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Journal Articles

FLT3 is genetically essential for ITD-mutated leukemic stem cells but dispensable for human hematopoietic stem cells

Blood blood.2024025886.

https://doi.org/10.1182/blood.2024025886

Published: 2025

Includes: Supplemental data

Journal Articles

Leptin-Enhanced JAK-STAT Signaling in Acute Myeloid Leukemia-Derived Mesenchymal Stromal Cells and Its Implications for Disease Progression

Muzaffar Bhatti, Anthea Travas, Oyeronke Ayansola, Amirthagowri Ambalavanan, Jaeyoon John Kim, Danielle Pyne, Troy Ketela, Andrea Arruda, Mark D. Minden, Armand Keating, Dennis Dong Hwan Kim

Blood (2024) 144 (Supplement 1): 5664.

https://doi.org/10.1182/blood-2024-211349

Published: 2024

Journal Articles

Multiparameter Flow Cytometry-Based Measurable Residual Disease Assessment in the Patients with CCAAT Enhancer-Binding Protein a Gene (CEBPA) Mutated Acute Myeloid Leukemia

Swe Mar Linn, Nihar Desai, Steven M. Chan, Andre C. Schuh, Aniket Banker, Marta Beata Davidson, Guillaume Richard-Carpentier, Aron Shimmer, Dawn C. Maze, Karen Yee, Mark D. Minden, Vikas Gupta, Tracy Stockley, Hassan Sibai, Jose-Mario Capo-Chichi, Anne Maria Tierens, Dennis Dong Hwan Kim

Blood (2024) 144 (Supplement 1): 1570.

https://doi.org/10.1182/blood-2024-211434

Published: 2024

Journal Articles

Single-Cell Proteogenomic Analysis of Clonal Evolution in Patient-Derived Xenograft Models of AML Treated with IDH Inhibitors

Alex Liu, Severine Cathelin, Yitong Yang, Farzaneh Aboualizadeh, Amina Abow, Gurbaksh Basi, Lance Li, David L Dai, Abdula Maher, Eric Grignano, Mohsen Hosseini, Dhanoop Manikoth Ayyathan, Vivian Wang, Troy Ketela, Dylan Marchione, Adriana Tron, Andrea Arruda, Mark D. Minden, Steven M. Chan

Blood (2024) 144 (Supplement 1): 4995.

https://doi.org/10.1182/blood-2024-211634

Published: 2024

Journal Articles

The Mitochondrial Unfolded Protein Response (UPR mt ) Is Upregulated in Acute Myeloid Leukemia (AML) and Inhibiting the UPR mt Protease, LONP1, Leads to Mitochondrial Protein Aggregation and Cell Death Selectively in AML

Matthew Tcheng, Veronique Voisin, Marcela Gronda, Rose Hurren, Dakai Ling, Yongran Yan, Lan Xin Zhang, Yue Feng, Zaynab Mamai, Yulia Jitkova, Chaitra Sarathy, Andrea Arruda, Steven M. Kornblau, Mark D. Minden, Aaron D Schimmer

Blood (2024) 144 (Supplement 1): 2778.

https://doi.org/10.1182/blood-2024-205308

Published: 2024

Journal Articles

What Is the Prognostic Relevance of Responses Less Than a CR(Sub-CR) to Initial AML Treatment?

Akhil Rajendra, Elliot Smith, Eshetu Atenafu, Aniket Bankar, Steven M. Chan, Marta Beata Davidson, Vikas Gupta, Mark D. Minden, Maria Agustina Perusini, Guillaume Richard-Carpentier, Aaron D Schimmer, Andre C. Schuh, Hassan Sibai, Karen Yee, Dawn C. Maze

Blood (2024) 144 (Supplement 1): 5193.

https://doi.org/10.1182/blood-2024-208884

Published: 2024

Journal Articles

Blood-Based Proteomic Profiling Identifies Osmr As a Novel Biomarker

Hussein A. Abbas, Bofei Wang, Jennifer Marvin-Peek, Bin Yuan, Araceli Isabella Garza, Jessica Lynn Root, Andrea Arruda, Yiwei Liu, Courtney D. DiNardo, Tapan M. Kadia, Naval Daver, Philip L Lorenzi, Koji Sasaki, Steven M. Kornblau, Mark D. Minden, Farhad Ravandi, Hagop M. Kantarjian, Patrick K. Reville

Blood (2024) 144 (Supplement 1): 2912.

https://doi.org/10.1182/blood-2024-201725

Published: 2024

Journal Articles

Targeted Protein Degradation Reveals a Repressive Role of Mecom at the CEBPA Locus to Prevent Differentiation in High-Risk Acute Myeloid Leukemia

Travis Fleming, Richard A Voit, Mateusz Antoszewski, Sander Lambo, Michael Gundry, Riccardo Piussi, Sanjana Shah, Lara Wahlster, Andrea Arruda, Volker Hovestadt, Mark D. Minden, Vijay G. Sankaran

Blood (2024) 144 (Supplement 1): 953.

https://doi.org/10.1182/blood-2024-199697

Published: 2024

Journal Articles

Intensive Chemotherapy Vs. Azacitidine + Venetoclax for AML with Secondary Mutations

Elliot Smith, Akhil Rajendra Kurup, Eshetu Atenafu, Aniket Bankar, Steven M. Chan, Marta Beata Davidson, Vikas Gupta, Mark D. Minden, Guillaume Richard-Carpentier, Aaron D Schimmer, Andre C. Schuh, Hassan Sibai, Karen Yee, Dawn C. Maze

Blood (2024) 144 (Supplement 1): 1483.

https://doi.org/10.1182/blood-2024-202069

Published: 2024

Journal Articles

Inhibition of Peroxisome Proliferation-Activated Receptor Delta (PPARδ) Selectively Kills Acute Myeloid Leukemia Cells

Yingying Yang, Ekaterina Parfenova, Nikolina Vrdoljak, Mark D. Minden, Jessica Luc, Andrew Doxey, Paul A. Spagnuolo

Blood (2024) 144 (Supplement 1): 2762.

https://doi.org/10.1182/blood-2024-210432

Published: 2024

Journal Articles

Real-World Experience with CPX-351 for Secondary Acute Myeloid Leukemia: Comparison with FLAG-IDA in a Propensity Score Matching Analysis

Blood (2024) 144 (Supplement 1): 1506.

https://doi.org/10.1182/blood-2024-204004

Published: 2024

Journal Articles

The Exportin, CSE1L, Regulates Ribosome Biogenesis and Is a Selective Dependency in Childhood and Young Adult Acute Myeloid Leukemia

Grace Egan, Amit Kumar, Veronique Voisin, Rose Hurren, Ali Chegini, Dakai Ling, Geethu Emily Thomas, Youngran Yan, Yue Feng, Suraj Bansal, Andy G.X. Zeng, Andrea Arruda, John Edgar Dick, Gary D Bader, Mark D. Minden, Aaron D Schimmer

Blood (2024) 144 (Supplement 1): 2724.

https://doi.org/10.1182/blood-2024-200148

Published: 2024

Journal Articles

AML Cells Have Increased Mitochondrial RNA Degradation and Inhibiting This Degradation Promotes Cell Differentiation, Decreases Viability, and Increases Sensitivity to Immune-Mediated Killing

Geethu Emily Thomas, Kazem Nouri, Rose Hurren, JongBok Lee, Veronique Voisin, Yongran Yan, Neil Maclean, Marcela Gronda, Yulia Jitkova, Taylor Barbieri, Li Ma, Xiaoming Wang, Andrea Arruda, Mark D. Minden, Li Zhang, Aaron D Schimmer

Blood (2024) 144 (Supplement 1): 2723.

https://doi.org/10.1182/blood-2024-194861

Published: 2024

Journal Articles

Examining the Clinical Relevance of the AML Plasma Metabolome

Cristiana O'Brien, Nirvana Nursimulu, Rachel Culp-Hill, Julie A Reisz Haines, Andrea Arruda, Mark D. Minden, Angelo D'Alessandro, Sushant Kumar, Kristin J. Hope, Courtney Jones

Blood (2024) 144 (Supplement 1): 2937.

https://doi.org/10.1182/blood-2024-203960

Published: 2024

Journal Articles

FLAG-IDA Plus Venetoclax in High-Risk Newly Diagnosed and Relapsed or Refractory Acute Myeloid Leukemia: The Princess Margaret Cancer Center Experience

Eshrak Al-Shaibani, Marta Beata Davidson, Aniket Bankar, Steven M. Chan, Hassan Sibai, Dawn C. Maze, Aaron D Schimmer, Mark D. Minden, Karen Yee, Vikas Gupta, Andre C. Schuh, Guillaume Richard-Carpentier

Blood (2024) 144 (Supplement 1): 4273.

https://doi.org/10.1182/blood-2024-209476

Published: 2024

Journal Articles

Identifying Stress Granules As Determinants of Leukemia Stem Cell Maintenance and Stress Adaptation

Blood (2023) 142 (Supplement 1): 405.

https://doi.org/10.1182/blood-2023-180919

Published: 2023

Journal Articles

AML Drug Tolerant Persister (DTP) Cells Survive Chemotherapy By Transiently Altering Cellular Lipidomics to Increase Plasma Membrane Rigidity, but Also Increases Sensitivity to Immune Cell Killing

Yael Morgenstern, JongBok Lee, Yoosu Na, William Gwynne, Rose Hurren, Li Ma, Marcela Gronda, Chaitra Sarathy, Arvind Mer, Andrea Arruda, Avraham Frisch, Tsila Zuckerman, Yishai Ofran, Mark D. Minden, Li Zhang, Catherine O'Brien, J. Rafael Montenegro-Burke, Aaron D. Schimmer

Blood (2023) 142 (Supplement 1): 2806.

https://doi.org/10.1182/blood-2023-178995

Published: 2023

Journal Articles

Prognostic Role of Multiparameter Flow Cytometry-Based Measurable Residual Disease Assessment in Acute Myeloid Leukemia Patients with FMS3-like Tyrosine Kinase-3 Internal Tandem Duplication (FLT3-ITD)

Josephine Anne Lucero, Aniket Bankar, Marta Beata Davidson, Guillaume Richard-Carpentier, Aaron D. Schimmer, Andre C. Schuh, Dawn C. Maze, Karen Yee, Mark D. Minden, Steven M. Chan, Jonas Mattsson, Rajat Kumar, Vikas Gupta, Jose-Mario Capo-Chichi, Tracy Stockley, Hassan Sibai, Anne Maria Tierens, Dennis Dong Hwan Kim

Blood (2023) 142 (Supplement 1): 1595.

https://doi.org/10.1182/blood-2023-190694

Published: 2023

Journal Articles

Final Results of the Phase Ib/II Study Evaluating Enasidenib in Combination with Venetoclax in Patients with IDH2 -Mutated Relapsed/Refractory Myeloid Malignancies

Guillaume Richard-Carpentier, Gopila Gupta, Charina Cameron, Severine Cathelin, Aniket Bankar, Marta Beata Davidson, Vikas Gupta, Dawn C. Maze, Mark D. Minden, Tracy Murphy, Aaron D. Schimmer, Andre C. Schuh, Hassan Sibai, Karen Yee, Courtney D. DiNardo, Joseph Brandwein, Caroline Jane McNamara, Steven M. Chan

Blood (2023) 142 (Supplement 1): 159.

https://doi.org/10.1182/blood-2023-188341

Published: 2023

Journal Articles

Inhibiting Mitochondrial RNA Degradosome Complex SUV3 and PNPT1 Increases dsRNA in the Cytoplasm, Triggers Viral Mimicry Response and Sensitizes AML Cells to Immune Mediated Killing

Geethu Emily Thomas, Kazem Nouri, Jong Bok Lee, Rose Hurren, Yongran Yan, Neil Maclean, Yulia Jitkova, Li Ma, Xiaoming Wang, Chaitra Sarathy, Andrea Arruda, Mark D. Minden, Li Zhang, Vito Spadavecchio, Aaron D. Schimmer

Blood (2023) 142 (Supplement 1): 2742.

https://doi.org/10.1182/blood-2023-178696

Published: 2023

NARROW

FLT3 is genetically essential for ITD-mutated leukemic stem cells but dispensable for human hematopoietic stem cells

Leptin-Enhanced JAK-STAT Signaling in Acute Myeloid Leukemia-Derived Mesenchymal Stromal Cells and Its Implications for Disease Progression

Multiparameter Flow Cytometry-Based Measurable Residual Disease Assessment in the Patients with CCAAT Enhancer-Binding Protein a Gene (CEBPA) Mutated Acute Myeloid Leukemia

Single-Cell Proteogenomic Analysis of Clonal Evolution in Patient-Derived Xenograft Models of AML Treated with IDH Inhibitors

The Mitochondrial Unfolded Protein Response (UPR mt ) Is Upregulated in Acute Myeloid Leukemia (AML) and Inhibiting the UPR mt Protease, LONP1, Leads to Mitochondrial Protein Aggregation and Cell Death Selectively in AML

What Is the Prognostic Relevance of Responses Less Than a CR(Sub-CR) to Initial AML Treatment?

Blood-Based Proteomic Profiling Identifies Osmr As a Novel Biomarker

Targeted Protein Degradation Reveals a Repressive Role of Mecom at the CEBPA Locus to Prevent Differentiation in High-Risk Acute Myeloid Leukemia

Intensive Chemotherapy Vs. Azacitidine + Venetoclax for AML with Secondary Mutations

Inhibition of Peroxisome Proliferation-Activated Receptor Delta (PPARδ) Selectively Kills Acute Myeloid Leukemia Cells

Real-World Experience with CPX-351 for Secondary Acute Myeloid Leukemia: Comparison with FLAG-IDA in a Propensity Score Matching Analysis

The Exportin, CSE1L, Regulates Ribosome Biogenesis and Is a Selective Dependency in Childhood and Young Adult Acute Myeloid Leukemia

AML Cells Have Increased Mitochondrial RNA Degradation and Inhibiting This Degradation Promotes Cell Differentiation, Decreases Viability, and Increases Sensitivity to Immune-Mediated Killing

Examining the Clinical Relevance of the AML Plasma Metabolome

FLAG-IDA Plus Venetoclax in High-Risk Newly Diagnosed and Relapsed or Refractory Acute Myeloid Leukemia: The Princess Margaret Cancer Center Experience

Identifying Stress Granules As Determinants of Leukemia Stem Cell Maintenance and Stress Adaptation

AML Drug Tolerant Persister (DTP) Cells Survive Chemotherapy By Transiently Altering Cellular Lipidomics to Increase Plasma Membrane Rigidity, but Also Increases Sensitivity to Immune Cell Killing

Prognostic Role of Multiparameter Flow Cytometry-Based Measurable Residual Disease Assessment in Acute Myeloid Leukemia Patients with FMS3-like Tyrosine Kinase-3 Internal Tandem Duplication (FLT3-ITD)

Final Results of the Phase Ib/II Study Evaluating Enasidenib in Combination with Venetoclax in Patients with IDH2 -Mutated Relapsed/Refractory Myeloid Malignancies

Inhibiting Mitochondrial RNA Degradosome Complex SUV3 and PNPT1 Increases dsRNA in the Cytoplasm, Triggers Viral Mimicry Response and Sensitizes AML Cells to Immune Mediated Killing

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American Society of Hematology

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American Society of Hematology

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