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Journal Articles

Polyamines Are Required for AML LSC Function through Their Role in Regulating eIF5A Dependent Protein Synthesis

Vincent Rondeau, Rachel Culp-Hill, Julie A Reisz, Duhan Yendi, Aarushi Gupta, Jacob Berman, Cristiana O'Brien, Tianyi Ling, Aleksandra Bourdine, Mary Shi, Jonathan St-Germain, Soheil Jahangiri, Anastasia N. Tikhonova, Andrea Arruda, Mark D. Minden, Brian Raught, Angelo D'Alessandro, Courtney L Jones
Journal: Blood
Blood (2023) 142 (Supplement 1): 585.
https://doi.org/10.1182/blood-2023-187283
Published: 2023
Journal Articles

Intracellular IL-23 Receptor (IL-23R) Is a Regulator of Mitotic Spindle and Centrosome Formation and Is Essential for AML Viability

Nathan Duong, Dilshad H. Khan, Geethu Emily Thomas, Rose Hurren, Jong Bok Lee, Jonathan St-Germain, Lily Drimmer, Yongran Yan, Neil Maclean, Marcela Gronda, Vincent Rondeau, Brandon D. Brown, Courtney L Jones, Hong Chang, Andrea Arruda, Mark D. Minden, Li Zhang, Steven M. Kornblau, Brian Raught, Vito Spadavecchio, Aaron D. Schimmer
Journal: Blood
Blood (2023) 142 (Supplement 1): 5694.
https://doi.org/10.1182/blood-2023-174536
Published: 2023
Journal Articles

XPO2 Is Essential for a Subset of AML Cells and Is a Biomarker for Poor Response and Survival in Pediatric and AYA AML

Grace Egan, Geethu Emily Thomas, Rose Hurren, Suraj Bansal, Andy G.X. Zeng, Chaitra Sarathy, Dilshad H. Khan, Yongran Yan, Yue Feng, Jonathan St-Germain, Brian Raught, John E. Dick, Aaron D. Schimmer
Journal: Blood
Blood (2023) 142 (Supplement 1): 5681.
https://doi.org/10.1182/blood-2023-180968
Published: 2023
Journal Articles

Serine Phosphorylation Marks Proteins for Degradation By the Mitochondrial Serine Protease Complex, Clpxp

Yue Feng, Yulia Jitkova, Alexander Keszei, Chaitra Sarathy, Vincent Trudel, Jonathan St-Germain, Matthew Tcheng, Monica M Goncalves, Yongran Yan, Rose Hurren, Matthew Schultz, Siavash Vahidi, Brian Raught, Andrei Yudin, Mohammad Mazhab-Jafari, Aaron D. Schimmer
Journal: Blood
Blood (2023) 142 (Supplement 1): 5675.
https://doi.org/10.1182/blood-2023-173385
Published: 2023
Journal Articles

Simultaneous Inhibition of SIRT3 and Cholesterol Homeostasis Targets AML Stem Cells By Perturbing Fatty Acid β-Oxidation and Inducing Lipotoxicity

Cristiana O'Brien, Tianyi Ling, Jacob Berman, Rachel Culp-Hill, Julie A. Reisz, Vincent Rondeau, Soheil Jahangiri, Jonathan St-Germain, Vinitha Macwan, Audrey Astori, Andy G.X. Zeng, Jun Young Hong, Meng Li, Min Yang, Sadhan Jana, John E. Dick, Hening Lin, Ari Melnick, Anastasia N Tikhonova, Andrea Arruda, Mark D. Minden, Brian Raught, Angelo D'Alessandro, Courtney L Jones
Journal: Blood
Blood (2022) 140 (Supplement 1): 104–106.
https://doi.org/10.1182/blood-2022-157794
Published: 2022
Journal Articles

A Novel Role for PLK1 in Leukemia Stem Cell Function in Acute Myeloid Leukemia

Qiang Liu, Alex Murison, Andy G.X. Zeng, Changjiang Xu, Veronique Voisin, Faith Yeung, Amit Subedi, Steven M. Chan, Brian Raught, Gary D Bader, John E. Dick, Jean C.Y. Wang
Journal: Blood
Blood (2022) 140 (Supplement 1): 5920–5921.
https://doi.org/10.1182/blood-2022-169732
Published: 2022
Journal Articles

Intracellular IL-23 Receptor (IL-23R) Is Necessary for AML Viability and Regulates Mitotic Spindle and Centrosome Formation

Nathan Duong, Dilshad H. Khan, Geethu Emily Thomas, Rose Hurren, Jong Bok Lee, Jonathan St-Germain, Lily Drimmer, Yongran Yan, Neil MacLean, Marcela Gronda, Brandon D Brown, Brian Raught, Andrea Arruda, Mark D. Minden, Li Zhang, Steven M. Kornblau, Vito Spadevecchio, Aaron D. Schimmer
Journal: Blood
Blood (2022) 140 (Supplement 1): 3005–3006.
https://doi.org/10.1182/blood-2022-157626
Published: 2022
Journal Articles

Phosphorylated Serine Marks Proteins for Degradation By the Mitochondrial Matrix Protease, Clpxp

Yue Feng, Yulia Jitkova, Alexander Keszei, Jonathan St-Germain, Yongran Yan, Brian Raught, Mohammad Mazhab-Jafari, Aaron D. Schimmer
Journal: Blood
Blood (2022) 140 (Supplement 1): 3023–3024.
https://doi.org/10.1182/blood-2022-157338
Published: 2022
Journal Articles

IPO11 Regulates the Nuclear Import of BZW1/2 and Is Necessary for AML Cells and Stem Cells

Boaz Nachmias, MDPhD, Veronique Voisin, PhD, Geethu Emily Thomas, PhDMSc,BSc, Dilshad H. Khan, Rose Hurren, BSc, Aaron Botham, Xiaoming Wang, Neil Maclean, Ayesh K Seneviratne, BSc, MSc, Changjiang Xu, Jonathan St-Germain, Andrea Arruda, MSc, Elias Orouji, Liran I. Shlush, MD, Mark D. Minden, Brian Raught, Gary D Bader, Aaron D Schimmer, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 22–23.
https://doi.org/10.1182/blood-2020-134787
Published: 2020
Journal Articles

Divergent Levels of CD112 and INKA1 Define a Subset of Human Hematopoietic Stem Cells That Resists Regenerative Stress to Preserve Stemness

Kerstin B Kaufmann, PhD, Andy G.X. Zeng, BSc, Etienne Coyaud, Laura Garcia Prat, PhD BSc, MSc, Efthymia Papalexi, BA, Estelle MN Laurent, Michelle Chan-Seng-Yue, Olga I. Gan, PhD, Kristele Pan, Jessica L. McLeod, Sasan Zandi, Shin-Ichiro Takayanagi, PhD, Rahul Satija, Brian Raught, Stephanie Zhi-Juan Xie, PhD, John E. Dick, PhD FRS
Journal: Blood
Blood (2020) 136 (Supplement 1): 5.
https://doi.org/10.1182/blood-2020-137725
Published: 2020
Journal Articles

The Mitochondrial Protease, Neurolysin (NLN), Regulates Respiratory Chain Complex and Supercomplex Formation and Is Necessary for AML Viability

Sara Mirali, BSc, Botham Aaron, Veronique Voisin, PhD, Changjiang Xu, Jonathan St-Germain, David Sharon, PhD, Fieke W Hoff, BSc, Yihua Qiu, Rose Hurren, BSc, Marcela Gronda, MSc, Yulia Jitkova, PhD, G Wei Xu, Boaz Nachmias, MD PhD, Neil MacLean, Xiaoming Wang, Andrea Arruda, Mark D. Minden, MD PhD, Terzah M Horton, MD PhD, Steven M. Kornblau, MD, Steven M Chan, MD PhD, Gary D Bader, Brian Raught, Aaron D Schimmer, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 729.
https://doi.org/10.1182/blood-2019-122784
Published: 2019
Journal Articles

Targeting The Mitochondrial ClpP As a Novel Therapeutic Strategy For Acute Myeloid Leukemia

Alicia Cole, PhD, Zezhou Wang, PhD, Rachel Mattson, Etienne Coyaud, PhD, Rose Hurren, Marcela Gronda, MSc, Fengshu Lin, PhD, Neil Maclean, BSc, Elisa Leung, BSc, Yihua Qiu, MD, Nianxiang Zhang, PhD, Kevin R. Coombes, PhD, Mark D. Minden, MD PhD, Walid A. Houry, PhD, Zenyaho Hao, PhD, Steven M. Kornblau, MD, Brian Raught, PhD, Aaron Schimmer, PhD, MD
Journal: Blood
Blood (2013) 122 (21): 3937.
https://doi.org/10.1182/blood.V122.21.3937.3937
Published: 2013