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Richard Koche
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Journal Articles

Genome-Wide Mapping of R-Loops in Single Cells Reveals Cell-Type Specific Roles for R-Loops in Hematopoietic Cell Identity

Bin Lu, Pu Zhang, Sisi Chen, Salima Benbarche, Cynthia Castro, Nina Fox, Mohammad Abubakar, Jeetayu Biswas, Ruslan Soldatov, Richard Koche, Omar Abdel-Wahab
Journal: Blood
Blood (2023) 142 (Supplement 1): 242.
https://doi.org/10.1182/blood-2023-180913
Published: 2023
Journal Articles

MPN Transformation Is Characterized By Heterogeneous Shifts in Lineage Character

Deepika Dilip, Kamal Menghrajani, Jacob Glass, Raajit K. Rampal, Christopher Famulare, Maria Sirenko, Ross L Levine, Richard Koche
Journal: Blood
Blood (2023) 142 (Supplement 1): 749.
https://doi.org/10.1182/blood-2023-189767
Published: 2023
Journal Articles

HMGA1 Chromatin Regulators Drive Immune Evasion in MPN Progression through Epigenetic Rewiring to Repress Antigen Presentation

Joseph Kim, Audrey-Ann Supreme, Bailey West, Mariah C. Antopia, Karen Reddy, Leslie Cope, Jung-Hyun Kim, Raajit K. Rampal, Richard Koche, Jerry L. Spivak, Alison R. Moliterno, Linda Resar
Journal: Blood
Blood (2023) 142 (Supplement 1): 992.
https://doi.org/10.1182/blood-2023-186452
Published: 2023
Journal Articles

Precision Lineage Deconvolution in Mixed Phenotype Acute Leukemia Using Cite-Seq Derived Hematopoietic Stages Identifies Lineage Dynamics Associated with Treatment Response

Deepika Dilip, Pallavi Galera, David Nemirovsky, Morgan Lallo, Kamal Menghrajani, Andriy Derkach, Ross L Levine, Richard Koche, Wenbin Xiao, Jacob Glass
Journal: Blood
Blood (2023) 142 (Supplement 1): 4324.
https://doi.org/10.1182/blood-2023-188871
Published: 2023
Journal Articles

CXCL8/CXCR2 signaling mediates bone marrow fibrosis and is a therapeutic target in myelofibrosis

Andrew J. Dunbar, Dongjoo Kim, Min Lu, Mirko Farina, Robert L. Bowman, Julie L. Yang, Young Park, Abdul Karzai, Wenbin Xiao, Zach Zaroogian, Kavi O’Connor, Shoron Mowla, Francesca Gobbo, Paola Verachi, Fabrizio Martelli, Giuseppe Sarli, Lijuan Xia, Nada Elmansy, Maria Kleppe, Zhuo Chen, Yang Xiao, Erin McGovern, Jenna Snyder, Aishwarya Krishnan, Corrine Hill, Keith Cordner, Anouar Zouak, Mohamed E. Salama, Jayden Yohai, Eric Tucker, Jonathan Chen, Jing Zhou, Timothy McConnell, Anna R. Migliaccio, Richard Koche, Raajit Rampal, Rong Fan, Ross L. Levine, Ronald Hoffman
Journal: Blood
Blood (2023) 141 (20): 2508–2519.
https://doi.org/10.1182/blood.2022015418
Published: 2023
Includes: Supplemental data
Journal Articles

Escape from Type II JAK2 Inhibition in MPN Depends on AXL/MAPK Activation and Is Targetable

Tamara Codilupi, Jakub Szybinski, Sime Brkic, Simona Stivala, Julie Yang, Nilabh Ghosh, Katarzyna Buczak, Jakob Passweg, Anne Angelillo-Scherrer, Stefan Dirnhofer, Ross L. Levine, Richard Koche, Sara C. Meyer
Journal: Blood
Blood (2022) 140 (Supplement 1): 3850–3851.
https://doi.org/10.1182/blood-2022-159068
Published: 2022
Journal Articles

The AP-1/ETS Transcription Factor Network Regulates Stem Cell Quiescence and Chemotherapy Resistance in Acute Myeloid Leukemia

Sumiko Takao, Victor Morell, Fiona C. Brown, Richard Koche, Alex Kentsis
Journal: Blood
Blood (2022) 140 (Supplement 1): 8682–8683.
https://doi.org/10.1182/blood-2022-165325
Published: 2022
Journal Articles

Jak2 V617F Reversible Activation Shows an Essential Requirement for Jak2 V617F in Myeloproliferative Neoplasms (MPNs)

Andrew Dunbar, Robert L. Bowman, Young Park, Franco Izzo, Robert M. Myers, Abdul Karzai, Won Jun Kim, Inés Fernández Maestre, Michael R. Waarts, Abbas Nazir, Wenbin Xiao, Max Brodsky, Mirko Farina, Louise Cai, Sheng F Cai, Benjamin Wang, Wenbin An, Julie Yang, Shoron Mowla, Shira E. Eisman, Tanmay Mishra, Remie Houston, Emily Guzzardi, Anthony R. Martinez Benitez, Aaron D Viny, Richard Koche, Dan A. Landau, Ross L. Levine
Journal: Blood
Blood (2022) 140 (Supplement 1): 803–804.
https://doi.org/10.1182/blood-2022-164827
Published: 2022
Journal Articles

The High Mobility Group A1 Chromatin Regulator Drives Immune Evasion during MPN Progression By Repressing Genes Involved in Antigen Presentation

Joseph Kim, Jung-Hyun Kim, Leslie Cope, Liping Li, Raajit K Rampal, Richard Koche, Jerry L. Spivak, Alison R. Moliterno, Linda Resar
Journal: Blood
Blood (2022) 140 (Supplement 1): 801–802.
https://doi.org/10.1182/blood-2022-166969
Published: 2022
Journal Articles

Erythroid and Megakaryocytic Differentiation Program in JAK2 -Mutated Acute Myeloid Leukemia with or without Antecedent Myeloproliferative Neoplasm

Ying Liu, Shenon Sethi, Richard Koche, Qi Gao, Deepika Dilip, Jacob L Glass, Pallavi K Galera, Sonali Persaud, Tanmay Mishra, Xiaotian Sun, Dory Londono, Robert Cimera, Menglei Zhu, Christopher Famulare, Jeeyeon Baik, Himanshu Bhurtel, Maria E. Arcila, Ahmet Dogan, Ross L. Levine, Yanming Zhang, Mikhail Roshal, Raajit K Rampal, Wenbin Xiao
Journal: Blood
Blood (2022) 140 (Supplement 1): 9160–9162.
https://doi.org/10.1182/blood-2022-169215
Published: 2022
Journal Articles

The High Mobility Group A1 Chromatin Regulator Drives Immune Evasion during MPN Progression By Repressing Genes Involved in Antigen Presentation and Immune Attack

Joseph Kim, Jung-Hyun Kim, Leslie Cope, Liping Li, Raajit Rampal, Richard Koche, Donna M Williams, Jerry L. Spivak, Alison R. Moliterno, Linda Resar
Journal: Blood
Blood (2021) 138 (Supplement 1): 2546.
https://doi.org/10.1182/blood-2021-151139
Published: 2021
Journal Articles

Single Cell ATAC Lineage Deconvolution Reveals Overlapping Subclones in Epigenetically Distinct AML Samples

Deepika Dilip, Richard Koche, Kamal Menghrajani, Ari Melnick, Olivier Elemento, Ross L. Levine, Jacob L Glass
Journal: Blood
Blood (2021) 138 (Supplement 1): 2381.
https://doi.org/10.1182/blood-2021-154517
Published: 2021
Journal Articles

HMGA1 Chromatin Regulators Drive Progression in Myeloproliferative Neoplasms through Epigenetic Rewiring to Induce Networks Involved in GATA2 and Proliferation

Liping Li, Jung-Hyun Kim, Wenyan Lu, Leslie Cope, Donna M Williams, Joseph Kim, Raajit Rampal, Richard Koche, Lingling Xian, Li Luo, Marija Vasiljevic, Daniel R Matson, Zhizhuang Joe Zhao, Ophelia Rogers, Matthew C. Stubbs, Karen Reddy, Jerry L. Spivak, Alison R. Moliterno, Linda Resar
Journal: Blood
Blood (2021) 138 (Supplement 1): 625.
https://doi.org/10.1182/blood-2021-144712
Published: 2021
Journal Articles

The BMP/SMAD Pathway Is a Key Mediator of Leukemic Transformation of TP53-Mutant Post-MPN AML

Bing Li, Wenbin An, Hua Wang, Aishwarya Krishnan, Shoron Mowla, Timour Baslan, Richard Koche, Wenbin Xiao, Scott Lowe, Ross L. Levine, Raajit Rampal
Journal: Blood
Blood (2021) 138 (Supplement 1): 626.
https://doi.org/10.1182/blood-2021-152036
Published: 2021
Journal Articles

Isogenic MDS-RS Patient-Derived iPSCs Define the Mis-Spliced Transcript Repertoire and Chromatin Landscape of SF3B1-Mutant Hematopoietic Stem/Progenitor Cells

George Asimomitis, André G. Deslauriers, Andriana G. Kotini, Elsa Bernard, Davide Esposito, Malgorzata Olszewska, Nikolaos Spyrou, Juan Arango Ossa, Teresa Mortera-Blanco, Richard Koche, Stuart Aaronson, Eva Hellström-Lindberg, Elli Papaemmanuil, Eirini P. Papapetrou
Journal: Blood
Blood (2021) 138 (Supplement 1): 147.
https://doi.org/10.1182/blood-2021-149830
Published: 2021
Journal Articles

Leukemia Cell of Origin Influences p53 Activity and Therapeutic Sensitivity Via an Evi1-Dependent Mechanism

Sheng F Cai, MD PhD, S Haihua Chu, PhD, Aaron D Goldberg, MD PhD, Salma Parvin, PhD, Richard Koche, PhD, Jacob L Glass, MD PhD, Eytan M. Stein, MD, Martin S. Tallman, MD, Filiz Sen, MD, Christopher Famulare, MS, Monica Cusan, MD, Chun-Hao Huang, PhD, Chun-Wei David Chen, PhD, Lihua Zou, PhD, Keith B Cordner, BS, Vidushi Durani, MS, Mitali Kini, BS, Madison Rex, Johannes Zuber, Timour Baslan, PhD, Scott W. Lowe, PhD, Hugh Young Rienhoff, Jr., MD, Ross L. Levine, MD, Scott A. Armstrong, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 109.
https://doi.org/10.1182/blood-2019-122483
Published: 2019
Journal Articles

Stag2 Regulates Hematopoietic Differentiation and Self-Renewal through Alterations in Gene Expression and Topological Control

Aaron D Viny, MDMS, Robert L Bowman, PhD, Yu Liu, PhD, Vincent-Philippe Lavallee, MD, Shira Eisman, Wenbin Xiao, MD PhD, Benjamin H Durham, MD, Anastasia Navitski, Jane Park, Stephanie Braunstein, Besmira Alija, Abdul Karzai, Isabelle S. Csete, Matthew Witkin, Elham Azizi, PhD, Timour Baslan, Christopher J. Ott, PhD, Dana Pe'er, PhD, Job Dekker, Richard Koche, PhD, Ross L. Levine, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 279.
https://doi.org/10.1182/blood-2019-123464
Published: 2019
Journal Articles

The Lysine Histone Methyltransferase SETD2 Is Required for Appropriate Immunoglobulin VDJ Recombination

S. Haihua Chu, PhD, Jonathan Chabon, BS, Janna Minehart, BS, Chloe N Matovina, BS, Jian Zhang, Bo-Ruei Chen, PhD, Elsa Callen-Moreu, PhD, Putzer J Hung, Zhaohui Feng, BM, BS, Richard Koche, PhD, X. Shirley Liu, Jayanta Chaudhuri, Andre Nussenzweig, PhD, Barry Sleckman, Scott A. Armstrong, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 511.
https://doi.org/10.1182/blood-2018-99-111952
Published: 2018
Journal Articles

Functional Profiling of Patient AML Stem Cells Reveals Mechanisms of Epigenetic Plasticity Controlling Therapy Resistance

Sumiko Takao, MD PhD, Richard Koche, PhD, Paolo Cifani, PhD, Zheng Ser, Alex Kentsis, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1318.
https://doi.org/10.1182/blood-2018-99-114433
Published: 2018
Journal Articles

AML with Mutations in IDH1 and DNMT3A Exhibits a Distinct Epigenetic Signature with Poorer Overall Survival

Katya Ahr, BA, Christopher Famulare, MS, Richard Koche, PhD, Barbara Spitzer, MD, Ross L. Levine, MD, Martin S. Tallman, MD, Aaron D Goldberg, MD PhD, Eytan M. Stein, MD, Jacob L Glass, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1471.
https://doi.org/10.1182/blood-2018-99-118407
Published: 2018