeloid Leukemia Stem Cells

Amit Subedi, PhD, Qiang Liu, PhD BSc, David Sharon, PhD, Changjiang Xu, Veronique Voisin, PhD, Gary D Bader, Jean Wang, MD, Steven M Chan, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3932.
https://doi.org/10.1182/blood-2018-99-120258
Published: 2018
Journal Articles

Identification of Compounds That Target Acute Myeloid Leukemia Stem Cells Using a Scalable Next-Generation Screening Platform

Qiang Liu, PhD BSc, Amit Subedi, PhD, Changjiang Xu, Veronique Voisin, PhD, Gary D Bader, Steven M Chan, MD PhD, Jean C.Y. Wang, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 259.
https://doi.org/10.1182/blood-2018-99-115323
Published: 2018
Journal Articles

Targeting the Mitochondrial Metallochaperone Cox17 Reduces DNA Methylation and Promotes AML Differentiation through a Copper Dependent Mechanism

Rashim Pal Singh, MSc,PhD, Danny V. Jeyaraju, PhD, Veronique Voisin, PhD, Changjiang Xu, Samir H Barghout, BSPharm, MSc, Dilshad H. Khan, Rose Hurren, BSc, Marcela Gronda, MSc, Xiaoming Wang, Yulia Jitkova, PhD, David Sharon, PhD, Sanduni U. Liyanage, Hon. B. Sc, PhD, Joelle Soriano, Eric R. Lechman,, PhD MSC, Neil MacLean, Mark D. Minden, MD PhD, Steven M Chan, MD PhD, John E. Dick, Gary D Bader, Aaron Schimmer, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1339.
https://doi.org/10.1182/blood-2018-99-111015
Published: 2018
Journal Articles

Inhibiting the Mitochondrial Sulfhydryl Oxidase Alr Reduces Cox17 and Alters Mitochondrial Cristae Structure Leading to the Differentiation of AML and Stem Cells

Danny V. Jeyaraju, PhD, Veronique Voisin, Changjiang Xu, Samir H. Barghout, BSPharm, MSc, Dilshad H. Khan, Rose Hurren, BSc, Marcela Gronda, MSc, Xiaoming Wang, Yulia Jitkova, PhD, David Sharon, PhD, Sanduni U. Liyanage, Hon. B. Sc, PhD, Joelle Soriano, Eric R. Lechman, PhD, Neil MacLean, Mark D. Minden, MD PhD, Steven M. Chan, MDPhD, John E. Dick, PhD, Gary D Bader, Aaron D. Schimmer, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 881.
https://doi.org/10.1182/blood.V130.Suppl_1.881.881
Published: 2017
Journal Articles

Leveraging increased cytoplasmic nucleoside kinase activity to target mtDNA and oxidative phosphorylation in AML

Sanduni U. Liyanage, Rose Hurren, Veronique Voisin, Gaëlle Bridon, Xiaoming Wang, ChangJiang Xu, Neil MacLean, Thirushi P. Siriwardena, Marcela Gronda, Dana Yehudai, Shrivani Sriskanthadevan, Daina Avizonis, Aisha Shamas-Din, Mark D. Minden, Gary D. Bader, Rebecca Laposa, Aaron D. Schimmer
Journal: Blood
Blood (2017) 129 (19): 2657–2666.
https://doi.org/10.1182/blood-2016-10-741207
Published: 2017
Includes: Supplemental data
Journal Articles

Inhibition of the Mitochondrial Protein Import Machinery Is Selectively Cytotoxic to Acute Myeloid Leukemia (AML) Cells and Stem Cells

Danny V Jeyaraju, Veronique Voisin, Changjiang Xu, Rose Hurren, Marcela Gronda, Xiaoming Wang, Yulia Jitkova, Joelle Soriano, Neil MacLean, Gary D Bader, Aaron D. Schimmer, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1572.
https://doi.org/10.1182/blood.V128.22.1572.1572
Published: 2016
Journal Articles

Leveraging Increased Nucleoside Kinase Activity to Selectively Deplete Mitochondrial DNA (mtDNA), Impair Oxidative Phosphorylation, and Target AML Cells

Sanduni U. Liyanage, Hon. B. Sc., Rose Hurren, Veronique Voisin, Wang Xiaoming, Gaëlle Bridon, Changjiang Xu, Neil MacLean, Thirushi Siriwardena, Aisha Shamas-Din, PhD, Shrivani Sriskanthadevan, Mark D. Minden, MD PhD, Gary D Bader, Rebecca Laposa, Aaron D. Schimmer, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1573.
https://doi.org/10.1182/blood.V128.22.1573.1573
Published: 2016