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Journal Articles

Genome-Wide Mapping of R-Loops in Single Cells Reveals Cell-Type Specific Roles for R-Loops in Hematopoietic Cell Identity

Bin Lu, Pu Zhang, Sisi Chen, Salima Benbarche, Cynthia Castro, Nina Fox, Mohammad Abubakar, Jeetayu Biswas, Ruslan Soldatov, Richard Koche, Omar Abdel-Wahab

Blood (2023) 142 (Supplement 1): 242.

https://doi.org/10.1182/blood-2023-180913

Published: 2023

Journal Articles

Genome-Wide CRISPR/Cas9 Knockout Screen Reveals Novel Gilteritinib Combinations Targeting Oxidative Phosphorylation and De-Novo Purine Biosynthesis Pathways for FLT3-ITD + Acute Myeloid Leukemia

Blood (2022) 140 (Supplement 1): 681–682.

https://doi.org/10.1182/blood-2022-165573

Published: 2022

Journal Articles

Myeloid lncRNA LOUP mediates opposing regulatory effects of RUNX1 and RUNX1-ETO in t(8;21) AML

Blood (2021) 138 (15): 1331–1344.

https://doi.org/10.1182/blood.2020007920

Published: 2021

Includes: Supplemental data

Journal Articles

Identification of Novel Synthetic Lethal Partners of NAMPT Inhibitor By CRISPR-Cas9 Screens in Acute Myeloid Leukemia

Pu Zhang, Lindsey Brinton, PhD, James S. Blachly, MD, John C. Byrd, MD, Rosa Lapalombella, PhD

Blood (2019) 134 (Supplement_1): 2072.

https://doi.org/10.1182/blood-2019-129036

Published: 2019

Journal Articles

Long Noncoding RNA Loup Interacts with Runx1 and Regulates Long-Range Transcription of PU.1 in Acute Myeloid Leukemia

Bon Q Trinh, PhD, Pu Zhang, MD, Alexander Ebralidze, PhD, Junyan Zhang, Chan-Shuo Guo, Abby Thurm, Henry Yang, PhD, Ying Li, Annalisa Di Ruscio, MD, Daniel G. Tenen, MD

Blood (2018) 132 (Supplement 1): 1281.

https://doi.org/10.1182/blood-2018-99-120252

Published: 2018

Journal Articles

CRISPR/Cas9 Gene-Edited Hematopoietic Stem Cell Therapy for Sickle Cell Disease

Blood (2017) 130 (Supplement 1): 535.

https://doi.org/10.1182/blood.V130.Suppl_1.535.535

Published: 2017

Journal Articles

The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells

Philipp B. Staber, Pu Zhang, Min Ye, Robert S. Welner, Elena Levantini, Annalisa Di Ruscio, Alexander K. Ebralidze, Christian Bach, Hong Zhang, Junyan Zhang, Katrina Vanura, Ruud Delwel, Henry Yang, Gang Huang, Daniel G. Tenen

Blood (2014) 124 (15): 2391–2399.

https://doi.org/10.1182/blood-2014-01-550855

Published: 2014

Includes: Supplemental data

Journal Articles

The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations

Gang Huang, Xinghui Zhao, Lan Wang, Shannon Elf, Hao Xu, Xinyang Zhao, Goro Sashida, Yue Zhang, Yan Liu, Jennifer Lee, Silvia Menendez, Youyang Yang, Xiaomei Yan, Pu Zhang, Daniel G. Tenen, Motomi Osato, James J.-D. Hsieh, Stephen D. Nimer

Blood (2011) 118 (25): 6544–6552.

https://doi.org/10.1182/blood-2010-11-317909

Published: 2011

Includes: Supplemental data

Journal Articles

Runx1 Induced Chromatin Folding of the PU.1 Gene Locus Is Necessary for Adult Long-Term Hematopoietic Stem Cell Maintenance

Philipp B. Staber, M.D., Pu Zhang, M.D., Min Ye, PhD, Gang Huang, Annalisa Di Ruscio, MD, Alexander K Ebralidze, PhD, Daniel G. Tenen

Blood (2011) 118 (21): 2364.

https://doi.org/10.1182/blood.V118.21.2364.2364

Published: 2011

Journal Articles

PU.1 Is a Downstream Target of C/EBPα in Normal Hematopoiesis and Acute Myeloid Leukemia

Christian Bach, Ph.D., Philipp B. Staber, M.D., Min Ye, Ph.D., Pu Zhang, M.D., Alan D. Friedman, M.D., Ruud Delwel, Ph.D., Daniel G. Tenen

Blood (2011) 118 (21): 1353.

https://doi.org/10.1182/blood.V118.21.1353.1353

Published: 2011

Journal Articles

Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia

Florence C. Guibal, Meritxell Alberich-Jorda, Hideyo Hirai, Alexander Ebralidze, Elena Levantini, Annalisa Di Ruscio, Pu Zhang, Barbara A. Santana-Lemos, Donna Neuberg, Amy J. Wagers, Eduardo M. Rego, Daniel G. Tenen

Blood (2009) 114 (27): 5415–5425.

https://doi.org/10.1182/blood-2008-10-182071

Published: 2009

Includes: Supplemental data

Journal Articles

Increasing C/Ebpα Expression Regulates the Transition of Hematopoietic Stem Cells During Development.

Min Ye, PhD, Hong Zhang, PhD, Pu Zhang, MD, Daniel G. Tenen, MD

Blood (2009) 114 (22): 1506.

https://doi.org/10.1182/blood.V114.22.1506.1506

Published: 2009

Journal Articles

Autoregulation of the Transcription Factor PU.1 Via Its Evolutionarily Conserved Upstream Regulatory Element Is Critical in Adult Mouse Hematopoiesis.

Philipp B. Staber, M.D., Pu Zhang, M.D., Min Ye, Ph.D., Gang Huang, Ph.D., Boris Bartholdy, Ph.D., Annalisa DiRuscio, M.D., Alexander K. Ebralidze, Ph.D., Daniel G. Tenen, M.D.

Blood (2009) 114 (22): 1468.

https://doi.org/10.1182/blood.V114.22.1468.1468

Published: 2009

Journal Articles

Genetics and Epigenetics of the PU.1 Upstream Regulatory Element: AML1 Binding Sites Are Critical for Leuekmia Induced by the AML/ETO9a Fusion Oncogene

Pu Zhang, MD, Gang Huang, Alex Ebralidze, Jun-Yan Zhang, Annalisa DiRuscio, Chris Hetherington, Elena Levantini, Daniel G. Tenen

Blood (2008) 112 (11): 594.

https://doi.org/10.1182/blood.V112.11.594.594

Published: 2008

Journal Articles

Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1

Bas J. Wouters, Meritxell Alberich Jordà, Karen Keeshan, Irene Louwers, Claudia A. J. Erpelinck-Verschueren, Dennis Tielemans, Anton W. Langerak, Yiping He, Yumi Yashiro-Ohtani, Pu Zhang, Christopher J. Hetherington, Roel G. W. Verhaak, Peter J. M. Valk, Bob Löwenberg, Daniel G. Tenen, Warren S. Pear, Ruud Delwel

Blood (2007) 110 (10): 3706–3714.

https://doi.org/10.1182/blood-2007-02-073486

Published: 2007

Includes: Supplemental data

Journal Articles

Regulation of the PU.1 Gene by Sense and Functional Antisense RNAs Generated through the Same Chromatin Architecture.

Alex Ebralidze, PhD, Pu Zhang, MD, Frank Rosenbauer, Ph.D., Gang Huang, Ph.D., Ulrich Steidl, M.D., Tajhal Dayaram, B.S., Florence Guibal, Ph.D., Johanna Klupp, B.S., Dana Neel, Constanze Bonifer, Ph.D., Daniel G. Tenen, M.D.

Blood (2006) 108 (11): 781.

https://doi.org/10.1182/blood.V108.11.781.781

Published: 2006

Journal Articles

Complete Absence of the Lineage-Determining Transcription Factor C/EBPα Results in Loss of Myeloid Identity in Bcr/abl Induced Malignancy.

Katharina Wagner, MD, Pu Zhang, MD, Frank Rosenbauer, PhD, Bettina Drescher, PhD, Susumu Kobayashi, MD, Hanna S. Radomska, PhD, Jeffery L. Kutok, MD, Jürgen Krauter, MD, Daniel G. Tenen, MD

Blood (2005) 106 (11): 646.

https://doi.org/10.1182/blood.V106.11.646.646

Published: 2005

Journal Articles

3′ Distal Regulatory Elements Required for Human CD34 Expression in Transgenic Mice.

Elena Levantini, PhD, Yutaka Okuno, MD, PhD, Pu Zhang, MD, Steffen Koschmieder, MD, Hanna S. Radomska, PhD, Maris Fenyus, Maureen Guiney, Daniel G. Tenen, MD

Blood (2005) 106 (11): 125.

https://doi.org/10.1182/blood.V106.11.125.125

Published: 2005

Journal Articles

Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation

Hiromi Iwasaki, Chamorro Somoza, Hirokazu Shigematsu, Estelle A. Duprez, Junko Iwasaki-Arai, Shin-ichi Mizuno, Yojiro Arinobu, Kristin Geary, Pu Zhang, Tajhal Dayaram, Maris L. Fenyus, Shannon Elf, Susan Chan, Philippe Kastner, Claudia S. Huettner, Richard Murray, Daniel G. Tenen, Koichi Akashi

Blood (2005) 106 (5): 1590–1600.

https://doi.org/10.1182/blood-2005-03-0860

Published: 2005

Includes: Supplemental data

Journal Articles

Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogenesis

Steffen Koschmieder, Berthold Göttgens, Pu Zhang, Junko Iwasaki-Arai, Koichi Akashi, Jeffery L. Kutok, Tajhal Dayaram, Kristin Geary, Anthony R. Green, Daniel G. Tenen, Claudia S. Huettner

Blood (2005) 105 (1): 324–334.

https://doi.org/10.1182/blood-2003-12-4369

Published: 2005

NARROW

Genome-Wide Mapping of R-Loops in Single Cells Reveals Cell-Type Specific Roles for R-Loops in Hematopoietic Cell Identity

Genome-Wide CRISPR/Cas9 Knockout Screen Reveals Novel Gilteritinib Combinations Targeting Oxidative Phosphorylation and De-Novo Purine Biosynthesis Pathways for FLT3-ITD + Acute Myeloid Leukemia

Myeloid lncRNA LOUP mediates opposing regulatory effects of RUNX1 and RUNX1-ETO in t(8;21) AML

Identification of Novel Synthetic Lethal Partners of NAMPT Inhibitor By CRISPR-Cas9 Screens in Acute Myeloid Leukemia

Long Noncoding RNA Loup Interacts with Runx1 and Regulates Long-Range Transcription of PU.1 in Acute Myeloid Leukemia

CRISPR/Cas9 Gene-Edited Hematopoietic Stem Cell Therapy for Sickle Cell Disease

The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells

The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations

Runx1 Induced Chromatin Folding of the PU.1 Gene Locus Is Necessary for Adult Long-Term Hematopoietic Stem Cell Maintenance

PU.1 Is a Downstream Target of C/EBPα in Normal Hematopoiesis and Acute Myeloid Leukemia

Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia

Increasing C/Ebpα Expression Regulates the Transition of Hematopoietic Stem Cells During Development.

Autoregulation of the Transcription Factor PU.1 Via Its Evolutionarily Conserved Upstream Regulatory Element Is Critical in Adult Mouse Hematopoiesis.

Genetics and Epigenetics of the PU.1 Upstream Regulatory Element: AML1 Binding Sites Are Critical for Leuekmia Induced by the AML/ETO9a Fusion Oncogene

Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1

Regulation of the PU.1 Gene by Sense and Functional Antisense RNAs Generated through the Same Chromatin Architecture.

Complete Absence of the Lineage-Determining Transcription Factor C/EBPα Results in Loss of Myeloid Identity in Bcr/abl Induced Malignancy.

3′ Distal Regulatory Elements Required for Human CD34 Expression in Transgenic Mice.

Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation

Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogenesis

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American Society of Hematology

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American Society of Hematology

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