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Sanduni U. Liyanage
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Journal Articles

Targeting the Mitochondrial Metallochaperone Cox17 Reduces DNA Methylation and Promotes AML Differentiation through a Copper Dependent Mechanism

Rashim Pal Singh, MSc,PhD, Danny V. Jeyaraju, PhD, Veronique Voisin, PhD, Changjiang Xu, Samir H Barghout, BSPharm, MSc, Dilshad H. Khan, Rose Hurren, BSc, Marcela Gronda, MSc, Xiaoming Wang, Yulia Jitkova, PhD, David Sharon, PhD, Sanduni U. Liyanage, Hon. B. Sc, PhD, Joelle Soriano, Eric R. Lechman,, PhD MSC, Neil MacLean, Mark D. Minden, MD PhD, Steven M Chan, MD PhD, John E. Dick, Gary D Bader, Aaron Schimmer, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1339.
https://doi.org/10.1182/blood-2018-99-111015
Published: 2018
Journal Articles

Patients Who Are Refractory to Ida-FLAG As Initial Induction Chemotherapy for AML Have Persistence of the Dominant Genetic Mutations and a Poor Clinical Outcome

Simon Kavanagh, Emily Heath, Rose Hurren, BSc, Samir H. Barghout, BSPharm, MSc, Sanduni U. Liyanage, Hon. B. Sc, PhD, Thirushi Siriwardena, Jaime Claudio, Tong Zhang, Mahadeo Sukhai, Tracy L. Stockley, Suzanne Kamel-Reid, Amr Rostom, MD, Dina Khalaf, BSc, MSc, MD, Andrzej Lutynski, Anna Rydlewski, MD, Andre C. Schuh, MD FRCPC, Vikas Gupta, MD PhD, Hassan Sibai, MBBS, Dawn Maze, MD FRCPC, MSc, Steven M. Chan, MDPhD, Aaron D. Schimmer, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2596.
https://doi.org/10.1182/blood.V130.Suppl_1.2596.2596
Published: 2017
Journal Articles

The Thymidine Dideoxynucleoside Analogue, Alovudine, Inhibits the Mitochondrial DNA Polyermase, POLG, Impairs Oxidative Phosphorylation and Promotes Monocytic Differentiation in AML

Dana Yehudai-Ofir, MD, Sanduni U. Liyanage, Hon. B. Sc, PhD, Rose Hurren, BSc, Marcela Gronda, MSc, Danny V. Jeyaraju, PhD, Xiaoming Wang, Thirushi Siriwardena, Yulia Jitkova, PhD, Aaron D. Schimmer, MDPhD, Biljana Rizoska, PhD, Paul Targett-Adams, PhD, Mark Albertella, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2524.
https://doi.org/10.1182/blood.V130.Suppl_1.2524.2524
Published: 2017
Journal Articles

Inhibiting the Mitochondrial Sulfhydryl Oxidase Alr Reduces Cox17 and Alters Mitochondrial Cristae Structure Leading to the Differentiation of AML and Stem Cells

Danny V. Jeyaraju, PhD, Veronique Voisin, Changjiang Xu, Samir H. Barghout, BSPharm, MSc, Dilshad H. Khan, Rose Hurren, BSc, Marcela Gronda, MSc, Xiaoming Wang, Yulia Jitkova, PhD, David Sharon, PhD, Sanduni U. Liyanage, Hon. B. Sc, PhD, Joelle Soriano, Eric R. Lechman, PhD, Neil MacLean, Mark D. Minden, MD PhD, Steven M. Chan, MDPhD, John E. Dick, PhD, Gary D Bader, Aaron D. Schimmer, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 881.
https://doi.org/10.1182/blood.V130.Suppl_1.881.881
Published: 2017
Journal Articles

Leveraging increased cytoplasmic nucleoside kinase activity to target mtDNA and oxidative phosphorylation in AML

Sanduni U. Liyanage, Rose Hurren, Veronique Voisin, Gaëlle Bridon, Xiaoming Wang, ChangJiang Xu, Neil MacLean, Thirushi P. Siriwardena, Marcela Gronda, Dana Yehudai, Shrivani Sriskanthadevan, Daina Avizonis, Aisha Shamas-Din, Mark D. Minden, Gary D. Bader, Rebecca Laposa, Aaron D. Schimmer
Journal: Blood
Blood (2017) 129 (19): 2657–2666.
https://doi.org/10.1182/blood-2016-10-741207
Published: 2017
Includes: Supplemental data
Journal Articles

Leveraging Increased Nucleoside Kinase Activity to Selectively Deplete Mitochondrial DNA (mtDNA), Impair Oxidative Phosphorylation, and Target AML Cells

Sanduni U. Liyanage, Hon. B. Sc., Rose Hurren, Veronique Voisin, Wang Xiaoming, Gaëlle Bridon, Changjiang Xu, Neil MacLean, Thirushi Siriwardena, Aisha Shamas-Din, PhD, Shrivani Sriskanthadevan, Mark D. Minden, MD PhD, Gary D Bader, Rebecca Laposa, Aaron D. Schimmer, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1573.
https://doi.org/10.1182/blood.V128.22.1573.1573
Published: 2016